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  1. Article ; Online: NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma.

    Zhang, Meixia / Wang, Zhonghou / Yang, Guang / Han, Linfu / Wang, Xiaofeng

    Journal of bioenergetics and biomembranes

    2023  Volume 55, Issue 6, Page(s) 467–478

    Abstract: Oral squamous cell carcinoma (OSCC) is a common head and neck malignancy with increasing mortality and high recurrence. In this work, we aim to explore the functional role of NFE2 like bZIP transcription factor 1 (NFE2L1) in OSCC progression. Based on ... ...

    Abstract Oral squamous cell carcinoma (OSCC) is a common head and neck malignancy with increasing mortality and high recurrence. In this work, we aim to explore the functional role of NFE2 like bZIP transcription factor 1 (NFE2L1) in OSCC progression. Based on databases analysis, we found that NFE2L1 was overexpressed in OSCC tumor tissues, and elevated NFE2L1 level induced poor prognosis of OSCC patients. Our results showed that NFE2L1 is upregulated in OSCC cells and overexpression of NFE2L1 promotes cell proliferation, and reduces the sensitivity of OSCC cells to erastin-induced ferroptosis. NFE2L1 upregulation decreased the levels of Fe
    MeSH term(s) Humans ; Carcinoma, Squamous Cell/pathology ; Squamous Cell Carcinoma of Head and Neck/genetics ; Mouth Neoplasms/metabolism ; Ferroptosis ; Cell Line, Tumor ; Cell Proliferation ; Head and Neck Neoplasms ; MicroRNAs/metabolism ; Gene Expression Regulation, Neoplastic ; Cell Movement ; NF-E2-Related Factor 1/metabolism
    Chemical Substances MicroRNAs ; NFE2L1 protein, human ; NF-E2-Related Factor 1
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 198499-8
    ISSN 1573-6881 ; 0145-479X ; 0449-5705
    ISSN (online) 1573-6881
    ISSN 0145-479X ; 0449-5705
    DOI 10.1007/s10863-023-09987-2
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Education can improve response to flash floods.

    Wang, Lu / Nie, Ruihua / Slater, Louise J / Xu, Zhonghou / Guan, Dawei / Yang, Yifan

    Science (New York, N.Y.)

    2022  Volume 377, Issue 6613, Page(s) 1391–1392

    MeSH term(s) Animals ; Civil Defense/education ; Disasters ; Floods ; Humans ; Rivers
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Letter
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.ade6616
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  3. Article: The Role of IAA in Regulating Root Architecture of Sweetpotato (

    Liu, Ming / Zhang, Qiangqiang / Jin, Rong / Zhao, Peng / Zhu, Xiaoya / Wang, Jing / Yu, Yongchao / Tang, Zhonghou

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: Plants can adapt to the spatial heterogeneity of soil nutrients by changing the morphology and architecture of the root system. Here, we explored the role of auxin in the response of sweetpotato roots to potassium ( ... ...

    Abstract Plants can adapt to the spatial heterogeneity of soil nutrients by changing the morphology and architecture of the root system. Here, we explored the role of auxin in the response of sweetpotato roots to potassium (K
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12091779
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  4. Article ; Online: Long-Term Organic Fertilization Strengthens the Soil Phosphorus Cycle and Phosphorus Availability by Regulating the pqqC- and phoD-Harboring Bacterial Communities.

    Wang, Lei / Wang, Jing / Yuan, Jie / Tang, Zhonghou / Wang, Jidong / Zhang, Yongchun

    Microbial ecology

    2023  Volume 86, Issue 4, Page(s) 2716–2732

    Abstract: The pqqC and phoD genes encode pyrroloquinoline quinone synthase and alkaline phosphomonoesterase (ALP), respectively. These genes play a crucial role in regulating the solubilization of inorganic phosphorus (Pi) and the mineralization of organic ... ...

