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Buch ; Dissertation / Habilitation: Molekulare Epidemiologie humaner Astroviren in Deutschland und Bestimmung einer Astrovirus-Totalsequenz vom Serotyp 3

Oh, Djin-Ye

2002

Verfasserangabe	von Djin-Ye Oh
Sprache	Deutsch
Umfang	87 Bl. : Ill., graph. Darst.
Erscheinungsland	Deutschland
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Berlin, Humboldt-Univ., Diss. 2002
HBZ-ID	HT013463437
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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2002 E 3957	bestellbar zur Ausleihe	Magazin

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Artikel ; Online: Surveillance of endemic human Coronaviruses in Germany, 2019/2020

Barbara Biere / Djin-Ye Oh / Thorsten Wolff / Ralf Dürrwald

The Lancet Regional Health. Europe, Vol 11, Iss , Pp 100262- (2021)

2021

Schlagwörter	Public aspects of medicine ; RA1-1270
Sprache	Englisch
Erscheinungsdatum	2021-12-01T00:00:00Z
Verlag	Elsevier
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Surveillance of endemic human Coronaviruses in Germany, 2019/2020.

Biere, Barbara / Oh, Djin-Ye / Wolff, Thorsten / Dürrwald, Ralf

The Lancet regional health. Europe

2021 Band 11, Seite(n) 100262

Sprache	Englisch
Erscheinungsdatum	2021-11-04
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2666-7762
ISSN (online)	2666-7762
DOI	10.1016/j.lanepe.2021.100262
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: COVIDStrategyCalculator: A software to assess testing and quarantine strategies for incoming travelers, contact management, and de-isolation.

van der Toorn, Wiep / Oh, Djin-Ye / von Kleist, Max

Patterns (New York, N.Y.)

2021 Band 2, Heft 6, Seite(n) 100264

Abstract: While large-scale vaccination campaigns against SARS-CoV-2 are rolled out at the time of writing, non-pharmaceutical interventions (NPIs), including the isolation of infected individuals and quarantine of exposed individuals, remain central measures to ... ...

Abstract	While large-scale vaccination campaigns against SARS-CoV-2 are rolled out at the time of writing, non-pharmaceutical interventions (NPIs), including the isolation of infected individuals and quarantine of exposed individuals, remain central measures to contain the spread of SARS-CoV-2. Strategies that combine NPIs with innovative SARS-CoV-2 testing strategies may increase containment efficacy and help to shorten quarantine durations. We developed a user-friendly software tool that implements a recently published stochastic within-host viral dynamics model that captures temporal attributes of the viral infection, such as test sensitivity, infectiousness, and the occurrence of symptoms. Based on this model, the software allows to evaluate the efficacy of user-defined, arbitrary NPI and testing strategies in reducing the transmission potential in different contexts. The software thus enables decision makers to explore NPI strategies and perform hypothesis testing, e.g., with regard to the utilization of novel diagnostics or with regard to containing novel virus variants.
Sprache	Englisch
Erscheinungsdatum	2021-04-20
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2666-3899
ISSN (online)	2666-3899
DOI	10.1016/j.patter.2021.100264
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: SARS-CoV-2-Übertragungswege und Implikationen für den Selbst- und Fremdschutz.

Oh, Djin-Ye / Böttcher, Sindy / Kröger, Stefan / von Kleist, Max

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

2021 Band 64, Heft 9, Seite(n) 1050–1057

Abstract: The global spread of the coronavirus SARS-CoV‑2 has massively impacted health, economic, and social systems. Although effective vaccines are now available, it is likely that this pathogen will become endemic and stay with us for years. In order to most ... ...

