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  1. Article: Revolutionising outpatient clinic experience (RevOCE): the future of chronic kidney disease care and associated multimorbidity.

    Al-Chalabi, Saif / Santhirasekaran, Schanhave / Kalra, Philip A / Ritchie, James / Poulikakos, Dimitrios / Sinha, Smeeta

    Future healthcare journal

    2024  Volume 10, Issue Suppl 3, Page(s) 13–14

    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/fhj.10-3-s13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Travel arrangements in hemodialysis patients during the COVID-19 pandemic including London-style "black cabs" for transfer to a designated isolation unit.

    Fox, Victoria / Poulikakos, Dimitrios

    Hemodialysis international. International Symposium on Home Hemodialysis

    2021  Volume 25, Issue 4, Page(s) 563–564

    MeSH term(s) COVID-19 ; Humans ; London ; Pandemics ; Renal Dialysis ; SARS-CoV-2
    Language English
    Publishing date 2021-06-24
    Publishing country Canada
    Document type Letter ; Comment
    ZDB-ID 2192458-2
    ISSN 1542-4758 ; 1492-7535
    ISSN (online) 1542-4758
    ISSN 1492-7535
    DOI 10.1111/hdi.12959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Remote surveillance technology of dialysis arteriovenous access. Retrospective evaluation in a UK renal centre.

    Eltahan, Alshymaa Rafiek / Pondor, Zulfikar / Donne, Rosemary L / Lewis, David / Raman, Maharajan / Hinchliffe, Paul / Cowperthwaite, Jan / Poulikakos, Dimitrios

    Nephron

    2024  

    Abstract: Background: Early identification of dysfunctional arteriovenous hemodialysis (HD) vascular access (VA) is important for timely referral and intervention.: Method: We retrospectively calculated the VA risk score using Vasc-Alert surveillance software ... ...

    Abstract Background: Early identification of dysfunctional arteriovenous hemodialysis (HD) vascular access (VA) is important for timely referral and intervention.
    Method: We retrospectively calculated the VA risk score using Vasc-Alert surveillance software technology from HD treatment sessions in 2 satellite HD units over 18 months. We included in the analysis HD patients dialyzing with arteriovenous fistula or graft (AVF/G) with available Vasc-Alert data for≥ 2 months. For group one (eventful) which included patients who developed vascular access thrombosis or stenosis over the study period, we collected Vasc-Alert risk score 2 months prior to the event, and for group two (uneventful) over 5 consecutive months. Vasc-Alert technology utilizes routinely collected data during HD to calculate the VA risk score and triggers an alert if the score is ≥7 in 3 consecutive dialysis sessions. Patients with> 2 alerts (vascular access score ≥ 7) per month were considered to have positive alerts.
    Results: From 140 HD patients, 81 patients dialyzed via AVF/G. 77/81 had available Vasc-Alert data and were included in the final analysis. Out of 17 eventful patients, 11 (64.7%) had positive alerts 2 months prior to the vascular event. Out of the 60 patients without vascular events, 20 patients (33.3%) had positive alerts. Vasc-Alert's sensitivity and specificity for vascular events were 64.7% and 66.6% respectively. Within the 6 patients with thrombosed access, 2 patients (33.3%) detected by Vasc-Alert were not detected with clinical monitoring.
    Conclusion: Vascular access risk score can be a useful non-invasive vascular access surveillance method to assist clinical decision-making.
    Language English
    Publishing date 2024-04-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000538820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Delivering Personalized, Goal-Directed Care to Older Patients Receiving Peritoneal Dialysis.

    Wu, Henry H L / Poulikakos, Dimitrios / Hurst, Helen / Lewis, David / Chinnadurai, Rajkumar

    Kidney diseases (Basel, Switzerland)

    2023  Volume 9, Issue 5, Page(s) 358–370

    Abstract: Background: An aging population living with chronic kidney disease and progressing to kidney failure, subsequently receiving peritoneal dialysis (PD) is growing. A significant proportion of these patients are also living with multi-morbidities and some ... ...

    Abstract Background: An aging population living with chronic kidney disease and progressing to kidney failure, subsequently receiving peritoneal dialysis (PD) is growing. A significant proportion of these patients are also living with multi-morbidities and some degree of frailty. Recent practice recommendations from the International Society of Peritoneal Dialysis advocate for high-quality, goal-directed PD prescription, and the Standardized Outcomes of Nephrology-PD initiative emphasized the need for an individualized, goal-based care approach in all patients receiving PD treatment. In older patients, this approach to PD care is even more important. A frailty screening assessment, followed by a comprehensive geriatric assessment (CGA) prior to PD initiation and when dictated by change in relevant circumstances is paramount in tailoring PD care and prescription according to the needs, life goals, as well as clinical status of older patients with kidney failure.
    Summary: Our review aimed to summarize the different dimensions to be taken into account when delivering PD care to the older patient - from frailty screening and CGA in older patients receiving PD to employing a personalized, goal-directed PD prescription strategy, to preserving residual kidney function, optimizing blood pressure (BP) control, and managing anemia, to addressing symptom burden, to managing nutritional intake and promoting physical exercise, and to explore telehealth opportunities for the older PD population.
    Key messages: What matters most to older PD patients may not be simply extending survival, but more importantly, to be living comfortably on PD treatment with minimal symptom burden in a home environment and to minimize treatment complications.
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2817963-8
    ISSN 2296-9357 ; 2296-9381
    ISSN (online) 2296-9357
    ISSN 2296-9381
    DOI 10.1159/000531367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A pilot project evaluating a fixed drainage system (U-Drain) for automated peritoneal dialysis.