    Abstract The pqqC and phoD genes encode pyrroloquinoline quinone synthase and alkaline phosphomonoesterase (ALP), respectively. These genes play a crucial role in regulating the solubilization of inorganic phosphorus (Pi) and the mineralization of organic phosphorus (Po), making them valuable markers for P-mobilizing bacterial. However, there is limited understanding of how the interplay between soil P-mobilizing bacterial communities and abiotic factors influences P transformation and availability in the context of long-term fertilization scenarios. We used real-time polymerase chain reaction and high-throughput sequencing to explore the characteristics of soil P-mobilizing bacterial communities and their relationships with key physicochemical properties and P fractions under long-term fertilization scenarios. In a 38-year fertilization experiment, six fertilization treatments were selected. These treatments were sorted into three groups: the non-P-amended group, including no fertilization and mineral NK fertilizer; the sole mineral-P-amended group, including mineral NP and NPK fertilizer; and the organically amended group, including sole organic fertilizer and organic fertilizer plus mineral NPK fertilizer. The organically amended group significantly increased soil labile P (Ca
    MeSH term(s) Soil/chemistry ; Phosphorus/metabolism ; Fertilizers/analysis ; Carbon ; Bacteria/genetics ; Bacteria/metabolism ; Soil Microbiology ; Minerals ; Fertilization
    Chemical Substances Soil ; Phosphorus (27YLU75U4W) ; Fertilizers ; Carbon (7440-44-0) ; Minerals
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1462065-0
    ISSN 1432-184X ; 0095-3628
    ISSN (online) 1432-184X
    ISSN 0095-3628
    DOI 10.1007/s00248-023-02279-7
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  5. Article ; Online: Comparative physiological and transcriptome analysis between potassium-deficiency tolerant and sensitive sweetpotato genotypes in response to potassium-deficiency stress.

    Jin, Rong / Yan, Mengxiao / Li, Guanghua / Liu, Ming / Zhao, Peng / Zhang, Zhe / Zhang, Qiangqiang / Zhu, Xiaoya / Wang, Jing / Yu, Yongchao / Zhang, Aijun / Yang, Jun / Tang, Zhonghou

    BMC genomics

    2024  Volume 25, Issue 1, Page(s) 61

    Abstract: Background: Sweetpotato is a typical ''potassium (K: Result: We found Xu32 had the higher capability of K: Conclusions: The common and distinct expression pattern between the two sweetpotato genotypes illuminate a complex mechanism response to low ...

    Abstract Background: Sweetpotato is a typical ''potassium (K
    Result: We found Xu32 had the higher capability of K
    Conclusions: The common and distinct expression pattern between the two sweetpotato genotypes illuminate a complex mechanism response to low potassium exist in sweetpotato. The study provides some candidate genes, which can be used in sweetpotato breeding program for improving low potassium stress tolerance.
    MeSH term(s) Gene Expression Regulation, Plant ; Gene Expression Profiling ; Genotype ; Potassium/metabolism ; Photosynthesis/genetics ; Transcriptome ; Stress, Physiological/genetics
    Chemical Substances Potassium (RWP5GA015D)
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-023-09939-5
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  6. Article: A Novel High-Affinity Potassium Transporter

    Jiang, Wei / Jin, Rong / Wang, Danfeng / Yang, Yufeng / Zhao, Peng / Liu, Ming / Zhang, Aijun / Tang, Zhonghou

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: The high-affinity potassium transporters (HKT) mediate ... ...

    Abstract The high-affinity potassium transporters (HKT) mediate K
    Language English
    Publishing date 2022-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11111389
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  7. Article: Taste papilla cell differentiation requires tongue mesenchyme via ALK3-BMP signaling to regulate the production of secretory proteins.

    Ishan, Mohamed / Wang, Zhonghou / Zhao, Peng / Yao, Yao / Stice, Steven / Wells, Lance / Mishina, Yuji / Liu, Hong-Xiang

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Taste papillae are specialized organs each of which is comprised of an epithelial wall hosting taste buds and a core of mesenchymal tissue. In the present study, we report that during the early stages of embryonic development, bone morphogenetic protein ( ...

    Abstract Taste papillae are specialized organs each of which is comprised of an epithelial wall hosting taste buds and a core of mesenchymal tissue. In the present study, we report that during the early stages of embryonic development, bone morphogenetic protein (BMP) signaling mediated by type 1 receptor ALK3 in the tongue mesenchyme is required for the epithelial Wnt/β-catenin activity and taste papilla cell differentiation. Mesenchyme-specific knockout (
    Summary statement: This is the first set of data to implicate the requirement of tongue mesenchyme in taste papilla cell differentiation.
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.03.535414
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  8. Article: LncRNA LINC01134 Contributes to Radioresistance in Hepatocellular Carcinoma by Regulating DNA Damage Response

    Wang, Zhiyi / Wang, Xinxing / Rong, Zhonghou / Dai, Longfei / Qin, Chengkun / Wang, Shikang / Geng, Wenmao

    Frontiers in pharmacology

    2022  Volume 12, Page(s) 791889

    Abstract: Hepatocellular carcinoma (HCC) is a highly mortal cancer that could be treated by radiotherapy. DNA damage response (DDR) is a vital factor affecting cancer development after radiotherapy. Long non-coding RNAs (lncRNAs) have been revealed to regulate DNA ...

