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  1. Article: Uniting minds and methods: how interprofessional education advances male infertility research.

    Sengupta, Pallav / Dutta, Sulagna

    EXCLI journal

    2024  Volume 23, Page(s) 92–94

    Language English
    Publishing date 2024-01-12
    Publishing country Germany
    Document type Journal Article
    ISSN 1611-2156
    ISSN 1611-2156
    DOI 10.17179/excli2023-6641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: ChatGPT guidance for reproductive specialists: Dr. Jekyll or Mr. Hyde?

    Sengupta, Pallav / Dutta, Sulagna

    EXCLI journal

    2023  Volume 22, Page(s) 911–914

    Language English
    Publishing date 2023-08-29
    Publishing country Germany
    Document type Journal Article
    ISSN 1611-2156
    ISSN 1611-2156
    DOI 10.17179/excli2023-6120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genomes of extinct hominins and human reproductive evolution.

    Sengupta, Pallav / Dutta, Sulagna / Chhikara, Bhupender S

    EXCLI journal

    2023  Volume 22, Page(s) 392–394

    Language English
    Publishing date 2023-03-22
    Publishing country Germany
    Document type Journal Article
    ISSN 1611-2156
    ISSN 1611-2156
    DOI 10.17179/excli2022-5991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Revolutionizing semen analysis: introducing Mojo AISA, the next-gen artificial intelligence microscopy.

    Sengupta, Pallav / Dutta, Sulagna / Roychoudhury, Shubhadeep / Vizzarri, Francesco / Slama, Petr

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1203708

    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1203708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genomes of extinct hominins and human reproductive evolution

    Pallav Sengupta / Sulagna Dutta / Bhupender S. Chhikara

    EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 392-

    2023  Volume 394

    Keywords hominins ; reproductive evolution ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Novel sequence type of carbapenem-resistant Acinetobacter pittii ST1451 with enhanced virulence isolated from septicaemic neonates in India.

    Roy, Subhasree / Morita, Daichi / Bhattacharya, Sushmita / Dutta, Shanta / Basu, Sulagna

    The Journal of antimicrobial chemotherapy

    2024  Volume 79, Issue 4, Page(s) 779–783

    Abstract: Background: The clinical relevance of Acinetobacter pittii is increasing, but reports of this organism causing neonatal sepsis are rare.: Objectives: To understand the mechanisms of resistance and virulence of A. pittii isolated from neonatal blood ... ...

    Abstract Background: The clinical relevance of Acinetobacter pittii is increasing, but reports of this organism causing neonatal sepsis are rare.
    Objectives: To understand the mechanisms of resistance and virulence of A. pittii isolated from neonatal blood belonging to a novel sequence type.
    Materials and methods: Antibiotic susceptibility, MLST, WGS, phylogenomic comparison with a global collection of carbapenemase-harbouring A. pittii were done. To study the pathogenic potential of novel A. pittii, in vitro and in vivo assays were carried out.
    Results and discussion: Two novel multidrug-resistant A. pittii from neonatal blood belonging to a novel sequence type 1451 (ST1451) were isolated. WGS revealed that the isolates were almost similar (147 SNP distant) and harbouring two carbapenem resistance genes blaNDM-1 with upstream ISAba125 and downstream bleMBL along with blaOXA-58 with upstream ISAba3. Other resistance genes included blaADC-25, blaOXA-533, aph(3″)-Ib, aph(3')-VIa, aph(6)-Id, aac(3)-IId, mph(E), msr(E), sul2 and tet(39), different efflux pump genes and amino acid substitutions within GyrA (Ser81Leu) and ParC (Ser84Leu; Glu88Ala) were detected among the isolates. The study genomes were closely related to four strains belonging to ST119. The isolates showed biofilm production, serum resistance, growth under iron limiting condition, surface-associated motility and adherence to host cell. Isolates induced cytokine production in the host cell and showed mice mortality.
    Discussion and conclusions: This study is the first report of the presence of blaNDM-1 in A. pittii from India along with another carbapenemase blaOXA-58. Emergence of highly virulent, multidrug-resistant A. pittii with attributes similar to A. baumannii calls for surveillance to identify the novel strains and their pathogenic and resistance potential.
    MeSH term(s) Animals ; Mice ; Carbapenems/pharmacology ; Anti-Bacterial Agents/pharmacology ; Virulence ; Multilocus Sequence Typing ; Acinetobacter Infections/epidemiology ; Microbial Sensitivity Tests ; Bacterial Proteins/genetics ; beta-Lactamases/genetics ; beta-Lactamases/metabolism ; Acinetobacter baumannii/genetics ; Acinetobacter
    Chemical Substances Carbapenems ; Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkae024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Role of Nitric Oxide on Male and Female Reproduction.

