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  1. Article ; Online: B Cell Recognition of

    Ferreira-Gomes, Marta / Wich, Melissa / Böde, Sally / Hube, Bernhard / Jacobsen, Ilse D / Jungnickel, Berit

    Frontiers in immunology

    2021  Volume 12, Page(s) 698849

    Abstract: ... Candida ... ...

    Abstract Candida albicans
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; B-Lymphocytes/microbiology ; Candida albicans/immunology ; Candida albicans/pathogenicity ; Candidiasis/immunology ; Candidiasis/metabolism ; Candidiasis/microbiology ; Cell Differentiation ; Cells, Cultured ; Coculture Techniques ; Host-Pathogen Interactions ; Humans ; Hyphae/immunology ; Hyphae/pathogenicity ; Immunoglobulin G/metabolism ; Interleukin-6/metabolism ; Lymphocyte Activation ; Mice, Inbred C57BL ; Phenotype ; Secretory Pathway ; Signal Transduction ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Th17 Cells/microbiology ; Toll-Like Receptor 2/metabolism ; Mice
    Chemical Substances IL6 protein, human ; Immunoglobulin G ; Interleukin-6 ; TLR2 protein, human ; Tlr2 protein, mouse ; Toll-Like Receptor 2 ; interleukin-6, mouse
    Language English
    Publishing date 2021-11-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.698849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: O Subdiagnóstico da Hidradenite Supurativa e o Desafio da Morbilidade Crónica Associada.

    Gomes Madeira, Catarina / Ramos, Clara / Monteiro Ferreira, Marta

    Acta medica portuguesa

    2023  Volume 36, Issue 5, Page(s) 373

    Title translation Underdiagnosis of Hidradenitis Suppurativa and the Challenge of Associated Chronic Morbidity.
    MeSH term(s) Humans ; Hidradenitis Suppurativa/diagnosis ; Morbidity
    Language Portuguese
    Publishing date 2023-04-10
    Publishing country Portugal
    Document type Letter ; Comment
    ZDB-ID 603078-6
    ISSN 1646-0758 ; 0870-399X
    ISSN (online) 1646-0758
    ISSN 0870-399X
    DOI 10.20344/amp.19833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2343: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Functionality of the human antibody response to

    Wich, Melissa / Greim, Stephanie / Ferreira-Gomes, Marta / Krüger, Thomas / Kniemeyer, Olaf / Brakhage, Axel A / Jacobsen, Ilse D / Hube, Bernhard / Jungnickel, Berit

    Virulence

    2021  Volume 12, Issue 1, Page(s) 3137–3148

    Abstract: ... Candida ... ...

    Abstract Candida albicans
    MeSH term(s) Antibody Formation ; Antifungal Agents/pharmacology ; Aspartic Acid Endopeptidases ; Aspartic Acid Proteases ; Candida albicans ; Humans
    Chemical Substances Antifungal Agents ; Aspartic Acid Proteases (EC 3.4.-) ; Aspartic Acid Endopeptidases (EC 3.4.23.-)
    Language English
    Publishing date 2021-12-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2021.2015116
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  4. Article: May-Thurner Syndrome: The Worst-Case Scenario.

    Costa, Marta / Ferreira, Gonçalo / Gomes, Dora / Oliveira, Catarina / Domingues, Nelson

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55742

    Abstract: May-Thurner syndrome (MTS) is caused by compression of the left common iliac vein by the right common iliac artery against the spinal column. It can range from asymptomatic or present with subtle and unspecific signs and symptoms and rarely exhibit ... ...

