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Article ; Online: Neonatologist responsibility to ensure placentas are received for pathologic examination-response to comment on criteria for placental examination for obstetric and neonatal providers.

Roberts, Drucilla J / Baergen, Rebecca N / Boyd, Theonia K / Carreon, Chrystalle Katte / Duncan, Virginia E / Ernst, Linda M / Faye-Petersen, Ona M / Folkins, Ann K / Hecht, Jonathon L / Heerema-McKenney, Amy / Heller, Debra S / Linn, Rebecca L / Polizzano, Carolyn / Ravishankar, Sanjita / Redline, Raymond W / Salafia, Carolyn M / Torous, Vanda F / Castro, Eumenia C

American journal of obstetrics and gynecology

2023 Volume 228, Issue 6, Page(s) 762–763

MeSH term(s)	Infant, Newborn ; Pregnancy ; Female ; Humans ; Placenta/pathology ; Neonatologists ; Placenta Diseases/diagnosis ; Placenta Diseases/pathology
Language	English
Publishing date	2023-01-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2023.01.027
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Article ; Online: Limited TCR repertoire and

Wang, Na / Vuerich, Marta / Kalbasi, Ahmadreza / Graham, Jonathon J / Csizmadia, Eva / Manickas-Hill, Zachary James / Woolley, Ann / David, Clement / Miller, Eric M / Gorman, Kara / Hecht, Jonathan L / Shaefi, Shahzad / Robson, Simon C / Longhi, Maria Serena

iScience

2021 Volume 24, Issue 10, Page(s) 103205

Abstract: T cell exhaustion and dysfunction are hallmarks of severe COVID-19. To gain insights into the pathways underlying these alterations, we performed a comprehensive transcriptome analysis of peripheral-blood-mononuclear-cells (PBMCs), spleen, lung, kidney, ... ...

Abstract	T cell exhaustion and dysfunction are hallmarks of severe COVID-19. To gain insights into the pathways underlying these alterations, we performed a comprehensive transcriptome analysis of peripheral-blood-mononuclear-cells (PBMCs), spleen, lung, kidney, liver, and heart obtained at autopsy from COVID-19 patients and matched controls, using the nCounter CAR-T-Characterization panel. We found substantial gene alterations in COVID-19-impacted organs, especially the lung where altered TCR repertoires are noted. Reduced TCR repertoires are also observed in PBMCs of severe COVID-19 patients.
Language	English
Publishing date	2021-09-30
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2021.103205
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The journal of cardiovascular computed tomography: A year in review: 2022.

Pontone, Gianluca / Mushtaq, Saima / Al'Aref, Subhi J / Andreini, Daniele / Baggiano, Andrea / Canan, Arzu / Cavalcante, Joao L / Chelliah, Anjali / Chen, Marcus / Choi, Andrew / Damini, Dey / De Cecco, Carlo Nicola / Farooqi, Kanwal M / Ferencik, Maros / Feuchtner, Gudrun / Hecht, Harvey / Gransar, Heidi / Kolossváry, Márton / Leipsic, Jonathon /

Lu, Michael T / Marwan, Mohamed / Ng, Ming-Yen / Maurovich-Horvat, Pál / Nagpal, Prashant / Nicol, Ed / Weir-McCall, Jonathan / Whelton, Seamus P / Williams, Michelle C / Reid, Anna / Fairbairn, Timothy A / Villines, Todd / Vliegenthart, Rosemarie / Arbab-Zadeh, Armin

Journal of cardiovascular computed tomography

2023 Volume 17, Issue 2, Page(s) 86–95

Abstract: This review aims to summarize key articles published in the Journal of Cardiovascular Computed Tomography (JCCT) in 2022, focusing on those that had the most scientific and educational impact. The JCCT continues to expand; the number of submissions, ... ...