    Dutta, Sulagna / Sengupta, Pallav

    The Malaysian journal of medical sciences : MJMS

    2022  Volume 29, Issue 2, Page(s) 18–30

    Abstract: Nitric oxide (NO), a reactive nitrogen species, is a molecule of high physiological as well as pathological importance. Physiological mechanisms mediated by NO mainly include angiogenesis, growth, puberty and senescence. NO has vital roles in normal ... ...

    Abstract Nitric oxide (NO), a reactive nitrogen species, is a molecule of high physiological as well as pathological importance. Physiological mechanisms mediated by NO mainly include angiogenesis, growth, puberty and senescence. NO has vital roles in normal reproduction, including steroidogenesis, gametogenesis and the regulation of germ-cell apoptosis. In females, NO stimulates an inflammatory cascade to induce ovulation, decreases steroidogenesis in luteal and granulosa cells, and acts as a paracrine factor to mediate reproductive cycles and implantation. In males, NO is a key player for steroidogenesis, erectile functions, sperm capacitation and acrosome reaction. Moreover, NO is also a regulator of Sertoli cell-germ cell interaction and maintenance of the blood-testis barrier. In pathological conditions such as infections, increased nitric oxide synthase (NOS) activities stimulate the excessive synthesis of NO which acts as a proinflammatory mediator inducing oxidative stress (OS), which is detrimental to reproductive functions in both males and females. During impregnation, the overproduction of NO results in uterine epithelial cell inflammation and immune rejection of implantation. Excessive NO synthesis disrupts gonadal functions, and induces germ cell apoptosis and oxidative damage to the germ cells. This review elucidates how the differences in NO expression levels account for its beneficial and adverse impacts upon male and female fertility.
    Language English
    Publishing date 2022-04-21
    Publishing country Malaysia
    Document type Journal Article ; Review
    ZDB-ID 2197205-9
    ISSN 2180-4303 ; 1394-195X
    ISSN (online) 2180-4303
    ISSN 1394-195X
    DOI 10.21315/mjms2022.29.2.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: N-acetyl cysteine as a potential regulator of SARS-CoV-2-induced male reproductive disruptions.

    Sengupta, Pallav / Dutta, Sulagna

    Middle East Fertility Society journal

    2022  Volume 27, Issue 1, Page(s) 14

    Abstract: Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), has shown its persistent pandemic strength. This viral infectivity, kinetics, and the mechanisms of its actions in human body ... ...

    Abstract Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), has shown its persistent pandemic strength. This viral infectivity, kinetics, and the mechanisms of its actions in human body are still not completely understood. In addition, the infectivity and COVID-19 severity reportedly differ with patient's gender with men being more susceptible to the disease. Thus, different studies have also suggested the adverse impact of COVID-19 on male reproductive functions, mainly emphasizing on high expressions of angiotensin-converting enzyme 2 (ACE2) in the testes that allows the viral entry into the cells.
    Main body: The N-acetylcysteine (NAC), a potent therapeutic agent of COVID-19, may be effective in reducing the impairing impacts of this disease on male reproductive functions. NAC acts as mucolytic agent by reducing sulfide bonds in the cross-linked glycoprotein matrix in mucus owing to its free sulfhydryl group. Since NAC also breaks the viral disulfide bonds required for the host cell invasion, it may help to prevent direct SARS-CoV-2 invasion into the testicular cells as well. NAC also acts as a potent anti-inflammatory and antioxidant, directly scavenging reactive oxygen species (ROS) and regulating the redox state by maintaining the thiol pool being a precursor of cysteine (an essential substrate for glutathione synthesis). Since it is suggested that male reproductive impairment in COVID-19 patient may be caused by secondary immune responses owing to systemic inflammation and OS, the anti-inflammatory and antioxidant properties of NAC explained above may attribute in protecting the male reproduction functions from these COVID-19-mediated damages.
    Conclusion: This article explains the mechanisms how NAC treatment for COVID-19 may prevent the infection-mediated disruptions in male reproduction.
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2006354-4
    ISSN 2090-3251 ; 1110-5690
    ISSN (online) 2090-3251
    ISSN 1110-5690
    DOI 10.1186/s43043-022-00104-8
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    Zs.A 5147: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: 'Intracytoplasmic sperm injection (ICSI) paradox' and 'andrological ignorance': AI in the era of fourth industrial revolution to navigate the blind spots.

