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  1. Article ; Online: SARS-COV2 pandemic impact on suicide attempts admitted to pediatric critical care: A monographical observational retrospective study.

    Moral-Larraz, Ana / García-Salido, Alberto / Lamagrande-Casanova, Nuria / Di Campli-Zaghlul, Marianna / Braza-Claver, Mar / Nieto-Moro, Montserrat

    Spanish journal of psychiatry and mental health

    2023  Volume 16, Issue 4, Page(s) 259–261

    MeSH term(s) Humans ; Child ; RNA, Viral ; Retrospective Studies ; Suicide, Attempted ; Pandemics ; COVID-19/epidemiology ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2023-09-21
    Publishing country Spain
    Document type Observational Study ; Case Reports
    ISSN 2950-2853
    ISSN (online) 2950-2853
    DOI 10.1016/j.sjpmh.2023.05.003
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  2. Article ; Online: Uterus Transplantation as a Surgical Innovation.

    Pérez-Blanco, Alicia / Seoane, José-Antonio / Pallás, Teresa Aldabo / Nieto-Moro, Montserrat / Calonge, Rocío Núñez / de la Fuente, Alfonso / Martin, Dominique E

    Journal of bioethical inquiry

    2023  Volume 20, Issue 3, Page(s) 367–378

    Abstract: Uterus transplantation (UTx) research has been introduced in several countries, with trials in Sweden and the United States producing successful outcomes. The growing interest in developing UTx trials in other countries, such as Spain, the Netherlands, ... ...

    Abstract Uterus transplantation (UTx) research has been introduced in several countries, with trials in Sweden and the United States producing successful outcomes. The growing interest in developing UTx trials in other countries, such as Spain, the Netherlands, Japan, and Australia, raises important questions regarding the ethics of surgical innovation research in the field of UTx. This paper examines the current state of UTx in the context of the surgical innovation paradigm and IDEAL framework and discusses the ethical challenges faced by those considering the introduction of new trials. We argue that UTx remains an experimental procedure at a relatively early stage of the IDEAL framework, especially in the context of de novo trials, where protocols are likely to deviate from those used previously and where researchers are likely to have limited experience of UTx. We conclude that countries considering the introduction of UTx trials should build on the strengths of the reported outcomes to consolidate the evidence base and shed light on the uncertainties of the procedure. Authorities responsible for the ethical governance of UTx trials are advised to draw on the ethical framework used in the oversight of surgical innovation.
    MeSH term(s) Female ; Humans ; Infertility, Female/surgery ; Organ Transplantation ; Uterus/transplantation ; Japan ; Sweden
    Language English
    Publishing date 2023-06-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2253038-1
    ISSN 1872-4353 ; 1176-7529
    ISSN (online) 1872-4353
    ISSN 1176-7529
    DOI 10.1007/s11673-023-10272-5
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  3. Article ; Online: IgG antispike persistence and immunophenotype in children infected by SARS-CoV-2.

    García-Salido, Alberto / Flores-Pérez, Patricia / González-Murillo, África / Sánchez-Marcos, Elena / Leoz-Gordillo, Inés / Cano-Fernández, Julia / Castillo-Robleda, Ana / Nieto-Moro, Montserrat / Jiménez-García, Raquel

    Acta paediatrica (Oslo, Norway : 1992)

    2023  Volume 112, Issue 4, Page(s) 805–812

    Abstract: Aim: The immune status of children recovering from SARS-CoV-2 infection is not completely understood. We describe IgG antispike persistence in children infected during the first two pandemic waves. In addition, we compared with healthy controls their ... ...

