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Book ; Online ; Conference proceedings: MEDINFO 2017 : Precision healthcare trough informatics

Gundlapalli, Adi V. / Jaulent, Marie-Christine / Zhao, Dong-sheng

proceedings of the 16th World Congress on Medical and Health Informatics

(Studies in health technology and informatics ; 245)

2017

Event/congress	World Congress on Medical and Health Informatics (16., 2017, Hangzhou)
Author's details	Edited by Adi V. Gundlapalli, Marie-Christine Jaulent and Dongsheng Zhao
Series title	Studies in health technology and informatics ; 245
Collection
Language	English
Size	1 Online-Ressource (xxxvi, 1440 Seiten)
Publisher	IOS Press
Publishing place	Amsterdam ; Berlin ; Tokyo ; Washington, DC
Publishing country	China
Document type	Book ; Online ; Conference proceedings
Note	kostenfreier Zugang nach Registrierung
HBZ-ID	HT019633571
ISBN	978-1-61499-830-3 ; 9781614998297 ; 1-61499-830-2 ; 1614998299
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Severity Outcomes among Adult Patients with Primary Immunodeficiency and COVID-19 Seen in Emergency Departments, United States, April 2020-August 2021.

Drzymalla, Emily / Moonesinghe, Ramal / Kolor, Katherine / Khoury, Muin J / Schieber, Lyna / Gundlapalli, Adi V

Journal of clinical medicine

2023 Volume 12, Issue 10

Abstract: Primary immunodeficiencies (PIs) are a group of diseases that increase susceptibility to infectious diseases. Few studies have examined the relationship between PI and COVID-19 outcomes. In this study, we used Premier Healthcare Database, which contains ... ...

Abstract	Primary immunodeficiencies (PIs) are a group of diseases that increase susceptibility to infectious diseases. Few studies have examined the relationship between PI and COVID-19 outcomes. In this study, we used Premier Healthcare Database, which contains information on inpatient discharges, to analyze COVID-19 outcomes among 853 adult PI and 1,197,430 non-PI patients who visited the emergency department. Hospitalization, intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and death had higher odds in PI patients than in non-PI patients (hospitalization aOR: 2.36, 95% CI: 1.87-2.98; ICU admission aOR: 1.53, 95% CI: 1.19-1.96; IMV aOR: 1.41, 95% CI: 1.15-1.72; death aOR: 1.37, 95% CI: 1.08-1.74), and PI patients spent on average 1.91 more days in the hospital than non-PI patients when adjusted for age, sex, race/ethnicity, and chronic conditions associated with severe COVID-19. Of the largest four PI groups, selective deficiency of the immunoglobulin G subclass had the highest hospitalization frequency (75.2%). This large study of United States PI patients provides real-world evidence that PI is a risk factor for adverse COVID-19 outcomes.
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12103516
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Increased Hospitalizations Involving Fungal Infections during COVID-19 Pandemic, United States, January 2020-December 2021.

Gold, Jeremy A W / Adjei, Stacey / Gundlapalli, Adi V / Huang, Ya-Lin A / Chiller, Tom / Benedict, Kaitlin / Toda, Mitsuru

Emerging infectious diseases

2023 Volume 29, Issue 7, Page(s) 1433–1437

Abstract: Hospitalizations involving fungal infections increased 8.5% each year in the United States during 2019-2021. During 2020-2021, patients hospitalized with COVID-19-associated fungal infections had higher (48.5%) in-hospital mortality rates than those with ...

Abstract	Hospitalizations involving fungal infections increased 8.5% each year in the United States during 2019-2021. During 2020-2021, patients hospitalized with COVID-19-associated fungal infections had higher (48.5%) in-hospital mortality rates than those with non-COVID-19-associated fungal infections (12.3%). Improved fungal disease surveillance is needed, particularly during respiratory virus pandemics.
MeSH term(s)	Humans ; United States/epidemiology ; Pandemics ; Aspergillosis ; Histoplasmosis ; Coccidioidomycosis ; Blastomycosis ; Mucormycosis ; Cryptococcosis ; Nocardia Infections ; Actinomycosis ; COVID-19/epidemiology ; Mycoses/epidemiology
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2907.221771
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Article ; Online: Digital Health COVID-19 Impact Assessment: Lessons Learned and Compelling Needs.