    Abstract May-Thurner syndrome (MTS) is caused by compression of the left common iliac vein by the right common iliac artery against the spinal column. It can range from asymptomatic or present with subtle and unspecific signs and symptoms and rarely exhibit severe complications such as pulmonary embolism (PE). The diagnosis is confirmed by typical imaging findings. Treatment may include conservative measures, anticoagulation, endovascular or even surgical options. We report the case of a 20-year-old female who presented with cardiac arrest caused by an acute massive PE. Further study showed partial thrombosis of the internal iliac veins resulting from MTS. She continued anticoagulation therapy with low-molecular-weight heparin and then switched to edoxaban with a good clinical outcome. She was also referred to Vascular Surgery to discuss the possibility of iliac vein stenting. Abdominopelvic vascular compression syndromes include a large spectrum of conditions, and they are rarely considered as an etiology for venous thromboembolism. The clinical presentation of PE varies with several triggering factors and atypical presentation is more common in nonmalignant causes. The combination of noninvasive and invasive imaging modalities might be beneficial to establish a definitive diagnosis. Nevertheless, invasive procedures are often restricted to doubtful cases or to guide endovascular procedures which is the current treatment of choice. There is little evidence using nonvitamin K oral anticoagulants, but there are some case reports detailing their successful use. This case aims to point out the need for a profound understanding of different causes of deep vein and pulmonary thromboembolism; common entities in our practice but with a variety of clinical presentations and potentially caused by rare underlying conditions. MTS can be the origin of serious and deadly complications, hence the importance of early recognition and treatment.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: O Subdiagnóstico da Hidradenite Supurativa e o Desafio da Morbilidade Crónica Associada

    Catarina Gomes Madeira / Clara Ramos / Marta Monteiro Ferreira

    Acta Médica Portuguesa (2023)

    2023  

    Abstract: N/a. ...

    Abstract N/a.
    Keywords Diagnóstico Tardio ; Hidradenite Supurativa/diagnóstico ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Ordem dos Médicos
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Metastatic Crohn's disease in paediatrics: Vulvar lesions as the first clinical presentation.

    Ferreira de Castro, Luís / Gomes, Rita / Sá, Diogo Carvalho / Fernandes, Eugénia / Lima, Rosa / Tavares, Marta

    Journal of paediatrics and child health

    2023  Volume 59, Issue 9, Page(s) 1092–1094

    MeSH term(s) Female ; Humans ; Child ; Crohn Disease/diagnosis ; Vulvar Diseases/diagnosis ; Vulvar Diseases/pathology ; Neoplasms ; Pediatrics
    Language English
    Publishing date 2023-08-04
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.16471
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Conference proceedings: Durch TGFβ-induzierte Immunanergie kennzeichnet das Pediatric Inflammatory Multisystem Syndrome

    Goetzke, Carl Christoph / Massoud, Mona / Durek, Pawel / Frischbutter, Stefan / Heinrich, Frederik / von Stuckrad, Anne Sae-Lim / Witkowski, Mario / Guerra, Gabriela Maria / Heusen, Anja / Sahin, Bengü / Ehlers, Lisa / Unterwalder, Nadine / Ferreira-Gomes, Marta / von Bernuth, Horst / Peter, Lena / Schmück-Henneresse, Michael / Maurer, Marcus / Mall, Marcus / Radbruch, Andreas /
    Kallinich, Tilmann / Mashreghi, Mir-Farzin

    2023  , Page(s) KI.18

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh140
    Database German Medical Science

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  8. Article ; Online: Ecotoxicological assessment of natural soil amended with sewage sludge: the impacts on soil edaphic organisms and microbial community.

    Martins, Marcela Ravanelli / Zanatta, Maraline Conservani Klingohr / Ferreira, Wallace Gomes / Poletti, Elaine Cristina Catapani / Pires, Marta Siviero Guilherme

    Environmental monitoring and assessment

    2023  Volume 195, Issue 11, Page(s) 1325

    Abstract: Sewage sludge usage as agricultural soil amendment is a well-known practice employed worldwide. However, certain components may pose risks to the soil ecosystem. For a better verification of the potential adverse effects on the soil biota, biological ... ...

    Abstract Sewage sludge usage as agricultural soil amendment is a well-known practice employed worldwide. However, certain components may pose risks to the soil ecosystem. For a better verification of the potential adverse effects on the soil biota, biological assays have become an indispensable tool for an accurate understanding of the residue's behavior on soil, as well as its potential toxicity. Accordingly, to properly assess the effects of natural tropical soil (Oxisoil) amended with sewage sludge, we conducted toxicological tests with edaphic organisms (Enchytraeus crypticus and Folsomia candida) and microbial biomass (through respirometric assessment). Results indicate that E. crypticus and F. candida present similar reproduction sensitivity behavior to sewage sludge. For the microbiological analysis, the results suggest that microbial activity was stimulated by sludge application. For further evaluation of respiration of the microbial community and CO
    MeSH term(s) Animals ; Soil ; Sewage ; Carbon Dioxide ; Soil Pollutants/toxicity ; Environmental Monitoring ; Microbiota
    Chemical Substances Soil ; Sewage ; Carbon Dioxide (142M471B3J) ; Soil Pollutants
    Language English
    Publishing date 2023-10-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-023-11953-9
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    In stock of ZB MED Bonn / Germany

    Z 5186: Show issues

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  9. Article ; Online: B Cell Numbers Predict Humoral and Cellular Response Upon SARS-CoV-2 Vaccination Among Patients Treated With Rituximab.