    Abstract Aim: The immune status of children recovering from SARS-CoV-2 infection is not completely understood. We describe IgG antispike persistence in children infected during the first two pandemic waves. In addition, we compared with healthy controls their leukocyte populations and CD64 expression.
    Methods: Cross-sectional study. Carried out from October 2021 to February 2022 in nonreinfected and nonvaccinated children with SARS-CoV-2 in 2020. The presence of antispike IgG was studied using chemiluminescent immunoassay. Leukocyte populations were analysed using flow cytometry and marked for CD45, CD4, CD8 and CD64. Statistical minor than 0.05 was considered significant.
    Results: One hundred and eighty-three control and 77 patients were included. IgG antispike determinations were performed after a median of 501 days (262-464); 52 of 77 children were positive. Cases showed significantly higher percentages of monocytes, lymphocytes, CD8
    Conclusion: In our series, the SARS-CoV-2 IgG antispike protein was usually positive beyond 1 year after infection. Furthermore, leukocyte populations from cases differ from controls, with higher CD64 expression on neutrophils and monocytes. Prospective clinical observations are required to confirm the implications of these findings.
    MeSH term(s) Humans ; Child ; SARS-CoV-2 ; Prospective Studies ; Cross-Sectional Studies ; COVID-19 ; Receptors, IgG/genetics ; Receptors, IgG/metabolism ; Immunoglobulin G ; Antibodies, Viral
    Chemical Substances Receptors, IgG ; Immunoglobulin G ; Antibodies, Viral
    Language English
    Publishing date 2023-02-17
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16705
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  4. Article ; Online: High-flow nasal cannula and non-invasive mechanical ventilation in pediatric asthma exacerbation: two-year prospective observational study in intensive care.

    Delgado, Carolina S / García-Salido, Alberto / García-Teresa, María Á / Azagra-Garde, Amelia Martínez de / Leoz-Gordillo, Inés / Caro-Patón, Gema de Lama / Nieto-Moro, Montserrat

    Boletin medico del Hospital Infantil de Mexico

    2023  Volume 80, Issue 6, Page(s) 355–360

    Abstract: Background: Asthma is a common cause of admission to the pediatric intensive care unit (PICU). We described and analyzed the therapies applied to children admitted to a tertiary PICU because of asthma. Later, we evaluated high-flow nasal cannula (HFNC) ... ...

    Title translation Cánula nasal de alto flujo y ventilación no invasiva en asma pediátrico grave: estudio observacional prospectivo de dos años de duración en cuidados intensivos.
    Abstract Background: Asthma is a common cause of admission to the pediatric intensive care unit (PICU). We described and analyzed the therapies applied to children admitted to a tertiary PICU because of asthma. Later, we evaluated high-flow nasal cannula (HFNC) use in these patients and compared their evolution and complications with those who received non-invasive ventilation.
    Methods: We conducted a prospective observational study (October 2017-October 2019). Collected data: epidemiological, clinical, respiratory support therapy needed, complementary tests, and PICU and hospital stay. Patients were divided into three groups: (1) only HFNC; (2) HFNC and non-invasive mechanical ventilation (NIMV); and (3) only NIMV.
    Results: Seventy-six patients were included (39 female). The median age was 2 years and 1 month. The median pulmonary score was 5. The median PICU stay was 3 days, and the hospital stay was 6 days. Children with HNFC only (56/76) had fewer PICU days (p = 0.025) and did not require NIMV (6/76). Children with HFNC had a higher oxygen saturation/fraction of inspired oxygen ratio ratio (p = 0.025) and lower PCO
    Conclusion: HFNC was a safe approach that did not increase the number of PICU or hospital days. On admission, normal initial blood gases and the absence of high oxygen requirements were useful in selecting responders to HFNC. Further randomized and multicenter clinical trials are needed to verify these data.
    MeSH term(s) Humans ; Child ; Female ; Child, Preschool ; Respiration, Artificial ; Cannula ; Oxygen Inhalation Therapy/adverse effects ; Asthma/therapy ; Oxygen ; Critical Care
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-12-27
    Publishing country Mexico
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 730519-9
    ISSN 1665-1146 ; 1665-1146 ; 0539-6115 ; 0539-6123
    ISSN (online) 1665-1146
    ISSN 1665-1146 ; 0539-6115 ; 0539-6123
    DOI 10.24875/BMHIM.23000070
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  5. Article ; Online: Apnea neonatal como manifestación inicial de infección por SARS-CoV-2.

    González Brabin, Anthony / Iglesias-Bouzas, María Isabel / Nieto-Moro, Montserrat / Martínez de Azagra-Garde, Amelia / García-Salido, Alberto

    Anales de pediatria

    2020  Volume 93, Issue 3, Page(s) 215–216

    Title translation Neonatal apnea as initial manifestation of SARS-CoV-2 infection.
    MeSH term(s) Apnea/diagnosis ; Apnea/virology ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Female ; Humans ; Infant, Newborn ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/physiopathology
    Keywords covid19
    Language Spanish
    Publishing date 2020-06-11
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 2830901-7
    ISSN 2341-2879 ; 2341-2879
    ISSN (online) 2341-2879
    ISSN 2341-2879
    DOI 10.1016/j.anpedi.2020.05.008
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  6. Article: Increase in Incidence Rates and Risk Factors for Multidrug Resistant Bacteria in Septic Children: A Nationwide Spanish Cohort Study (2013-2019).