Lee, Peter / Abernethy, Amy / Shaywitz, David / Gundlapalli, Adi V / Weinstein, Jim / Doraiswamy, P Murali / Schulman, Kevin / Madhavan, Subha

NAM perspectives

2022 Volume 2022

Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2578-6865
ISSN (online)	2578-6865
DOI	10.31478/202201c
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Article ; Online: Deployment of the National Notifiable Diseases Surveillance System during the 2022-23 mpox outbreak in the United States-Opportunities and challenges with case notifications during public health emergencies.

Rainey, Jeanette J / Lin, Xia Michelle / Murphy, Sylvia / Velazquez-Kronen, Raquel / Do, Tuyen / Hughes, Christine / Harris, Aaron M / Maitland, Aaron / Gundlapalli, Adi V

PloS one

2024 Volume 19, Issue 4, Page(s) e0300175

Abstract: Timely case notifications following the introduction of an uncommon pathogen, such as mpox, are critical for understanding disease transmission and for developing and implementing effective mitigation strategies. When Massachusetts public health ... ...

Abstract	Timely case notifications following the introduction of an uncommon pathogen, such as mpox, are critical for understanding disease transmission and for developing and implementing effective mitigation strategies. When Massachusetts public health officials notified the Centers for Disease Control and Prevention (CDC) about a confirmed orthopoxvirus case on May 17, 2023, which was later confirmed as mpox at CDC, mpox was not a nationally notifiable disease. Because existing processes for new data collections through the National Notifiable Disease Surveillance System were not well suited for implementation during emergency responses at the time of the mpox outbreak, several interim notification approaches were established to capture case data. These interim approaches were successful in generating daily case counts, monitoring disease transmission, and identifying high-risk populations. However, the approaches also required several data collection approvals by the federal government and the Council for State and Territorial Epidemiologists, the use of four different case report forms, and the establishment of complex data management and validation processes involving data element mapping and record-level de-duplication steps. We summarize lessons learned from these interim approaches to inform and improve case notifications during future outbreaks. These lessons reinforce CDC's Data Modernization Initiative to work in close collaboration with state, territorial, and local public health departments to strengthen case-based surveillance prior to the next public health emergency.
MeSH term(s)	United States/epidemiology ; Humans ; Public Health ; Emergencies ; Mpox (monkeypox) ; Disease Outbreaks ; Massachusetts/epidemiology ; Population Surveillance
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300175
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Article ; Online: Literature Review of Pathogen Agnostic Molecular Testing of Clinical Specimens From Difficult-to-Diagnose Patients: Implications for Public Health.

Downie, Diane L / Rao, Preetika / David-Ferdon, Corinne / Courtney, Sean / Lee, Justin S / Kugley, Shannon / MacDonald, Pia D M / Barnes, Keegan / Fisher, Shelby / Andreadis, Joanne L / Chaitram, Jasmine / Mauldin, Matthew R / Salerno, Reynolds M / Schiffer, Jarad / Gundlapalli, Adi V

Health security

2024 Volume 22, Issue 2, Page(s) 93–107

Abstract: To better identify emerging or reemerging pathogens in patients with difficult-to-diagnose infections, it is important to improve access to advanced molecular testing methods. This is particularly relevant for cases where conventional microbiologic ... ...

Abstract	To better identify emerging or reemerging pathogens in patients with difficult-to-diagnose infections, it is important to improve access to advanced molecular testing methods. This is particularly relevant for cases where conventional microbiologic testing has been unable to detect the pathogen and the patient's specimens test negative. To assess the availability and utility of such testing for human clinical specimens, a literature review of published biomedical literature was conducted. From a corpus of more than 4,000 articles, a set of 34 reports was reviewed in detail for data on where the testing was being performed, types of clinical specimens tested, pathogen agnostic techniques and methods used, and results in terms of potential pathogens identified. This review assessed the frequency of advanced molecular testing, such as metagenomic next generation sequencing that has been applied to clinical specimens for supporting clinicians in caring for difficult-to-diagnose patients. Specimen types tested were from cerebrospinal fluid, respiratory secretions, and other body tissues and fluids. Publications included case reports and series, and there were several that involved clinical trials, surveillance studies, research programs, or outbreak situations. Testing identified both known human pathogens (sometimes in new sites) and previously unknown human pathogens. During this review, there were no apparent coordinated efforts identified to develop regional or national reports on emerging or reemerging pathogens. Therefore, development of a coordinated sentinel surveillance system that applies advanced molecular methods to clinical specimens which are negative by conventional microbiological diagnostic testing would provide a foundation for systematic characterization of emerging and underdiagnosed pathogens and contribute to national biodefense strategy goals.
MeSH term(s)	Humans ; Public Health ; Molecular Diagnostic Techniques ; Disease Outbreaks/prevention & control ; Metagenomics/methods ; High-Throughput Nucleotide Sequencing
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2823049-8
ISSN	2326-5108 ; 2326-5094
ISSN (online)	2326-5108
ISSN	2326-5094
DOI	10.1089/hs.2023.0100
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Surveillance for Emerging and Reemerging Pathogens Using Pathogen Agnostic Metagenomic Sequencing in the United States: A Critical Role for Federal Government Agencies.