Abstract	This review aims to summarize key articles published in the Journal of Cardiovascular Computed Tomography (JCCT) in 2022, focusing on those that had the most scientific and educational impact. The JCCT continues to expand; the number of submissions, published manuscripts, cited articles, article downloads, social media presence, and impact factor continues to grow. The articles selected by the Editorial Board of the JCCT in this review highlight the role of cardiovascular computed tomography (CCT) to detect subclinical atherosclerosis, assess the functional relevance of stenoses, and plan invasive coronary and valve procedures. A section is dedicated to CCT in infants and other patients with congenital heart disease, in women, and to the importance of training in CT. In addition, we highlight key consensus documents and guidelines published in JCCT last year. The Journal values the tremendous work by authors, reviewers, and editors to accomplish these contributions.
MeSH term(s)	Female ; Humans ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Cardiovascular System ; Computed Tomography Angiography ; Constriction, Pathologic ; Heart ; Predictive Value of Tests ; Tomography, X-Ray Computed/methods ; Transcatheter Aortic Valve Replacement/methods
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Editorial
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2023.03.001
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Article ; Online: Criteria for placental examination for obstetrical and neonatal providers.

American journal of obstetrics and gynecology

2022 Volume 228, Issue 5, Page(s) 497–508.e4

Abstract: Pathologic examination of the placenta can provide insight into likely (and unlikely) causes of antepartum and intrapartum events, diagnoses with urgent clinical relevance, prognostic information for mother and infant, support for practice evaluation and ...

Abstract	Pathologic examination of the placenta can provide insight into likely (and unlikely) causes of antepartum and intrapartum events, diagnoses with urgent clinical relevance, prognostic information for mother and infant, support for practice evaluation and improvement, and insight into advancing the sciences of obstetrics and neonatology. Although it is true that not all placentas require pathologic examination (although alternative opinions have been expressed), prioritization of placentas for pathologic examination should be based on vetted indications such as maternal comorbidities or pregnancy complications in which placental pathology is thought to be useful for maternal or infant care, understanding pathophysiology, or practice modifications. Herein we provide placental triage criteria for the obstetrical and neonatal provider based on publications and expert opinion of 16 placental pathologists and a pathologists' assistant, formulated using a modified Delphi approach. These criteria include indications in which placental pathology has clinical relevance, such as pregnancy loss, maternal infection, suspected abruption, fetal growth restriction, preterm birth, nonreassuring fetal heart testing requiring urgent delivery, preeclampsia with severe features, or neonates with early evidence of multiorgan system failure including neurologic compromise. We encourage a focused gross examination by the provider or an attendant at delivery for all placentas and provide guidance for this examination. We recommend that any placenta that is abnormal on gross examination undergo a complete pathology examination. In addition, we suggest practice criteria for placental pathology services, including a list of critical values to be used by the relevant provider. We hope that these sets of triage indications, criteria, and practice suggestions will facilitate appropriate submission of placentas for pathologic examination and improve its relevance to clinical care.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Female ; Humans ; Placenta/pathology ; Premature Birth ; Pregnancy Complications ; Obstetrics ; Fetal Growth Retardation/pathology
Language	English
Publishing date	2022-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2022.12.017
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Article ; Online: SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers.

Hecht, Jonathon L / Quade, Bradley / Deshpande, Vikram / Mino-Kenudson, Mari / Ting, David T / Desai, Niyati / Dygulska, Beata / Heyman, Taryn / Salafia, Carolyn / Shen, Dejun / Bates, Sara V / Roberts, Drucilla J

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

2020 Volume 33, Issue 11, Page(s) 2092–2103

Abstract: Congenital infection of SARS-CoV-2 appears to be exceptionally rare despite many cases of COVID-19 during pregnancy. Robust proof of placental infection requires demonstration of viral localization within placental tissue. Only two of the few cases of ... ...

