LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 16

Search options

  1. Article ; Online: Author Correction: Generation of human islet cell type-specific identity genesets.

    van Gurp, Léon / Fodoulian, Leon / Oropeza, Daniel / Furuyama, Kenichiro / Bru-Tari, Eva / Vu, Anh Nguyet / Kaddis, John S / Rodríguez, Iván / Thorel, Fabrizio / Herrera, Pedro L

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2574

    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46525-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Publisher Correction: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

    Horgue, Luis Flores / Assens, Alexis / Fodoulian, Leon / Marconi, Leonardo / Tuberosa, Joël / Haider, Alexander / Boillat, Madlaina / Carleton, Alan / Rodriguez, Ivan

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1156

    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36849-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.

    Dietschi, Quentin / Tuberosa, Joël / Fodoulian, Leon / Boillat, Madlaina / Kan, Chenda / Codourey, Julien / Pauli, Véronique / Feinstein, Paul / Carleton, Alan / Rodriguez, Ivan

    Science advances

    2022  Volume 8, Issue 46, Page(s) eabn7450

    Abstract: Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered ... ...

    Abstract Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abn7450
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity.

    Horgue, Luis Flores / Assens, Alexis / Fodoulian, Leon / Marconi, Leonardo / Tuberosa, Joël / Haider, Alexander / Boillat, Madlaina / Carleton, Alan / Rodriguez, Ivan

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2929

    Abstract: In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities ... ...

    Abstract In mammals, chemoperception relies on a diverse set of neuronal sensors able to detect chemicals present in the environment, and to adapt to various levels of stimulation. The contribution of endogenous and external factors to these neuronal identities remains to be determined. Taking advantage of the parallel coding lines present in the olfactory system, we explored the potential variations of neuronal identities before and after olfactory experience. We found that at rest, the transcriptomic profiles of mouse olfactory sensory neuron populations are already divergent, specific to the olfactory receptor they express, and are associated with the sequence of these latter. These divergent profiles further evolve in response to the environment, as odorant exposure leads to reprogramming via the modulation of transcription. These findings highlight a broad range of sensory neuron identities that are present at rest and that adapt to the experience of the individual, thus adding to the complexity and flexibility of sensory coding.
    MeSH term(s) Animals ; Mammals ; Mice ; Odorants ; Olfactory Receptor Neurons/physiology ; Receptors, Odorant/genetics ; Sensory Receptor Cells ; Smell
    Chemical Substances Receptors, Odorant
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30511-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Generation of human islet cell type-specific identity genesets.

    van Gurp, Léon / Fodoulian, Leon / Oropeza, Daniel / Furuyama, Kenichiro / Bru-Tari, Eva / Vu, Anh Nguyet / Kaddis, John S / Rodríguez, Iván / Thorel, Fabrizio / Herrera, Pedro L

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2020

    Abstract: Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity. Here, we ... ...

    Abstract Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity. Here, we conduct a thorough single-cell transcriptomics meta-analysis to identify robustly expressed markers used to build genesets describing the identity of human α-, β-, γ- and δ-cells. These genesets define islet cellular identities better than previously published genesets. We show their efficacy to outline cell identity changes and unravel some of their underlying genetic mechanisms, whether during embryonic pancreas development or in experimental setups aiming at developing glucose-responsive insulin-secreting cells, such as pluripotent stem-cell differentiation or in adult islet cell reprogramming protocols. These islet cell type-specific genesets represent valuable tools that accurately benchmark gain and loss in islet cell identity traits.
    MeSH term(s) Cell Differentiation/genetics ; Humans ; Insulin/genetics ; Insulin-Secreting Cells ; Islets of Langerhans ; Pluripotent Stem Cells
    Chemical Substances Insulin
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29588-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Dynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning.

    Chéreau, Ronan / Bawa, Tanika / Fodoulian, Leon / Carleton, Alan / Pagès, Stéphane / Holtmaat, Anthony

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 3245

    Abstract: Neurons in primary sensory cortex encode a variety of stimulus features upon perceptual learning. However, it is unclear whether the acquired stimulus selectivity remains stable when the same input is perceived in a different context. Here, we monitor ... ...

    Abstract Neurons in primary sensory cortex encode a variety of stimulus features upon perceptual learning. However, it is unclear whether the acquired stimulus selectivity remains stable when the same input is perceived in a different context. Here, we monitor the activity of individual neurons in the mouse primary somatosensory cortex during reward-based texture discrimination. We track their stimulus selectivity before and after changing reward contingencies, which allows us to identify various classes of neurons. We find neurons that stably represented a texture or the upcoming behavioral choice, but the majority is dynamic. Among those, a subpopulation of neurons regains texture selectivity contingent on the associated reward value. These value-sensitive neurons forecast the onset of learning by displaying a distinct and transient increase in activity, depending on past behavioral experience. Thus, stimulus selectivity of excitatory neurons during perceptual learning is dynamic and largely relies on behavioral contingencies, even in primary sensory cortex.
    MeSH term(s) Animals ; Behavior, Animal ; Calcium Signaling ; Choice Behavior ; Discrimination, Psychological ; Male ; Mice, Inbred C57BL ; Neurons/physiology ; Perception/physiology ; Reversal Learning/physiology ; Reward ; Sensation ; Somatosensory Cortex/physiology ; Time Factors
    Language English
    Publishing date 2020-06-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-17005-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Transcriptional adaptation of olfactory sensory neurons to GPCR identity and activity

    Luis Flores Horgue / Alexis Assens / Leon Fodoulian / Leonardo Marconi / Joël Tuberosa / Alexander Haider / Madlaina Boillat / Alan Carleton / Ivan Rodriguez

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 16

    Abstract: Olfaction in mammals relies on a toolbox composed of a varied set of sensory neurons. Here, the authors report in mice that this olfactory neuronal diversity relies both on the chemoreceptor that each neuron expresses and on the experience of this neuron. ...

    Abstract Olfaction in mammals relies on a toolbox composed of a varied set of sensory neurons. Here, the authors report in mice that this olfactory neuronal diversity relies both on the chemoreceptor that each neuron expresses and on the experience of this neuron.
    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Generation of human islet cell type-specific identity genesets

    Léon van Gurp / Leon Fodoulian / Daniel Oropeza / Kenichiro Furuyama / Eva Bru-Tari / Anh Nguyet Vu / John S. Kaddis / Iván Rodríguez / Fabrizio Thorel / Pedro L. Herrera

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: Cell therapy to replace β-cells is a potential therapeutic avenue to treat diabetes, but the production of insulin-secreting replacement cells requires reliable tools to assess islet cellular identity. Here the authors use single-cell transcriptomics ... ...

    Abstract Cell therapy to replace β-cells is a potential therapeutic avenue to treat diabetes, but the production of insulin-secreting replacement cells requires reliable tools to assess islet cellular identity. Here the authors use single-cell transcriptomics meta-analysis to construct gene sets that describe the identity of human α-, β-, γ- and δ-cells.
    Keywords Science ; Q
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Dynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning

    Ronan Chéreau / Tanika Bawa / Leon Fodoulian / Alan Carleton / Stéphane Pagès / Anthony Holtmaat

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 14

    Abstract: Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the ... ...

    Abstract Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the associated reward and forecasts the onset of learning.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Dynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning

    Ronan Chéreau / Tanika Bawa / Leon Fodoulian / Alan Carleton / Stéphane Pagès / Anthony Holtmaat

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 14

    Abstract: Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the ... ...

    Abstract Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the associated reward and forecasts the onset of learning.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top