LIVIVO - Search results -

Search results

Result 1 - 10 of total 19

Search options

Article ; Online: Virtual high-throughput screening

Ruan Zijing / Tang Jiaxi / Zeng Mingtang / Fan Ping

Open Life Sciences, Vol 18, Iss 1, Pp e2449-

Potential inhibitors targeting aminopeptidase N (CD13) and PIKfyve for SARS-CoV-2

2023 Volume 20

Keywords	sars-cov-2 ; virtual screening ; potential inhibitor ; cd13 ; pikfyve ; drug repurposing ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Virtual high-throughput screening: Potential inhibitors targeting aminopeptidase N (CD13) and PIKfyve for SARS-CoV-2.

Ruan, Zijing / Tang, Jiaxi / Zeng, Mingtang / Fan, Ping

Open life sciences

2023 Volume 18, Issue 1, Page(s) 20220637

Abstract: Since the outbreak of the novel coronavirus nearly 3 years ago, the world's public health has been under constant threat. At the same time, people's travel and social interaction have also been greatly affected. The study focused on the potential host ... ...

Abstract	Since the outbreak of the novel coronavirus nearly 3 years ago, the world's public health has been under constant threat. At the same time, people's travel and social interaction have also been greatly affected. The study focused on the potential host targets of SARS-CoV-2, CD13, and PIKfyve, which may be involved in viral infection and the viral/cell membrane fusion stage of SARS-CoV-2 in humans. In this study, electronic virtual high-throughput screening for CD13 and PIKfyve was conducted using Food and Drug Administration-approved compounds in ZINC database. The results showed that dihydroergotamine, Saquinavir, Olysio, Raltegravir, and Ecteinascidin had inhibitory effects on CD13. Dihydroergotamine, Sitagliptin, Olysio, Grazoprevir, and Saquinavir could inhibit PIKfyve. After 50 ns of molecular dynamics simulation, seven compounds showed stability at the active site of the target protein. Hydrogen bonds and van der Waals forces were formed with target proteins. At the same time, the seven compounds showed good binding free energy after binding to the target proteins, providing potential drug candidates for the treatment and prevention of SARS-CoV-2 and SARS-CoV-2 variants.
Language	English
Publishing date	2023-07-07
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2817958-4
ISSN	2391-5412 ; 2391-5412
ISSN (online)	2391-5412
ISSN	2391-5412
DOI	10.1515/biol-2022-0637
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Association Between Monocyte-to-High-Density Lipoprotein Ratio and Prediabetes: A Cross-Sectional Study in Chinese Population.

Ruan, Cairong / Li, Yuchen / Ran, Zijing / Liu, Guodong / Li, Weihao / Zhang, Xinyu / Shao, Shanshan / Li, Yuan

Diabetes, metabolic syndrome and obesity : targets and therapy

2024 Volume 17, Page(s) 1093–1103

Abstract: Background: The monocyte-to-high-density lipoprotein cholesterol (MHR) ratio has been linked to metabolic disorders. However, there is limited research on the predisposition to MHR and prediabetes. Hence, we conducted a study to investigate the ... ...

Abstract	Background: The monocyte-to-high-density lipoprotein cholesterol (MHR) ratio has been linked to metabolic disorders. However, there is limited research on the predisposition to MHR and prediabetes. Hence, we conducted a study to investigate the relationship between MHR and the prevalence of prediabetes. Methods: In total, 85,293 participants were included in our cross-sectional observational study. Multivariable regression analysis, subgroup analyses, and interaction testing were used to determine the relationship between MHR and prediabetes. To explore the non-linear association of MHR with prediabetes risk, generalized additive model (GAM) and smoothing splines were applied. The threshold effect analysis of MHR on the risk of prediabetes was further employed to identify the turning point. Results: After controlling for covariates, the results indicated that a positive correlation persisted between MHR and prediabetes (odds ratio (OR) =1.64, 95% confidence interval (CI), 1.48-1.82), and subgroup analyses found a more robust correlation between MHR and prediabetes in individuals with lower age, SBP, DBP, TG, TC and higher values of BMI and LDL-C than in their counterparts. Additionally, the correlation between MHR and the risk of prediabetes was found to be non-linear, with a turning point of -0.4 (Log-Likelihood Ratio, P< 0.001). The impact of variables on the two sides of the turning point were 1.94 (1.72, 2.19) and 0.88 (0.69, 1.14). Conclusion: The positive correlation between MHR and the risk of prediabetes in Chinese participants was observed to be non-linear, and MHR ≤ -0.4 was strongly positively correlated with prediabetes risk.
Language	English
Publishing date	2024-03-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S451189
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Generation, evolution, interfering factors, applications, and challenges of patient-derived xenograft models in immunodeficient mice.

