LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 170

Search options

  1. Article ; Online: Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review.

    Abufaraj, Mohammad / Ramadan, Raghad / Alkhatib, Amro

    Current oncology (Toronto, Ont.)

    2024  Volume 31, Issue 3, Page(s) 1618–1632

    Abstract: Neuroendocrine prostate cancer (NEPC) is a rare subtype of prostate cancer (PCa) that usually results in poor clinical outcomes and may be accompanied by paraneoplastic syndromes (PNS). NEPC is becoming more frequent. It can initially manifest as PNS, ... ...

    Abstract Neuroendocrine prostate cancer (NEPC) is a rare subtype of prostate cancer (PCa) that usually results in poor clinical outcomes and may be accompanied by paraneoplastic syndromes (PNS). NEPC is becoming more frequent. It can initially manifest as PNS, complicating diagnosis. Therefore, we reviewed the literature on the different PNS associated with NEPC. We systematically reviewed English-language articles from January 2017 to September 2023, identifying 17 studies meeting PRISMA guidelines for NEPC and associated PNS. A total of 17 articles were included in the review. Among these, Cushing's Syndrome (CS) due to ectopic Adrenocorticotropic hormone (ACTH) secretion was the most commonly reported PNS. Other PNS included syndrome of inappropriate Anti-Diuretic Hormone secretion (SIADH), Anti-Hu-mediated chronic intestinal pseudo-obstruction (CIPO), limbic encephalitis, Evans Syndrome, hypercalcemia, dermatomyositis, and polycythemia. Many patients had a history of prostate adenocarcinoma treated with androgen deprivation therapy (ADT) before neuroendocrine features developed. The mean age was 65.5 years, with a maximum survival of 9 months post-diagnosis. NEPC is becoming an increasingly more common subtype of PCa that can result in various PNS. This makes the diagnosis and treatment of NEPC challenging. Further research is crucial to understanding these syndromes and developing standardized, targeted treatments to improve patient survival.
    MeSH term(s) Male ; Humans ; Aged ; Prostatic Neoplasms/therapy ; Androgen Antagonists ; Paraneoplastic Syndromes
    Chemical Substances Androgen Antagonists
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31030123
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Chitosan-Based Nanocarriers for Pulmonary and Intranasal Drug Delivery Systems: A Comprehensive Overview of their Applications.

    Alwahsh, Wasan / Sahudin, Shariza / Alkhatib, Hatim / Bostanudin, Mohammad F / Alwahsh, Mohammad

    Current drug targets

    2024  

    Abstract: The optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory ...

    Abstract The optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory system, providing advantages, such as sustained regional drug concentration, tunable drug release, extended duration of action, and enhanced patient compliance. IND, renowned for its non-invasive nature and swift onset of action, presents a promising path for advancement. Modern PDDS and IND utilize various polymers, among which Chitosan (CS) stands out. CS is a biocompatible and biodegradable polysaccharide with unique physicochemical properties, making it well-suited for medical and pharmaceutical applications. The multiple positively charged amino groups present in CS facilitate its interaction with negatively charged mucous membranes, allowing CS to adsorb easily onto the mucosal surface. In addition, CS-based nanocarriers have been an important topic of research. Polymeric Nanoparticles (NPs), liposomes, dendrimers, microspheres, nanoemulsions, Solid Lipid Nanoparticles (SLNs), carbon nanotubes, and modified effective targeting systems compete as important ways of increasing pulmonary drug delivery with chitosan. This review covers the latest findings on CS-based nanocarriers and their applications.
    Language English
    Publishing date 2024-04-26
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/0113894501301747240417103321
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Asthma-COPD Overlap in Clinical Practice (ACO_CP 2023): Toward Precision Medicine.

    Alsayed, Ahmad R / Abu-Samak, Mahmoud S / Alkhatib, Mohammad

    Journal of personalized medicine

    2023  Volume 13, Issue 4

    Abstract: Asthma and COPD have characteristic symptoms, yet patients with both are prevalent. Despite this, there is currently no globally accepted definition for the overlap between asthma and COPD, commonly referred to as asthma-COPD overlap (ACO). Generally, ... ...

    Abstract Asthma and COPD have characteristic symptoms, yet patients with both are prevalent. Despite this, there is currently no globally accepted definition for the overlap between asthma and COPD, commonly referred to as asthma-COPD overlap (ACO). Generally, ACO is not considered a distinct disease or symptom from either clinical or mechanistic perspectives. However, identifying patients who present with both conditions is crucial for guiding clinical therapy. Similar to asthma and COPD, ACO patients are heterogeneous and presumably have multiple underlying disease processes. The variability of ACO patients led to the establishment of multiple definitions describing the condition's essential clinical, physiological, and molecular characteristics. ACO comprises numerous phenotypes, which affects the optimal medication choice and can serve as a predictor of disease prognosis. Various phenotypes of ACO have been suggested based on host factors including but not limited to demographics, symptoms, spirometric findings, smoking history, and underlying airway inflammation. This review provides a comprehensive clinical guide for ACO patients to be used in clinical practice based on the available limited data. Future longitudinal studies must evaluate the stability of ACO phenotypes over time and explore their predictive powers to facilitate a more precise and effective management approach.
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13040677
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: On graded classical B-2-absorbing submodules.

