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  1. Book ; Online: Epigenetics Traits in Mammalian Tissues. From New Technology to New Hypotheses

    Symonds, Michael E. / Franco, Rafael

    2019  

    Keywords Science: general issues ; Medical genetics ; histone deacetylation ; CpG methylation ; cytocrin ; epigenetic factors ; Epigenetic traits ; Pregnancy ; Sugar metabolism ; eye epigenetics ; in vitro fertilization
    Size 1 electronic resource (70 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230321
    ISBN 9782889630370 ; 2889630374
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Editorial: Rising stars in clinical microbiology: 2022.

    Franco, Rafael

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 1066181

    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.1066181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: On the Mechanistic Perceptions of Consciousness: From Quantum Mechanics to Consciousness and Free Will and from David Bohm to Benjamin Libet.

    Franco, Rafael

    Journal of integrative neuroscience

    2022  Volume 21, Issue 6, Page(s) 153

    MeSH term(s) Consciousness ; Personal Autonomy ; Brain ; Quantum Theory
    Language English
    Publishing date 2022-11-25
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2136427-8
    ISSN 0219-6352
    ISSN 0219-6352
    DOI 10.31083/j.jin2106153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6117: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Geoffrey Burnstock (1929-2020): the finest pharmacologist and an inspiring scientist.

    Franco, Rafael

    Purinergic signalling

    2021  Volume 17, Issue 1, Page(s) 135

    MeSH term(s) Animals ; Duodenum/metabolism ; History, 20th Century ; Humans ; Receptors, Purinergic P1/metabolism ; Research/history
    Chemical Substances Receptors, Purinergic P1
    Language English
    Publishing date 2021-02-02
    Publishing country Netherlands
    Document type Biography ; Historical Article ; Letter
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-021-09769-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Current Issues in Molecular Biology

    Franco, Rafael

    Current issues in molecular biology

    2021  Volume 43, Issue 1, Page(s) 384–388

    Abstract: Current Issues in Molecular ... ...

    Abstract Current Issues in Molecular Biology
    MeSH term(s) Animals ; Biotechnology/methods ; Biotechnology/trends ; Epigenomics/methods ; Epigenomics/trends ; Genomics/methods ; Genomics/trends ; Humans ; Molecular Biology/statistics & numerical data ; Molecular Biology/trends ; Periodicals as Topic/statistics & numerical data ; Periodicals as Topic/trends ; Proteomics/methods ; Proteomics/trends
    Language English
    Publishing date 2021-06-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb43010031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Online: Environmentally Friendly Polymers and Polymer Composites

    Balart Gimeno, Rafael Antonio / Montañés Muñoz, Nestor / Dominici, Franco / Torres-Giner, Sergio / Boronat Vitoria, Teodomiro / Dominici, Franco

    2021  

    Keywords Research & information: general ; PLA ; PCL ; TPS ; biopolymer blends ; mechanical properties ; compostable plastics ; green composites ; natural fillers ; poly(butylene succinate) (PBS) ; almond shell flour (ASF) ; poly (lactic acid) (PLA) ; poly(butylene succinate-co-adipate) (PBSA) ; binary blends ; shape memory behaviour ; polymer‒matrix composites (PMCs) ; thermomechanical ; electron microscopy ; compatibilizers ; poly(lactic acid) (PLA) ; natural fibre (NF) ; nano-hydroxyapatite (nHA) ; flammability ; crab shell ; chitin ; spherical microgels ; reverse micelle ; gelation ; chitosan (CS) ; anti-oxidant ; anti-apoptotic activity ; rotenone ; Parkinson's disease (PD) ; composite materials ; hybrid resin ; natural reinforcement ; non-uniformities ; mechanical behavior ; antifungal activity ; dendrimer ; Origanum majorana L. essential oil ; Phytophthora infestans ; maleinized linseed oil MLO ; poly(lactic acid) ; diatomaceous earth ; biocomposites ; active containers ; polymer mixtures ; blends ; cashew nut shell liquid (CNSL) ; polypropylene ; high impact polystyrene ; compatibilization ; PHB ; PHBV ; rice husk ; biosustainability ; waste valorization ; bacterial cellulose ; natural rubber ; reinforcing ; biodegradable polymers ; Arboform ; epoxidized oil ; maleinized linseed oil ; toughness ; thermal stability ; pectin ; food packaging ; active compounds ; agro-waste residues ; circular economy ; graphene oxide ; size selection ; sodium alginate ; bio-based polymers ; biodegradable polyesters ; wood plastic composites ; natural additives and fillers ; composites characterization ; bioplastics manufacturing
    Size 1 electronic resource (296 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044746
    ISBN 9783036500379 ; 3036500375
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Current Issues in Molecular Biology Journal Enters a New Era

    Rafael Franco

    Current Issues in Molecular Biology, Vol 43, Iss 31, Pp 384-

    2021  Volume 388

    Abstract: Current Issues in Molecular Biology ( CIMB ) (https://www [.] ...

    Abstract Current Issues in Molecular Biology ( CIMB ) (https://www [.]
    Keywords n/a ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  8. Article ; Online: One-way or two-way sweet link between theobromine and depression?