Zeng, Mingtang / Ruan, Zijing / Tang, Jiaxi / Liu, Maozhu / Hu, Chengji / Fan, Ping / Dai, Xinhua

Cancer cell international

2023 Volume 23, Issue 1, Page(s) 120

Abstract: Establishing appropriate preclinical models is essential for cancer research. Evidence suggests that cancer is a highly heterogeneous disease. This follows the growing use of cancer models in cancer research to avoid these differences between xenograft ... ...

Abstract	Establishing appropriate preclinical models is essential for cancer research. Evidence suggests that cancer is a highly heterogeneous disease. This follows the growing use of cancer models in cancer research to avoid these differences between xenograft tumor models and patient tumors. In recent years, a patient-derived xenograft (PDX) tumor model has been actively generated and applied, which preserves both cell-cell interactions and the microenvironment of tumors by directly transplanting cancer tissue from tumors into immunodeficient mice. In addition to this, the advent of alternative hosts, such as zebrafish hosts, or in vitro models (organoids and microfluidics), has also facilitated the advancement of cancer research. However, they still have a long way to go before they become reliable models. The development of immunodeficient mice has enabled PDX to become more mature and radiate new vitality. As one of the most reliable and standard preclinical models, the PDX model in immunodeficient mice (PDX-IM) exerts important effects in drug screening, biomarker development, personalized medicine, co-clinical trials, and immunotherapy. Here, we focus on the development procedures and application of PDX-IM in detail, summarize the implications that the evolution of immunodeficient mice has brought to PDX-IM, and cover the key issues in developing PDX-IM in preclinical studies.
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-023-02953-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Mn

Zhu, Yihong / Sun, Zijing / Deng, Yun / Liu, Fudong / Ruan, Wenquan / Xie, Lijuan

The Science of the total environment

2022 Volume 839, Page(s) 156075

Abstract: In this work, a ... ...

Abstract	In this work, a Mn
MeSH term(s)	Aluminum Oxide ; Benzhydryl Compounds/chemistry ; Magnesium Oxide ; Oxygen ; Phenols ; Superoxides
Chemical Substances	Benzhydryl Compounds ; Phenols ; spinell ; Superoxides (11062-77-4) ; Magnesium Oxide (3A3U0GI71G) ; Aluminum Oxide (LMI26O6933) ; bisphenol A (MLT3645I99) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-05-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.156075
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 949: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: TSHR signaling promotes hippocampal dependent memory formation through modulating Wnt5a/β-catenin mediated neurogenesis.

Li, Yuchen / Luan, Sisi / Ruan, Cairong / Li, Weihao / Zhang, Xinyu / Ran, Zijing / Bi, Wenkai / Tong, Yuelin / Gao, Ling / Zhao, Jiajun / Li, Yuan / He, Zhao

Biochemical and biophysical research communications

2024 Volume 704, Page(s) 149723

Abstract: Subclinical hyperthyroidism is defined biochemically as a low or undetectable thyroid-stimulating hormone (TSH) with normal thyroid hormone levels. Low TSHR signaling is considered to associate with cognitive impairment. However, the underlying molecular ...

