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  1. Article: Predictability in Contemporary Medicine.

    Ciulla, Michele M

    Frontiers in medicine

    2021  Volume 8, Page(s) 510421

    Abstract: Medical practice is increasingly coming under the guidance of statistical-mathematical models that are, undoubtedly, valuable tools but are also only a partial representation of reality. Indeed, given that statistics may be more or less adequate, a model ...

    Abstract Medical practice is increasingly coming under the guidance of statistical-mathematical models that are, undoubtedly, valuable tools but are also only a partial representation of reality. Indeed, given that statistics may be more or less adequate, a model is still a subjective interpretation of the researcher and is also influenced by the historical context in which it operates. From this opinion, I will provide a short historical excursus that retraces the advent of probabilistic medicine as a long process that has a beginning that should be sought in the discovery of the complexity of disease. By supporting the belonging of this evolution to the scientific domain it is also acknowledged that the underlying model can be imperfect or fallible and, therefore, confutable as any product of science. Indeed, it seems non-trivial here to recover these concepts, especially today where clinical decisions are entrusted to practical guidelines, which are a hybrid product resulting from the aggregation of multiple perspectives, including the probabilistic approach, to disease. Finally, before the advent of precision medicine, by limiting the use of guidelines to the original consultative context, an
    Language English
    Publishing date 2021-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.510421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The puzzle of sharing bio-molecular targets between coronaviruses and mediators of the cardiovascular system in humans: Looking for plausible hypotheses.

    Ciulla, Michele M

    Medical hypotheses

    2020  Volume 141, Page(s) 109793

    MeSH term(s) Cardiovascular System ; Coronavirus ; Humans
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Contemporary Medicine: Making Sense of Implementation Models and Methods.

    Ciulla, Michele M / Cioffi, Ugo

    Frontiers in medicine

    2022  Volume 9, Page(s) 912045

    Language English
    Publishing date 2022-05-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.912045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Switching to another antihypertensive effective drug when using ACEIs/ARBs to treat arterial hypertension during COVID-19.

    Ciulla, Michele M

    European heart journal

    2020  Volume 41, Issue 19, Page(s) 1856

    MeSH term(s) Angiotensins ; Antihypertensive Agents ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Hypertension ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Angiotensins ; Antihypertensive Agents
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Coronavirus uses as binding site in humans angiotensin-converting enzyme 2 functional receptor that is involved in arterial blood pressure control and fibrotic response to damage and is a drug target in cardiovascular disease. Is this just a phylogenetic coincidence?

    Ciulla, Michele M

    Journal of medical virology

    2020  Volume 92, Issue 10, Page(s) 1713–1714

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Arterial Pressure ; Binding Sites ; COVID-19 ; Cardiovascular Diseases ; Coronavirus ; Humans ; Hypertension ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pharmaceutical Preparations ; Phylogeny ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Pharmaceutical Preparations ; Spike Glycoprotein, Coronavirus ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SARS-CoV-2 downregulation of ACE2 and pleiotropic effects of ACEIs/ARBs.

    Ciulla, Michele M

    Hypertension research : official journal of the Japanese Society of Hypertension

    2020  Volume 43, Issue 9, Page(s) 985–986

    MeSH term(s) Angiotensin Receptor Antagonists/pharmacology ; Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Betacoronavirus/metabolism ; COVID-19 ; Coronavirus Infections/virology ; Host-Pathogen Interactions ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/virology ; SARS-CoV-2
    Chemical Substances Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Editorial
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-020-0488-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: History repeating. The plague of 1630 in Milan and the COVID-19 pandemia.

    Ciulla, Michele M

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 2, Page(s) 234–235

    Abstract: In western democracies, individual behaviour will be crucial to control the spread of COVID-19, as well as government actions [1] that unfortunately, except China, South Korea and Italy, followed by others,  seems to be generally unconvinced and, ... ...

    Abstract In western democracies, individual behaviour will be crucial to control the spread of COVID-19, as well as government actions [1] that unfortunately, except China, South Korea and Italy, followed by others,  seems to be generally unconvinced and, speculatively, late. Indeed human history has been marked by epidemics/pandemics which have affected, more or less, large geographical areas [2]. Italy, as well as the rest of Europe, has often been affected by these phenomena and, Lombardy, due to his position, was, as today by COVID-19, severely stroked in Italy that is, after China, the second most affected country [3]. This is also linked to the position of Lombardy and its capital, Milan, but this is beyond this brief comment. There are several differences between the past plagues and the actual COVID-19 pandemic and these must be sought in the increased ability to transmit diseases at-distance through the mobility of humans and goods [4], and in the catastrophic consequences of the breakdown of ecosystems, as told, a few years ago, by David Quammen in the book Spillover [5].
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; History, 17th Century ; Italy/epidemiology ; Pandemics ; Plague/epidemiology ; Plague/history ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country Italy
    Document type Historical Article ; Letter
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i2.9553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editorial

    Michele M. Ciulla / Ugo Cioffi

    Frontiers in Medicine, Vol

    Contemporary Medicine: Making Sense of Implementation Models and Methods

    2022  Volume 9

    Keywords disease ; guidelines ; mathematical models ; statistic ; clinical medicine ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Predictability in Contemporary Medicine

    Michele M. Ciulla

    Frontiers in Medicine, Vol

    2021  Volume 8

    Abstract: Medical practice is increasingly coming under the guidance of statistical-mathematical models that are, undoubtedly, valuable tools but are also only a partial representation of reality. Indeed, given that statistics may be more or less adequate, a model ...

    Abstract Medical practice is increasingly coming under the guidance of statistical-mathematical models that are, undoubtedly, valuable tools but are also only a partial representation of reality. Indeed, given that statistics may be more or less adequate, a model is still a subjective interpretation of the researcher and is also influenced by the historical context in which it operates. From this opinion, I will provide a short historical excursus that retraces the advent of probabilistic medicine as a long process that has a beginning that should be sought in the discovery of the complexity of disease. By supporting the belonging of this evolution to the scientific domain it is also acknowledged that the underlying model can be imperfect or fallible and, therefore, confutable as any product of science. Indeed, it seems non-trivial here to recover these concepts, especially today where clinical decisions are entrusted to practical guidelines, which are a hybrid product resulting from the aggregation of multiple perspectives, including the probabilistic approach, to disease. Finally, before the advent of precision medicine, by limiting the use of guidelines to the original consultative context, an aged approach is supported, namely, a relationship with the individual patient.
    Keywords diseases ; Koch's postulates ; multifactorial ; risk factors ; COVID-19 ; susceptibility ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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