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  1. Article: Editorial: Challenges in fertilization and implantation success.

    Massarotti, Claudia / Makieva, Sofia / Stigliani, Sara

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1268635

    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1268635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Algorithm vs. clinical experience: controlled ovarian stimulations with follitropin-delta and individualised doses of follitropin-alpha/beta.

    Gazzo, Irene / Bovis, Francesca / Colia, Denise / Sozzi, Fausta / Costa, Mauro / Anserini, Paola / Massarotti, Claudia

    Reproduction & fertility

    2024  

    Abstract: In the registrational trials, follitropin delta was compared with a fixed dose of 150 UI of follitropin alpha/beta, finding higher chances to reach a target response of 8-14 oocytes compared to controls. For this reason, follitropin delta is marketed as ... ...

    Abstract In the registrational trials, follitropin delta was compared with a fixed dose of 150 UI of follitropin alpha/beta, finding higher chances to reach a target response of 8-14 oocytes compared to controls. For this reason, follitropin delta is marketed as particularly useful in expected hyper-responder patients. The main outcome of this study is to report if comparable results are reached in a real-life scenario with follitropin alpha/beta personalized doses, based on patients' characteristics. This is a retrospective study performed in two public fertility centres. All first cycles from January 2020 to June 2022 with either follitropin delta (cases) or alpha/beta (controls) in patients with antiMüllerian hormone >2.5 ng/ml were compared by an inverse probability weighting approach based on propensity score. The follitropin total dose was higher in controls (1179.06 ± 344.93 vs. 1668.67 ± 555.22 IU, p<0.001). The target response of 8-14 oocytes was reached by 40.2% of cases and 40.7% of controls (odds ratio (OR) 0.99, 95% confidence interval (CI) 0.65-1.53, p=0.98). Fewer than 8 oocytes were collected in 24.1% of cases and 22% of controls (OR 1.10, 95% CI 0.71-1.69, p=0.67); more than 14 oocytes in 35.7% of cases and 37.3% of controls (OR 0.83, 95% CI 0.54-1.28, p=0.40). Our experience did not find worse results in term of proportion of patients who reached the target response with an algorithm-chosen dose of follitropin delta compared to a personalised starting dose of follitropin alpha/beta, with follitropin delta having the advantage of objectivity. Larger numbers are needed to confirm these results.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ISSN 2633-8386
    ISSN (online) 2633-8386
    DOI 10.1530/RAF-23-0045
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  3. Article ; Online: Mother's PCOS: a blueprint for children's health?

    Ali, Zoya / Fraire-Zamora, Juan J / Serdarogullari, Munevver / Massarotti, Claudia / Busby, Maureen / Uraji, Julia

    Human reproduction (Oxford, England)

    2023  Volume 38, Issue 7, Page(s) 1426–1428

    MeSH term(s) Child ; Female ; Humans ; Mothers ; Polycystic Ovary Syndrome/complications ; Child Health
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/dead078
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  4. Article: Assisted Reproductive Technology and Breech Delivery: A Nationwide Cohort Study in Singleton Pregnancies.

    Londero, Ambrogio P / Massarotti, Claudia / Xholli, Anjeza / Fruscalzo, Arrigo / Cagnacci, Angelo

    Journal of personalized medicine

    2023  Volume 13, Issue 7

    Abstract: Since essential factors have changed in recent years in assisted reproduction technologies (ARTs), this study reassessed the association between ART and breech presentation. We primarily aimed to estimate the correlation between ART and breech at ... ...

    Abstract Since essential factors have changed in recent years in assisted reproduction technologies (ARTs), this study reassessed the association between ART and breech presentation. We primarily aimed to estimate the correlation between ART and breech at delivery. Secondary purposes were to evaluate the correlation between other subfertility treatments (OSTs) and breech and to assess possible confounding factors and temporal trends. This study investigated the 31,692,729 live birth certificates from US states and territories in the 2009-2020 period. The inclusion criteria were singleton births reporting the method of conception and the presentation at delivery. The outcome was the breech presentation at delivery, while the primary exposure was ART, the secondary exposure was OST, and the potential confounding factors from the literature were considered. ART (OR 2.32 CI.95 2.23-2.41) and OST (OR 1.79 CI.95 1.71-1.87) were independent and significant risk factors for breech at delivery (
    Language English
    Publishing date 2023-07-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13071144
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  5. Article ; Online: A Pilot Analysis of Whole Transcriptome of Human Cryopreserved Sperm.

    Stigliani, Sara / Amaro, Adriana / Reggiani, Francesco / Maccarini, Elena / Massarotti, Claudia / Lambertini, Matteo / Anserini, Paola / Scaruffi, Paola

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Sperm cryopreservation is a procedure widely used to store gametes for later use, to preserve fertility in patients prior to gonadotoxic treatments or surgery, and for sperm donation programs. The purpose of the study was to assess the impact of ... ...