    Al-Zoubi, Khaldoun / Ali, Mohammed / Alkhatib, Mohammad

    Heliyon

    2022  Volume 8, Issue 10, Page(s) e11230

    Abstract: In this paper, we introduce the concept of graded ... ...

    Abstract In this paper, we introduce the concept of graded classical
    Language English
    Publishing date 2022-10-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e11230
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Towards Improving Privacy and Security of Identity Management Systems Using Blockchain Technology

    Haifa Alanzi / Mohammad Alkhatib

    Applied Sciences, Vol 12, Iss 12415, p

    A Systematic Review

    2022  Volume 12415

    Abstract: An identity management system (IDMS) manages and organizes identities and credentials information exchanged between users, identity providers (IDPs), and service providers (SPs) to ensure confidentiality and enhance privacy of users’ personal data. ... ...

    Abstract An identity management system (IDMS) manages and organizes identities and credentials information exchanged between users, identity providers (IDPs), and service providers (SPs) to ensure confidentiality and enhance privacy of users’ personal data. Traditional or centralized IDMS rely on a third party to store a user’s personal information, authenticate the user, and organize the entire process. This clearly constitutes threats to the privacy of the user, in addition to other issues, such as single point of failure (SPOF), user tracking, and data availability issues. Blockchain technology has many useful features that can contribute to solving traditional IDMS issues, such as decentralization, immutability, and anonymity. Blockchain represents an attractive solution for many issues related to traditional IDMS, including privacy, third-party control, data leakage, and SPOF, supported by Distributed Ledger Technology (DLT) security features and powerful smart contracts technology. The current study presents a systematic literature review and analysis for recently proposed solutions that adopt the traditional centralized approach, as well as solutions based on blockchain technology. The study also aims to provide a deep understanding of proposed IDMS solutions and best practices, and highlight the research gaps and open issues related to IDMSs and users’ privacy. In particular, the current research focuses on analyzing the blockchain-based solutions and illustrating their strengths and weaknesses, as well as highlighting the promising blockchain technology framework that can be utilized to enhance privacy and solve security issues in a centralized IDMS. Such a study is an important step towards developing efficient solutions that address the pressing needs in the field.
    Keywords identity management ; blockchain ; distributed ledger technology ; self-sovereign identity ; privacy ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 005
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: LARLUS: laparoscopic augmented reality from laparoscopic ultrasound.

    Kalantari, Mohammad Mahdi / Ozgur, Erol / Alkhatib, Mohammad / Buc, Emmanuel / Le Roy, Bertrand / Modrzejewski, Richard / Mezouar, Youcef / Bartoli, Adrien

    International journal of computer assisted radiology and surgery

    2024  

    Abstract: Purpose: This research endeavors to improve tumor localization in minimally invasive surgeries, a challenging task primarily attributable to the absence of tactile feedback and limited visibility. The conventional solution uses laparoscopic ultrasound ( ... ...

    Abstract Purpose: This research endeavors to improve tumor localization in minimally invasive surgeries, a challenging task primarily attributable to the absence of tactile feedback and limited visibility. The conventional solution uses laparoscopic ultrasound (LUS) which has a long learning curve and is operator-dependent.
    Methods: The proposed approach involves augmenting LUS images onto laparoscopic images to improve the surgeon's ability to estimate tumor and internal organ anatomy. This augmentation relies on LUS pose estimation and filtering.
    Results: Experiments conducted with clinical data exhibit successful outcomes in both the registration and augmentation of LUS images onto laparoscopic images. Additionally, noteworthy results are observed in filtering, leading to reduced flickering in augmentations.
    Conclusion: The outcomes reveal promising results, suggesting the potential of LUS augmentation in surgical images to assist surgeons and serve as a training tool. We have used the LUS probe's shaft to disambiguate the rotational symmetry. However, in the long run, it would be desirable to find more convenient solutions.
    Language English
    Publishing date 2024-04-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2365628-1
    ISSN 1861-6429 ; 1861-6410
    ISSN (online) 1861-6429
    ISSN 1861-6410
    DOI 10.1007/s11548-024-03134-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6615: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Highlighting the Need for MD-PhD Programs in Developing Countries.

