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  1. Article: Physical virology: how physics is enabling a better understanding of recent viral invaders.

    Cardoso-Lima, Ruana / Santos-Oliveira, Ralph / Souza, Pedro Filho Noronha / Barbosa, Leandro R S / Wuite, Gijs J L / Alencar, Luciana Magalhães Rebelo

    Biophysical reviews

    2023  Volume 15, Issue 4, Page(s) 611–623

    Abstract: The world is frequently afflicted by several viral outbreaks that bring diseases and health crises. It is vital to comprehend how viral assemblies' fundamental components work to counteract them. Determining the ultrastructure and nanomechanical ... ...

    Abstract The world is frequently afflicted by several viral outbreaks that bring diseases and health crises. It is vital to comprehend how viral assemblies' fundamental components work to counteract them. Determining the ultrastructure and nanomechanical characteristics of viruses from a physical standpoint helps categorize their mechanical characteristics, offers insight into new treatment options, and/or shows weak spots that can clarify methods for medication targeting. This study compiles the findings from studies on the ultrastructure and nanomechanical behavior of SARS-CoV-2, ZIKV (Zika virus), and CHIKV (Chikungunya virus) viral particles. With results that uncovered aspects of the organization and the spatial distribution of the proteins on the surface of the viral particle as well as the deformation response of the particles when applied a recurring loading force, this review aims to provide further discussion on the mechanical properties of viral particles at the nanoscale, offering new prospects that could be employed for designing strategies for the prevention and treatment of viral diseases.
    Supplementary information: The online version contains supplementary material available at 10.1007/s12551-023-01075-4.
    Language English
    Publishing date 2023-06-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2486483-3
    ISSN 1867-2469 ; 1867-2450
    ISSN (online) 1867-2469
    ISSN 1867-2450
    DOI 10.1007/s12551-023-01075-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SARS-CoV-2 Unrevealed: Ultrastructural and Nanomechanical Analysis.

    Cardoso-Lima, Ruana / Souza, Pedro Filho Noronha / Guedes, Maria Izabel Florindo / Santos-Oliveira, Ralph / Rebelo Alencar, Luciana M

    Langmuir : the ACS journal of surfaces and colloids

    2021  Volume 37, Issue 36, Page(s) 10762–10769

    Abstract: The ongoing outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) started in late 2019 and spread across the world, infecting millions of people, with over 3.3 million deaths worldwide. To fight back the virus, it is necessary to ... ...

    Abstract The ongoing outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) started in late 2019 and spread across the world, infecting millions of people, with over 3.3 million deaths worldwide. To fight back the virus, it is necessary to understand how the main structures work, especially those responsible for the virus infectivity pathogenicity. Here, using the most advanced atomic force microscopy techniques, SARS-CoV-2 viral particles were analyzed, with a special focus on their ultrastructure, adsorption conformation, and nanomechanical behavior. The results uncovered the aspects of the organization and the spatial distribution of the proteins on the surface of the viral particles. It also showed the compliant behavior of the membrane and ability to recover from mechanical injuries. At least three layers composing the membrane and their thickness were measured, protecting the virus from external stress. This study provides new insight into the ultrastructure of SARS-CoV-2 particles at the nanoscale, offering new prospects that could be employed for mapping viral surfaces. The understanding of the viruses' capacity to survive mechanical disruptions at any level and their ability to recover from such injuries can shed a light on the structure-function relationship and help us to find targets for drug action, especially for this virus that, to this day, has no course of treatment approved.
    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Virion
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.1c01488
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  3. Article ; Online: Zika Virus (ZIKV): A New Perspective on the Nanomechanical and Structural Properties.

    de Araujo Dorneles, Maria Luiza / Cardoso-Lima, Ruana / Souza, Pedro Filho Noronha / Santoro Rosa, Daniela / Magne, Tais Monteiro / Santos-Oliveira, Ralph / Alencar, Luciana Magalhães Rebelo

    Viruses

    2022  Volume 14, Issue 8

    Abstract: Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) from Flavivirus. In 2015, Brazil and other Latin American countries experienced an outbreak of ZIKV infections associated with severe neurological disorders such as Guillain-Barre syndrome (GBS), ... ...