    Abstract Sperm cryopreservation is a procedure widely used to store gametes for later use, to preserve fertility in patients prior to gonadotoxic treatments or surgery, and for sperm donation programs. The purpose of the study was to assess the impact of cryopreservation on human sperm transcriptome. Semen samples were collected from 13 normospermic men. Each sample was divided into two aliquots. The total RNA was immediately extracted from one aliquot. The second aliquot was frozen and total RNA was extracted after a week of storage in liquid nitrogen. The RNA samples were randomized in four pools, each of six donors, and analyzed by microarrays. The paired Significance Analysis of Microarray was performed. We found 219 lower abundant transcripts and 28 higher abundant transcripts in cryopreserved sperm than fresh sperm. The gene ontology analysis disclosed that cryopreservation alters transcripts of pathways important for fertility (i.e., spermatogenesis, sperm motility, mitochondria function, fertilization, calcium homeostasis, cell differentiation, and early embryo development), although the increase of some transcripts involved in immune response can compensate for the harmful effects of freezing.
    MeSH term(s) Humans ; Male ; Semen ; Transcriptome ; Sperm Motility/genetics ; Spermatozoa ; Cryopreservation ; RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25074131
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  6. Article ; Online: Semen parameters and male reproductive potential are not adversely affected after three or more months of recovery from COVID-19 disease.

    Stigliani, Sara / Massarotti, Claudia / Bovis, Francesca / Maccarini, Elena / Anserini, Paola / Scaruffi, Paola

    Frontiers in reproductive health

    2023  Volume 4, Page(s) 1114308

    Abstract: Background: The male reproductive system may be a potential target for SARS-CoV-2 since the presence of ACE and TMPRS2 receptors. After a first report of the presence of SARS-CoV-2 in semen of COVID-19 patients, several papers reported that SARS-CoV-2 ... ...

    Abstract Background: The male reproductive system may be a potential target for SARS-CoV-2 since the presence of ACE and TMPRS2 receptors. After a first report of the presence of SARS-CoV-2 in semen of COVID-19 patients, several papers reported that SARS-CoV-2 was not detected in the semen. However, some evidences indicated that COVID-19 disease could impair semen parameters. During the infection, or in a short period after, a reduction in sperm concentration and motility and an increase in DNA fragmentation were observed, even in asymptomatic patients. There is no conclusive data exploring whether this damage changes with time. We investigated whether COVID-19 disease has a negative impact on semen parameters and male reproductive potential after recovery.
    Methods: In this longitudinal retrospective study, we enrolled 20 men who had COVID-19 disease. We compared sperm parameters in samples collected before COVID-19 and after infection (8.3 ± 4.8 months). We also evaluated the reproductive potential in pre- and post-COVID-19 infertility treatments of 8 self-controlled couples as well as in 40 cycles after COVID-19 infection of the male partner.
    Results: For most patients, we obtained results of more than one semen analysis before and after COVID-19. After adjusting for age, days of sexual abstinence, frequency of ejaculations and presence of fever, we found no significant difference over time in any semen parameter. The interval between COVID-19 infection and subsequent infertility treatments was 10.7 ± 7.5 months. There were no differences in the embryological and clinical outcomes of infertility treatments performed before and after male infection. One couple obtained a single pregnancy in the post COVID-19 IUI. Normal fertilization (65%), cleavage (99%) and blastocyst development (40%) rates in treatments performed after male infection were within the expected range of competencies. A total of 5 singleton and 1 twin clinical pregnancies were obtained, and 6 healthy children were born. A total of 10 blastocysts have been cryopreserved.
    Conclusion: Our data are reassuring that COVID-19 disease has no negative effect on semen quality and male reproductive potential when semen samples are collected three months or more after infection.
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2022.1114308
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  7. Article ; Online: Chemoprotection of the ovary: a leading role or a complementary strategy in fertility preservation?

    Massarotti, Claudia / Ammar, Omar F / Liperis, George / Mincheva, Mina / Fraire-Zamora, Juan J / Sharma, Kashish / Rosario, Roseanne / Winship, Amy L / Lambertini, Matteo / Makieva, Sofia

    Human reproduction (Oxford, England)

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/deae069
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  8. Article ; Online: Oxidative stress and ovarian aging: from cellular mechanisms to diagnostics and treatment.

    Ammar, Omar F / Massarotti, Claudia / Mincheva, Mina / Sharma, Kashish / Liperis, George / Herraiz, Sonia / Rodríguez-Nuevo, Aida / Zambelli, Filippo / Mihalas, Bettina P / Fraire-Zamora, Juan J

    Human reproduction (Oxford, England)

    2024  

    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/deae082
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  9. Article ; Online: Fertility in multiple sclerosis patients: still many unanswered questions.

    Massarotti, Claudia / Inglese, Matilde / Anserini, Paola

    Reproductive biomedicine online

    2020  Volume 41, Issue 3, Page(s) 567

    MeSH term(s) Female ; Fertility ; Humans ; Live Birth ; Multiple Sclerosis ; Pregnancy ; Research Design ; Women
    Language English
    Publishing date 2020-06-14
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2113823-0
    ISSN 1472-6491 ; 1472-6483
    ISSN (online) 1472-6491
    ISSN 1472-6483
    DOI 10.1016/j.rbmo.2020.06.003
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  10. Article ; Online: Understanding and addressing unexplained infertility: from diagnosis to treatment.

    Massarotti, Claudia / Fraire-Zamora, Juan J / Liperis, George / Uraji, Julia / Sharma, Kashish / Serdarogullari, Munevver / Ammar, Omar F / Makieva, Sofia / Ali, Zoya E / Romualdi, Daniela / Somigliana, Edgardo / Sakkas, Denny / Dancet, Eline / Mincheva, Mina

    Human reproduction (Oxford, England)

    2024  

    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/deae054
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