    Slocker-Barrio, María / López-Herce-Cid, Jesús / Bustinza-Arriortúa, Amaya / Fresán-Ruiz, Elena / Jordán-García, Iolanda / de Carlos-Vicente, Juan Carlos / Morteruel-Arizcuren, Elvira / García-Soler, Patricia / Nieto-Moro, Montserrat / Schüffelmann, Cristina / Belda-Hofheinz, Sylvia / Herrera-Castillo, Laura Ximena / Uriona-Tuma, Sonia María / Pinós-Tella, Laia / Peña-López, Yolanda / On Behalf Of The Pediatric-Envin-Helics Study Group

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 11

    Abstract: The emergence of multidrug-resistant (MDR) bacteria in children is a growing concern, particularly among septic patients, given the need for first-right dosing. Our aim was to determine the incidence rates and factors associated with MDR-sepsis in the ... ...

    Abstract The emergence of multidrug-resistant (MDR) bacteria in children is a growing concern, particularly among septic patients, given the need for first-right dosing. Our aim was to determine the incidence rates and factors associated with MDR-sepsis in the pediatric intensive care unit (PICU), using data from the Spanish ENVIN-HELICS PICU registry between 2013 and 2019. The rate of MDR bacteria among septic children ranged between 5.8 and 16.2% throughout this study period, with a significant increase since 2015 (
    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12111626
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  7. Article ; Online: Shock and Myocardial Injury in Children With Multisystem Inflammatory Syndrome Associated With SARS-CoV-2 Infection: What We Know. Case Series and Review of the Literature.

    Caro-Patón, Gema de Lama / de Azagra-Garde, Amelia Martínez / García-Salido, Alberto / Cabrero-Hernández, Marta / Tamariz, Amalia / Nieto-Moro, Montserrat

    Journal of intensive care medicine

    2020  Volume 36, Issue 4, Page(s) 392–403

    Abstract: Background: Multisystem inflammatory syndrome associated with SARS-CoV-2 infection can lead to myocardial injury and shock in children, likely the result of a severe inflammatory state, and can mimic Kawasaki disease.: Objective: To describe the ... ...

    Abstract Background: Multisystem inflammatory syndrome associated with SARS-CoV-2 infection can lead to myocardial injury and shock in children, likely the result of a severe inflammatory state, and can mimic Kawasaki disease.
    Objective: To describe the characteristics of shock and myocardial injury in children with confirmed or suspeted COVID-19 during the SARS-CoV-2 pandemic in Spain, including clinical presentation, laboratory and imaging findings, treatment, disease course, and outcome. An extensive literature review is provided.
    Methods: Retrospective case series including all children (age 1 month-18 years) admitted to a pediatric intensive care unit in Madrid, Spain, between March 15 and April 30, 2020 with suspected or confirmed SARS-CoV-2 infection and shock.
    Results: Twelve previously healthy patients with shock, age 5 to 14 years, were included. All required volume resuscitation and 75% required vasoactive/inotropic support. Distributive shock was present on admission in 67% (n = 8), and 4 patients (33%) showed features of cardiogenic shock. Myocardial injury was diagnosed in 67% (n = 8) and ventricular dysfunction in 33% (n = 4). The most common symptoms on presentation were fever (100%), anorexia (100%), diarrhea (75%), and vomiting (75%). Five patients showed signs of Kawasaki disease but none met the criteria for the classic form. Laboratory findings revealed lymphopenia (83%), thrombocytopenia (83%), and increased inflammatory markers (100%). Respiratory status was not significantly impacted. Chest X-ray showed bilateral alveolar infiltrates in 7 (58%) and bilateral pneumonia in 3 (25%). COVID-19 was confirmed in 11 cases (92%). All received empirical therapy against COVID-19, thromboprophylaxis and immunomodulation. Median stay in the PICU and inpatient ward was 4.5 and 10 days, respectively. No patients died.
    Conclusion: Multisystem inflammatory syndrome in children with COVID-19 can mimic Kawasaki disease and lead to a combination of distributive and cardiogenic shock, probably secondary to a hyperinflammatory state that remains to be precisely defined. Treatment strategies include hemodynamic support, empirical therapies against COVID-19, thromboprophylaxis, and immunomodulation.
    MeSH term(s) Adolescent ; COVID-19/complications ; Child ; Child, Preschool ; Female ; Heart Injuries/virology ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units, Pediatric ; Male ; Mucocutaneous Lymph Node Syndrome/virology ; Retrospective Studies ; SARS-CoV-2 ; Shock/virology ; Spain ; Systemic Inflammatory Response Syndrome/complications ; Ventricular Dysfunction/virology
    Keywords covid19
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632828-3
    ISSN 1525-1489 ; 0885-0666
    ISSN (online) 1525-1489
    ISSN 0885-0666
    DOI 10.1177/0885066620969350
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    Zs.A 2158: Show issues Location:
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  8. Article ; Online: PIMS-TS immunophenotype: description and comparison with healthy children, Kawasaki disease and severe viral and bacterial infections.