    Poulikakos, Dimitrios / Martin, Joanne / Collier, Joanne / Lewis, David

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2021  Volume 42, Issue 5, Page(s) 530–534

    Abstract: U-Drain is a fixed drainage system for automated peritoneal dialysis (APD) connecting the dialysis effluent outflow directly to the household drainage system thus avoiding the need for drain bags, with considerable potential advantages for patient ... ...

    Abstract U-Drain is a fixed drainage system for automated peritoneal dialysis (APD) connecting the dialysis effluent outflow directly to the household drainage system thus avoiding the need for drain bags, with considerable potential advantages for patient convenience and reduction of plastic clinical waste. Here we present a pilot project reporting on U-Drain patient and staff experience based on questionnaires and on the safety of the technology derived from analysis of characteristics of peritonitis episodes. Overall, 15 patients were included in the pilot project and were followed up over 3 years; 11 patients completed a questionnaire exploring their experiences of APD and U-Drain. A family member 55%, carer 10%, healthcare assistant 10% and patient themselves 25% would normally carry the full drainage bags for disposal. Following the installation of U-Drain, 90% of patients reported that the system saved them time setting up and clearing the machine after dialysis, 80% noted a reduction in storage space required for consumables and all patients noted a reduction in non-recyclable waste requiring disposal. All patients who completed the questionnaire were very satisfied with the installation. All staff members who completed the questionnaire reported that their role was easier and the system was time saving. In total, there were 8 peritonitis episodes, including 2 recurrent infections due to biofilm, over 313 patient months follow up. There was no increase in incidence of peritonitis infection (0.3 episodes per year at risk) compared to that in the unit's population (0.64, 0.42 and 0.5 episodes per year at risk for the years 2017, 2018 and 2019, respectively) or delays in diagnosis. Approximately 0.8 kg of non-recyclable clinical waste was saved per treatment day from domestic waste by avoiding the use of PD drain bags. This pilot demonstrates increased patient satisfaction and acceptable safety profile of U-Drain technology.
    MeSH term(s) Drainage/adverse effects ; Humans ; Peritoneal Dialysis/adverse effects ; Peritoneal Dialysis, Continuous Ambulatory/adverse effects ; Peritonitis/etiology ; Pilot Projects
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.1177/08968608211035952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SARS-CoV-2 antibody screening in healthcare workers in a tertiary centre in North West England.

    Poulikakos, Dimitrios / Sinha, Smeeta / Kalra, Philip A

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2020  Volume 129, Page(s) 104545

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; England ; Germany ; Health Personnel ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-07
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2020.104545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A High-Performance Antibacterial Nanostructured ZnO Microfluidic Device for Controlled Bacterial Lysis and DNA Release.

    Xesfyngi, Yvonni / Georgoutsou-Spyridonos, Maria / Tripathy, Abinash / Milionis, Athanasios / Poulikakos, Dimos / Mastellos, Dimitrios C / Tserepi, Angeliki

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 8

    Abstract: In this work, the antibacterial properties of nanostructured zinc oxide (ZnO) surfaces are explored by incorporating them as walls in a simple-to-fabricate microchannel device. Bacterial cell lysis is demonstrated and quantified in such a device, which ... ...

    Abstract In this work, the antibacterial properties of nanostructured zinc oxide (ZnO) surfaces are explored by incorporating them as walls in a simple-to-fabricate microchannel device. Bacterial cell lysis is demonstrated and quantified in such a device, which functions due to the action of its nanostructured ZnO surfaces in contact with the working fluid. To shed light on the mechanism responsible for lysis,
    Language English
    Publishing date 2023-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12081276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Delivering Personalized, Goal-Directed Care to Older Patients Receiving Peritoneal Dialysis

    Henry H.L. Wu / Dimitrios Poulikakos / Helen Hurst / David Lewis / Rajkumar Chinnadurai

    Kidney Diseases, Pp 1-

    2023  Volume 13

    Abstract: Background: An aging population living with chronic kidney disease and progressing to kidney failure, subsequently receiving peritoneal dialysis (PD) is growing. A significant proportion of these patients are also living with multi-morbidities and some ... ...

