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  1. Article ; Online: Metabolomic analysis reveals a protective effect of Fu-Fang-Jin-Qian-Chao herbal granules on oxalate-induced kidney injury.

    Chen, Wei / Liu, Wen-Rui / Hou, Jie-Bin / Ding, Jia-Rong / Peng, Zhong-Jiang / Gao, Song-Yan / Dong, Xin / Ma, Jun-Hua / Lin, Qi-Shan / Lu, Jian-Rao / Guo, Zhi-Yong

    Bioscience reports

    2019  Volume 39, Issue 2

    Abstract: ... of persistent renal dysfunction. Fu-Fang-Jin-Qian-Chao granules (FFJQC), a traditional Chinese herb formula, is ...

    Abstract Nephrolithiasis is one of the world's major public health burdens with a high incidence and a risk of persistent renal dysfunction. Fu-Fang-Jin-Qian-Chao granules (FFJQC), a traditional Chinese herb formula, is commonly used in treatment of nephrolithiasis. However, the therapeutic mechanism of FFJQC on kidney stone has still been a mystery. The objective of the present study is to explore the therapeutic mechanism of FFJQC on kidney injury and identify unique metabolomics patterns using a mouse model of kidney stone induced by a calcium oxalate (CaOx) deposition. Von Kossa staining and immuno-histopathological staining of osteopontin (OPN), cluster of differentiation 44 (CD44) and calbindin-D28k were conducted on renal sections. Biochemical analysis was performed on serum, urine, and kidney tissues. A metabolomics approach based on ultra-HPLC coupled with quadrupole-TOF-MS (UHPLC-Q-TOF/MS) was used for serum metabolic profiling. The immunohistopathological and biochemical analysis showed the therapeutic benefits of FFJQC. The expression levels of OPN and CD44 were decreased while calbindin-D28k increased after the CaOx injured mice were treated with FFJQC. In addition, total of 81 serum metabolites were identified to be associated with protective effects of FFJQC on CaOx crystal injured mice. Most of these metabolites were involved in purine, amino acid, membrane lipid and energy metabolism. Potential metabolite biomarkers were found for CaOx crystal-induced renal damage. Potential metabolite biomarkers of CaOx crystal-induced renal damage were found. FFJQC shows therapeutic benefits on CaOx crystal injured mice via regulation of multiple metabolic pathways including amino acids, purine, pyrimidine, glycerolipid, arachidonic acid (AA), sphingolipid, glycerophospholipid, and fatty acid.
    MeSH term(s) Animals ; Calcium Oxalate/adverse effects ; Disease Models, Animal ; Drugs, Chinese Herbal/therapeutic use ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Kidney Calculi/drug therapy ; Kidney Calculi/etiology ; Kidney Calculi/metabolism ; Kidney Calculi/pathology ; Male ; Metabolome/drug effects ; Metabolomics ; Mice, Inbred C57BL ; Protective Agents/therapeutic use
    Chemical Substances Drugs, Chinese Herbal ; Protective Agents ; Calcium Oxalate (2612HC57YE)
    Language English
    Publishing date 2019-02-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1042/BSR20181833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1676: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Re: Guohua Zeng, Chao Cai, Xianzhong Duan, et al. Mini Percutaneous Nephrolithotomy Is a Noninferior Modality to Standard Percutaneous Nephrolithotomy for the Management of 20-40 mm Renal Calculi: A Multicenter Randomized Controlled Trial. Eur Urol 2021;80:114-21.

    Gao, Xiaoshuai / Chen, Guo / Jin, Tao

    European urology

    2021  Volume 80, Issue 6, Page(s) e150

    MeSH term(s) Drugs, Chinese Herbal ; Female ; Humans ; Kidney Calculi/surgery ; Male ; Nephrolithotomy, Percutaneous
    Chemical Substances Drugs, Chinese Herbal ; xianzhong
    Language English
    Publishing date 2021-09-16
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

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  3. Article: Modeling the impacts of water transfer on water transport pattern in Lake Chao, China

    Huang, Jiacong / Junfeng Gao / Lingyan Qi / Renhua Yan / Zhiming Zhang

    Ecological engineering. 2016 Oct., v. 95

    2016  

    Abstract: ... on the water transport pattern of Lake Chao, China. The Xinanjiang model simulated the inflow discharges for the EFDC ...

