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Article ; Online: Effect of initial periodontal therapy on metallothionein levels in smokers and non-smokers with periodontitis.

Yadav, Vikender Singh / Bhatia, Anu / Yadav, Rakhee / Makker, Kanika / Singh, Dhiraj Kumar / Mir, Riyaz Ahmad

2024

Abstract: The aim of this study was to determine the effect of non-surgical periodontal therapy (NSPT) on mRNA expression of metallothionein (MT) and its levels in serum, saliva and gingival crevicular fluid (GCF) of smokers (S) and non-smokers (NS) with ... ...

Abstract	The aim of this study was to determine the effect of non-surgical periodontal therapy (NSPT) on mRNA expression of metallothionein (MT) and its levels in serum, saliva and gingival crevicular fluid (GCF) of smokers (S) and non-smokers (NS) with periodontitis (P).A total of 100 participants were included: 48 periodontally healthy (PH) subjects (24 S [PH + S] and 24 NS [PH + NS]) and 52 patients with P (27 S [P + S] and 25 NS [P + NS]). Clinical parameters were recorded, and biofluids (serum, saliva and GCF) and gingival tissue samples were obtained at baseline in all groups and 3 months after NSPT in P groups. MT levels in biofluids were determined by ELISA. In gingival tissues, MT-mRNA expression was quantified using real-time PCR. mRNA expression of MT and its levels in biofluids were significantly higher in P + S compared to other groups, and the differences between P + NS and PH + S were non-significant. A significant decrease was observed for MT levels in biofluids, and MT-mRNA expression in periodontitis patients after NSPT. In conclusion, smoking and periodontitis are associated with higher MT expression which decreases after NSPT. MT as an oxidative stress biomarker and its therapeutic role in periodontitis should be investigated in future studies.Clinical trial registration: The study was prospectively registered at Clinical Trials Registry-India (ctri.nic.in) as CTRI/2018/08/015427 on August 23, 2018.
Language	English
Publishing date	2024-04-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2092085-4
ISSN	1618-1255 ; 1618-1247
ISSN (online)	1618-1255
ISSN	1618-1247
DOI	10.1007/s10266-024-00937-x
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Article ; Online: Mechanistic insights into Thorium-232 induced liver carcinogenesis: The driving role of Wnt/β-catenin signaling pathway.

Yadav, Rakhee / Das, Sourav Kumar / Ali, Manjoor / Shetake, Neena G / Pandey, Badri N / Kumar, Amit

The Science of the total environment

2023 Volume 907, Page(s) 168065

Abstract: Thorium-232 (Th-232), a naturally-occurring radioactive element with high potential of nuclear fuel is now being utilized in advanced nuclear reactors for ... ...

Abstract	Thorium-232 (Th-232), a naturally-occurring radioactive element with high potential of nuclear fuel is now being utilized in advanced nuclear reactors for CO
MeSH term(s)	Animals ; Mice ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/chemically induced ; Liver Neoplasms/genetics ; Wnt Signaling Pathway/genetics ; beta Catenin/metabolism ; Carcinogenesis/chemically induced
Chemical Substances	beta Catenin ; Thorium-232
Language	English
Publishing date	2023-10-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.168065
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Article: Novel formulation development from

Rakhee / Mishra, Jigni / Yadav, Renu Bala / Meena, D K / Arora, Rajesh / Sharma, R K / Misra, Kshipra

3 Biotech

2021 Volume 11, Issue 1, Page(s) 9

Abstract: Ophiocordyceps ... ...

Abstract	Ophiocordyceps sinensis
Language	English
Publishing date	2021-01-02
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-020-02536-3
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Article ; Online: Expression analysis of MMP14: Key enzyme action in modulating visceral adipose tissue plasticity in patients with obesity.

Sachan, Astha / Aggarwal, Sandeep / Pol, Manjunath Maruti / Singh, Archna / Yadav, Rakhee

Clinical obesity

2023 Volume 13, Issue 5, Page(s) e12607

Abstract: Compromised adipose tissue plasticity is a hallmark finding of obesity orchestrated by the intricate interplay between various extracellular matrix components. Collagen6 (COL6) is well characterized in obese visceral adipose tissue (VAT), not much is ... ...