    Franco, Rafael / Martínez-Pinilla, Eva

    BMC psychiatry

    2023  Volume 23, Issue 1, Page(s) 411

    Abstract: Theobromine is an abundant methylxanthine in cocoa/chocolate. A recent article in BMC Psychiatry concludes that theobromine consumption increases the risk of depression. In our opinion, it is difficult to make a correlation between dietary habits and the ...

    Abstract Theobromine is an abundant methylxanthine in cocoa/chocolate. A recent article in BMC Psychiatry concludes that theobromine consumption increases the risk of depression. In our opinion, it is difficult to make a correlation between dietary habits and the risk of depression, the diagnosis of which is not simple to make. Also, it is not easy to assess the amount of theobromine because it varies from one brand of chocolate to another and/or depending on the percentage of cocoa it has. Assuming that there is a correlation, we postulate that the conclusion may be the opposite, that is, that depressed individuals benefit from the intake of products containing theobromine. Since some antidepressant drugs alter the craving for sweet products, it would be interesting to try to correlate the data on theobromine intake with the kind of therapy used in depressed individuals.
    MeSH term(s) Humans ; Theobromine ; Depression ; Cacao ; Feeding Behavior ; Craving
    Chemical Substances Theobromine (OBD445WZ5P)
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-023-04662-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Neuroprotection afforded by targeting G protein-coupled receptors in heteromers and by heteromer-selective drugs.

    Franco, Rafael / Navarro, Gemma

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1222158

    Abstract: G protein-coupled receptors (GPCRs) are the target of hundreds of approved drugs. Although these drugs were designed to target individual receptors, it is becoming increasingly apparent that GPCRs interact with each other to form heteromers. Approved ... ...

    Abstract G protein-coupled receptors (GPCRs) are the target of hundreds of approved drugs. Although these drugs were designed to target individual receptors, it is becoming increasingly apparent that GPCRs interact with each other to form heteromers. Approved drug targets are often part of a GPCR heteromer, and therefore new drugs can be developed with heteromers in mind. This review presents several strategies to selectively target GPCRs in heteromeric contexts, namely, taking advantage of i) heteromer-mediated biased agonism/signalling, ii) discovery of drugs with higher affinity for the receptor if it is part of a heteromer (heteromer selective drugs), iii) allosteric compounds directed against the interacting transmembrane domains and, eventually, iv) antagonists that block both GPCRs in a heteromer. Heteromers provide unique allosteric sites that should help designing a new type of drug that by definition would be a heteromer selective drug. The review also provides examples of rhodopsin-like class A receptors in heteromers that could be targeted to neuroprotect and/or delay the progression of diseases such as Parkinson's and Alzheimer's. GPCRs in heteromers (GriH) with the potential to address dyskinesias, a common complication of dopaminergic replacement therapy in parkinsonian patients, are also described.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1222158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Olfactory Trail of Neurodegenerative Diseases.

    Franco, Rafael / Garrigós, Claudia / Lillo, Jaume

    Cells

    2024  Volume 13, Issue 7

    Abstract: Alterations in olfactory functions are proposed as possible early biomarkers of neurodegenerative diseases. Parkinson's and Alzheimer's diseases manifest olfactory dysfunction as a symptom, which is worth mentioning. The alterations do not occur in all ... ...

    Abstract Alterations in olfactory functions are proposed as possible early biomarkers of neurodegenerative diseases. Parkinson's and Alzheimer's diseases manifest olfactory dysfunction as a symptom, which is worth mentioning. The alterations do not occur in all patients, but they can serve to rule out neurodegenerative pathologies that are not associated with small deficits. Several prevalent neurodegenerative conditions, including impaired smell, arise in the early stages of Parkinson's and Alzheimer's diseases, presenting an attractive prospect as a snitch for early diagnosis. This review covers the current knowledge on the link between olfactory deficits and Parkinson's and Alzheimer's diseases. The review also covers the emergence of olfactory receptors as actors in the pathophysiology of these diseases. Olfactory receptors are not exclusively expressed in olfactory sensory neurons. Olfactory receptors are widespread in the human body; they are expressed, among others, in the testicles, lungs, intestines, kidneys, skin, heart, and blood cells. Although information on these ectopically expressed olfactory receptors is limited, they appear to be involved in cell recognition, migration, proliferation, wound healing, apoptosis, and exocytosis. Regarding expression in non-chemosensory regions of the central nervous system (CNS), future research should address the role, in both the glia and neurons, of olfactory receptors. Here, we review the limited but relevant information on the altered expression of olfactory receptor genes in Parkinson's and Alzheimer's diseases. By unraveling how olfactory receptor activation is involved in neurodegeneration and identifying links between olfactory structures and neuronal death, valuable information could be gained for early diagnosis and intervention strategies in neurodegenerative diseases.
    MeSH term(s) Humans ; Neurodegenerative Diseases/pathology ; Smell/physiology ; Alzheimer Disease/metabolism ; Parkinson Disease/metabolism ; Olfaction Disorders/diagnosis ; Receptors, Odorant
    Chemical Substances Receptors, Odorant
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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