    Abstract Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) from Flavivirus. In 2015, Brazil and other Latin American countries experienced an outbreak of ZIKV infections associated with severe neurological disorders such as Guillain-Barre syndrome (GBS), encephalopathy, and encephalitis. Here, a complete mechanical and structural analysis of the ZIKV has been performed using Atomic Force Microscopy (AFM). AFM analysis corroborated the virus mean size (~50 nm) and icosahedral geometry and revealed high mechanical resistance of both: the viral surface particle (~200 kPa) and its internal content (~800 kPa). The analysis demonstrated the detailed organization of the nucleocapsid structure (such as RNA strips). An interesting finding was the discovery that ZIKV has no surface self-assembling property. These results can contribute to the development of future treatment candidates and circumscribe the magnitude of viral transmission.
    MeSH term(s) Brazil/epidemiology ; Disease Outbreaks ; Humans ; Microscopy, Atomic Force ; Zika Virus/genetics ; Zika Virus Infection/epidemiology
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14081727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nanomechanical and Vibrational Signature of Chikungunya Viral Particles.

    Cardoso-Lima, Ruana / Filho, Joel Félix Silva Diniz / de Araujo Dorneles, Maria Luiza / Gaspar, Renato Simões / Souza, Pedro Filho Noronha / Costa Dos Santos, Clenilton / Santoro Rosa, Daniela / Santos-Oliveira, Ralph / Alencar, Luciana Magalhães Rebelo

    Viruses

    2022  Volume 14, Issue 12

    Abstract: Chikungunya virus (CHIKV) belongs to the genus Alphaviridae, with a single-stranded positive-sense RNA genome of 11.8 kbp encoding a polyprotein that generates both non-structural proteins and structural proteins. The virus is transmitted by the Aedes ... ...

    Abstract Chikungunya virus (CHIKV) belongs to the genus Alphaviridae, with a single-stranded positive-sense RNA genome of 11.8 kbp encoding a polyprotein that generates both non-structural proteins and structural proteins. The virus is transmitted by the Aedes aegypti and A. albopictus mosquitoes, depending on the location. CHIKV infection leads to dengue-like musculoskeletal symptoms and has been responsible for several outbreaks worldwide since its discovery in 1952. Patients often experience fever, headache, muscle pain, joint swelling, and skin rashes. However, the ultrastructural and mechanical properties of CHIKV have not been fully characterized. Thus, this study aims to apply a physical approach to investigate CHIKV's ultrastructural morphology and mechanical properties, using atomic force microscopy and Raman spectroscopy as the main tools. Using nanomechanical assays of AFM and a gold nanoparticles substrate for Raman signal enhancement, we explored the conformational plasticity, morphology, vibrational signature, and nanomechanical properties of the chikungunya virus, providing new information on its ultrastructure at the nanoscale and offering a novel understanding of the virus' behavior upon mechanical disruptions besides its molecular composition.
    MeSH term(s) Animals ; Humans ; Chikungunya Fever ; Gold ; Metal Nanoparticles ; Chikungunya virus/genetics ; Aedes ; RNA ; Virion
    Chemical Substances Gold (7440-57-5) ; RNA (63231-63-0)
    Language English
    Publishing date 2022-12-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14122821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: SARS-CoV-2 Unrevealed: Ultrastructural and Nanomechanical Analysis

    Cardoso-Lima, Ruana / Souza, Pedro Filho Noronha / Guedes, Maria Izabel Florindo / Santos-Oliveira, Ralph / Rebelo Alencar, Luciana M.

    Langmuir. 2021 Aug. 05, v. 37, no. 36

    2021  

    Abstract: The ongoing outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) started in late 2019 and spread across the world, infecting millions of people, with over 3.3 million deaths worldwide. To fight back the virus, it is necessary to ... ...

