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  1. Article: Editorial: HBV and lymphoma.

    Gentile, Giuseppe / Arcaini, Luca / Antonelli, Guido / Martelli, Maurizio

    Frontiers in oncology

    2023  Volume 13, Page(s) 1236816

    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1236816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reflections after 2 years of COVID-19 pandemic.

    Focosi, Daniele / Casadevall, Arturo / Maggi, Fabrizio / Antonelli, Guido

    Reviews in medical virology

    2022  Volume 32, Issue 5, Page(s) e2351

    MeSH term(s) COVID-19/epidemiology ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Editorial
    ZDB-ID 1086043-5
    ISSN 1099-1654 ; 1052-9276
    ISSN (online) 1099-1654
    ISSN 1052-9276
    DOI 10.1002/rmv.2351
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    Zs.A 3308: Show issues Location:
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  3. Article: Susceptibility Testing of Colistin for

    Sacco, Federica / Visca, Paolo / Runci, Federica / Antonelli, Guido / Raponi, Giammarco

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 1

    Language English
    Publishing date 2021-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10010048
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  4. Article ; Online: Botulinum neurotoxin as early treatment in acute-onset lesional hemiballism.

    Di Rauso, Giulia / Orlandi, Niccolò / Jacopetti, Marco / Bigliardi, Guido / Antonelli, Francesca / Meletti, Stefano / Rispoli, Vittorio

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  

    Abstract: Background: Hemiballism (HB) and hemichorea (HC) are the most frequent secondary movement disorders, usually caused by cerebrovascular diseases. In only a minority of cases, these involuntary movements are not self-limited, and they may severely ... ...

    Abstract Background: Hemiballism (HB) and hemichorea (HC) are the most frequent secondary movement disorders, usually caused by cerebrovascular diseases. In only a minority of cases, these involuntary movements are not self-limited, and they may severely compromise patients' quality of life, so that symptomatic treatments are required. Typical and atypical neuroleptics as well as tetrabenazine are considered therapies of choice. However, anecdotal reports of antiseizures medications and botulinum neurotoxin injection effectiveness have been described.
    Methods: We described a case of severely disabling acute-onset lesional HB/HC, where high dosage of first- and second-line therapies was contraindicated due to patient's comorbidities.
    Results: After botulin neurotoxin (BoNT) injections in his left upper limb muscles (biceps brachii, triceps brachii, teres major, and deltoid), the patient experienced gradual reduction of hyperkinetic movements. The gradual discontinuation of topiramate (TPM) did not worsen the clinical picture.
    Discussion: The reduction of hyperkinetic movements led to rhabdomyolysis resolution as well as cutaneous injuries healing with renal function improvement, so that the patient was able to be eligible for rehabilitation, which was prevented by HB/HC itself. The clinical improvement was consistent with BoNT pharmacokinetic. The administration of BoNT early after the onset of lesional HB/HC remarkably modified the clinical management and drove toward comorbidities resolution and rehabilitation.
    Conclusion: The present case highlights the effectiveness of unconventional therapeutic options in disabling acute onset lesional HB/HC when first-line therapies are contraindicated. Particularly, this report may encourage BoNT application in the early stage of movement disorder emergencies.
    Language English
    Publishing date 2024-03-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-024-07465-0
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  5. Article: Genome-Based Retrospective Analysis of a

    Capitani, Valerio / Arcari, Gabriele / Oliva, Alessandra / Sacco, Federica / Menichincheri, Gaia / Fenske, Linda / Polani, Riccardo / Raponi, Giammarco / Antonelli, Guido / Carattoli, Alessandra

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: Providencia ... ...

    Abstract Providencia stuartii
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12050943
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  6. Article ; Online: Nirmatrelvir and COVID-19: development, pharmacokinetics, clinical efficacy, resistance, relapse, and pharmacoeconomics.

    Focosi, Daniele / McConnell, Scott / Shoham, Shmuel / Casadevall, Arturo / Maggi, Fabrizio / Antonelli, Guido

    International journal of antimicrobial agents

    2023  Volume 61, Issue 2, Page(s) 106708

    Abstract: Nirmatrelvir/ritonavir (N/R) is one of the most effective antiviral drugs against SARS-CoV-2. The preclinical development, pharmacodynamics and pharmacokinetics of N/R are reviewed herein. Randomized clinical trials have been conducted exclusively with ... ...

    Abstract Nirmatrelvir/ritonavir (N/R) is one of the most effective antiviral drugs against SARS-CoV-2. The preclinical development, pharmacodynamics and pharmacokinetics of N/R are reviewed herein. Randomized clinical trials have been conducted exclusively with pre-Omicron variants of concern, but in vitro studies show that efficacy against all Omicron sublineages is preserved, as confirmed by post-marketing observational studies. Nevertheless, investigations of large viral genome repositories have shown that mutation in the main protease causing resistance to N/R are increasingly frequent. In addition, virological and clinical rebounds after N/R discontinuation have been reported in immunocompetent patients. This finding is of concern when translated to immunocompromised patients, in whom N/R efficacy has not been formally investigated in clinical trials. Economical sustainability and perspectives for this therapeutic arena are discussed.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Economics, Pharmaceutical ; Treatment Outcome ; Chronic Disease ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Recurrence ; Ritonavir/therapeutic use ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2023-01-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2022.106708
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    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  7. Article: A Current-Mode Analog Front-End for Capacitive Length Transducers in Pneumatic Muscle Actuators.