    Ashour, Laith / Schoumann-Alkhatib, Ali / Alshawabkeh, Anmar / Alsouri, Mohammad / Sawalmeh, Mohammad / Hatamleh, Hamzeh / Sawahreh, Hamza

    Avicenna journal of medicine

    2023  Volume 13, Issue 2, Page(s) 65–67

    Language English
    Publishing date 2023-04-26
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2664414-9
    ISSN 2249-4464 ; 2231-0770
    ISSN (online) 2249-4464
    ISSN 2231-0770
    DOI 10.1055/s-0043-1768445
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Gadolinium contrast agents- challenges and opportunities of a multidisciplinary approach: Literature review.

    Iyad, Nebal / S Ahmad, Muntaser / Alkhatib, Sanaa G / Hjouj, Mohammad

    European journal of radiology open

    2023  Volume 11, Page(s) 100503

    Abstract: Contrast agents is used in magnetic resonance imaging (MRI) to improve the visibility of the details of the organ structures. Gadolinium-based contrast agent (GBCA) has been used since 1988 in MRI for diagnostic and follow-up of patients, the gadolinium ... ...

    Abstract Contrast agents is used in magnetic resonance imaging (MRI) to improve the visibility of the details of the organ structures. Gadolinium-based contrast agent (GBCA) has been used since 1988 in MRI for diagnostic and follow-up of patients, the gadolinium good properties make it an effective choice for enhance the signal in MRI by increase its intensity and shortening the relaxation time of the proton. Recently, many studies show a gadolinium deposition in different human organs due to release of free gadolinium various body organs or tissue, which led to increased concern about the use of gadolinium agents, in this study, the potential diseases that may affect the patient and side effects that appear on the patient and related to accumulation of gadolinium were clarified, the study focused on the organs such as brain and bones in which gadolinium deposition was found and the lesions associated with it, and the diseases associated with gadolinium retention includes Nephrogenic Systemic Fibrosis (NSF) and Gadolinium deposition disease (GDD). Some studies tended to improve the contrast agents by developing a new non-gadolinium agents or development of next-generation gadolinium agents. In this review article the latest knowledge about MRI contrast agent.
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2810314-2
    ISSN 2352-0477
    ISSN 2352-0477
    DOI 10.1016/j.ejro.2023.100503
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Sickle cell leg ulcer successfully managed by hyperbaric oxygen: a case report.

    Alshurafa, Awni / Alkhatib, Mohammed / Abu-Tineh, Mohammad / Yassin, Mohamed A

    Frontiers in medicine

    2023  Volume 10, Page(s) 1171971

    Abstract: Sickle cell leg ulcers (SCLUs) are usually chronic, painful, and devastating complications of sickle cell disease. Skin vaso-occlusion with compromised blood flow, chronic inflammation, and endothelial dysfunction is thought to be the underlying ... ...

    Abstract Sickle cell leg ulcers (SCLUs) are usually chronic, painful, and devastating complications of sickle cell disease. Skin vaso-occlusion with compromised blood flow, chronic inflammation, and endothelial dysfunction is thought to be the underlying mechanism. It is usually slow to heal, and it may become chronic and superinfected. The management of SCLUs is usually challenging and requires a multidisciplinary team. Multiple systemic and local therapies have been tried in SCLU treatment. However, the outcome is variable: currently, there are no official recommendations for the best effective treatment. Herein, we report a 34-year-old male patient with non-transfusion-dependent sickle cell disease who was suffering from a chronic left ankle ulcer and was successfully managed with hyperbaric oxygen therapy, resulting in a complete resolution of this devastating complication.
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1171971
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Sickle cell leg ulcer successfully managed by hyperbaric oxygen

    Awni Alshurafa / Mohammed Alkhatib / Mohammad Abu-Tineh / Mohamed A. Yassin

    Frontiers in Medicine, Vol

    a case report

    2023  Volume 10

    Abstract: Sickle cell leg ulcers (SCLUs) are usually chronic, painful, and devastating complications of sickle cell disease. Skin vaso-occlusion with compromised blood flow, chronic inflammation, and endothelial dysfunction is thought to be the underlying ... ...

    Abstract Sickle cell leg ulcers (SCLUs) are usually chronic, painful, and devastating complications of sickle cell disease. Skin vaso-occlusion with compromised blood flow, chronic inflammation, and endothelial dysfunction is thought to be the underlying mechanism. It is usually slow to heal, and it may become chronic and superinfected. The management of SCLUs is usually challenging and requires a multidisciplinary team. Multiple systemic and local therapies have been tried in SCLU treatment. However, the outcome is variable: currently, there are no official recommendations for the best effective treatment. Herein, we report a 34-year-old male patient with non-transfusion-dependent sickle cell disease who was suffering from a chronic left ankle ulcer and was successfully managed with hyperbaric oxygen therapy, resulting in a complete resolution of this devastating complication.
    Keywords sickle cell disease ; leg ulcer ; hyperbaric oxygen ; wound care ; wound healing ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top