    Abstract Background: An aging population living with chronic kidney disease and progressing to kidney failure, subsequently receiving peritoneal dialysis (PD) is growing. A significant proportion of these patients are also living with multi-morbidities and some degree of frailty. Recent practice recommendations from the International Society of Peritoneal Dialysis advocate for high-quality, goal-directed PD prescription, and the Standardized Outcomes of Nephrology-PD initiative emphasized the need for an individualized, goal-based care approach in all patients receiving PD treatment. In older patients, this approach to PD care is even more important. A frailty screening assessment, followed by a comprehensive geriatric assessment (CGA) prior to PD initiation and when dictated by change in relevant circumstances is paramount in tailoring PD care and prescription according to the needs, life goals, as well as clinical status of older patients with kidney failure. Summary: Our review aimed to summarize the different dimensions to be taken into account when delivering PD care to the older patient – from frailty screening and CGA in older patients receiving PD to employing a personalized, goal-directed PD prescription strategy, to preserving residual kidney function, optimizing blood pressure (BP) control, and managing anemia, to addressing symptom burden, to managing nutritional intake and promoting physical exercise, and to explore telehealth opportunities for the older PD population. Key Messages: What matters most to older PD patients may not be simply extending survival, but more importantly, to be living comfortably on PD treatment with minimal symptom burden in a home environment and to minimize treatment complications.
    Keywords peritoneal dialysis ; older patients ; geriatric assessment ; multi-disciplinary management ; quality of life ; Internal medicine ; RC31-1245
    Subject code 616
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Karger Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Improving outpatient clinic experience: the future of chronic kidney disease care and associated multimorbidity.

    Al-Chalabi, Saif / Alderson, Helen / Garratt, Natalie / Green, Darren / Kalra, Philip A / Ritchie, James / Santhirasekaran, Schanhave / Poulikakos, Dimitrios / Sinha, Smeeta

    BMJ open quality

    2023  Volume 12, Issue 3

    Abstract: Background: Chronic kidney disease (CKD) is estimated to affect more than 2.5 million adults in England, and this is expected to rise to 4.2 million by 2036 (1). Population-level digital healthcare systems have the potential to enable earlier detection ... ...

    Abstract Background: Chronic kidney disease (CKD) is estimated to affect more than 2.5 million adults in England, and this is expected to rise to 4.2 million by 2036 (1). Population-level digital healthcare systems have the potential to enable earlier detection of CKD providing an opportunity to introduce interventions that attenuate progression and reduce the risk of end-stage kidney disease (ESKD) and cardiovascular diseases (CVD). Services that can support patients with CKD, CVD, and diabetes mellitus (DM) have the potential to reduce fragmented clinical care and optimise pharmaceutical management.
    Methods and results: The Salford renal service has established an outpatient improvement programme which aims to address these issues via two projects. Firstly, the development of a CKD dashboard that can stratify patients by their kidney failure risk equation (KFRE) risk. High-risk patients would be invited to attend an outpatient clinic if appropriate. Specialist advice and guidance would be offered to primary care providers looking after patients with medium risk. Patients with lower risk would continue with standard care via their primary care provider unless there was another indication for a nephrology referral. The CKD dashboard identified 11546 patients (4.4% of the total adult population in Salford) with T2DM and CKD. The second project is the establishment of the Metabolic CardioRenal (MRC) clinic. It provided care for 209 patients in the first 8 months of its establishment with a total of 450 patient visits. Initial analysis showed clustering of cardiorenal metabolic diseases with 85% having CKD stages 3 and 4 and 73.2% having DM. In addition, patients had a significant burden of CVD with 50.2% having hypertension and 47.8% having heart failure.
    Conclusion: There is a pressing need to create new outpatient models of care to tackle the rising epidemic of cardio-renal metabolic diseases. This model of service has potential benefits at both organisational and patient levels including improving patient management via risk stratification, increased care capacity and reduction of variation of care. Patients will benefit from earlier intervention, appropriate referral for care, reduction in CKD-related complications, and reduction in hospital visits and cardiovascular events. In addition, this combined digital and patient-facing model of care will allow rapid translation of advances in cardio-renal metabolic diseases into clinical practice.
    MeSH term(s) Adult ; Humans ; Multimorbidity ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Renal Insufficiency, Chronic/complications ; England/epidemiology ; Ambulatory Care Facilities ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/therapy
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-6641
    ISSN (online) 2399-6641
    DOI 10.1136/bmjoq-2022-002188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of Shielding and First Dose of COVID-19 Vaccination in Kidney Transplant Recipients.

    Middleton, Rachel J / Gorton, Julie / O'Riordan, Edmond / Knight, Sean / Kalra, Philip A / Poulikakos, Dimitrios

    Nephron

    2021  Volume 146, Issue 1, Page(s) 64–66

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Kidney Transplantation ; SARS-CoV-2 ; Transplant Recipients ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-09-02
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000518631
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