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  1. Article: Burden of bradycardia and barriers to accessing bradycardia therapy in underserved countries.

    Egas, Diego / Rodriguez, Francisco / Jaswal, Aparna / Jeilan, Mohamed / Milasinovic, Goran / Al Fagih, Ahmed

    European heart journal supplements : journal of the European Society of Cardiology

    2023  Volume 25, Issue Suppl H, Page(s) H1–H17

    Abstract: Bradycardia, a condition characterized by an abnormally slow heart rate, poses significant challenges in terms of diagnosis and treatment. While it is a concern world-wide, low- and middle-income countries (LMICs) face substantial barriers in accessing ... ...

    Abstract Bradycardia, a condition characterized by an abnormally slow heart rate, poses significant challenges in terms of diagnosis and treatment. While it is a concern world-wide, low- and middle-income countries (LMICs) face substantial barriers in accessing appropriate bradycardia therapy. This article aims to explore the global aetiology and incidence of bradycardia, compare the prevalence and management of the condition in high-income countries versus LMICs, identify the key reasons behind the disparities in access to bradycardia therapy in LMICs, and emphasize the urgent need to address these disparities to ensure equitable healthcare on a global scale.
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suad125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563 -Suppl.-: Show issues Location:
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  2. Article ; Online: Epidemiological characterization of ischemic heart disease at different altitudes

    Esteban Ortiz-Prado / Juan S. Izquierdo-Condoy / Raúl Fernández-Naranjo / Jorge Vásconez-González / Leonardo Cano / Ana Carolina González / Estefanía Morales-Lapo / Galo S. Guerrero-Castillo / Erick Duque / Maria Gabriela Davila Rosero / Diego Egas / Ginés Viscor

    PLoS ONE, Vol 18, Iss

    A nationwide population-based analysis from 2011 to 2021 in Ecuador

    2023  Volume 12

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Epidemiological characterization of ischemic heart disease at different altitudes: A nationwide population-based analysis from 2011 to 2021 in Ecuador.

    Ortiz-Prado, Esteban / Izquierdo-Condoy, Juan S / Fernández-Naranjo, Raúl / Vásconez-González, Jorge / Cano, Leonardo / González, Ana Carolina / Morales-Lapo, Estefanía / Guerrero-Castillo, Galo S / Duque, Erick / Rosero, Maria Gabriela Davila / Egas, Diego / Viscor, Ginés

    PloS one

    2023  Volume 18, Issue 12, Page(s) e0295586

    Abstract: Background: Cardiovascular diseases, including ischemic heart disease, are the leading cause of premature death and disability worldwide. While traditional risk factors such as smoking, obesity, and diabetes have been thoroughly investigated, non- ... ...

    Abstract Background: Cardiovascular diseases, including ischemic heart disease, are the leading cause of premature death and disability worldwide. While traditional risk factors such as smoking, obesity, and diabetes have been thoroughly investigated, non-traditional risk factors like high-altitude exposure remain underexplored. This study aims to examine the incidence and mortality rates of ischemic heart disease over the past decade in Ecuador, a country with a diverse altitude profile spanning from 0 to 4,300 meters.
    Methods: We conducted a geographic distribution analysis of ischemic heart disease in Ecuador, utilizing hospital discharge and mortality data from the National Institute of Census and Statistics for the years 2011-2021. Altitude exposure was categorized according to two distinct classifications: the traditional division into low (< 2,500 m) and high (> 2,500 m) altitudes, as well as the classification proposed by the International Society of Mountain Medicine, which delineates low (< 1,500 m), moderate (1,500-2,500 m), high (2,500-3,500 m), and very high (3,500-5,800 m) altitudes.
    Findings: From 2011-2021, we analyzed 49,765 IHD-related hospital admissions and 62,620 deaths. Men had an age-adjusted incidence rate of 55.08/100,000 and a mortality rate of 47.2/100,000, compared to 20.77/100,000 and 34.8/100,000 in women. Incidence and mortality surged in 2020 by 83% in men and 75% in women. Altitudinal stratification revealed higher IHD rates at lower altitudes (<2500 m), averaging 61.65 and 121.8 per 100,000 for incidence and mortality, which declined to 25.9 and 38.5 at elevations >2500 m. Men had more pronounced rates across altitudes, exhibiting 138.7% and 150.0% higher incidence at low and high altitudes respectively, and mortality rates increased by 48.3% at low altitudes and 23.2% at high altitudes relative to women.
    Conclusion: Ecuador bears a significant burden of ischemic heart disease (IHD), with men being more affected than women in terms of incidence. However, women have a higher percentage of mortality post-hospital admission. Regarding elevation, our analysis, using two different altitude cutoff points, reveals higher mortality rates in low-altitude regions compared to high-altitude areas, suggesting a potential protective effect of high elevation on IHD risk. Nevertheless, a definitive dose-response relationship between high altitude and reduced IHD risk could not be conclusively established.
    MeSH term(s) Male ; Humans ; Female ; Altitude ; Ecuador/epidemiology ; Myocardial Ischemia/epidemiology ; Risk Factors ; Smoking
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0295586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: SARS-CoV-2 detection and sequencing in heart tissue associated with myocarditis and persistent arrhythmia: A case report.

    Egas, Diego / Guadalupe, Juan José / Prado-Vivar, Belén / Becerra-Wong, Mónica / Márquez, Sully / Castillo, Stalin / Latta, Johanna / Rodriguez, Francisco / Escorza, Giovanni / Trueba, Gabriel / Grunauer, Michelle / Barragán, Verónica / Rojas-Silva, Patricio / Cárdenas, Paúl

    IDCases

    2021  Volume 25, Page(s) e01187

    Abstract: Background: SARS-CoV-2 uses the human cell receptor angiotensin-converting enzyme (ACE2). ACE2 is widely present in the cardiovascular system including the myocardium and the conduction system. COVID-19 patients that present severe symptoms have been ... ...

    Abstract Background: SARS-CoV-2 uses the human cell receptor angiotensin-converting enzyme (ACE2). ACE2 is widely present in the cardiovascular system including the myocardium and the conduction system. COVID-19 patients that present severe symptoms have been reported to have complications involving myocardial injuries caused by the virus. Here we report the detection of SARS-CoV-2 by whole genome sequencing in the endocardium of a patient with severe bradycardia.
    Case presentation: We report a case of a 34-year-old male patient with COVID-19 tested by PCR, he started with gastrointestinal symptoms, however, he quickly deteriorated his hemodynamic state by means of myocarditis and bradycardia. After performing an endocardium biopsy, it was possible to identify the presence of SARS-CoV-2 in the heart tissue and to sequence its whole genome using the ARTIC-Network protocol and a modified tissue RNA extraction method. The patient's outcome was improved after a permanent pacemaker was implanted.
    Conclusions: It was possible to identify a SARS-CoV-2 clade 20A in the endocardium of the reported patient.
    Language English
    Publishing date 2021-06-11
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2021.e01187
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