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Article ; Online: Using two self-developed InDel panels to explore forensic traits and ancestral components in the Hui group.

Yuan, Xi / Wang, Xi / Lan, Qiong / Li, Shuanglin / Lin, Yifeng / Zhao, Ming / Xu, Hui / Lei, Fanzhang / Shen, Chunmei / Zhu, Bofeng

Genomics

2023 Volume 116, Issue 1, Page(s) 110756

Abstract: ... of these two panels were tested in the Chinese Hui group. By calculating forensic parameters and simulating ... paternity testing, and could assist in kinship identification in the Hui group. For full siblings, the true ...

Abstract	To address the challenges faced by forensic examiners in degraded DNA analysis, we have developed two different panels for various forensic applications, encompassing an AIM-InDel panel for ancestry inference and a Multi-InDel panel for individual identification, respectively. Herein, the efficiencies of these two panels were tested in the Chinese Hui group. By calculating forensic parameters and simulating family relationships, we verified that the Multi-InDel panel could be an effective tool for individual identification, paternity testing, and could assist in kinship identification in the Hui group. For full siblings, the true positive rate of kinship discrimination was 96.553%, when the threshold of log
MeSH term(s)	Humans ; China ; Ethnicity/genetics ; Gene Frequency ; Genetics, Population ; INDEL Mutation ; Minority Groups ; Phenotype ; East Asian People/genetics
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2023.110756
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Article ; Online: Genetic polymorphisms of pharmacogenomic VIP variants in the Hui population from Ningxia Province of China.

Zhou, Wenqian / Guo, Jinping / Li, Yujie / Ma, Xiaoya / Yang, Shuangyu / Wei, Jie / Zhang, Huan / Zhang, Shanshan / Jin, Tianbo

Functional & integrative genomics

2023 Volume 23, Issue 2, Page(s) 85

Abstract: ... among different populations. However, there is little pharmacogenomic information about the Chinese Hui population ... Our research aimed to reveal the outstandingly different loci in the Hui population, and provide a theoretical ... foundation for personalized drug use in the Hui population, so as to facilitate more effective treatment ...

Abstract	Pharmacogenomics has been widely used to study the very important pharmacogenetic (VIP) variants among different populations. However, there is little pharmacogenomic information about the Chinese Hui population. Our research aimed to reveal the outstandingly different loci in the Hui population, and provide a theoretical foundation for personalized drug use in the Hui population, so as to facilitate more effective treatment of diseases. This study genotyped 53 VIP variants of 26 genes in 200 independent Hui individuals based on the Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB). Remarkable differences in the genotype and allele frequencies between the Hui and 26 other populations from the 1000 Genomes Project were assessed using the χ
MeSH term(s)	Humans ; Pharmacogenetics ; Cytochrome P-450 CYP2D6/genetics ; Cyclooxygenase 2/genetics ; Ethnicity/genetics ; Polymorphism, Single Nucleotide ; Genotype ; China ; Arylamine N-Acetyltransferase/genetics
Chemical Substances	Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; NAT2 protein, human (EC 2.3.1.5) ; Arylamine N-Acetyltransferase (EC 2.3.1.5)
Language	English
Publishing date	2023-03-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-023-01021-3
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Article ; Online: Rapid classification and identification of chemical compositions of Pu-zhi-hui-ling decoction by UHPLC-Q-Orbitrap HRMS.

Shao, Jia / Zheng, Yanxue / Wang, Yuanyuan / Li, Guohui / Wei, Jinxia / Cheng, Wenbo / Li, Yubo

Natural product research

2024 , Page(s) 1–10

Abstract: Pu-zhi-hui-ling decoction (PZHLD) is a traditional Chinese medicine (TCM) formula for the treatment ...

Abstract	Pu-zhi-hui-ling decoction (PZHLD) is a traditional Chinese medicine (TCM) formula for the treatment of Alzheimer's disease (AD), but its chemical composition has not been reported. In this study, we aimed to establish a mass spectrometry (MS) analysis method for rapid classification and identification of the chemical constituents in PZHLD. The sample was analysed by ultrahigh-performance liquid chromatography coupled to quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS). The chemical constituents of PZHLD were identified based on accurate MS data, fragmentation characteristics of MS/MS, and reference information described in the literature. A total of 123 chemical constituents were identified. In addition, we summarised the fragmentation pathways of the chemical constituents in PZHLD. Our finding might lay the foundation for the further pharmacodynamic study and clinical application of PZHLD.
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2023.2299302
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Article: Quality of Life and Glucose Regulation in Pediatric Patients with Type 1 Diabetes: A Study in the Ningxia Hui Autonomous Region.