    Abstract Hepatocellular carcinoma (HCC) is a highly mortal cancer that could be treated by radiotherapy. DNA damage response (DDR) is a vital factor affecting cancer development after radiotherapy. Long non-coding RNAs (lncRNAs) have been revealed to regulate DNA damage response and repair in cancer cells. Nevertheless, the function of long intergenic non-protein coding RNA 1134 (LINC01134) has not been explored in DDR. In this study, we targeted digging into the function of LINC01134 in DDR and exploring the underlying mechanism in HCC cells. RT-qPCR was employed to measure LINC01134 expression, and we found LINC01134 was significantly upregulated in HCC cells. Functional analysis suggested that LINC01134 depletion attenuated radioresistance of HCC cells by facilitating DNA damage.
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.791889
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  9. Article: Creation of a watermelon haploid inducer line via

    Chen, Xiner / Li, Yuxiu / Ai, Gongli / Chen, Jinfan / Guo, Dalong / Zhu, Zhonghou / Zhu, Xuejie / Tian, Shujuan / Wang, Jiafa / Liu, Man / Yuan, Li

    Horticulture research

    2023  Volume 10, Issue 6, Page(s) uhad081

    Abstract: The use of doubled haploids is one of the most efficient breeding methods in modern agriculture. Irradiation of pollen grains has been shown to induce haploids in cucurbit crops, possibly because it causes preferential fertilization of the central cell ... ...

    Abstract The use of doubled haploids is one of the most efficient breeding methods in modern agriculture. Irradiation of pollen grains has been shown to induce haploids in cucurbit crops, possibly because it causes preferential fertilization of the central cell over the egg cell. Disruption of the
    Language English
    Publishing date 2023-04-19
    Publishing country England
    Document type Journal Article
    ISSN 2662-6810
    ISSN 2662-6810
    DOI 10.1093/hr/uhad081
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  10. Article ; Online: Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme.

    Ishan, Mohamed / Wang, Zhonghou / Zhao, Peng / Yao, Yao / Stice, Steven L / Wells, Lance / Mishina, Yuji / Liu, Hong-Xiang

    Development (Cambridge, England)

    2023  Volume 150, Issue 18

    Abstract: Taste papillae are specialized organs, each of which comprises an epithelial wall hosting taste buds and a core of mesenchymal tissue. In the present study, we report that during early taste papilla development in mouse embryos, bone morphogenetic ... ...

    Abstract Taste papillae are specialized organs, each of which comprises an epithelial wall hosting taste buds and a core of mesenchymal tissue. In the present study, we report that during early taste papilla development in mouse embryos, bone morphogenetic protein (BMP) signaling mediated by type 1 receptor ALK3 in the tongue mesenchyme is required for epithelial Wnt/β-catenin activity and taste papilla differentiation. Mesenchyme-specific knockout (cKO) of Alk3 using Wnt1-Cre and Sox10-Cre resulted in an absence of taste papillae at E12.0. Biochemical and cell differentiation analyses demonstrated that mesenchymal ALK3-BMP signaling governed the production of previously unappreciated secretory proteins, i.e. it suppressed those that inhibit and facilitated those that promote taste papilla differentiation. Bulk RNA-sequencing analysis revealed many more differentially expressed genes (DEGs) in the tongue epithelium than in the mesenchyme in Alk3 cKO versus control. Moreover, we detected downregulated epithelial Wnt/β-catenin signaling and found that taste papilla development in the Alk3 cKO was rescued by the GSK3β inhibitor LiCl, but not by Wnt3a. Our findings demonstrate for the first time the requirement of tongue mesenchyme in taste papilla cell differentiation.
    MeSH term(s) Animals ; Mice ; Taste Buds ; beta Catenin ; Taste ; Tongue ; Cell Differentiation/genetics ; Mesoderm
    Chemical Substances beta Catenin
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.201838
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