    Stefanski, Ana-Luisa / Rincon-Arevalo, Hector / Schrezenmeier, Eva / Karberg, Kirsten / Szelinski, Franziska / Ritter, Jacob / Jahrsdörfer, Bernd / Schrezenmeier, Hubert / Ludwig, Carolin / Sattler, Arne / Kotsch, Katja / Chen, Yidan / Claußnitzer, Anne / Haibel, Hildrun / Proft, Fabian / Guerra, Gabriela / Durek, Pawel / Heinrich, Frederik / Ferreira-Gomes, Marta /
    Burmester, Gerd R / Radbruch, Andreas / Mashreghi, Mir-Farzin / Lino, Andreia C / Dörner, Thomas

    Arthritis & rheumatology (Hoboken, N.J.)

    2022  Volume 74, Issue 6, Page(s) 934–947

    Abstract: Objective: Patients with autoimmune inflammatory rheumatic diseases receiving rituximab (RTX) therapy are at higher risk of poor COVID-19 outcomes and show substantially impaired humoral immune response to anti-SARS-CoV-2 vaccine. However, the complex ... ...

    Abstract Objective: Patients with autoimmune inflammatory rheumatic diseases receiving rituximab (RTX) therapy are at higher risk of poor COVID-19 outcomes and show substantially impaired humoral immune response to anti-SARS-CoV-2 vaccine. However, the complex relationship between antigen-specific B cells and T cells and the level of B cell repopulation necessary to achieve anti-vaccine responses remain largely unknown.
    Methods: Antibody responses to SARS-CoV-2 vaccines and induction of antigen-specific B and CD4/CD8 T cell subsets were studied in 19 patients with rheumatoid arthritis (RA) or antineutrophil cytoplasmic antibody-associated vasculitis receiving RTX, 12 patients with RA receiving other therapies, and 30 healthy controls after SARS-CoV-2 vaccination with either messenger RNA or vector-based vaccines.
    Results: A minimum of 10 B cells per microliter (0.4% of lymphocytes) in the peripheral circulation appeared to be required for RTX-treated patients to mount seroconversion to anti-S1 IgG upon SARS-CoV-2 vaccination. RTX-treated patients who lacked IgG seroconversion showed reduced receptor-binding domain-positive B cells (P = 0.0005), a lower frequency of Tfh-like cells (P = 0.0481), as well as fewer activated CD4 (P = 0.0036) and CD8 T cells (P = 0.0308) compared to RTX-treated patients who achieved IgG seroconversion. Functionally relevant B cell depletion resulted in impaired interferon-γ secretion by spike-specific CD4 T cells (P = 0.0112, r = 0.5342). In contrast, antigen-specific CD8 T cells were reduced in both RA patients and RTX-treated patients, independently of IgG formation.
    Conclusion: In RTX-treated patients, a minimum of 10 B cells per microliter in the peripheral circulation is a candidate biomarker for a high likelihood of an appropriate cellular and humoral response after SARS-CoV-2 vaccination. Mechanistically, the data emphasize the crucial role of costimulatory B cell functions for the proper induction of CD4 responses propagating vaccine-specific B cell and plasma cell differentiation.
    MeSH term(s) Antibodies, Viral ; Arthritis, Rheumatoid/drug therapy ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Cell Count ; Humans ; Immunity, Humoral ; Immunoglobulin G ; Rituximab/therapeutic use ; SARS-CoV-2 ; Vaccination/methods
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin G ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2022-04-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 24: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: The Extracellular Small Leucine-Rich Proteoglycan Biglycan Is a Key Player in Gastric Cancer Aggressiveness.

    Pinto, Filipe / Santos-Ferreira, Liliana / Pinto, Marta T / Gomes, Catarina / Reis, Celso A

    Cancers

    2021  Volume 13, Issue 6

    Abstract: Biglycan ( ...

    Abstract Biglycan (
    Language English
    Publishing date 2021-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13061330
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