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Article ; Online: Application of nanoformulations as a strategy to optimize chemotherapeutic treatment of glioblastoma: a systematic review.

de Oliveira, Victor Alves / Negreiros, Helber Alves / de Sousa, Igor Gabriel Barbosa / Farias Mendes, Layza Karyne / Alves Damaceno Do Lago, João Pedro / Alves de Sousa, Athanara / Alves Nobre, Taline / Pereira, Irislene Costa / Carneiro da Silva, Felipe Cavalcanti / Lopes Magalhães, Janildo / de Castro E Sousa, João Marcelo

Journal of toxicology and environmental health. Part B, Critical reviews

2024 Volume 27, Issue 4, Page(s) 131–152

Abstract: The aim of this review was to explore the advances of nanoformulations as a strategy to optimize glioblastoma treatment, specifically focusing on targeting and controlling drug delivery systems to the tumor. This review followed the PRISMA ... ...

Abstract	The aim of this review was to explore the advances of nanoformulations as a strategy to optimize glioblastoma treatment, specifically focusing on targeting and controlling drug delivery systems to the tumor. This review followed the PRISMA recommendations. The studies were selected through a literature search conducted in the electronic databases PubMed Central, Science Direct, Scopus and Web of Science, in April 2023, using the equation descriptors: (nanocapsule OR nanoformulation) AND (glioblastoma). Forty-seven investigations included were published between 2011 and 2023 to assess the application of different nanoformulations to optimize delivery of chemotherapies including temozolomide, carmustine, vincristine or cisplatin previously employed in brain tumor therapy, as well as investigating another 10 drugs. Data demonstrated the possible application of different matrices employed as nanocarriers and utilization of functionalizing agents to improve internalization of chemotherapeutics. Functionalization was developed with the application of peptides, micronutrients/vitamins, antibodies and siRNAs. Finally, this review demonstrated the practical and clinical application of nanocarriers to deliver multiple drugs in glioblastoma models. These nanomodels might ideally be developed using functionalizing ligand agents that preferably act synergistically with the drug these agents carry. The findings showed promising results, making nanoformulations one of the best prospects for innovation and improvement of glioblastoma treatment.
MeSH term(s)	Humans ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Temozolomide/therapeutic use ; Carmustine/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Drug Delivery Systems/methods
Chemical Substances	Temozolomide (YF1K15M17Y) ; Carmustine (U68WG3173Y)
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1415246-0
ISSN	1521-6950 ; 1093-7404
ISSN (online)	1521-6950
ISSN	1093-7404
DOI	10.1080/10937404.2024.2326679
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Article ; Online: Increase in plasma resveratrol levels and in acid-resistant proteins in the acquired enamel pellicle after use of resveratrol-containing orodispersible tablets.

Reis, Fernanda Navas / Câmara, João Victor Frazão / Dionizio, Aline / Araujo, Tamara Teodoro / Gomes da Silva, Natara Dias / Levy, Flávia Mauad / Ximenes, Valdecir Farias / Buzalaf, Marília Afonso Rabelo

Journal of dentistry

2024 Volume 143, Page(s) 104876

Abstract: Objective: This study evaluated the effect of administration of trans-resveratrol-containing orodispersible tablets on the protein composition of the AEP and on blood plasma trans-resveratrol concentrations.: Methods: Ten volunteers participated in ... ...

Abstract	Objective: This study evaluated the effect of administration of trans-resveratrol-containing orodispersible tablets on the protein composition of the AEP and on blood plasma trans-resveratrol concentrations. Methods: Ten volunteers participated in two crossover double-blind phases. In each phase, after dental prophylaxis, they received a trans-resveratrol (15 mg) orodispersible tablet, or a placebo tablet (without actives). The AEP formed after 120 min was collected with electrode filter papers soaked in 3 % citric acid. Blood samples were collected 30, 45, 60 and 120 min after the use of the tablet. After protein extraction, AEP samples were analyzed by shotgun labelfree quantitative proteomics and plasma samples were analyzed by high-performance liquid chromatography (HPLC). Results: Eight hundred and two proteins were identified in the AEP. Among them, 336 and 213 were unique to the trans-resveratrol and control groups, respectively, while 253 were common to both groups. Proteins with important functions in the AEP had increased expression in the trans-resveratroltreated group, such as neutrophil defensins, S100 protein isoforms, lysozyme C, cystatin-D, mucin-7, alphaamylase, albumin, haptoglobin and statherin. Trans-resveratrol was detected in the plasma at all the times evaluated, with the peak at 30 min. Conclusions: The administration of trans-resveratrol in sublingual orodispersible tablets was effective both to increase the bioavailability of the polyphenol and the expression of antibacterial and acid-resistant proteins in the AEP, which might benefit oral and general health.
MeSH term(s)	Humans ; Dental Pellicle ; Proteins/analysis ; Proteins/metabolism ; Proteins/pharmacology ; Resveratrol/pharmacology ; Resveratrol/analysis ; Resveratrol/metabolism ; Cross-Over Studies ; Double-Blind Method
Chemical Substances	Proteins ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	186068-9
ISSN	1879-176X ; 0300-5712
ISSN (online)	1879-176X
ISSN	0300-5712
DOI	10.1016/j.jdent.2024.104876
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Article ; Online: SARS-CoV-2 in the first trimester of pregnancy: potential interference in placentation.