    Abstract Water transport pattern plays an important role in determining water and pollution transport, and is worth our investigation. In this study, a hydrological model (Xinanjiang) and a hydrodynamic model (Environmental Fluid Dynamics Code, EFDC) were coupled to investigate the impacts of a water transfer project on the water transport pattern of Lake Chao, China. The Xinanjiang model simulated the inflow discharges for the EFDC model. The validation results were acceptable with a Nash–Sutcliffe coefficient of 0.74 and 0.84 for the Xinanjiang and EFDC models. Based on the calibrated models, four simulations were implemented and compared to evaluate the impacts of the water transfer project on the water transport pattern, described by water age and residence time. The simulation results revealed that the water transfer project had the potential to shorten water age and residence time of the lake, however, should be carried out by considering the influences of wind conditions and water transfer route. This study demonstrated a successful adaption of water age and residence time for describing water transport pattern, and highlighted the importance of model coupling approach in addressing multidisciplinary questions from the complex natural ecosystem.
    Keywords ecosystems ; hydrodynamics ; hydrologic models ; lakes ; water pollution ; wind ; China
    Language English
    Dates of publication 2016-10
    Size p. 271-279.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1127407-4
    ISSN 0925-8574
    ISSN 0925-8574
    DOI 10.1016/j.ecoleng.2016.06.074
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5865: Show issues

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  4. Article: Predictive Value of the CHA

    Wu, Yaxin / Gao, Yanxiang / Li, Qing / Wu, Chao / Xie, Enmin / Tu, Yimin / Guo, Ziyu / Ye, Zixiang / Li, Peizhao / Li, Yike / Yu, Xiaozhai / Ren, Jingyi / Zheng, Jingang

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 790193

    Abstract: ... of coronary artery disease and a high risk of cardiovascular events. The present study assessed the value of the CHA ... from January 2015 to May 2020. The CHA: Results: A total of 313 eligible patients were included in the study ... with a mean CHA: Conclusion: The CHA ...

    Abstract Background: Chronic kidney disease (CKD) patients have a high prevalence of coronary artery disease and a high risk of cardiovascular events. The present study assessed the value of the CHA
    Methods: This was a retrospective cohort study that included CKD patients who were hospitalized for ACS from January 2015 to May 2020. The CHA
    Results: A total of 313 eligible patients were included in the study, with a mean CHA
    Conclusion: The CHA
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.790193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Mapping the exposome and investigating its role in human and environmental health.

    Gao, Peng / Ju, Feng / Jiang, Chao

    Frontiers in microbiology

    2024  Volume 14, Page(s) 1353623

    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1353623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Integrating single-cell multimodal epigenomic data using 1D-convolutional neural networks.

    Gao, Chao / Welch, Joshua D

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Recent experimental developments enable single-cell multimodal epigenomic profiling, which measures multiple histone modifications and chromatin accessibility within the same cell. Such parallel measurements provide exciting new opportunities to ... ...

    Abstract Recent experimental developments enable single-cell multimodal epigenomic profiling, which measures multiple histone modifications and chromatin accessibility within the same cell. Such parallel measurements provide exciting new opportunities to investigate how epigenomic modalities vary together across cell types and states. A pivotal step in using this type of data is integrating the epigenomic modalities to learn a unified representation of each cell, but existing approaches are not designed to model the unique nature of this data type. Our key insight is to model single-cell multimodal epigenome data as a multi-channel sequential signal. Based on this insight, we developed ConvNet-VAEs, a novel framework that uses 1D-convolutional variational autoencoders (VAEs) for single-cell multimodal epigenomic data integration. We evaluated ConvNet-VAEs on nano-CT and scNTT-seq data generated from juvenile mouse brain and human bone marrow. We found that ConvNet-VAEs can perform dimension reduction and batch correction better than previous architectures while using significantly fewer parameters. Furthermore, the performance gap between convolutional and fully-connected architectures increases with the number of modalities, and deeper convolutional architectures can increase performance while performance degrades for deeper fully-connected architectures. Our results indicate that convolutional autoencoders are a promising method for integrating current and future single-cell multimodal epigenomic datasets.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.16.580655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Research on the assignment of elderly care service personnel with time window constraints.

    Yu, Chao / Gao, Tianxiang

    Heliyon

    2024  Volume 10, Issue 8, Page(s) e28991

    Abstract: As the population continues to age, there is a growing need for elderly care services. In China, home care is widely embraced as a preferred method of caring for the elderly, and it has a promising commercial outlook. The strategic allocation of Elderly ... ...