Bai, Hua / He, Na / Zhang, Yan / Ahmad, Aqsa / Yang, Xing-Xing / Ma, Yan / Liang, Li-Jun

Diabetes, metabolic syndrome and obesity : targets and therapy

2024 Volume 17, Page(s) 1267–1278

Abstract: ... in the Ningxia Hui autonomous region.: Methods: The study involved children with T1DM admitted ...

Abstract	Objective: In this study, we aimed to evaluate the current status of the quality of life (QOL) of pediatric patients and plasma glucose concentration regulation in children with type 1 diabetes (T1DM) in the Ningxia Hui autonomous region. Methods: The study involved children with T1DM admitted to the General Hospital of Ningxia Medical University between October 2011 and October 2021. The children and their parents completed general information and quality of life (QOL) questionnaires. The regulation of plasma glucose concentration was assessed based on HbA1c levels, and plasma glucose and QOL-influencing components were investigated. Results: Among the 136 pediatric patients diagnosed with T1DM, the mean glycated hemoglobin (HbA1c) level was recorded at 8.7% (7.2%, 10.5%). A breakdown of the patient cohort revealed that 44 patients (32.4%) demonstrated good regulation of plasma glucose, 33 patients (24.3%) exhibited acceptable glycemic control, and 59 patients (43.3%) displayed poor regulation of plasma glucose. The control of plasma glucose in pediatric patients diagnosed with T1DM was affected by the duration of the disease, the patient's age, the frequency of daily plasma glucose measurements, the use of CGM, diabetic ketoacidosis (DKA), and the education level of the mother. The control of plasma glucose, dietary management, DKA, the ability to learn, and health education are interfering factors of quality of life in children diagnosed with T1DM. Effective control of plasma glucose may ensure the QOL in children with T1DM, and DKA was the risk factor for QOL. Conclusion: In Ningxia, the regulation of plasma glucose in pediatric and adolescent patients with T1DM remains suboptimal, leading to poor QOL. There is a pressing need to enhance glucose regulation and QOL through comprehensive strategies, which include reinforced dietary management, rigorous monitoring of plasma glucose levels, and heightened health education levels.
Language	English
Publishing date	2024-03-12
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S446387
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Article ; Online: Analysis of the Natural Conditions and Geographical Factors of the Formation of Hui-Style Prints.

Li, Shangke

publication RETRACTED

Journal of environmental and public health

2022 Volume 2022, Page(s) 4627215

Abstract: In order to analyze the natural conditions and geographical factors of the formation of Hui-style ... meaning of Hui-style printmaking, the internal system of Hui-style printmaking during its operation can be ... for the formation of Hui-style prints by means of empirical analysis. In this way, during the implementation ...

Abstract	In order to analyze the natural conditions and geographical factors of the formation of Hui-style prints, big data analysis technology is brought in, through which more audiences can understand the true meaning of Hui-style printmaking, the internal system of Hui-style printmaking during its operation can be improved, and artists can complete the analysis of natural conditions and geographical factors for the formation of Hui-style prints by means of empirical analysis. In this way, during the implementation of artistic acts, the benefits of the city and even the society can be increased, and the social and economic benefits can be improved accordingly and involved in information management systems directionally, and the natural conditions and geographical factors related to the formation of Hui-style prints can be deeply analyzed, so as to ensure that the formation of Hui-style prints has a social and economic promotion.
Language	English
Publishing date	2022-07-14
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2022/4627215
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Article ; Online: Population data and phylogenetic analysis of 37 Y-STR loci in the Hui population from Yunnan Province, Southwest China.

Zhang, Xiufeng / Li, Kunya / Duan, Yifan

Annals of human biology

2023 Volume 50, Issue 1, Page(s) 196–199

Abstract: ... characteristics of Chinese Hui residing in Yunnan province, Southwest China, remain unclear.: Aim: To provide ... genetic data for 37 Y-STRs in the Chinese Hui population of Yunnan province, as well as to investigate ... population genetic relationships between the Chinese Hui and another 26 populations from China and neighbouring ...