    Sengupta, Pallav / Dutta, Sulagna / Jegasothy, Ravindran / Slama, Petr / Cho, Chak-Lam / Roychoudhury, Shubhadeep

    Reproductive biology and endocrinology : RB&E

    2024  Volume 22, Issue 1, Page(s) 22

    Abstract: The quandary known as the Intracytoplasmic Sperm Injection (ICSI) paradox is found at the juncture of Assisted Reproductive Technology (ART) and 'andrological ignorance' - a term coined to denote the undervalued treatment and comprehension of male ... ...

    Abstract The quandary known as the Intracytoplasmic Sperm Injection (ICSI) paradox is found at the juncture of Assisted Reproductive Technology (ART) and 'andrological ignorance' - a term coined to denote the undervalued treatment and comprehension of male infertility. The prevalent use of ICSI as a solution for severe male infertility, despite its potential to propagate genetically defective sperm, consequently posing a threat to progeny health, illuminates this paradox. We posit that the meteoric rise in Industrial Revolution 4.0 (IR 4.0) and Artificial Intelligence (AI) technologies holds the potential for a transformative shift in addressing male infertility, specifically by mitigating the limitations engendered by 'andrological ignorance.' We advocate for the urgent need to transcend andrological ignorance, envisaging AI as a cornerstone in the precise diagnosis and treatment of the root causes of male infertility. This approach also incorporates the identification of potential genetic defects in descendants, the establishment of knowledge platforms dedicated to male reproductive health, and the optimization of therapeutic outcomes. Our hypothesis suggests that the assimilation of AI could streamline ICSI implementation, leading to an overall enhancement in the realm of male fertility treatments. However, it is essential to conduct further investigations to substantiate the efficacy of AI applications in a clinical setting. This article emphasizes the significance of harnessing AI technologies to optimize patient outcomes in the fast-paced domain of reproductive medicine, thereby fostering the well-being of upcoming generations.
    MeSH term(s) Male ; Humans ; Sperm Injections, Intracytoplasmic ; Artificial Intelligence ; Semen ; Infertility, Male/diagnosis ; Infertility, Male/genetics ; Infertility, Male/therapy ; Reproductive Techniques, Assisted
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Letter
    ZDB-ID 2119215-7
    ISSN 1477-7827 ; 1477-7827
    ISSN (online) 1477-7827
    ISSN 1477-7827
    DOI 10.1186/s12958-024-01193-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: COVID-19 and hypogonadism: secondary immune responses rule-over endocrine mechanisms.

    Sengupta, Pallav / Dutta, Sulagna

    Human fertility (Cambridge, England)

    2021  Volume 26, Issue 1, Page(s) 182–185

    Abstract: Men show higher vulnerability to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection (COVID-19) and present with depleted testosterone levels. Reports pertaining to high luteinizing hormone (LH), while diminished levels of in COVID-19 ... ...

    Abstract Men show higher vulnerability to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection (COVID-19) and present with depleted testosterone levels. Reports pertaining to high luteinizing hormone (LH), while diminished levels of in COVID-19 patients negate the hypothalamic-pituitary-testicular (HPT) axis mediated lowering of testosterone. Although not evidenced, high testicular expression of angiotensin-converting enzymes-2 (ACE2), that aids viral entry into cells, may suggest direct viral-testicular invasion. However, secondary inflammation and oxidative stress (OS), owing to SARS-CoV-2 infection, are more likely to impair steroidogenesis. Moreover, blockage of ACE2 aided angiotensin II into angiotensin (1-7) conversion may also affect testosterone synthesis. SARS-CoV-2, by mimicking adrenocorticotrophic (ACTH) hormones, may trigger host antibodies against the ACTH molecules to suppress host stress response. This commentary concisely presents the possible mechanisms by which SARS-CoV-2 infection may affect testosterone levels, which possibly result in compromised male reproductive health.
    MeSH term(s) Humans ; Male ; COVID-19 ; SARS-CoV-2/metabolism ; Angiotensin-Converting Enzyme 2 ; Peptidyl-Dipeptidase A/metabolism ; Hypogonadism ; Testosterone ; Immunity
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2021-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2086960-5
    ISSN 1742-8149 ; 1464-7273
    ISSN (online) 1742-8149
    ISSN 1464-7273
    DOI 10.1080/14647273.2020.1867902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5775: Show issues Location:
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