Abstract	Congenital infection of SARS-CoV-2 appears to be exceptionally rare despite many cases of COVID-19 during pregnancy. Robust proof of placental infection requires demonstration of viral localization within placental tissue. Only two of the few cases of possible vertical transmission have demonstrated placental infection. None have shown placental expression of the ACE2 or TMPRSS2 protein, both required for viral infection. We examined 19 COVID-19 exposed placentas for histopathologic findings, and for expression of ACE2, and TMPRSS2 by immunohistochemistry. Direct placental SARS-CoV-2 expression was studied by two methods-nucleocapsid protein expression by immunohistochemistry, and RNA expression by in situ hybridization. ACE2 membranous expression in the syncytiotrophoblast (ST) of the chorionic villi is predominantly in a polarized pattern with expression highest on the stromal side of the ST. In addition, cytotrophoblast and extravillous trophoblast express ACE2. No ACE2 expression was detected in villous stroma, Hofbauer cells, or endothelial cells. TMPRSS2 expression was only present weakly in the villous endothelium and rarely in the ST. In 2 of 19 cases, SARS-CoV-2 RNA was present in the placenta focally in the ST and cytotrophoblast. There was no characteristic histopathology present in our cases including the two placental infections. We found that the placenta is capable of being infected but that this event is rare. We propose one explanation could be the polarized expression of ACE2 away from the maternal blood and pronounced paucity of TMPRSS2 expression in trophoblast.
MeSH term(s)	Adult ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Female ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/biosynthesis ; Placenta/metabolism ; Placenta/pathology ; Placenta/virology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Pregnancy ; Pregnancy Complications, Infectious/metabolism ; Pregnancy Complications, Infectious/pathology ; Pregnancy Complications, Infectious/virology ; RNA, Viral/analysis ; SARS-CoV-2 ; Serine Endopeptidases/biosynthesis
Chemical Substances	RNA, Viral ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
Keywords	covid19
Language	English
Publishing date	2020-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	645073-8
ISSN	1530-0285 ; 0893-3952
ISSN (online)	1530-0285
ISSN	0893-3952
DOI	10.1038/s41379-020-0639-4
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Article ; Online: Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19

Na Wang / Marta Vuerich / Ahmadreza Kalbasi / Jonathon J. Graham / Eva Csizmadia / Zachary James Manickas-Hill / Ann Woolley / Clement David / Eric M. Miller / Kara Gorman / Jonathan L. Hecht / Shahzad Shaefi / Simon C. Robson / Maria Serena Longhi

iScience, Vol 24, Iss 10, Pp 103205- (2021)

2021

Abstract: Summary: T cell exhaustion and dysfunction are hallmarks of severe COVID-19. To gain insights into the pathways underlying these alterations, we performed a comprehensive transcriptome analysis of peripheral-blood-mononuclear-cells (PBMCs), spleen, lung, ...

Abstract	Summary: T cell exhaustion and dysfunction are hallmarks of severe COVID-19. To gain insights into the pathways underlying these alterations, we performed a comprehensive transcriptome analysis of peripheral-blood-mononuclear-cells (PBMCs), spleen, lung, kidney, liver, and heart obtained at autopsy from COVID-19 patients and matched controls, using the nCounter CAR-T-Characterization panel. We found substantial gene alterations in COVID-19-impacted organs, especially the lung where altered TCR repertoires are noted. Reduced TCR repertoires are also observed in PBMCs of severe COVID-19 patients. ENTPD1/CD39, an ectoenzyme defining exhausted T-cells, is upregulated in the lung, liver, spleen, and PBMCs of severe COVID-19 patients where expression positively correlates with markers of vasculopathy. Heightened ENTPD1/CD39 is paralleled by elevations in STAT-3 and HIF-1α transcription factors; and by markedly reduced CD39-antisense-RNA, a long-noncoding-RNA negatively regulating ENTPD1/CD39 at the post-transcriptional level. Limited TCR repertoire and aberrant regulation of ENTPD1/CD39 could have permissive roles in COVID-19 progression and indicate potential therapeutic targets to reverse disease.
Keywords	Immunology ; Virology ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SARS-CoV-2 Can Infect the Placenta and Is Not Associated with Specific Placental Histopathology

Hecht, Jonathon L. / Quade, Bradley / Deshpande, Vikram / Mino-Kenudson, Mari / Ting, David T. / Desai, Niyati / Dygulska, Beata / Heyman, Taryn / Salafia, Carolyn / Shen, Dejun / Bates, Sara V. / Roberts, Drucilla J.