Abstract	Background: Previous studies of the genetic polymorphism of the Y-chromosomal short tandem repeat (Y-STR) of Huis were focussed on the northwest of China. However, the population genetic characteristics of Chinese Hui residing in Yunnan province, Southwest China, remain unclear. Aim: To provide genetic data for 37 Y-STRs in the Chinese Hui population of Yunnan province, as well as to investigate population genetic relationships between the Chinese Hui and another 26 populations from China and neighbouring countries. Subjects and methods: In total, 326 unrelated healthy male individuals were genotyped using the Goldeneye Results: A total of 279 haplotypes were detected, out of which 244 were unique. The overall haplotype diversity (HD) and discrimination capacity (DC) were 0.9989 and 0.8611, respectively. The gene diversity (GD) ranged from 0.0544 (DYS645) to 0.9656 (DYS385). Conclusions: The population comparison indicated that Muslim populations (Hui, Salar and Uighur) showed significantly more genetic affinity than other populations. Our results could be applied in forensic practice and population genetic studies.
MeSH term(s)	Humans ; Male ; Phylogeny ; China ; Ethnicity/genetics ; Chromosomes, Human, Y/genetics ; Genetics, Population ; Microsatellite Repeats/genetics ; Haplotypes
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	186656-4
ISSN	1464-5033 ; 0301-4460
ISSN (online)	1464-5033
ISSN	0301-4460
DOI	10.1080/03014460.2023.2188258
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Article ; Online: Interpreting regional ecological security from perspective of ecological networks: a case study in Ningxia Hui Autonomous Region, China.

Ji, Xianglin / Wu, Dan / Yan, Yueguan / Guo, Wei / Li, Kai

Environmental science and pollution research international

2023 Volume 30, Issue 24, Page(s) 65412–65426

Abstract: ... This study proposes a multimodel coupling framework to explore the ecological security status of Ningxia Hui ...

Abstract	The rapid economic development and intense human activities have seriously restricted the sustainable development of ecology and the maintenance of ecosystem services. Ecological network can effectively connect fragmented habitats and is an important way to couple landscape structure, ecological process, and function. This study proposes a multimodel coupling framework to explore the ecological security status of Ningxia Hui Autonomous Region (NHAR) under different development scenarios from the perspective of ecological networks. The conclusions are as follows: (1) From 2000 to 2030, grassland and arable land were the main land types of NHAR. Grassland is the main expansion land type under the ecological land protection (ELP) scenario, while construction land is the main expansion land type in two other scenarios. (2) The main gather and change of the ecological sources occurred in the central region, and the ecological expansion should develop from the middle to the south. (3) The average area of ecological sources under BAU and RED scenarios is smaller than that under ELP scenario, and more ecological corridors are needed to connect. (4) The centrality of the ecological sources under the BAU scenario is generally high, but the ecological sources under ELP and RED scenarios have undergone spatial migration. In addition, the urbanization trend of NHAR is different under different scenarios, and more attention should be paid to the maintenance and protection of ecological networks in typical areas. This study can provide important reference for NHAR's ecological space planning and ecological protection policy formulation.
MeSH term(s)	Humans ; Ecosystem ; Ecology ; Conservation of Natural Resources ; Urbanization ; China
Language	English
Publishing date	2023-04-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-26997-0
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Article ; Online: Genetic polymorphisms of pharmacogenomic VIP variants in the Hui population from Ningxia Province of China

Zhou, Wenqian / Guo, Jinping / Li, Yujie / Ma, Xiaoya / Yang, Shuangyu / Wei, Jie / Zhang, Huan / Zhang, Shanshan / Jin, Tianbo

Funct Integr Genomics. 2023 June, v. 23, no. 2 p.85-85

2023

Abstract	Pharmacogenomics has been widely used to study the very important pharmacogenetic (VIP) variants among different populations. However, there is little pharmacogenomic information about the Chinese Hui population. Our research aimed to reveal the outstandingly different loci in the Hui population, and provide a theoretical foundation for personalized drug use in the Hui population, so as to facilitate more effective treatment of diseases. This study genotyped 53 VIP variants of 26 genes in 200 independent Hui individuals based on the Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB). Remarkable differences in the genotype and allele frequencies between the Hui and 26 other populations from the 1000 Genomes Project were assessed using the χ² test. The genotype and allele frequencies of single nucleotide polymorphisms (SNPs) in PTGS2 (rs20417), NAT2 (rs1801280), NAT2 (rs1208), ACE (rs4291), and CYP2D6 (rs1065852) were considerably different in the Hui population compared with those in the other 26 populations. Besides, using the PharmGKB database, we identified several VIP variants that may alter the drug metabolism of ibuprofen, rofecoxib (PTGS2), captopril (ACE), citalopram, and escitalopram (CYP2D6). We also discovered other variants associated with adverse reactions to cisplatin and cyclophosphamide (NAT2). Our study indicated that the loci of PTGS2 (rs20417), NAT2 (rs1801280 and rs1208), ACE (rs4291), and CYP2D6 (rs1065852) in the Hui population were obviously different from those in the other 26 populations, which provides reliable information for predicting drug efficacy. Besides, it supplements the pharmacogenomic knowledge of the Hui population and lays the foundation for the individualized treatment for the Hui population.
Keywords	alleles ; cisplatin ; cyclophosphamide ; databases ; genotype ; ibuprofen ; pharmacogenomics ; pharmacokinetics ; China
Language	English
Dates of publication	2023-06
Size	p. 85.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-023-01021-3
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The effect and pharmacology of Yizhi Sheng Hui decoction on Alzheimer's disease.

