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  1. Book ; Online ; E-Book: Mathematical modeling and soft computing in epidemiology

    Mishra, Jyoti / Agarwal, Ritu / Atangana, Abdon

    (Information technology, management and operations research practices)

    2021  

    Author's details edited by Jyoti Mishra, Ritu Agarwal, Abdon Atangana
    Series title Information technology, management and operations research practices
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (XX, 419 Seiten), Illustrationen
    Publisher CRC Press
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020705308
    ISBN 978-1-000-22694-2 ; 9780367903053 ; 1-000-22694-8 ; 0367903059
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Correction to "Engineered Recombinant EGFP-Azurin Theranostic Nanosystem for Targeted Therapy of Prostate Cancer".

    Bhardwaj, Ritu / Mishra, Prashant

    Molecular pharmaceutics

    2024  Volume 21, Issue 2, Page(s) 992

    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.4c00011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Engineered Recombinant EGFP-Azurin Theranostic Nanosystem for Targeted Therapy of Prostate Cancer.

    Bhardwaj, Ritu / Mishra, Prashant

    Molecular pharmaceutics

    2023  Volume 20, Issue 12, Page(s) 6066–6078

    Abstract: Erythropoietin-producing hepatocellular (Eph) receptors and their ligands, ephrins, are the largest subfamily of receptor tyrosine kinases (RTKs) that have emerged as a new class of cancer biomarkers due to their aberrant expression in cancer progression. ...

    Abstract Erythropoietin-producing hepatocellular (Eph) receptors and their ligands, ephrins, are the largest subfamily of receptor tyrosine kinases (RTKs) that have emerged as a new class of cancer biomarkers due to their aberrant expression in cancer progression. The activation of Eph receptors either due to their hyperexpression or via high affinity binding with their respective ephrin ligands initiates a cascade of signals that impacts cancer development and progression. In prostate cancer, the overexpression of the EphA6 receptor has been correlated with increased metastatic potential. Azurin, a small redox protein, is known to prevent tumor progression by binding to cell surface Eph receptors, inhibiting its autophosphorylation in the kinase domain and thereby disrupting Eph-ephrin signaling. Hence, a self-assembled, theranostic nanosystem of recombinant fusion protein his
    MeSH term(s) Male ; Humans ; Receptors, Eph Family/chemistry ; Receptors, Eph Family/metabolism ; Azurin/genetics ; Receptor, EphA6 ; Precision Medicine ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/metabolism ; Ephrins/chemistry ; Ephrins/metabolism
    Chemical Substances Receptors, Eph Family (EC 2.7.10.1) ; Azurin (12284-43-4) ; enhanced green fluorescent protein ; Receptor, EphA6 (EC 2.7.10.1) ; Ephrins
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c00387
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  4. Article ; Online: Multiresponsive Nanoscale Self-Assembly of Azurin-Elastin-like Polypeptide Fusion Protein for Enhanced Prostate Cancer Therapy.

    Bhardwaj, Ritu / Mishra, Prashant

    Biomacromolecules

    2023  Volume 25, Issue 1, Page(s) 508–521

    Abstract: A fusion protein composed of a bacterial protein, azurin, having antineoplastic properties and a thermally responsive structural cationic elastin-like protein (ELP), is designed, cloned, expressed, and purified. A simple method of inverse transition ... ...

    Abstract A fusion protein composed of a bacterial protein, azurin, having antineoplastic properties and a thermally responsive structural cationic elastin-like protein (ELP), is designed, cloned, expressed, and purified. A simple method of inverse transition cycle (ITC) is employed to purify the fusion protein azurin-ELP diblock copolymer (d-bc). The molecular weight of the azurin-ELP fusion protein is ∼32 kDa. Further, its self-assembly properties are investigated. Interestingly, the engineered azurin-ELP d-bc in response to increasing temperature shows a dual-step phase separation into biofunctional nanostructures. Around the physiological temperature, azurin-ELP d-bc forms stable coacervates, which is dependent on the concentration and time of incubation. These coacervates are formed below the lower critical solubility temperature (LCST) of the ELP block at physiological temperature. Above LCST, i.e., 50-55°C, micelles of size ranging from 25 to 30 nm are formed. The cytotoxicity of azurin-ELP d-bc depends on the size of the coacervates formed and their cellular uptake at physiological temperature. Further, MTT assay of azurin-ELP d-bc in the cross-linked micelles prepared ex situ shows > six times higher killing of LNCaP cells than the unimeric form of azurin-ELP at 5 μM concentration. The flow cytometric results of these micelles at 20 μM concentration show ∼97% LNCaP cells in the apoptotic phase. Thus, azurin-ELP cross-linked micelles have enhanced potential for anticancer therapy due to their higher avidity.
    MeSH term(s) Humans ; Male ; Elastin-Like Polypeptides ; Micelles ; Azurin/genetics ; Peptides/chemistry ; Elastin/chemistry ; Prostatic Neoplasms/drug therapy
    Chemical Substances Elastin-Like Polypeptides ; Micelles ; Azurin (12284-43-4) ; Peptides ; Elastin (9007-58-3)
    Language English
    Publishing date 2023-12-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c01125
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  5. Article ; Online: The effects of food anthropomorphism on consumer behavior: A systematic literature review with integrative framework and future research directions.

    Mishra, Ria / Mehta, Ritu

    Appetite

    2023  Volume 190, Page(s) 107035

    Abstract: Anthropomorphizing or humanizing food is a common marketing practice that has gained significant scholarly attention in the past few years. The present systematic review analyzes articles that examined the effects of anthropomorphizing various food and ... ...

    Abstract Anthropomorphizing or humanizing food is a common marketing practice that has gained significant scholarly attention in the past few years. The present systematic review analyzes articles that examined the effects of anthropomorphizing various food and food ingredients on consumers' behavior to synthesize the existing body of work into an integrative framework, provide managerial recommendations, and identify avenues for future research. Using the Prisma 2020 statement for systematic reviews, a systematic search of four databases (EBSCO, PubMed, SCOPUS, and Web of Science) for peer-reviewed, quantitative articles published in English till the March 10, 2023 was undertaken, resulting in a final number of 21 articles meeting our selection criteria. The identified articles studied anthropomorphism of one of the three categories of food - regular food, misshapen/irregularly-shaped food, and meat animal. Analysis based on an integrative framework suggests that, in general, anthropomorphizing misshapen produce and regular food has a positive effect on behavior towards the food (e.g., purchase intention) and the restaurant/brand (e.g., restaurant visit intention) among adult consumers through elicitation of cognitive and affective responses. However, anthropomorphizing meat animals reduces consumers' intention to buy or eat meat by evoking negative emotions such as guilt. Similarly, anthropomorphizing regular food discourages consumption among children. The framework highlights several moderating variables of these effects. Based on the insights from this literature review, several recommendations for practitioners and researchers are suggested.
    MeSH term(s) Adult ; Animals ; Child ; Humans ; Consumer Behavior ; Systematic Reviews as Topic ; Intention ; Meat ; Guilt
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1461347-5
    ISSN 1095-8304 ; 0195-6663
    ISSN (online) 1095-8304
    ISSN 0195-6663
    DOI 10.1016/j.appet.2023.107035
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  6. Article ; Online: Primary sclerosing cholangitis with high immunoglobulin-G4.

    Malakar, Sayan / Mishra, Piyush / Paturu, Radha / Verma, Ritu / Ghoshal, Uday C

    Journal of hepatology

    2023  Volume 80, Issue 4, Page(s) e168–e170

    MeSH term(s) Humans ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/diagnosis ; Autoimmune Diseases ; Immunoglobulins ; Diagnosis, Differential
    Chemical Substances Immunoglobulins
    Language English
    Publishing date 2023-10-07
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.09.026
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    Zs.A 2027: Show issues Location:
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  7. Article ; Online: A systematic review on deep learning-based automated cancer diagnosis models.

    Tandon, Ritu / Agrawal, Shweta / Rathore, Narendra Pal Singh / Mishra, Abhinava K / Jain, Sanjiv Kumar

    Journal of cellular and molecular medicine

    2024  Volume 28, Issue 6, Page(s) e18144

    Abstract: Deep learning is gaining importance due to its wide range of applications. Many researchers have utilized deep learning (DL) models for the automated diagnosis of cancer patients. This paper provides a systematic review of DL models for automated ... ...

    Abstract Deep learning is gaining importance due to its wide range of applications. Many researchers have utilized deep learning (DL) models for the automated diagnosis of cancer patients. This paper provides a systematic review of DL models for automated diagnosis of cancer patients. Initially, various DL models for cancer diagnosis are presented. Five major categories of cancers such as breast, lung, liver, brain and cervical cancer are considered. As these categories of cancers have a very high percentage of occurrences with high mortality rate. The comparative analysis of different types of DL models is drawn for the diagnosis of cancer at early stages by considering the latest research articles from 2016 to 2022. After comprehensive comparative analysis, it is found that most of the researchers achieved appreciable accuracy with implementation of the convolutional neural network model. These utilized the pretrained models for automated diagnosis of cancer patients. Various shortcomings with the existing DL-based automated cancer diagnosis models are also been presented. Finally, future directions are discussed to facilitate further research for automated diagnosis of cancer patients.
    MeSH term(s) Humans ; Deep Learning ; Lung ; Neural Networks, Computer ; Tomography, X-Ray Computed ; Neoplasms/diagnosis ; Diagnosis, Computer-Assisted
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.18144
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  8. Article: Role of Gabapentin in Traumatic Brain Injury: A Prospective Comparative Study.

    Singh, Ritu / Ambasta, Suruchi / Bais, Prateek S / Azim, Afzal / Kumar, Sanjeev / Upreti, Bhawesh / Singh, Siddharth / Mishra, Prabhakar

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2024  Volume 28, Issue 3, Page(s) 313

    Language English
    Publishing date 2024-02-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-24679
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  9. Article ; Online: SARS-CoV-2 Spike Targets USP33-IRF9 Axis

    Mishra, Ritu / Banerjea, Akhil C

    Frontiers in immunology

    2021  Volume 12, Page(s) 656700

    Abstract: SARS-CoV-2, the novel coronavirus infection has consistently shown an association with neurological anomalies in patients, in addition to its usual respiratory distress syndrome. Multi-organ dysfunctions including neurological sequelae during COVID-19 ... ...

    Abstract SARS-CoV-2, the novel coronavirus infection has consistently shown an association with neurological anomalies in patients, in addition to its usual respiratory distress syndrome. Multi-organ dysfunctions including neurological sequelae during COVID-19 persist even after declining viral load. We propose that SARS-CoV-2 gene product, Spike, is able to modify the host exosomal cargo, which gets transported to distant uninfected tissues and organs and can initiate a catastrophic immune cascade within Central Nervous System (CNS). SARS-CoV-2 Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590. microRNAs gets internalized by human microglia and suppress target gene expression of USP33 (Ubiquitin Specific peptidase 33) and downstream IRF9 levels. Cellular levels of USP33 regulate the turnover time of IRF9
    MeSH term(s) COVID-19/genetics ; COVID-19/metabolism ; COVID-19/physiopathology ; COVID-19/virology ; Cell Line ; Central Nervous System/immunology ; Central Nervous System/physiopathology ; Central Nervous System/virology ; Endopeptidases/metabolism ; Exosomes/genetics ; Exosomes/metabolism ; Exosomes/pathology ; Humans ; Inflammation/immunology ; Inflammation/virology ; Interferon-Stimulated Gene Factor 3, gamma Subunit/metabolism ; Interferon-beta/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Microglia/metabolism ; Microglia/pathology ; NF-kappa B/metabolism ; Protein Stability ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Ubiquitin Thiolesterase/metabolism
    Chemical Substances IRF9 protein, human ; Interferon-Stimulated Gene Factor 3, gamma Subunit ; MIRN148 microRNA, human ; MIRN590 microRNA, human ; MicroRNAs ; NF-kappa B ; Spike Glycoprotein, Coronavirus ; Tumor Necrosis Factor-alpha ; spike protein, SARS-CoV-2 ; Interferon-beta (77238-31-4) ; Endopeptidases (EC 3.4.-) ; USP33 protein, human (EC 3.4.19.12) ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; ubiquitin isopeptidase (EC 3.4.99.-)
    Language English
    Publishing date 2021-04-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.656700
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  10. Article: Nutritional Epigenetics: How Metabolism Epigenetically Controls Cellular Physiology, Gene Expression and Disease.

    Mishra, Pragyan / Beura, Shibangini / Ghosh, Ritu / Modak, Rahul

    Sub-cellular biochemistry

    2022  Volume 100, Page(s) 239–267

    Abstract: The regulation of gene expression is a dynamic process that is influenced by both internal and external factors. Alteration in the epigenetic profile is a key mechanism in the regulation process. Epigenetic regulators, such as enzymes and proteins ... ...

    Abstract The regulation of gene expression is a dynamic process that is influenced by both internal and external factors. Alteration in the epigenetic profile is a key mechanism in the regulation process. Epigenetic regulators, such as enzymes and proteins involved in posttranslational modification (PTM), use different cofactors and substrates derived from dietary sources. For example, glucose metabolism provides acetyl CoA, S-adenosylmethionine (SAM), α- ketoglutarate, uridine diphosphate (UDP)-glucose, adenosine triphosphate (ATP), nicotinamide adenine dinucleotide (NAD
    MeSH term(s) Humans ; Histones/metabolism ; Epigenesis, Genetic ; Neurodegenerative Diseases/genetics ; Chromatin ; NAD/genetics ; NAD/metabolism ; Ketoglutaric Acids ; Gene Expression
    Chemical Substances Histones ; Chromatin ; NAD (0U46U6E8UK) ; Ketoglutaric Acids
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ISSN 0306-0225 ; 0096-8757
    ISSN 0306-0225 ; 0096-8757
    DOI 10.1007/978-3-031-07634-3_8
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