    Abstract The ongoing outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) started in late 2019 and spread across the world, infecting millions of people, with over 3.3 million deaths worldwide. To fight back the virus, it is necessary to understand how the main structures work, especially those responsible for the virus infectivity pathogenicity. Here, using the most advanced atomic force microscopy techniques, SARS-CoV-2 viral particles were analyzed, with a special focus on their ultrastructure, adsorption conformation, and nanomechanical behavior. The results uncovered the aspects of the organization and the spatial distribution of the proteins on the surface of the viral particles. It also showed the compliant behavior of the membrane and ability to recover from mechanical injuries. At least three layers composing the membrane and their thickness were measured, protecting the virus from external stress. This study provides new insight into the ultrastructure of SARS-CoV-2 particles at the nanoscale, offering new prospects that could be employed for mapping viral surfaces. The understanding of the viruses’ capacity to survive mechanical disruptions at any level and their ability to recover from such injuries can shed a light on the structure–function relationship and help us to find targets for drug action, especially for this virus that, to this day, has no course of treatment approved.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; adsorption ; atomic force microscopy ; drugs ; pathogenicity ; structure-activity relationships ; ultrastructure ; viruses
    Language English
    Dates of publication 2021-0805
    Size p. 10762-10769.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.1c01488
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Zika Virus (ZIKV): A New Perspective on the Nanomechanical and Structural Properties

    de Araujo Dorneles, Maria Luiza / Cardoso-Lima, Ruana / Souza, Pedro Filho Noronha / Santoro Rosa, Daniela / Magne, Tais Monteiro / Santos-Oliveira, Ralph / Alencar, Luciana Magalhães Rebelo

    Viruses. 2022 Aug. 05, v. 14, no. 8

    2022  

    Abstract: Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) from Flavivirus. In 2015, Brazil and other Latin American countries experienced an outbreak of ZIKV infections associated with severe neurological disorders such as Guillain–Barre syndrome (GBS), ... ...

    Abstract Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) from Flavivirus. In 2015, Brazil and other Latin American countries experienced an outbreak of ZIKV infections associated with severe neurological disorders such as Guillain–Barre syndrome (GBS), encephalopathy, and encephalitis. Here, a complete mechanical and structural analysis of the ZIKV has been performed using Atomic Force Microscopy (AFM). AFM analysis corroborated the virus mean size (~50 nm) and icosahedral geometry and revealed high mechanical resistance of both: the viral surface particle (~200 kPa) and its internal content (~800 kPa). The analysis demonstrated the detailed organization of the nucleocapsid structure (such as RNA strips). An interesting finding was the discovery that ZIKV has no surface self-assembling property. These results can contribute to the development of future treatment candidates and circumscribe the magnitude of viral transmission.
    Keywords Guillain-Barre Syndrome ; RNA ; Zika virus ; arboviruses ; atomic force microscopy ; encephalitis ; encephalopathy ; geometry ; mechanical properties ; nucleocapsid ; virus transmission ; Brazil
    Language English
    Dates of publication 2022-0805
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14081727
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Graphene Quantum Dots for Molecular Radiotherapy: Radiolabeled Graphene Quantum Dots with Radium (

    Yang, Yang / Lima, Ruana Cardoso / Gemini-Piperni, Sara / Alencar, Luciana Magalhães Rebelo / Santos-Oliveira, Ralph

    Journal of biomedical nanotechnology

    2021  Volume 17, Issue 9, Page(s) 1858–1865

    Abstract: The necessity of new drugs with special attention for the therapy of cancer is increasing each day. Despite their properties, alpha therapeutic radiopharmaceuticals, especially based on the use of radium ( ...