SSRN Electronic Journal ; ISSN 1556-5068

A Series of 19 Placentas from COVID-19+ Mothers

2020

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.2139/ssrn.3624233
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology

Modern Pathology ; ISSN 0893-3952 1530-0285

a series of 19 placentas from COVID-19-positive mothers

2020

Keywords	Pathology and Forensic Medicine ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1038/s41379-020-0639-4
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers

Mod Pathol

Abstract	Congenital infection of SARS-CoV-2 appears to be exceptionally rare despite many cases of COVID-19 during pregnancy. Robust proof of placental infection requires demonstration of viral localization within placental tissue. Only two of the few cases of possible vertical transmission have demonstrated placental infection. None have shown placental expression of the ACE2 or TMPRSS2 protein, both required for viral infection. We examined 19 COVID-19 exposed placentas for histopathologic findings, and for expression of ACE2, and TMPRSS2 by immunohistochemistry. Direct placental SARS-CoV-2 expression was studied by two methods-nucleocapsid protein expression by immunohistochemistry, and RNA expression by in situ hybridization. ACE2 membranous expression in the syncytiotrophoblast (ST) of the chorionic villi is predominantly in a polarized pattern with expression highest on the stromal side of the ST. In addition, cytotrophoblast and extravillous trophoblast express ACE2. No ACE2 expression was detected in villous stroma, Hofbauer cells, or endothelial cells. TMPRSS2 expression was only present weakly in the villous endothelium and rarely in the ST. In 2 of 19 cases, SARS-CoV-2 RNA was present in the placenta focally in the ST and cytotrophoblast. There was no characteristic histopathology present in our cases including the two placental infections. We found that the placenta is capable of being infected but that this event is rare. We propose one explanation could be the polarized expression of ACE2 away from the maternal blood and pronounced paucity of TMPRSS2 expression in trophoblast.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #693331
Database	COVID19

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Article ; Online: CAC-DRS: Coronary Artery Calcium Data and Reporting System. An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT).

Hecht, Harvey S / Blaha, Michael J / Kazerooni, Ella A / Cury, Ricardo C / Budoff, Matt / Leipsic, Jonathon / Shaw, Leslee

Journal of cardiovascular computed tomography

2018 Volume 12, Issue 3, Page(s) 185–191

Abstract: The goal of CAC-DRS: Coronary Artery Calcium Data and Reporting System is to create a standardized method to communicate findings of CAC scanning on all noncontrast CT scans, irrespective of the indication, in order to facilitate clinical decision-making, ...

Abstract	The goal of CAC-DRS: Coronary Artery Calcium Data and Reporting System is to create a standardized method to communicate findings of CAC scanning on all noncontrast CT scans, irrespective of the indication, in order to facilitate clinical decision-making, with recommendations for subsequent patient management. The CAC-DRS classification is applied on a per-patient basis and represents the total calcium score and the number of involved arteries. General recommendations are provided for further management of patients with different degrees of calcified plaque burden based on CAC-DRS classification. In addition, CAC-DRS will provide a framework of standardization that may benefit quality assurance and tracking patient outcomes with the potential to ultimately result in improved quality of care.
MeSH term(s)	Computed Tomography Angiography/standards ; Consensus ; Coronary Angiography/methods ; Coronary Angiography/standards ; Coronary Artery Disease/diagnostic imaging ; Coronary Vessels/diagnostic imaging ; Electronic Health Records/standards ; Humans ; Predictive Value of Tests ; Prognosis ; Radiology Information Systems/standards ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Vascular Calcification/diagnostic imaging
Language	English
Publishing date	2018-03-30
Publishing country	United States
Document type	Journal Article ; Practice Guideline
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2018.03.008
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