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  1. Article ; Online: To err is human, to forgive may require different vaccines.

    Creech, C Buddy

    Cell host & microbe

    2022  Volume 30, Issue 8, Page(s) 1070–1071

    Abstract: In this issue of Cell Host & Microbe, Tsai et al. (2022) provide evidence that Staphylococcus aureus should be numbered among the pathogens for which original antigenic sin governs subsequent immune responses. Their approach may restore the utility of ... ...

    Abstract In this issue of Cell Host & Microbe, Tsai et al. (2022) provide evidence that Staphylococcus aureus should be numbered among the pathogens for which original antigenic sin governs subsequent immune responses. Their approach may restore the utility of murine models in staphylococcal vaccine development.
    MeSH term(s) Animals ; Humans ; Mice ; Staphylococcal Infections/prevention & control ; Staphylococcal Vaccines ; Staphylococcus aureus ; Vaccines
    Chemical Substances Staphylococcal Vaccines ; Vaccines
    Language English
    Publishing date 2022-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2022.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6578: Show issues Location:
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  2. Article ; Online: It's True Even in a Pandemic: Children Are Not Merely Little Adults.

    Creech, C Buddy

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 9, Page(s) 2480–2481

    MeSH term(s) Adult ; COVID-19 ; Child ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  3. Article ; Online: Amniotic membrane transplantation as part of a multimodal management approach to Streptococcus pyogenes necrotizing keratoconjunctivitis.

    Ruland, Kelly L / Beneschott, Natalya / Creech, C Buddy / Umfress, Allison

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2024  , Page(s) 103900

    Abstract: Streptococcus pyogenes (group A beta-hemolytic Streptococcus, GABHS) causes a range of human infections, including necrotizing fasciitis and toxic shock syndrome, because it produces exotoxins that damage host cells, facilitate immune evasion, and serve ... ...

    Abstract Streptococcus pyogenes (group A beta-hemolytic Streptococcus, GABHS) causes a range of human infections, including necrotizing fasciitis and toxic shock syndrome, because it produces exotoxins that damage host cells, facilitate immune evasion, and serve as T cell superantigens. GABHS conjunctivitis is rare. We report a case of membranous conjunctivitis in a 3-year-old child who was treated with a combination of targeted bactericidal antimicrobials, toxin-synthesis inhibition, and amniotic membrane transplantation.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2024.103900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5188: Show issues Location:
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  5. Article ; Online: The Johnson & Johnson Vaccine for COVID-19.

    Livingston, Edward H / Malani, Preeti N / Creech, C Buddy

    JAMA

    2021  Volume 325, Issue 15, Page(s) 1575

    MeSH term(s) Adenoviridae ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; Genetic Vectors ; Humans ; Immunogenicity, Vaccine
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Patient Education Handout
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.2927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Proposals to Accelerate Novel Vaccine Development for Children.

    Permar, Sallie / Creech, C Buddy / Edwards, Kathryn M / Walter, Emmanuel B

    Pediatrics

    2021  

    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-054593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 357: Show issues

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  7. Article ; Online: Proposals to Accelerate Novel Vaccine Development for Children.

    Permar, Sallie / Creech, C Buddy / Edwards, Kathryn M / Walter, Emmanuel B

    Pediatrics

    2021  

    Language English
    Publishing date 2021-12-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-054593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: SARS-CoV-2 Vaccines.

    Creech, C Buddy / Walker, Shannon C / Samuels, Robert J

    JAMA

    2021  Volume 325, Issue 13, Page(s) 1318–1320

    MeSH term(s) Adenoviridae ; COVID-19/prevention & control ; COVID-19 Vaccines ; Genetic Vectors ; Humans ; Mass Vaccination/organization & administration ; SARS-CoV-2 ; Vaccines, Inactivated ; Vaccines, Subunit ; Vaccines, Synthetic ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines, Inactivated ; Vaccines, Subunit ; Vaccines, Synthetic
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.3199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
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  9. Article ; Online: Metabolomic Signatures Differentiate Immune Responses in Avian Influenza Vaccine Recipients.

    Howard, Leigh M / Jensen, Travis L / Goll, Johannes B / Gelber, Casey E / Bradley, Matthew D / Sherrod, Stacy D / Hoek, Kristen L / Yoder, Sandra / Jimenez-Truque, Natalia / Edwards, Kathryn / Creech, C Buddy

    The Journal of infectious diseases

    2024  

    Abstract: Background: Avian influenza viruses pose significant risk to human health. Vaccines targeting the hemagglutinin of these viruses are poorly immunogenic without the use of adjuvants.: Methods: Twenty healthy men and women (18-49 years of age) were ... ...

    Abstract Background: Avian influenza viruses pose significant risk to human health. Vaccines targeting the hemagglutinin of these viruses are poorly immunogenic without the use of adjuvants.
    Methods: Twenty healthy men and women (18-49 years of age) were randomized to receive two doses of inactivated influenza A/H5N1 vaccine alone (IIV) or with AS03 adjuvant (IIV-AS03) one month apart. Urine and serum samples were collected on day 0 and on days 1, 3, and 7 following first vaccination and subjected to metabolomics analyses to identify metabolites, metabolic pathways, and metabolite clusters associated with immunization.
    Results: Seventy-three differentially abundant (DA) serum and 88 urine metabolites were identified for any post-vaccination day comparison. Pathway analysis revealed enrichment of tryptophan, tyrosine and nicotinate metabolism in urine and serum among IIV-AS03 recipients. Increased urine abundance of 4-vinylphenol sulfate on Day 1 was associated with serologic response based on hemagglutination inhibition responses. In addition, 9 DA urine metabolites were identified in participants with malaise compared to those without.
    Conclusions: Our findings suggest that tryptophan, tyrosine, and nicotinate metabolism are upregulated among IIV-AS03 recipients compared with IIV alone. Metabolites within these pathways may serve as measures of immunogenicity and may provide mechanistic insights for adjuvanted vaccines.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 445: Show issues

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  10. Article ; Online: Advances in pediatric antimicrobial agents development.

    Wood, James B / Cravens, Lauryn B / Creech, C Buddy

    Current opinion in pediatrics

    2018  Volume 31, Issue 1, Page(s) 135–143

    Abstract: Purpose of review: Rising rates of multidrug-resistant organisms has necessitated the development of novel antimicrobials. In this review, we will highlight agents that have recently received licensure and those that are in clinical development.: ... ...

    Abstract Purpose of review: Rising rates of multidrug-resistant organisms has necessitated the development of novel antimicrobials. In this review, we will highlight agents that have recently received licensure and those that are in clinical development.
    Recent findings: In recent years, development of novel antimicrobial agents has accelerated. Although most studies have targeted the adult population, studies in pediatric patients are underway. Adequately powered clinical trials are needed to establish the safety and role of these new drugs.
    Summary: The recent development of novel antimicrobials to combat multidrug-resistant organisms is encouraging; however, more studies in the pediatric population are needed.
    MeSH term(s) Anti-Bacterial Agents ; Anti-Infective Agents ; Child ; Drug Resistance, Multiple ; Humans
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2018-10-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000000713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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