    Abstract The necessity of new drugs with special attention for the therapy of cancer is increasing each day. Despite their properties, alpha therapeutic radiopharmaceuticals, especially based on the use of radium (
    MeSH term(s) Bone Neoplasms/radiotherapy ; Graphite ; Humans ; Osteosarcoma/radiotherapy ; Quantum Dots ; Radium
    Chemical Substances Graphite (7782-42-5) ; Radium (W90AYD6R3Q)
    Language English
    Publishing date 2021-10-23
    Publishing country United States
    Document type Journal Article
    ISSN 1550-7033
    ISSN 1550-7033
    DOI 10.1166/jbn.2021.3150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Ethnic/Racial Disparity in Mortality from COVID-19: Data for the Year 2020 in Brazil.

    Dos Santos, Marina / Oliveira Penteado, Júlia / de Lima Brum, Rodrigo / da Silva Bonifácio, Alicia / Florêncio Ramires, Paula / de Franceschi Gariboti, Diuster / Santos Cardoso, Ruana Michela / da Silva Júnior, Flavio Manoel Rodrigues

    Spatial demography

    2023  Volume 11, Issue 1, Page(s) 1–17

    Abstract: The study aimed to investigate ethnic/racial disparities in COVID-19 mortality in Brazilian federative units and their respective capitals in 2020. Population data and number of COVID-19 deaths were extracted by skin color (white, black, brown and ... ...

    Abstract The study aimed to investigate ethnic/racial disparities in COVID-19 mortality in Brazilian federative units and their respective capitals in 2020. Population data and number of COVID-19 deaths were extracted by skin color (white, black, brown and indigenous) from all Brazilian states and their respective capitals. The mortality rate of COVID-19 by ethnicity in Brazilian states was higher between people from brown skin color, followed by indigenous and black. Only in one state, in the Federal District and in the federal capital, age-standardized mortality rates were higher among white's people. There is a high percentage of deaths from COVID-19 higher than expected among non-white individuals, especially in south-central states and capitals of the country. Mortality from COVID-19 affect ethnic-racial groups unevenly in Brazil and the number of excess deaths among non-whites was over 9000. Urgent government measures are needed to reduce the racial disparity in health indicators in Brazil.
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2823492-3
    ISSN 2164-7070 ; 2364-2289
    ISSN (online) 2164-7070
    ISSN 2364-2289
    DOI 10.1007/s40980-022-00112-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: [

    Yang, Yang / Alencar, Luciana Magalhães Rebelo / Pijeira, Martha Sahylí Ortega / Batista, Beatriz da Silva / França, Alefe Roger Silva / Rates, Erick Rafael Dias / Lima, Ruana Cardoso / Gemini-Piperni, Sara / Santos-Oliveira, Ralph

    Drug delivery

    2022  Volume 29, Issue 1, Page(s) 186–191

    Abstract: The treatment of bone metastatsis as primary bone cancer itself is still a challenge. The use od radium dichloride ([ ...

    Abstract The treatment of bone metastatsis as primary bone cancer itself is still a challenge. The use od radium dichloride ([
    MeSH term(s) Bone Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Chemistry, Pharmaceutical ; Dose-Response Relationship, Drug ; Drug Carriers/chemistry ; Humans ; Micelles ; Nanoparticles/chemistry ; Osteosarcoma/pathology ; Particle Size ; Poloxamer/chemistry ; Radioisotopes/administration & dosage ; Radioisotopes/pharmacology ; Radiopharmaceuticals/administration & dosage ; Radiopharmaceuticals/pharmacology ; Radium/administration & dosage ; Radium/pharmacology
    Chemical Substances Drug Carriers ; Micelles ; Radioisotopes ; Radiopharmaceuticals ; Poloxamer (106392-12-5) ; radium Ra 223 dichloride (RJ00KV3VTG) ; Radium (W90AYD6R3Q)
    Language English
    Publishing date 2022-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1213261-5
    ISSN 1521-0464 ; 1071-7544
    ISSN (online) 1521-0464
    ISSN 1071-7544
    DOI 10.1080/10717544.2021.2005719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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