Li, Qiubing / Hou, Yi / Zhao, Baosheng / Li, Yingfan / Zhang, Xinyu / Mei, Rong / Wang, Shuo / Wang, Peng / Liu, Ying

Annals of palliative medicine

2021 Volume 10, Issue 5, Page(s) 5244–5251

Abstract: ... after treatment with the traditional Chinese medicine compound, Yizhi Sheng Hui (YZSH) decoction. This study ...

Abstract	Background: Alzheimer's disease (AD) has gradually increased as society has aged and is now a serious social problem. In the clinical treatment of AD, patients show improvement in cognitive function after treatment with the traditional Chinese medicine compound, Yizhi Sheng Hui (YZSH) decoction. This study systematically investigates the effect and pharmacology of the YZSH decoction on AD. Methods: In this study, 24 SAMP8 AD model mice were randomly divided into three groups: an untreated control group, a group treated with the YZSH decoction, and a positive control group treated with donepezil hydrochloride. Eight SAMR1 mice were placed in the normal control group. A Morris water maze test and a step-down test were conducted at 8 and 13 weeks after continuous intragastric administration of the two drugs. After 13 weeks of administration, the hippocampal expression of Aβ1-42 and tau protein were measured. Results: There was no change in the latent period duration and the number of platform crossings in each group after 8 weeks of administration, but after 13 weeks of administration, the latent period of the treatment group and the positive control group were significantly shorter than the untreated control group. Initially, the SAMP8 mice showed a lower spatial exploration ability than the SAMR1 mice. However, after 13 weeks of administration, the treatment group and the control group exhibited a better exploration ability. Compared with the SAMR1 mice, the on-stage evasion time and step-down errors significantly increased in the untreated group. Compared with the untreated group, mice in the treatment group and the positive control group showed a shorter latent period after 8 weeks of administration, and the on-stage evasion time for both groups was significantly reduced after 13 weeks of administration. The treatment group showed fewer instances of electric shock. Hippocampal expression of Aβ1-42 was high in the untreated group, was much lower in the positive control group, and no Aβ1-42 expression was observed in the treatment group. Conclusions: The YZSH decoction improved the learning and memory of mice with AD, related to the inhibition of Aβ1-42 expression.
MeSH term(s)	Aged ; Alzheimer Disease/drug therapy ; Animals ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Learning ; Memory ; Mice
Chemical Substances	Drugs, Chinese Herbal ; yi-zhi (1QBV21VOZI)
Language	English
Publishing date	2021-05-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-20-1629
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Article: Spatial-temporal changes of landscape and habitat quality in typical ecologically fragile areas of western China over the past 40 years: A case study of the Ningxia Hui Autonomous Region.

Wang, Ding / Hao, Haiguang / Liu, Hao / Sun, Lihui / Li, Yuyang

Ecology and evolution

2024 Volume 14, Issue 1, Page(s) e10847

Abstract: ... to assess the habitat quality of the Ningxia Hui Autonomous Region in Western China, which has ... utilization. The research results show that the overall habitat quality of Ningxia Hui Autonomous Region was ...

Abstract	In this paper, we use the InVEST model and five periods of land use data from 1980 to 2020 to assess the habitat quality of the Ningxia Hui Autonomous Region in Western China, which has characteristics of a typical fragile ecosystem. We further analyse the spatial and temporal characteristics of habitat quality evolution and its relationship with land use and landscape pattern indices to explore the close relationship between regional habitat quality changes and human natural resource conservation and utilization. The research results show that the overall habitat quality of Ningxia Hui Autonomous Region was stable and at a moderate level (0.57-0.60) during the 40 years from 1980 to 2020; Habitat patches (2020) with low (24.89%), high (22.45%) and very high (29.81%) quality occupy a larger proportion of the area, followed by very low (13.31%) and moderate levels (9.54%). Over the past 40 years, there have been 275 sample sites in Ningxia where habitat quality has deteriorated, 1593 sample sites where the habitat quality has remained stable, and 184 sample sites where the habitat quality has increased. From 1980 to 2020, the Mean Patch Area of landscape types in Ningxia decreased by 25.9 hm
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.10847
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