    Abstract As the population continues to age, there is a growing need for elderly care services. In China, home care is widely embraced as a preferred method of caring for the elderly, and it has a promising commercial outlook. The strategic allocation of Elderly Care Service Personnel (ECSP) is a crucial component of the operational procedures for home care services. By strategically assigning elderly service personnel, it is possible to enhance the satisfaction and simultaneously minimize expenses. The issue of rationalizing the assignment of ECSP in the face of restricted resources is a genuine challenge that requires a solution, given the many types of elderly service demands and the skill requirements and time limits of certain projects. This study presents a strategy for assigning personnel on an hourly basis, taking into account time frame limits. This method involves several steps. Firstly, it involves assessing the specific service needs of the elderly, including the required door-to-door service time, service level, and gender preferences. Secondly, it calculates the service satisfaction and service operation cost of the Home Care Service Platform (HCSP) separately. Finally, it constructs a multi-objective elderly service personnel assignment method. This method aims to minimize the ECSP 's travel time and wasted time, maximize the satisfaction of the elderly by considering priority levels and ECSP scores, and minimize the operation cost of the HCSP. A model is developed to assign ECSP for elderly individuals, with the goal of minimizing travel time and wasted time, maximizing elderly satisfaction by considering priority and service personnel rating, and minimizing operating costs for the HCSP. Additionally, if there are unserved elderly individuals, an optimized path model is constructed using a cross-modified genetic algorithm to obtain the optimal matching result. Ultimately, an arithmetic example is employed to demonstrate the practicality and efficiency of the strategy put forth in this research. The findings demonstrate that the model presented in this research possesses distinct advantages in comparison to other conventional models.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Engineering surface lattice hydroxyl groups toward highly efficient photocatalytic methane coupling.

    Ma, Zili / Chen, Yihong / Gao, Chao / Xiong, Yujie

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 9, Page(s) 1132–1135

    Abstract: ... ...

    Abstract Nb
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc04645a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Transient Reactive Phlebitis Induced during Anesthesia Induction.

    Liang, Chao / Gao, Huayuan / Chen, Youwen / Miao, Changhong

    Anesthesiology

    2024  Volume 140, Issue 4, Page(s) 803–804

    MeSH term(s) Humans ; Phlebitis/chemically induced ; Anesthesia, General/adverse effects
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.133: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 199: Show issues

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  10. Article ; Online: The association between Internet use and cognitive ability among rural left-behind children in China.

    Gao, Ai-Zhi / Chen, Wei-Chao

    Frontiers in public health

    2024  Volume 11, Page(s) 1341298

    Abstract: Introduction: This study focuses on the cognitive development of rural children aged 10-15 who have been left behind, utilizing data from the China Family Panel Studies (CFPS) datasets of 2016 and 2020. The primary objective is to investigate the ... ...

    Abstract Introduction: This study focuses on the cognitive development of rural children aged 10-15 who have been left behind, utilizing data from the China Family Panel Studies (CFPS) datasets of 2016 and 2020. The primary objective is to investigate the correlation between Internet usage and the cognitive ability of these children.
    Methods: An Ordinary Least Squares (OLS) regression model was initially employed to explore the potential influence of Internet use on the cognitive ability of rural left-behind children. To meticulously address potential endogeneity, we employed the instrumental variable (IV) method. Additionally, we performed robustness checks using Propensity Score Matching (PSM) to ensure the reliability of our findings.
    Results: The findings indicate a statistically significant positive correlation between Internet usage and the cognitive ability of left-behind rural children. Notably, the impact of Internet use is more pronounced in girls than in boys among this demographic. Furthermore, a significant influence of Internet usage on the cognitive ability is observed in rural children aged 10-12, whereas no significant correlation is found for those aged 13-15. Particularly noteworthy is the substantial impact of Internet use on the cognitive ability of left-behind children with an absent father. In addition, the cognitive benefits associated with Internet use were notably more pronounced among rural left-behind children, especially when considering factors such as attendance at a demonstration school and parental concern for the child's education.
    Conclusion: This study underscores the importance of understanding the relationship between Internet usage and cognitive development in left-behind rural children. These findings highlight the need for targeted interventions and inclusive access to online resources for the development of rural left-behind children.
    MeSH term(s) Male ; Child ; Female ; Humans ; Internet Use ; Reproducibility of Results ; Parents ; China/epidemiology ; Cognition
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1341298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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