Titelübersetzung	SARS-CoV-2 transmission routes and implications for self- and non-self-protection.
Abstract	The global spread of the coronavirus SARS-CoV‑2 has massively impacted health, economic, and social systems. Although effective vaccines are now available, it is likely that this pathogen will become endemic and stay with us for years. In order to most effectively protect others and oneself from SARS-CoV‑2 infection, an understanding of how SARS-CoV‑2 is transmitted is of utmost importance.In this review paper, we explain transmission routes with an eye towards protecting others and oneself. We also address characteristics of SARS-CoV‑2 transmission in the community. This work will help to clarify the following questions based on the available literature: When and for how long is an infected person contagious? How is the virus excreted? How is the virus taken up? How does the virus spread in society?Human-to-human transmission of SARS-CoV‑2 is strongly determined by pathogen molecular characteristics as well as the kinetics of replication, shedding, and infection. SARS-CoV‑2 is transmitted primarily via human aerosols, which infected persons can excrete even if symptoms of the disease are not (yet) present. Most infected people cause only a few secondary cases, whereas a few cases (so-called super-spreaders) cause a high number of secondary infections - at the population level one speaks of a so-called "overdispersion." These special characteristics of SARS-CoV‑2 (asymptomatic aerosol transmission and overdispersion) make the pandemic difficult to control.
Mesh-Begriff(e)	COVID-19/prevention & control ; COVID-19/transmission ; Communicable Disease Control ; Germany ; Humans ; Pandemics ; SARS-CoV-2
Sprache	Deutsch
Erscheinungsdatum	2021-07-29
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Review
ZDB-ID	1461973-8
ISSN	1437-1588 ; 1436-9990
ISSN (online)	1437-1588
ISSN	1436-9990
DOI	10.1007/s00103-021-03389-8
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Preparing for the Next Influenza Season: Monitoring the Emergence and Spread of Antiviral Resistance.

Oh, Djin-Ye / Milde, Jeanette / Ham, Youngsun / Ramos Calderón, Julia Patricia / Wedde, Marianne / Dürrwald, Ralf / Duwe, Susanne C

Infection and drug resistance

2023 Band 16, Seite(n) 949–959

Abstract: Purpose: The relaxation of pandemic restrictions in 2022 has led to a reemergence of respiratory virus circulation worldwide and anticipation of substantial influenza waves for the 2022/2023 Northern Hemisphere winter. Therefore, the antiviral ... ...

Abstract	Purpose: The relaxation of pandemic restrictions in 2022 has led to a reemergence of respiratory virus circulation worldwide and anticipation of substantial influenza waves for the 2022/2023 Northern Hemisphere winter. Therefore, the antiviral susceptibility profiles of human influenza viruses circulating in Germany were characterized. Methods: Between October 2019 (week 40/2019) and March 2022 (week 12/2022), nasal swabs from untreated patients with acute respiratory symptoms were collected in the national German influenza surveillance system. A total of 598 influenza viruses were isolated and analyzed for susceptibility to oseltamivir, zanamivir and peramivir, using a neuraminidase (NA) inhibition assay. In addition, next-generation sequencing was applied to assess molecular markers of resistance to NA, cap-dependent endonuclease (PA) and M2 ion channel inhibitors (NAI, PAI, M2I) in 367 primary clinical samples. Furthermore, a genotyping assay based on RT-PCR and pyrosequencing to rapidly assess the molecular resistance marker PA-I38X in PA genes was designed and established. Results: While NAI resistance in the strict sense, defined by a ≥ 10-fold (influenza A) or ≥5-fold (influenza B) increase of NAI IC Conclusion: Over the last three influenza seasons, the vast majority of influenza viruses in this national-level sentinel were susceptible to NAIs and PAIs. These findings support the use of antivirals in the upcoming influenza season.
Sprache	Englisch
Erscheinungsdatum	2023-02-15
Erscheinungsland	New Zealand
Dokumenttyp	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S389263
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Surveillance of endemic human Coronaviruses in Germany, 2019/2020

Biere, Barbara / Oh, Djin-Ye / Wolff, Thorsten / Dürrwald, Ralf

2021

Abstract: ... Peer ... ...