da Silva, João Victor Farias / Silva, Katheryne Suellen Cavalcante / Dos Santos Junior, Valdeci Elias

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2020 Volume 35, Issue 15, Page(s) 3004

MeSH term(s)	COVID-19 ; Female ; Humans ; Placenta ; Placentation ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Trimester, First ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-14
Publishing country	England
Document type	Letter
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2020.1792879
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Zs.A 3510: Show issues

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Article ; Online: Morphology of the small and large intestines of the six-banded armadillo (Euphractus sexcinctus) Linnaeus, 1758.

Fonseca, Clarisse Maria Barbosa / Farias, Ingrid Dos Santos / Araújo, João Victor Silva / Viana, Rita de Cássia / da Silva, Andrezza Braga Soares / Cavalcante, Maria Michele Araújo de Sousa / Conde Júnior, Airton Mendes

Microscopy research and technique

2023 Volume 87, Issue 4, Page(s) 767–773

Abstract: Euphractus sexcinctus has a diverse diet, so it needs anatomical and habitual features to help it get its meals. Therefore, the objective is to study the morphology of the small and large intestines of the six-banded armadillo (E. sexcinctus). The ... ...

Abstract	Euphractus sexcinctus has a diverse diet, so it needs anatomical and habitual features to help it get its meals. Therefore, the objective is to study the morphology of the small and large intestines of the six-banded armadillo (E. sexcinctus). The research was authorized and approved under number 136/16. Six animals, obtained from victims of predatory hunting, were dissected for the research. For the anatomical analysis, the specimens were dissected and photographed. The fragments of each organ were submitted to histological routine to obtain slides stained with hematoxylin-eosin, toluidine blue and Masson's trichrome for further analysis. The small intestine has three parts: duodenum, jejunum, and ileum. Histologically, it has the typical four layers of tubular organs. The mucosa is covered by simple cylindrical epithelium with the presence of specializations in the form of microvilli and variation in the number of goblet cells, depending on the portion observed. In the duodenal portion, the presence of the serous layer was not observed. In the jejunal portion, it is possible to observe lymphoid tissue aggregates in the submucosa, which become more evident in the ileum. The large intestine is divided into cecum, colon, and rectum and has the same histological subdivisions as the small intestine, but with some specializations. The presence of simple cylindrical intestinal crypts is clearly observed and the presence of a large number of goblet cells, which increase as it approaches the rectum. In the submucosa of the large intestine, the presence of organized lymphoid plaques is detected. RESEARCH HIGHLIGHTS: The presence of large numbers of goblet cells, which increase as one approaches the rectum. The presence of organized lymphoid plaques is detected. The duodenal portion was not observed presence of the serous layer.
MeSH term(s)	Animals ; Armadillos ; Intestinal Mucosa/pathology ; Digestive System ; Intestine, Small ; Rectum
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099714-3
ISSN	1097-0029 ; 1059-910X
ISSN (online)	1097-0029
ISSN	1059-910X
DOI	10.1002/jemt.24470
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Zs.A 2251: Show issues

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Article ; Online: Serum uric acid levels associated with biochemical parameters linked to preeclampsia severity and to adverse perinatal outcomes.

de Mendonça, Elaine Luiza Santos Soares / da Silva, João Victor Farias / Mello, Carolina Santos / de Oliveira, Alane Cabral Menezes

Archives of gynecology and obstetrics

2022 Volume 305, Issue 6, Page(s) 1453–1463

Abstract: Aims: Evaluating the association between serum uric acid levels and biochemical parameters linked to preeclampsia (PE) severity and to adverse perinatal outcomes.: Methods: Cross-sectional study. Information about gestational and biochemical ... ...