Downie, Diane L / Rao, Preetika / David-Ferdon, Corinne / Courtney, Sean / Lee, Justin S / Quiner, Claire / MacDonald, Pia D M / Barnes, Keegan / Fisher, Shelby / Andreadis, Joanne L / Chaitram, Jasmine / Mauldin, Matthew R / Salerno, Reynolds M / Schiffer, Jarad / Gundlapalli, Adi V

Health security

2024 Volume 22, Issue 2, Page(s) 85–92

Abstract: The surveillance and identification of emerging, reemerging, and unknown infectious disease pathogens is essential to national public health preparedness and relies on fluidity, coordination, and interconnectivity between public and private pathogen ... ...

Abstract	The surveillance and identification of emerging, reemerging, and unknown infectious disease pathogens is essential to national public health preparedness and relies on fluidity, coordination, and interconnectivity between public and private pathogen surveillance systems and networks. Developing a national sentinel surveillance network with existing resources and infrastructure could increase efficiency, accelerate the identification of emerging public health threats, and support coordinated intervention strategies that reduce morbidity and mortality. However, implementing and sustaining programs to detect emerging and reemerging pathogens in humans using advanced molecular methods, such as metagenomic sequencing, requires making large investments in testing equipment and developing networks of clinicians, laboratory scientists, and bioinformaticians. In this study, we sought to gain an understanding of how federal government agencies currently support such pathogen agnostic testing of human specimens in the United States. We conducted a landscape analysis of federal agency websites for publicly accessible information on the availability and type of pathogen agnostic testing and details on flow of clinical specimens and data. The website analysis was supplemented by an expert review of results with representatives from the federal agencies. Operating divisions within the US Department of Health and Human Services and the US Department of Veterans Affairs have developed and sustained extensive clinical and research networks to obtain patient specimens and perform metagenomic sequencing. Metagenomic facilities supported by US agencies were not equally geographically distributed across the United States. Although many entities have work dedicated to metagenomics and/or support emerging infectious disease surveillance specimen collection, there was minimal formal collaboration across agencies.
MeSH term(s)	Humans ; United States ; Communicable Diseases/epidemiology ; Government Agencies ; Federal Government ; Public Health
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2823049-8
ISSN	2326-5108 ; 2326-5094
ISSN (online)	2326-5108
ISSN	2326-5094
DOI	10.1089/hs.2023.0099
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Incidence of cancer among U.S. combat casualties: a DoD Trauma Registry study.

DeStefano, Christin B / Shaw, Krista / Gundlapalli, Adi V / Chung, Kevin K / Poltavskiy, Eduard / Stewart, Ian J

American journal of hematology

2021 Volume 96, Issue 9, Page(s) E324–E327

MeSH term(s)	Adult ; Female ; Humans ; Incidence ; Male ; Military Personnel ; Neoplasms/complications ; Neoplasms/epidemiology ; Registries ; United States/epidemiology ; United States Department of Defense ; Wounds and Injuries/complications ; Wounds and Injuries/epidemiology ; Young Adult
Language	English
Publishing date	2021-06-08
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.26252
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long-Term Health Care Costs for Service Members Injured in Iraq and Afghanistan.

Stewart, Ian J / Ambardar, Shiva / Howard, Jeffrey T / Janak, Jud C / Walker, Lauren E / Poltavskiy, Eduard / Alcover, Karl C / Watrous, Jessica / V Gundlapalli, Adi / B P Pettey, Warren / Suo, Ying / Nelson, Richard E

Military medicine

2023

Abstract: Introduction: Over the last two decades, the conflicts in Iraq and Afghanistan have cost the United States significantly in terms of lives lost, disabling injuries, and budgetary expenditures. This manuscript calculates the differences in costs between ... ...