Abstract	Subclinical hyperthyroidism is defined biochemically as a low or undetectable thyroid-stimulating hormone (TSH) with normal thyroid hormone levels. Low TSHR signaling is considered to associate with cognitive impairment. However, the underlying molecular mechanism by which TSHR signaling modulates memory is poorly understood. In this study, we found that Tshr-deficient in the hippocampal neurons impairs the learning and memory abilities of mice, accompanying by a decline in the number of newborn neurons. Notably, Tshr ablation in the hippocampus decreases the expression of Wnt5a, thereby inactivating the β-catenin signaling pathway to reduce the neurogenesis. Conversely, activating of the Wnt/β-catenin pathway by the agonist SKL2001 results in an increase in hippocampal neurogenesis, resulting in the amelioration in the deficits of memory caused by Tshr deletion. Understanding how TSHR signaling in the hippocampus regulates memory provides insights into subclinical hyperthyroidism affecting cognitive function and will suggest ways to rationally design interventions for neurocognitive disorders.
MeSH term(s)	Mice ; Animals ; beta Catenin/metabolism ; Receptors, Thyrotropin/genetics ; Receptors, Thyrotropin/metabolism ; Wnt Signaling Pathway/physiology ; Receptors, G-Protein-Coupled/metabolism ; Hippocampus/metabolism ; Neurogenesis/physiology ; Hyperthyroidism/metabolism
Chemical Substances	beta Catenin ; Receptors, Thyrotropin ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149723
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Nature of surface active centers in activation of peroxydisulfate by CuO for degradation of BPA with non-radical pathway

Sun, Zijing / Zhu, Yihong / Deng, Yun / Liu, Fudong / Ruan, Wenquan / Xie, Lijuan / Beadham, Ian

Colloids and surfaces. 2022 June 20, v. 643

2022

Abstract: Nowadays, the nature of active species and the role of peroxydisulfate (PDS) was still unclear in advance oxidation systems based on activation of PDS by CuO with non-radical pathway. In this paper, a sheet like CuO containing two kinds of Cu²⁺ was ... ...

Abstract	Nowadays, the nature of active species and the role of peroxydisulfate (PDS) was still unclear in advance oxidation systems based on activation of PDS by CuO with non-radical pathway. In this paper, a sheet like CuO containing two kinds of Cu²⁺ was prepared, one of which was electron deficient Cu²⁺ (Cu²⁺-h). The CuO/PDS system showed extraordinarily utilization of PDS (172.3%) for BPA degradation (after four cycles of PDS). The main degradation mechanism was dominated by non-radical pathway. SO₄•⁻ was not involved in the reaction. Cu₂SO₅ complex was identified as active species, which originated from PDS and two kinds of CuOₓ on surface of CuO. An electron deficient center [Cu(III)EDC] formed in Cu₂SO₅ due to the combination of Cu²⁺-h and PDS directly. [Cu(III)EDC] could capture electronics from pollutants and H₂O, leading to the degradation of BPA and the formation of •OH. PDS was locked by two CuOₓ units in Cu₂SO₅, which explained the trace consumption during the reaction.
Keywords	colloids ; electronics ; electrons ; oxidation ; pollutants ; surfaces
Language	English
Dates of publication	2022-0620
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2022.128731
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Mn2O3/Mn3O4-Cu1.5Mn1.5O4 spinel as an efficient Fenton-like catalyst activating persulfate for the degradation of bisphenol A: Superoxide radicals dominate the reaction

Zhu, Yihong / Sun, Zijing / Deng, Yun / Liu, Fudong / Ruan, Wenquan / Xie, Lijuan

Science of the total environment. 2022 May 16,

2022

Abstract: In this work, a Mn₂O₃/Mn₃O₄-Cu₁.₅Mn₁.₅O₄ spinel was fabricated and utilised as a catalyst to activate peroxydisulfate (PDS) leading to degradation of bisphenol A (BPA). The results showed that the system exhibited an excellent turnover frequency (TOF) of ...

Abstract	In this work, a Mn₂O₃/Mn₃O₄-Cu₁.₅Mn₁.₅O₄ spinel was fabricated and utilised as a catalyst to activate peroxydisulfate (PDS) leading to degradation of bisphenol A (BPA). The results showed that the system exhibited an excellent turnover frequency (TOF) of 2.7 × 10⁻³ s⁻¹ and high stability. The amount of ion leaching was small and the degree of mineralisation was up to 66.2%. Superoxide radicals (O₂⁻) were determined to be the dominant active species in the system. ≡Mn(II) and oxygen vacancies (Vₒ) were found to be the main active sites at the catalyst surface. The activation of PDS by the spinel catalyst and the reduction of dissolved oxygen both contributed to the production of O₂⁻ species. The synergistic effect of ≡Cu(I)/≡Cu(II) and ≡Mn(II)/≡Mn(III) redox pairs enabled the reaction to occur continuously. These results suggest the promise of this novel spinel catalyst in the removal of refractory organic compounds due to its excellent performance and stability. The catalyst may thus have great utility for environmental remediation.
Keywords	bisphenol A ; catalysts ; dissolved oxygen ; environment ; mineralization ; oxygen ; remediation ; synergism
Language	English
Dates of publication	2022-0516
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.156075
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 74/341: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Synergistic Effects from Combination of Cryptotanshinone and Fosfomycin Against Fosfomycin-Susceptible and Fosfomycin-Resistant