    Di Patrizio Stanchieri, Guido / De Marcellis, Andrea / Faccio, Marco / Palange, Elia / Antonelli, Michele Gabrio / Beomonte Zobel, Pierluigi

    Micromachines

    2024  Volume 15, Issue 3

    Abstract: This paper reports on the design, implementation, and characterization of a current-mode analog-front-end circuit for capacitance-to-voltage conversion that can be used in connection with a large variety of sensors and actuators in industrial and ... ...

    Abstract This paper reports on the design, implementation, and characterization of a current-mode analog-front-end circuit for capacitance-to-voltage conversion that can be used in connection with a large variety of sensors and actuators in industrial and rehabilitation medicine applications. The circuit is composed by: (i) an oscillator generating a square wave signal whose frequency and pulse width is a function of the value of input capacitance; (ii) a passive low-pass filter that extracts the DC average component of the square wave signal; (iii) a DC-DC amplifier with variable gain ranging from 1 to 1000. The circuit has been designed in the current-mode approach by employing the second-generation current conveyor circuit, and has been implemented by using commercial discrete components as the basic blocks. The circuit allows for gain and sensitivity tunability, offset compensation and regulation, and the capability to manage various ranges of variations of the input capacitance. For a circuit gain of 1000, the measured circuit sensitivity is equal to 167.34 mV/pF with a resolution in terms of capacitance of 5 fF. The implemented circuit has been employed to measure the variations of the capacitance of a McKibben pneumatic muscle associated with the variations of its length that linearly depend on the circuit output voltage. Under step-to-step conditions of movement of the pneumatic muscle, the overall system sensitivity is equal to 70 mV/mm with a standard deviation error of the muscle length variation of 0.008 mm.
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi15030377
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  8. Article ; Online: Corrigendum to "Virological and clinical rebounds of COVID-19 soon after nirmatrelvir/ritonavir discontinuation" [Clin Microbiol Infect 28 (12) (2022 Dec) 1657-1658].

    Antonelli, Guido / Focosi, Daniele / Turriziani, Ombretta / Tuccori, Marco / Brandi, Rossella / Fillo, Silvia / Ajassa, Camilla / Lista, Florigio / Mastroianni, Claudio M

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 30, Issue 3, Page(s) 408

    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.12.014
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    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  9. Article ; Online: HBV Reactivation in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Narrative Review.

    Gentile, Giuseppe / Antonelli, Guido

    Viruses

    2019  Volume 11, Issue 11

    Abstract: HBV reactivation (HBVr) can occur due to the ability of HBV to remain latent in the liver as covalently closed circular DNA and by the capacity of HBV to alter the immune system of the infected individuals. HBVr can occur in patients undergoing ... ...

    Abstract HBV reactivation (HBVr) can occur due to the ability of HBV to remain latent in the liver as covalently closed circular DNA and by the capacity of HBV to alter the immune system of the infected individuals. HBVr can occur in patients undergoing hematopoietic stem cell transplantation (HSCT) with a clinical spectrum that ranges from asymptomatic infection to fulminant hepatic failure. The risk of HBVr is determined by a complex interplay between host immunity, virus factors, and immunosuppression related to HSCT. All individuals who undergo HSCT should be screened for HBV. HSCT patients positive for HBsAg and also those HBcAb-positive/HBsAg-negative are at high risk of HBV reactivation (HBVr) due to profound and prolonged immunosuppression. Antiviral prophylaxis prevents HBVr, decreases HBVr-related morbidity and mortality in patients with chronic or previous HBV. The optimal duration of antiviral prophylaxis remains to be elucidated. The vaccination of HBV-naïve recipients and their donors against HBV prior to HSCT has an important role in the prevention of acquired HBV infection. This narrative review provides a comprehensive update on the current concepts, risk factors, molecular mechanisms, prevention, and management of HBVr in HSCT.
    MeSH term(s) Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Hepatitis B/drug therapy ; Hepatitis B/immunology ; Hepatitis B/prevention & control ; Hepatitis B/virology ; Hepatitis B Surface Antigens/immunology ; Hepatitis B Vaccines/immunology ; Hepatitis B virus/drug effects ; Hepatitis B virus/genetics ; Hepatitis B virus/immunology ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/immunology ; Hepatitis B, Chronic/virology ; Host-Pathogen Interactions/immunology ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Premedication ; Risk Factors ; Transplantation, Homologous/adverse effects ; Virus Activation/immunology
    Chemical Substances Hepatitis B Surface Antigens ; Hepatitis B Vaccines ; Immunosuppressive Agents
    Language English
    Publishing date 2019-11-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v11111049
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  10. Article ; Online: COVID-19 infodemics: the role of mainstream and social media.

    Focosi, Daniele / Navarro, David / Maggi, Fabrizio / Roilides, Emmanuel / Antonelli, Guido

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 27, Issue 11, Page(s) 1568–1569

    MeSH term(s) COVID-19/psychology ; Genetic Variation ; Health Communication/methods ; Health Communication/standards ; Humans ; Medical Laboratory Personnel/psychology ; SARS-CoV-2/genetics ; Social Media/standards ; Social Media/statistics & numerical data
    Language English
    Publishing date 2021-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.08.003
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