Abstract	Compromised adipose tissue plasticity is a hallmark finding of obesity orchestrated by the intricate interplay between various extracellular matrix components. Collagen6 (COL6) is well characterized in obese visceral adipose tissue (VAT), not much is known about MMP14 which is hypothesized to be the key player in matrix reorganization. Subjects with obesity (BMI ≥40; n = 50) aged 18-60 years undergoing bariatric surgery and their age-matched controls (BMI < 25; n = 30) were included. MMP14, Col6A3 and Tissue inhibitor of metalloproteinase 2 (TIMP2) mRNA expression was assessed in VAT and their serum levels along with endotrophin were estimated in both groups preoperatively and post-operatively in the obese group. The results were analysed statistically and correlated with anthropometric and glycaemic parameters, namely fasting glucose and insulin, HbA1c, HOMA-IR, HOMA-β and QUICKI. Circulating levels as well as mRNA expression profiling revealed significant differences between the individuals with and without obesity (p < .05), more so in individuals with diabetes and obesity (p < .05). Follow-up serum analysis revealed significantly raised MMP14 (p < .001), with decreased Col6A3, endotrophin and TIMP2 levels (p < .01, p < .001 and p < .01, respectively). A rise in serum MMP14 protein, simultaneous with post-surgical weight loss and decreased serum levels of associated extracellular matrix (ECM) remodellers, suggests its crucial role in modulating obesity-associated ECM fibrosis and pliability of VAT.
MeSH term(s)	Humans ; Tissue Inhibitor of Metalloproteinase-2/genetics ; Tissue Inhibitor of Metalloproteinase-2/metabolism ; Intra-Abdominal Fat ; Matrix Metalloproteinase 14/metabolism ; Obesity/genetics ; Obesity/surgery ; Insulin Resistance ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	Tissue Inhibitor of Metalloproteinase-2 (127497-59-0) ; Matrix Metalloproteinase 14 (EC 3.4.24.80) ; RNA, Messenger ; MMP14 protein, human (EC 3.4.24.80)
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2625816-X
ISSN	1758-8111 ; 1758-8103
ISSN (online)	1758-8111
ISSN	1758-8103
DOI	10.1111/cob.12607
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Article ; Online: Efficacy and safety of pomalidomide, bortezomib, and dexamethasone combination chemotherapy for newly diagnosed multiple myeloma: POMACE Phase II Study.

Saj, Fen / Nisha, Yadav / Ganesan, Prasanth / Kayal, Smita / Kar, Rakhee / Halanaik, Dhanapathi / Dubashi, Biswajit

Blood cancer journal

2023 Volume 13, Issue 1, Page(s) 45

Abstract: Bortezomib, lenalidomide, and dexamethasone induction chemotherapy (VRd), followed by autologous stem cell transplantation (ASCT), are the standard of care for patients with newly diagnosed multiple myeloma (NDMM). Pomalidomide is currently approved for ... ...

Abstract	Bortezomib, lenalidomide, and dexamethasone induction chemotherapy (VRd), followed by autologous stem cell transplantation (ASCT), are the standard of care for patients with newly diagnosed multiple myeloma (NDMM). Pomalidomide is currently approved for relapsed-refractory multiple myeloma. This single-arm, open-label, phase 2 study was the prospective evaluation of the efficacy and safety of bortezomib, pomalidomide, and dexamethasone (VPd) induction for NDMM. We used Fleming's two-stage design for sample size calculation. We included transplant-eligible and ineligible patients aged 18-75 years in the study. The patients received four cycles of VPd induction followed by response assessment. Thirty-four patients were included in the study, of which 31 completed all four cycles of induction. The median age was 52 years (32-72). Thirty (91%) patients had multiple myeloma, and three had multiple plasmacytomas with less than 10% bone marrow involvement. Nine (27%) had ISS-I, 9 (27%) had ISS-II, and 15 (46%) had ISS-III myeloma. Three patients had high-risk cytogenetic abnormalities. After four cycles of VPd induction, ten patients (32%) achieved stringent CR, nine had CR (29%), eight (26%) had VGPR, and 4 (13%) had PR. Fifteen (48%) had a complete metabolic response (CMR) on PET-CT. Two patients developed SAEs. Anemia was the most common hematological toxicity. Peripheral neuropathy and constipation were the most common non-hematological toxicities. Patients with ≥VGPR had significantly better 12-month PFS than those with PR. Patients with ≥VGPR and CMR on PET-CT had significantly better 12-month OS. Our study showed VPd induction is safe and efficacious in NDMM. Further Phase 3 studies are necessary to establish the superiority and survival benefits.
MeSH term(s)	Humans ; Middle Aged ; Multiple Myeloma/diagnosis ; Multiple Myeloma/drug therapy ; Bortezomib/adverse effects ; Hematopoietic Stem Cell Transplantation ; Positron Emission Tomography Computed Tomography ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Dexamethasone/adverse effects ; Transplantation, Autologous
Chemical Substances	Bortezomib (69G8BD63PP) ; pomalidomide (D2UX06XLB5) ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2600560-8
ISSN	2044-5385 ; 2044-5385
ISSN (online)	2044-5385
ISSN	2044-5385
DOI	10.1038/s41408-023-00816-8
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Article ; Online: Estimation and in-situ detection of thorium in human liver cell culture by arsenazo-III based colorimetric assay.