Ruan, Zijing / Cui, Jiaqi / He, Zhenqing / Guo, Yuting / Jia, Xu / Huang, Xinhe

Infection and drug resistance

2020 Volume 13, Page(s) 2837–2844

Abstract: Purpose: Fosfomycin is now widely used to treat methicillin-resistant : Methods: The MICs of fosfomycin and/or cryptanshinone were determined by agar dilution assay and checkerboard microdilution assay. Furthermore, synergistic effects from ... ...

Abstract	Purpose: Fosfomycin is now widely used to treat methicillin-resistant Methods: The MICs of fosfomycin and/or cryptanshinone were determined by agar dilution assay and checkerboard microdilution assay. Furthermore, synergistic effects from fosfomycin and/or cryptanshinone were analyzed by the time-kill assay in vitro. Results: The combination of fosfomycin and cryptotanshinone had a synergistic effect on most (71.43%) of the FRSA and had a partial (28.57%) synergistic effect on a small part. In addition, time sterilization curve verified synergistic activity between cryptanshinone and fosfomycin against FSSA and FRSA, especially when fosfomycin was added for a second time. Conclusion: These data suggest that cryptanshinone combined with fosfomycin could be a novel treatment for FRSA and provide a new direction for the treatment of bacterial infections in the future.
Language	English
Publishing date	2020-08-13
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S255296
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Phosphate enhanced uranium stable immobilization on biochar supported nano zero valent iron

Ruan, Yang / Zhang, Huimin / Yu, Zijing / Diao, Zenghui / Song, Gang / Su, Minhua / Hou, Li’an / Chen, Diyun / Wang, Shuao / Kong, Lingjun

Journal of hazardous materials. 2022 Feb. 15, v. 424

2022

Abstract: Uranium (U) immobilization from wastewater by zero valent iron (ZVI) was widely concerned through reduction and surface adsorption. Releasing of U due to re-oxidation of U(IV) into U(VI) limited the application of ZVI in U decontamination. In this work, ... ...

Abstract	Uranium (U) immobilization from wastewater by zero valent iron (ZVI) was widely concerned through reduction and surface adsorption. Releasing of U due to re-oxidation of U(IV) into U(VI) limited the application of ZVI in U decontamination. In this work, a kind of biochar supported nano zero valent iron (Fe/BC(900)) was obtained by carbothermal reduction of starch mixed with ferric nitrate at 900 °C. U immobilization behavior by Fe/BC(900) in the presence of phosphate (P) was investigated. The U immobilization reaction was adjusted by controlling the sequence of U, Fe/BC(900) and P. U immobilization efficiency was enhanced to 99.9% in the presence of P. Reaction sequence of U, Fe/BC(900) and P influenced the U immobilization efficiency, which followed the order of (U-P)+Fe/BC(900)>(U- Fe/BC(900))+P>U+Fe/BC(900)>(P-Fe/BC(900))+U. P and nZVI both contributed to enhancing U immobilization through precipitation of uranyl-P and reductive co-precipitate (U(IV)) in a wide pH range. The released Fe ions could precipitate with uranyl and phosphate. Consumption of P and nZVI in the (P-Fe/BC(900))+U system limited U immobilization ability. The precipitate is highly dependent on U, P and Fe elements. U desorption in (U-P)+Fe/BC(900) system was not observed with stability.
Keywords	adsorption ; biochar ; decontamination ; desorption ; iron ; nitrates ; pH ; phosphates ; starch ; uranium ; uranyl ions ; wastewater
Language	English
Dates of publication	2022-0215
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.127119
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito