Article ; Online: IgG from patients with mild or severe COVID‑19 reduces the frequency and modulates the function of peripheral mucosal-associated invariant T cells in PBMCs from healthy individuals.
2023 Volume 19, Issue 6, Page(s) 95
Abstract: Lower levels of peripheral mucosal-associated invariant T (MAIT) cells have been observed in the peripheral blood of patients with severe coronavirus disease 2019 (COVID-19). Following on from previous research into the effect of the IgG repertoire on ... ...
| Abstract | Lower levels of peripheral mucosal-associated invariant T (MAIT) cells have been observed in the peripheral blood of patients with severe coronavirus disease 2019 (COVID-19). Following on from previous research into the effect of the IgG repertoire on human lymphocytes, the present study aimed to evaluate if immunoglobulin G (IgG) antibodies obtained from patients with mild or severe COVID-19 contribute to these effects on MAIT cells. Culture experiments were performed using healthy human peripheral blood mononuclear cells (PBMCs) and different repertoires of IgG obtained from patients with COVID-19 as a mild or severe disease and compared with mock, healthy control or therapeutic IgG conditions. The results indicate that the IgG repertoire induced during the development of mild and severe COVID-19 has, |
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| Language | English |
| Publishing date | 2023-10-16 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2763624-0 |
| ISSN | 2049-9442 ; 2049-9434 |
| ISSN (online) | 2049-9442 |
| ISSN | 2049-9434 |
| DOI | 10.3892/br.2023.1677 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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