Abstract	Introduction: Over the last two decades, the conflicts in Iraq and Afghanistan have cost the United States significantly in terms of lives lost, disabling injuries, and budgetary expenditures. This manuscript calculates the differences in costs between veterans with combat injuries vs veterans without combat injuries. This work could be used to project future costs in subsequent studies. Materials and methods: In this retrospective cohort study, we randomly selected 7,984 combat-injured veterans between February 1, 2002, and June 14, 2016, from Veterans Affairs Health System administrative data. We matched injured veterans 1:1 to noninjured veterans on year of birth (± 1 year), sex, and first service branch. We observed patients for a maximum of 10 years. This research protocol was reviewed and approved by the David Grant USAF Medical Center institutional review board (IRB), the University of Utah IRB, and the Research Review Committee of the VA Salt Lake City Health Care System in accordance with all applicable Federal regulations. Results: Patients were primarily male (98.1% in both groups) and White (76.4% for injured patients, 72.3% for noninjured patients), with a mean (SD) age of 26.8 (6.6) years for the injured group and 27.7 (7.0) years for noninjured subjects. Average total costs for combat-injured service members were higher for each year studied. The difference was highest in the first year ($16,050 compared to $4,135 for noninjured). These differences remained significant after adjustment. Although this difference was greatest in the first year (marginal effect $12,386, 95% confidence interval $9,736-$15,036; P < 0.001), total costs continued to be elevated in years 2-10, with marginal effects ranging from $1,766 to $2,597 (P < 0.001 for all years). More severe injuries tended to increase costs in all categories. Conclusions: Combat injured patients have significantly higher long-term health care costs compared to their noninjured counterparts. If this random sample is extrapolated to the 53,251 total of combat wounded service members, it implies a total excess cost of $1.6 billion to date after adjustment for covariates and a median follow-up time of 10 years. These costs are likely to increase as injured veterans age and develop additional chronic conditions.
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usad008
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Article ; Online: Potential for Recurrent Mpox Outbreaks Among Gay, Bisexual, and Other Men Who Have Sex with Men - United States, 2023.

Pollock, Emily D / Clay, Patrick A / Keen, Adrienne / Currie, Dustin W / Carter, Rosalind J / Quilter, Laura A S / Gundlapalli, Adi V / Mermin, Jonathan / Spicknall, Ian H

MMWR. Morbidity and mortality weekly report

2023 Volume 72, Issue 21, Page(s) 568–573

Abstract: More than 30,000 monkeypox (mpox) cases have been diagnosed in the United States since May 2022, primarily among gay, bisexual, and other men who have sex with men (MSM) (1,2). In recent months, diagnoses have declined to one case per day on average. ... ...

Abstract	More than 30,000 monkeypox (mpox) cases have been diagnosed in the United States since May 2022, primarily among gay, bisexual, and other men who have sex with men (MSM) (1,2). In recent months, diagnoses have declined to one case per day on average. However, mpox vaccination coverage varies regionally, suggesting variable potential risk for mpox outbreak recurrence (3). CDC simulated dynamic network models representing sexual behavior among MSM to estimate the risk for and potential size of recurrent mpox outbreaks at the jurisdiction level for 2023 and to evaluate the benefits of vaccination for preparedness against mpox reintroduction. The risk for outbreak recurrence after mpox reintroduction is linearly (inversely) related to the proportion of MSM who have some form of protective immunity: the higher the population prevalence of immunity (from vaccination or natural infection), the lower the likelihood of recurrence in that jurisdiction across all immunity levels modeled. In contrast, the size of a potential recurrent outbreak might have thresholds: very small recurrences are predicted for jurisdictions with mpox immunity of 50%-100%; exponentially increasing sizes of recurrences are predicted for jurisdictions with 25%-50% immunity; and linearly increasing sizes of recurrences are predicted for jurisdictions with <25% immunity. Among the 50 jurisdictions examined, 15 are predicted to be at minimal risk for recurrence because of their high levels of population immunity. This analysis underscores the ongoing need for accessible and sustained mpox vaccination to decrease the risk for and potential size of future mpox recurrences.
MeSH term(s)	Humans ; Male ; Disease Outbreaks/prevention & control ; Homosexuality, Male ; Mpox (monkeypox)/epidemiology ; Recurrence ; Sexual and Gender Minorities ; Sexual Behavior ; United States/epidemiology
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm7221a1
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