Abstract	Aims: Evaluating the association between serum uric acid levels and biochemical parameters linked to preeclampsia (PE) severity and to adverse perinatal outcomes. Methods: Cross-sectional study. Information about gestational and biochemical parameters were collected before delivery, whereas perinatal outcomes were observed after it. Pregnant women were divided into hyperuricemia-HU (uric acid ≥ 6 mg/dL) or normouricemia (uric acid, 2.6-5.9 mg/dL) groups. Poisson regression models (prevalence ratio-PR; 95% confidence interval-95% CI), multinomial logistic regression (odds ratio-OR; 95% CI), and Pearson's correlation (correlation coefficient-r) were applied by taking into consideration p < 0.05 as significance level. Results: The total sample comprised 267 pregnant women with PE. HU was observed in 25.8% of patients; it was associated with black pregnant women (p = 0.014) and with primiparity (p = 0.007). Uric acid levels were higher in early PE cases than in late PE cases (p = 0.013); however, there was no significant difference between mild and severe PE cases (p = 0.121). Uric acid recorded a positive correlation to urea (p < 0.001), creatinine (p = 0.002), glutamic-oxaloacetic transaminase (p < 0.001), glutamic-pyruvic transaminase (p = 0.005), ferritin (p = 0.002) and globulin (p = 0.002); as well as negative correlation to platelets (p = 0.035), lactic dehydrogenase (p = 0.039) and albumin (p > 0.001). HU was a factor associated with cesarean delivery (p = 0.030), prematurity (p = 0.001), low birth weight (p < 0.001) and small for gestational age (p = 0.020). Conclusion: High serum uric acid levels were associated with early-onset PE. Maternal features were correlated to biochemical parameters linked to PE severity and to adverse perinatal outcomes.
MeSH term(s)	Cross-Sectional Studies ; Female ; Humans ; Hyperuricemia/complications ; Infant, Newborn ; Infant, Newborn, Diseases ; Infant, Small for Gestational Age ; Pre-Eclampsia ; Pregnancy ; Uric Acid
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2022-01-07
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-021-06313-2
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Article ; Online: Consumption and supplementation of vitamin E in breast cancer risk, treatment, and outcomes: A systematic review with meta-analysis.

de Oliveira, Victor Alves / Oliveira, Iara Katrynne Fonseca / Pereira, Irislene Costa / Mendes, Layza Karyne Farias / Carneiro da Silva, Felipe Cavalcanti / Torres-Leal, Francisco Leonardo / de Castro E Sousa, João Marcelo / Paiva, Adriana de Azevedo

Clinical nutrition ESPEN

2023 Volume 54, Page(s) 215–226

Abstract: Background: Robust evidence have shown diet or dietary components in playing a direct role on cancer chemoprevention such as breast cancer (BC), and also prevention against cancer therapy side effects. In this context, vitamin E isoforms have been ... ...

Abstract	Background: Robust evidence have shown diet or dietary components in playing a direct role on cancer chemoprevention such as breast cancer (BC), and also prevention against cancer therapy side effects. In this context, vitamin E isoforms have been associated with tumor suppression pathways, mainly related to proliferation, invasion, metastasis, tumor metabolism and chemoresistance. Objective: Therefore, we performed a systematic review with meta-analysis to assess the effects of vitamin E consumption and/or supplementation on breast cancer risk, treatment, and outcomes. Methods: The studies were selected in the electronic databases PubMed, Science Direct, Scopus and Web of Science. Results: A total of 22 articles were selected, which nine manuscripts we perform the meta-analysis. The summary effect estimate did not indicate any significant association between consumption versus non-consumption of total vitamin E and breast cancer risk. After assessing the effects of vitamin E supplementation on breast cancer risk, only two had data for comparison and vitamin E supplementation presented no impact on breast cancer risk. However, the summary effect estimate from the included studies indicated that vitamin E consumption was inversely associated with breast cancer recurrence in the control group. There are no significant results regarding dietary or supplemental vitamin E intake and BC risk reduction. Conclusion: Finally, regarding recurrence, survival, and mortality, the results indicated that vitamin E consumption was inversely associated with breast cancer recurrence, although no association was found for breast cancer mortality.
MeSH term(s)	Humans ; Female ; Vitamin E/therapeutic use ; Breast Neoplasms/prevention & control ; Neoplasm Recurrence, Local/prevention & control ; Diet ; Dietary Supplements
Chemical Substances	Vitamin E (1406-18-4)
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ISSN	2405-4577
ISSN (online)	2405-4577
DOI	10.1016/j.clnesp.2023.01.032
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Article: SARS-CoV-2 in the first trimester of pregnancy: potential interference in placentation

da Silva, João Victor Farias / Silva, Katheryne Suellen Cavalcante / Dos Santos Junior, Valdeci Elias