Yadav, Rakhee / Pandey, Badri N / Kumar, Amit

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

2020 Volume 33, Issue 1, Page(s) 75–85

Abstract: To understand the biological effects of Thorium-232 (Th) in human cells and animal models as well as to assess mitigation strategies for its detoxification, there is a need to develop a sensitive, specific, high-throughput and easily-implementable assay ... ...

Abstract	To understand the biological effects of Thorium-232 (Th) in human cells and animal models as well as to assess mitigation strategies for its detoxification, there is a need to develop a sensitive, specific, high-throughput and easily-implementable assay for detection and estimation of Th in biological samples. Here, we have optimized arsenazo-III dye based colorimetric assay to detect Th in biological samples. The concentration of arsenazo-III (i.e. 50 µM) was optimized, which can reliably estimate Th in the concentration range of 2.5 to 40 µM. The optimized assay can specifically detect Th without interference from other metal ions (La, Ce, U, Fe, Ca, Cu, Zn and Mn). A significant correlation (R
MeSH term(s)	Arsenazo III/chemistry ; Colorimetry ; Coloring Agents/chemistry ; Hep G2 Cells ; Humans ; Molecular Structure ; Thorium/analysis ; Tumor Cells, Cultured
Chemical Substances	Coloring Agents ; Thorium-232 ; Arsenazo III (1668-00-4) ; Thorium (60YU5MIG9W)
Language	English
Publishing date	2020-01-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1112688-7
ISSN	1572-8773 ; 0966-0844
ISSN (online)	1572-8773
ISSN	0966-0844
DOI	10.1007/s10534-019-00231-2
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Zs.A 2515: Show issues

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Article ; Online: SARS-CoV-2-host dynamics: Increased risk of adverse outcomes of COVID-19 in obesity.

Yadav, Rakhee / Aggarwal, Sandeep / Singh, Archna

Diabetes & metabolic syndrome

2020 Volume 14, Issue 5, Page(s) 1355–1360

Abstract: Background and aim: The pandemic of COVID-19 has put forward the public health system across countries to prepare themselves for the unprecedented outbreak of the present time. Recognition of the associated risks of morbidity and mortality becomes not ... ...

Abstract	Background and aim: The pandemic of COVID-19 has put forward the public health system across countries to prepare themselves for the unprecedented outbreak of the present time. Recognition of the associated risks of morbidity and mortality becomes not only imperative but also fundamental to determine the prevention strategies as well as targeting the high-risk populations for appropriate therapies. Methods: We reviewed, collated and analysed the online database i.e. Pubmed, Google scholar, Researchgate to highlight the demographic and mechanistic link between obesity and associated risks of severity in COVID-19. Results: We observed a changing dynamic in the reporting from the time of initial pandemic in China to currently reported research. While, initially body mass index (BMI) did not find a mention in the data, it is now clearly emerging that obesity is one of the profound risk factors for complications of COVID-19. Conclusion: Our review will help clinicians and health policy makers in considering the importance of obesity in making the prevention and therapeutic strategies of COVID-19. An extra attention and precaution for patients with obesity in COVID-19 pandemic is recommended.
MeSH term(s)	Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Host-Pathogen Interactions ; Humans ; Obesity/complications ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2020.07.030
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Article: Role of calcium ion channels and cytoskeletal proteins in Thorium-232 induced toxicity in normal human liver cells (WRL 68) and its validation in swiss mice

Yadav, Rakhee / Das, Sourav Kumar / Ali, Manjoor / Pandey, Badri N. / Kumar, Amit

Chemosphere. 2022 Feb., v. 288

2022

Abstract: Hepatic disorders reported in humans exposed to Thorium-232 (Th-232) rationalizes the present study investigating the toxicological response of normal human liver cells (WRL 68) and its validation in Swiss mice. Cell count analysis of WRL 68 cells- ... ...

Abstract	Hepatic disorders reported in humans exposed to Thorium-232 (Th-232) rationalizes the present study investigating the toxicological response of normal human liver cells (WRL 68) and its validation in Swiss mice. Cell count analysis of WRL 68 cells-treated with Th-nitrate (1–200 μM) estimated IC50 of ∼24 μM (at 24 h) and 35 μM (at 48 h). Analysis of cell viability (trypan blue assay) showed the IC50 of ∼172 μM. Phase contrast bright-field microscopy revealed Th-induced morphological changes and cell-released microvesicle-like structures in extracellular space. Th-estimation by ICP-MS (Inductively-coupled plasma mass-spectrometry) showed uptake of Th by cells as a function of concentration and incubation time. Employing DTPA as a chelating agent in cell harvesting solution, cell-internalized/strongly-bound Th was estimated to be ∼42% of total incubated Th. Th-uptake studies in the presence of ion-channel specific inhibitors (e.g. nifedipine, thapsigargin) revealed the role of plasma membrane calcium channels and cytoplasmic calcium in modulating the Th-uptake. Transmission electron microscopy of Th-treated cells showed cell-derived extracellular vesicles, alterations in the shape and size of nucleus and mitochondria as well as cytoplasmic inclusions. The order of Th accumulation in various sub-cellular protein fractions was found to be as cytoskeleton (43%) > cytoplasmic (15%) > chromatin (7%) > nuclear (5%) & membrane (5%). Immunofluorescence analysis of WRL 68 cells showed that Th significantly altered the expression of cytoskeleton proteins (F-actin and keratin), which was further validated in liver tissues of Swiss mice administered with Th-232. Findings herein highlight the role of calcium channels and cytoskeleton in Th-induced toxicity. Keywords: Thorium toxicity; Liver cells; Calcium channels; Sub-cellular targets, Cytoskeleton; Swiss Mice.
Keywords	actin ; calcium ; cell viability ; chromatin ; cytoskeleton ; extracellular space ; fluorescent antibody technique ; humans ; inhibitory concentration 50 ; keratin ; liver ; mass spectrometry ; mitochondria ; plasma membrane ; thorium ; toxicity ; transmission electron microscopy
Language	English
Dates of publication	2022-02
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.132557
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2540: Show issues

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Article: Novel formulation development from Ophiocordyceps sinensis (Berk.) for management of high-altitude maladies

Rakhee / Mishra, Jigni / Yadav, Renu Bala / Meena, D. K / Arora, Rajesh / Sharma, R. K / Misra, Kshipra

3 Biotech. 2021 Jan., v. 11, no. 1

2021

Abstract: Ophiocordyceps sinensis (Berk.) is a fungus closely related to medicinal mushroom, which belongs to the family Ophiocordycipitaceae. It is a well-known and rich herbal source of bioactive active constituents. The medicinal mushroom has garnered worldwide ...

Abstract	Ophiocordyceps sinensis (Berk.) is a fungus closely related to medicinal mushroom, which belongs to the family Ophiocordycipitaceae. It is a well-known and rich herbal source of bioactive active constituents. The medicinal mushroom has garnered worldwide attention owing to its multifarious bioactivities. This mushroom grows on the larva of ghost moths (Hepialidae) and produces fruiting bodies, which serve as a vital natural source of medicine and supplementary diets. On account of the diverse pharmacological and bioactive constituents present in O. sinensis, it has been established as a potential antioxidant, anticancer, antibacterial, anti-proliferative, anti-inflammatory agent that has been successfully used for treating several health issues, including hypoxia-related problems encountered by mountaineers, pilgrims, tourists and soldiers occurring at high-altitude regions such as acute mountain sickness (AMS), high-altitude pulmonary edema (HAPE), high-altitude cerebral edema (HACE), frostbite, chilblains, hypothermia, etc. The most important pharmacologically active compounds present in the O. sinensis include nucleobases and its derivatives (adenosine, cordycepin, 3-deoxyadenosine, AMP, GMP, UMP, guanosine, uridine), polysaccharides (mannose, glucose, galactose, rhamnose, arabinose, xylose, galactose), proteins, peptides and steroids. This article focuses on the various research endeavors undertaken to scientifically establish the medicinal properties of O. sinensis, highlighting the various principally active compounds, their pharmacological action, drug designing and development and future perspective for various health benefits.
Keywords	Hepialidae ; Ophiocordyceps sinensis ; adenosine ; altitude ; anti-inflammatory agents ; antioxidants ; arabinose ; cordycepin ; edema ; frostbite ; galactose ; glucose ; guanosine ; hypothermia ; mannose ; medicinal fungi ; medicinal properties ; medicine ; mushrooms ; nucleobases ; peptides ; polysaccharides ; rhamnose ; uridine ; xylose
Language	English
Dates of publication	2021-01
Size	p. 9.
Publishing place	Springer International Publishing
Document type	Article
Note	Review
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-020-02536-3
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Article ; Online: SARS-CoV-2-host dynamics

Yadav, Rakhee / Aggarwal, Sandeep / Singh, Archna

Diabetes & Metabolic Syndrome: Clinical Research & Reviews

Increased risk of adverse outcomes of COVID-19 in obesity

2020 Volume 14, Issue 5, Page(s) 1355–1360

Keywords	Internal Medicine ; Endocrinology, Diabetes and Metabolism ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2020.07.030
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