    García-Salido, Alberto / Leoz-Gordillo, Inés / González Brabin, Anthony / García-Teresa, María Ángeles / Martínez-de-Azagra-Garde, Amelia / Iglesias-Bouzas, María Isabel / Cabrero-Hernández, Marta / De Lama Caro-Patón, Gema / Unzueta-Roch, José Luis / Castillo-Robleda, Ana / Ramirez-Orellana, Manuel / Nieto-Moro, Montserrat

    Infectious diseases (London, England)

    2022  Volume 54, Issue 9, Page(s) 687–691

    Abstract: Background: A new clinical syndrome named Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) has been described. This new disease is a leading cause of hospital and paediatric intensive care unit (PICU). It has ... ...

    Abstract Background: A new clinical syndrome named Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) has been described. This new disease is a leading cause of hospital and paediatric intensive care unit (PICU). It has been related to immunity dysregulation.
    Methods: Prospective-retrospective observational study to describe the innate cell signature and immunophenotype of children admitted to PICU because of PIMS-TS (from March 2020 to September 2020). The immunophenotype was done through the expression analysis of these proteins of mononuclear cells: CD64, CD18, CD11a and CD11b. They were compared with previous healthy controls and children admitted to PICU because of bacterial infection, viral infection and Kawasaki disease (KD). Two hundred and forty-seven children were studied: 183 healthy controls, 25 viral infections, 20 bacterial infections, 6 KD and 13 PIMS-TS.
    Results: PIMT-TS showed the lowest percentage of lymphocytes and monocytes with higher relative numbers of CD4+ (
    Conclusion: We observed a differential cell innate signature in PIMS-TS. These findings are consistent with a proinflammatory status (CD64 elevated expression) and lymphocyte trafficking to tissues (CD11a and CD11b). More studies should be carried out to confirm our results.
    MeSH term(s) Bacterial Infections ; COVID-19/complications ; Child ; Humans ; Mucocutaneous Lymph Node Syndrome/complications ; Prospective Studies ; Receptors, IgG ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/complications ; Virus Diseases
    Chemical Substances Receptors, IgG
    Language English
    Publishing date 2022-04-08
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2022.2059561
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  9. Article: Cerebral Venous Sinus Thrombosis in a Pediatric Patient With COVID-19.

    Ippolito Bastidas, Hyaissa / Márquez-Pérez, Trinidad / García-Salido, Alberto / Luglietto, Davide / García Moreno, Rafael / Martínez de Azagra-Garde, Amelia / Nieto-Moro, Montserrat / Leoz-Gordillo, Inés / Budke, Marcelo / Rivero-Martín, Belén

    Neurology. Clinical practice

    2020  Volume 11, Issue 2, Page(s) e208–e210

    Language English
    Publishing date 2020-03-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000000899
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  10. Article ; Online: SARS-CoV-2 and Streptococcus pneumoniae coinfection as a cause of severe pneumonia in an infant.

    Nieto-Moro, Montserrat / Ecclesia, Francesco Giuseppe / Tomé-Masa, Irene / De Lama Caro-Patón, Gema / Leoz-Gordillo, Inés / Cabrero-Hernández, Marta / García-Salido, Alberto

    Pediatric pulmonology

    2020  Volume 55, Issue 9, Page(s) 2198–2200

    MeSH term(s) Adolescent ; Betacoronavirus ; COVID-19 ; Child ; Coinfection/epidemiology ; Coronavirus Infections ; Humans ; Infant ; Italy ; Pandemics ; Pneumonia, Viral/epidemiology ; Preliminary Data ; SARS-CoV-2 ; Streptococcus pneumoniae
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24916
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