J Matern Fetal Neonatal Med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #646271
Database	COVID19

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Article ; Online: SARS-CoV-2 in the first trimester of pregnancy

da Silva, João Victor Farias / Silva, Katheryne Suellen Cavalcante / dos Santos Junior, Valdeci Elias

The Journal of Maternal-Fetal & Neonatal Medicine

potential interference in placentation

2020 , Page(s) 1–1

Keywords	Obstetrics and Gynaecology ; Pediatrics, Perinatology, and Child Health ; covid19
Language	English
Publisher	Informa UK Limited
Publishing country	uk
Document type	Article ; Online
ISSN	1476-7058
DOI	10.1080/14767058.2020.1792879
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Toxicological Profile and Anti-Inflammatory Effect of Mucoadhesive Gel from Residues of

Fracasso, Júlia Amanda Rodrigues / Sikina, Ingrid Yuri Galindo / da Costa, Luísa Taynara Silvério / Guarnier, Lucas Pires / Ribeiro-Paes, João Tadeu / de Ferreira, Fernando Yutaka / de Almeida, Luan Victor Coelho / de Castro Silva, Beatriz / de Barros Barbosa, Débora / Ximenes, Valdecir Farias / Venkli, Desirre / Viel, Amanda Martins / Dos Santos, Lucinéia

Gels (Basel, Switzerland)

2023 Volume 9, Issue 12

Abstract: Inflammation is a natural protective reaction of the body against endogenous and exogenous damage, such as tissue injuries, trauma, and infections. Thus, when the response is adequate, inflammation becomes a defense mechanism to repair damaged tissue, ... ...

Abstract	Inflammation is a natural protective reaction of the body against endogenous and exogenous damage, such as tissue injuries, trauma, and infections. Thus, when the response is adequate, inflammation becomes a defense mechanism to repair damaged tissue, whereas when the response is inadequate and persistent, the increase in inflammatory cells, cytosines, and chymosins impair tissue regeneration and promote a response harmful to the organism. One example is chronic tissue inflammation, in which a simple lesion can progress to ulcers and even necrosis. In this situation, the anti-inflammatory medications available in therapy are not always effective. For this reason, the search for new treatments, developed from medicinal plants, has increased. In this direction, the plants
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels9120942
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Article ; Online: Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy.

Santiago, Veronica Feijoli / Dombrowski, Jamille Gregorio / Kawahara, Rebeca / Rosa-Fernandes, Livia / Mule, Simon Ngao / Murillo, Oscar / Santana, Thais Viggiani / Coutinho, Joao Victor Paccini / Macedo-da-Silva, Janaina / Lazari, Lucas Cardoso / Peixoto, Erika Paula Machado / Ramirez, Marcel Ivan / Larsen, Martin R / Marinho, Cláudio Romero Farias / Palmisano, Giuseppe

Genes

2023 Volume 14, Issue 8

Abstract: Malaria in pregnancy (MiP) is a public health problem in malaria-endemic areas, contributing to detrimental outcomes for both mother and fetus. Primigravida and second-time mothers are most affected by severe anemia complications and babies with low ... ...

Abstract	Malaria in pregnancy (MiP) is a public health problem in malaria-endemic areas, contributing to detrimental outcomes for both mother and fetus. Primigravida and second-time mothers are most affected by severe anemia complications and babies with low birth weight compared to multigravida women. Infected erythrocytes (IE) reach the placenta, activating the immune response by placental monocyte infiltration and inflammation. However, specific markers of MiP result in poor outcomes, such as low birth weight, and intrauterine growth restriction for babies and maternal anemia in women infected with
MeSH term(s)	Infant, Newborn ; Pregnancy ; Infant ; Female ; Humans ; Animals ; Mice ; Mice, Inbred CBA ; Placenta ; Complement Activation ; Malaria ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-08-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14081624
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