Abstract	Peer Reviewed
Schlagwörter	610 Medizin und Gesundheit ; ddc:610
Sprache	Englisch
Erscheinungsdatum	2021-11-04
Verlag	Robert Koch-Institut
Erscheinungsland	de
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Different populations of A(H1N1)pdm09 viruses in a patient with hemolytic-uremic syndrome

Yuguang Fu / Marianne Wedde / Sigrun Smola / Djin-Ye Oh / Thorsten Pfuhl / Jürgen Rissland / Michael Zemlin / Fidelis A. Flockerzi / Rainer M. Bohle / Andrea Thürmer / Susanne Duwe / Barbara Biere / Janine Reiche / Brunhilde Schweiger / Christin Mache / Thorsten Wolff / Georg Herrler / Ralf Dürrwald

International Journal of Medical Microbiology, Vol 314, Iss , Pp 151598- (2024)

2024

Abstract: Respiratory viral infections may have different impacts ranging from infection without symptoms to severe disease or even death though the reasons are not well characterized.A patient (age group 5–15 years) displaying symptoms of hemolytic uremic ... ...

Abstract	Respiratory viral infections may have different impacts ranging from infection without symptoms to severe disease or even death though the reasons are not well characterized.A patient (age group 5–15 years) displaying symptoms of hemolytic uremic syndrome died one day after hospitalization. qPCR, next generation sequencing, virus isolation, antigenic characterization, resistance analysis was performed and virus replication kinetics in well-differentiated airway cells were determined.Autopsy revealed hemorrhagic pneumonia as major pathological manifestation. Lung samples harbored a large population of A(H1N1)pdm09 viruses with the polymorphism H456H/Y in PB1 polymerase. The H456H/Y viruses replicated much faster to high viral titers than upper respiratory tract viruses in vitro. H456H/Y-infected air-liquid interface cultures of differentiated airway epithelial cells did reflect a more pronounced loss of ciliated cells. A different pattern of virus quasispecies was found in the upper airway samples where substitution S263S/F (HA1) was observed.The data support the notion that viral quasispecies had evolved locally in the lung to support high replicative fitness. This change may have initiated further pathogenic processes leading to rapid dissemination of inflammatory mediators followed by development of hemorrhagic lung lesions and fatal outcome.
Schlagwörter	A(H1N1)pdm09 virus ; Fatal influenza ; S263S/F (HA1) and H456H/Y (PB1) mutations ; Microbiology ; QR1-502 ; Other systems of medicine ; RZ201-999
Sprache	Englisch
Erscheinungsdatum	2024-03-01T00:00:00Z
Verlag	Elsevier
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: A robust, scalable, and cost-efficient approach to whole genome sequencing of RSV directly from clinical samples.

Köndgen, Sophie / Oh, Djin-Ye / Thürmer, Andrea / Sedaghatjoo, Somayyeh / Patrono, Livia V / Calvignac-Spencer, Sébastien / Biere, Barbara / Wolff, Thorsten / Dürrwald, Ralf / Fuchs, Stephan / Reiche, Janine

Journal of clinical microbiology

2024 Band 62, Heft 3, Seite(n) e0111123

Abstract: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections causing significant morbidity and mortality among children and the elderly; two RSV vaccines and a monoclonal antibody have recently been approved. Thus, ... ...

Abstract	Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections causing significant morbidity and mortality among children and the elderly; two RSV vaccines and a monoclonal antibody have recently been approved. Thus, there is an increasing need for a detailed and continuous genomic surveillance of RSV circulating in resource-rich and resource-limited settings worldwide. However, robust, cost-effective methods for whole genome sequencing of RSV from clinical samples that are amenable to high-throughput are still scarce. We developed Next-RSV-SEQ, an experimental and computational pipeline to generate whole genome sequences of historic and current RSV genotypes by in-solution hybridization capture-based next generation sequencing. We optimized this workflow by automating library preparation and pooling libraries prior to enrichment in order to reduce hands-on time and cost, thereby augmenting scalability. Next-RSV-SEQ yielded near-complete to complete genome sequences for 98% of specimens with Cp values ≤31, at median on-target reads >93%, and mean coverage depths between ~1,000 and >5,000, depending on viral load. Whole genomes were successfully recovered from samples with viral loads as low as 230 copies per microliter RNA. We demonstrate that the method can be expanded to other respiratory viruses like parainfluenza virus and human metapneumovirus. Next-RSV-SEQ produces high-quality RSV genomes directly from culture isolates and, more importantly, clinical specimens of all genotypes in circulation. It is cost-efficient, scalable, and can be extended to other respiratory viruses, thereby opening new perspectives for a future effective and broad genomic surveillance of respiratory viruses. Importance: Respiratory syncytial virus (RSV) is a leading cause of severe acute respiratory tract infections in children and the elderly, and its prevention has become an increasing priority. Recently, vaccines and a long-acting monoclonal antibody to protect effectively against severe disease have been approved for the first time. Hence, there is an urgent need for genomic surveillance of RSV at the global scale to monitor virus evolution, especially with an eye toward immune evasion. However, robust, cost-effective methods for RSV whole genome sequencing that are suitable for high-throughput of clinical samples are currently scarce. Therefore, we have developed Next-RSV-SEQ, an experimental and computational pipeline that produces reliably high-quality RSV genomes directly from clinical specimens and isolates.
Mesh-Begriff(e)	Child ; Humans ; Aged ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Tract Infections ; High-Throughput Nucleotide Sequencing ; Whole Genome Sequencing ; Antibodies, Monoclonal ; Respiratory Syncytial Virus Infections
Chemische Substanzen	Antibodies, Monoclonal
Sprache	Englisch
Erscheinungsdatum	2024-02-26
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/jcm.01111-23
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Different populations of A(H1N1)pdm09 viruses in a patient with hemolytic-uremic syndrome.

Fu, Yuguang / Wedde, Marianne / Smola, Sigrun / Oh, Djin-Ye / Pfuhl, Thorsten / Rissland, Jürgen / Zemlin, Michael / Flockerzi, Fidelis A / Bohle, Rainer M / Thürmer, Andrea / Duwe, Susanne / Biere, Barbara / Reiche, Janine / Schweiger, Brunhilde / Mache, Christin / Wolff, Thorsten / Herrler, Georg / Dürrwald, Ralf

International journal of medical microbiology : IJMM

2024 Band 314, Seite(n) 151598

Abstract: Respiratory viral infections may have different impacts ranging from infection without symptoms to severe disease or even death though the reasons are not well characterized. A patient (age group 5-15 years) displaying symptoms of hemolytic uremic ... ...

Abstract	Respiratory viral infections may have different impacts ranging from infection without symptoms to severe disease or even death though the reasons are not well characterized. A patient (age group 5-15 years) displaying symptoms of hemolytic uremic syndrome died one day after hospitalization. qPCR, next generation sequencing, virus isolation, antigenic characterization, resistance analysis was performed and virus replication kinetics in well-differentiated airway cells were determined. Autopsy revealed hemorrhagic pneumonia as major pathological manifestation. Lung samples harbored a large population of A(H1N1)pdm09 viruses with the polymorphism H456H/Y in PB1 polymerase. The H456H/Y viruses replicated much faster to high viral titers than upper respiratory tract viruses in vitro. H456H/Y-infected air-liquid interface cultures of differentiated airway epithelial cells did reflect a more pronounced loss of ciliated cells. A different pattern of virus quasispecies was found in the upper airway samples where substitution S263S/F (HA1) was observed. The data support the notion that viral quasispecies had evolved locally in the lung to support high replicative fitness. This change may have initiated further pathogenic processes leading to rapid dissemination of inflammatory mediators followed by development of hemorrhagic lung lesions and fatal outcome.
Mesh-Begriff(e)	Humans ; Child, Preschool ; Child ; Adolescent ; Influenza A Virus, H1N1 Subtype ; Epithelial Cells ; Lung ; Hemolytic-Uremic Syndrome ; Influenza, Human/epidemiology
Sprache	Englisch
Erscheinungsdatum	2024-01-11
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2006518-8
ISSN	1618-0607 ; 1438-4221
ISSN (online)	1618-0607
ISSN	1438-4221
DOI	10.1016/j.ijmm.2024.151598
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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