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  1. Article ; Online: SARS-CoV-2 associated Guillain-Barré syndrome.

    Pelea, Teodor / Reuter, Ursula / Schmidt, Christine / Laubinger, Raimondo / Siegmund, Robert / Walther, Bjoern Wito

    Journal of neurology

    2020  Volume 268, Issue 4, Page(s) 1191–1194

    Abstract: Presented herein is a severe case of SARS-CoV-2 associated Guillain-Barré syndrome (GBS), showing only slight improvement despite adequate therapy. To date, only few cases of GBS associated with this infection have been described. This case report ... ...

    Abstract Presented herein is a severe case of SARS-CoV-2 associated Guillain-Barré syndrome (GBS), showing only slight improvement despite adequate therapy. To date, only few cases of GBS associated with this infection have been described. This case report summarizes the insights gain so far to GBS with this antecedent trigger. So far, attention has mostly focused on complications of the CNS involvement. Taking into account that GBS can cause a considerable impairment of the respiratory system, clinicians dealing with SARS-CoV-2 positive-tested patients should pay attention to symptoms of the peripheral nervous system. As far as we know from this reported case and the review of the current literature, there seems to be no association with antiganglioside antibodies or a positive SARS-CoV-2 RT-PCR in CSF. An obvious frequent occurrence of a bilateral facial weakness or bilateral peripheral facial diplegia should be emphasized.
    MeSH term(s) COVID-19/complications ; Female ; Guillain-Barre Syndrome/physiopathology ; Guillain-Barre Syndrome/virology ; Humans ; Middle Aged ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-08
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-020-10133-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Comprehensive View on the Quercetin Impact on Colorectal Cancer.

    Neamtu, Andreea-Adriana / Maghiar, Teodor-Andrei / Alaya, Amina / Olah, Neli-Kinga / Turcus, Violeta / Pelea, Diana / Totolici, Bogdan Dan / Neamtu, Carmen / Maghiar, Adrian Marius / Mathe, Endre

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 6

    Abstract: Colorectal cancer (CRC) represents the third type of cancer in incidence and second in mortality worldwide, with the newly diagnosed case number on the rise. Among the diagnosed patients, approximately 70% have no hereditary germ-line mutations or family ...

    Abstract Colorectal cancer (CRC) represents the third type of cancer in incidence and second in mortality worldwide, with the newly diagnosed case number on the rise. Among the diagnosed patients, approximately 70% have no hereditary germ-line mutations or family history of pathology, thus being termed sporadic CRC. Diet and environmental factors are to date considered solely responsible for the development of sporadic CRC; therefore; attention should be directed towards the discovery of preventative actions to combat the CRC initiation, promotion, and progression. Quercetin is a polyphenolic flavonoid plant secondary metabolite with a well-characterized antioxidant activity. It has been extensively reported as an anti-carcinogenic agent in the scientific literature, and the modulated targets of quercetin have been also characterized in the context of CRC, mainly in original research publications. In this fairly comprehensive review, we summarize the molecular targets of quercetin reported to date in in vivo and in vitro CRC models, while also giving background information about the signal transduction pathways that it up- and downregulates. Among the most relevant modulated pathways, the Wnt/β-catenin, PI3K/AKT, MAPK/Erk, JNK, or p38, p53, and NF-κB have been described. With this work, we hope to encourage further quests in the elucidation of quercetin anti-carcinogenic activity as single agent, as dietary component, or as pharmaconutrient delivered in the form of plant extracts.
    MeSH term(s) Colorectal Neoplasms/metabolism ; Flavonoids ; Humans ; NF-kappa B ; Phosphatidylinositol 3-Kinases/metabolism ; Quercetin/pharmacology ; Quercetin/therapeutic use
    Chemical Substances Flavonoids ; NF-kappa B ; Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2022-03-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27061873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SARS-CoV-2 associated Guillain–Barré syndrome

    Pelea, Teodor / Reuter, Ursula / Schmidt, Christine / Laubinger, Raimondo / Siegmund, Robert / Walther, Bjoern Wito

    Journal of Neurology ; ISSN 0340-5354 1432-1459

    2020  

    Keywords Neurology ; Clinical Neurology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s00415-020-10133-w
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A Comprehensive View on the Quercetin Impact on Colorectal Cancer

    Andreea-Adriana Neamtu / Teodor-Andrei Maghiar / Amina Alaya / Neli-Kinga Olah / Violeta Turcus / Diana Pelea / Bogdan Dan Totolici / Carmen Neamtu / Adrian Marius Maghiar / Endre Mathe

    Molecules, Vol 27, Iss 1873, p

    2022  Volume 1873

    Abstract: Colorectal cancer (CRC) represents the third type of cancer in incidence and second in mortality worldwide, with the newly diagnosed case number on the rise. Among the diagnosed patients, approximately 70% have no hereditary germ-line mutations or family ...

    Abstract Colorectal cancer (CRC) represents the third type of cancer in incidence and second in mortality worldwide, with the newly diagnosed case number on the rise. Among the diagnosed patients, approximately 70% have no hereditary germ-line mutations or family history of pathology, thus being termed sporadic CRC. Diet and environmental factors are to date considered solely responsible for the development of sporadic CRC; therefore; attention should be directed towards the discovery of preventative actions to combat the CRC initiation, promotion, and progression. Quercetin is a polyphenolic flavonoid plant secondary metabolite with a well-characterized antioxidant activity. It has been extensively reported as an anti-carcinogenic agent in the scientific literature, and the modulated targets of quercetin have been also characterized in the context of CRC, mainly in original research publications. In this fairly comprehensive review, we summarize the molecular targets of quercetin reported to date in in vivo and in vitro CRC models, while also giving background information about the signal transduction pathways that it up- and downregulates. Among the most relevant modulated pathways, the Wnt/β-catenin, PI3K/AKT, MAPK/Erk, JNK, or p38, p53, and NF-κB have been described. With this work, we hope to encourage further quests in the elucidation of quercetin anti-carcinogenic activity as single agent, as dietary component, or as pharmaconutrient delivered in the form of plant extracts.
    Keywords quercetin ; flavonol ; polyphenol ; colorectal cancer ; PI3K/AKT ; Wnt/β-catenin ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article: SARS-CoV-2 associated Guillain-Barré syndrome

    Pelea, Teodor / Reuter, Ursula / Schmidt, Christine / Laubinger, Raimondo / Siegmund, Robert / Walther, Bjoern Wito

    J. neurol

    Abstract: Presented herein is a severe case of SARS-CoV-2 associated Guillain-Barré syndrome (GBS), showing only slight improvement despite adequate therapy. To date, only few cases of GBS associated with this infection have been described. This case report ... ...

    Abstract Presented herein is a severe case of SARS-CoV-2 associated Guillain-Barré syndrome (GBS), showing only slight improvement despite adequate therapy. To date, only few cases of GBS associated with this infection have been described. This case report summarizes the insights gain so far to GBS with this antecedent trigger. So far, attention has mostly focused on complications of the CNS involvement. Taking into account that GBS can cause a considerable impairment of the respiratory system, clinicians dealing with SARS-CoV-2 positive-tested patients should pay attention to symptoms of the peripheral nervous system. As far as we know from this reported case and the review of the current literature, there seems to be no association with antiganglioside antibodies or a positive SARS-CoV-2 RT-PCR in CSF. An obvious frequent occurrence of a bilateral facial weakness or bilateral peripheral facial diplegia should be emphasized.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #706655
    Database COVID19

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