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Article: A Rare Case Report of 17q23.1q23.2 Microdeletion With Homozygosity of 11p11.2q13.4 in a Newborn.

Barola, Sindhu / Parrill, Allison M / Mahmoudzadeh, Samaan / Bizargity, Peyman / Verma, Rita

2022 Volume 14, Issue 3, Page(s) e23290

Abstract: We present the case of a newborn with 17q23.1q23.2 microdeletion and additional homozygosity of 11p11.2q13.4. In the literature, 17q23.1q23.2 microdeletion syndrome is a novel syndrome reported in nine patients. Our patient is a full-term baby boy ... ...

Abstract	We present the case of a newborn with 17q23.1q23.2 microdeletion and additional homozygosity of 11p11.2q13.4. In the literature, 17q23.1q23.2 microdeletion syndrome is a novel syndrome reported in nine patients. Our patient is a full-term baby boy admitted to a neonatal intensive care unit for hypoglycemia, respiratory distress, presumed sepsis, and thrombocytopenia. General appearance revealed microcephaly, micrognathia, ankyloglossia, small mouth, and high arch palate. The patient also presented with hypotonia, poor feeding, and poor weight gain in the first week of life followed by hypertonia and tremors from the second week of life. The phenotypic and clinical presentation lead to the genetic investigation of microarray which revealed 17q23.1q23.2 microdeletion and additional homozygosity of 11p11.2q13.4.
Language	English
Publishing date	2022-03-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.23290
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Anti-NMDA Receptor Encephalitis Masquerades as Psychosis: A Case Report.

Giri, Yam R / Korie, Ijendu / Hashmi, Seema / Parrill, Allison / Ayed, Nisrin

Journal of psychiatric practice

2022 Volume 28, Issue 1, Page(s) 72–77

Abstract: A 28-year-old male patient with an unclear history of psychosis was admitted to the inpatient psychiatric unit. He presented with auditory hallucinations, agitation, and bizarre and disorganized behavior. He was treated with antipsychotic medications ... ...

Abstract	A 28-year-old male patient with an unclear history of psychosis was admitted to the inpatient psychiatric unit. He presented with auditory hallucinations, agitation, and bizarre and disorganized behavior. He was treated with antipsychotic medications without improvement. Magnetic resonance imaging of the brain showed hyperintensities throughout the brain parenchyma. Investigations for infectious, metabolic, autoimmune, and malignant etiologies were negative. Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis was suspected. Cerebrospinal fluid (CSF) and serum NMDA receptor antibody testing were performed. Both tests were positive, confirming anti-NMDA receptor encephalitis. The patient was treated with intravenous immunoglobulin and methylprednisolone, which resulted in the resolution of his psychosis. In the case of unexplained psychosis associated with seizures, early screening using serum and CSF testing for anti-NMDA receptor antibodies and brain magnetic resonance imaging may be an important diagnostic tool for detecting anti-NMDA receptor encephalitis. Detailed investigations of CSF and serum should be performed to rule out infectious, metabolic, and autoimmune causes. Imaging studies should also be performed to identify any tumors such as a teratoma. This approach may help identify patients with anti-NMDA receptor encephalitis masquerading as psychosis. Early diagnosis and treatment including intravenous steroids, immunosuppressants, plasmapheresis, and removal of any teratoma if present in patients with anti-NMDA receptor encephalitis can improve the overall outcome.
MeSH term(s)	Adult ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/therapy ; Autoantibodies ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Magnetic Resonance Imaging ; Male ; Psychotic Disorders/diagnosis ; Psychotic Disorders/drug therapy ; Psychotic Disorders/etiology ; Receptors, N-Methyl-D-Aspartate ; Teratoma
Chemical Substances	Autoantibodies ; Immunoglobulins, Intravenous ; Receptors, N-Methyl-D-Aspartate
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2022726-7
ISSN	1538-1145 ; 1527-4160
ISSN (online)	1538-1145
ISSN	1527-4160
DOI	10.1097/PRA.0000000000000603
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Zs.A 4753: Show issues

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Article ; Online: The Psychosocial Impact of Treating Patients with COVID-19 on Psychiatry Residents in a Community Hospital: a Qualitative Study.

Obele, Marusa / Mahmoudzadeh, Samaan / Parrill, Allison / Ayyanar, Sivaranjani / Anuniru, Oluchi / Sekhri, Shiana / Bangar, Rahul / Korie, Ijendu

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

2023 Volume 47, Issue 3, Page(s) 251–257

Abstract: Objective: The authors explored the experiences of psychiatry residents caring for patients during the COVID-19 pandemic on a medical unit.: Methods: From June 2020 through December 2020, structured, individual interviews were conducted with ... ...

Abstract	Objective: The authors explored the experiences of psychiatry residents caring for patients during the COVID-19 pandemic on a medical unit. Methods: From June 2020 through December 2020, structured, individual interviews were conducted with psychiatry residents deployed to internal medicine wards in a community hospital to provide medical care to COVID-19 patients for greater than or equal to 1 week. Interviews were recorded, transcribed verbatim, and analyzed using thematic analytical methods. Results: Psychiatry residents (n = 16) were interviewed individually for approximately 45 min each. During the interviews, many residents described emotions of fear, anxiety, uncertainty, lack of preparedness, and difficulty coping with high patient mortality rates. Many of the residents expressed concerns regarding insufficient personal protective equipment, with the subsequent worries of their own viral exposure and transmission to loved ones. Multiple residents expressed feeling ill-equipped to care for COVID-19 patients, in some cases stating that utilizing their expertise in mental health would have better addressed the mental health needs of colleagues and patients' families. Participants also described the benefits of processing emotions during supportive group sessions with their program director. Conclusions: The COVID-19 pandemic represents a public health crisis with potential negative impacts on patient care, professionalism, and physicians' well-being and safety. The psychiatry residents and fellows described the overwhelmingly negative impact on their training. The knowledge gained from this study will help establish the role of the psychiatrist not only in future crises but in healthcare as a whole.
MeSH term(s)	Humans ; Qualitative Research ; Hospitals, Community ; COVID-19/mortality ; COVID-19/therapy ; Inpatients ; Internship and Residency ; Physicians/psychology ; Internal Medicine ; Interviews as Topic ; Fear ; Anxiety ; Uncertainty ; Adaptation, Psychological ; Psychiatry ; Personal Protective Equipment ; Self-Help Groups ; Safety ; Male ; Female ; Adult ; Middle Aged ; Burnout, Professional ; Hospital Administration
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1045331-3
ISSN	1545-7230 ; 1042-9670
ISSN (online)	1545-7230
ISSN	1042-9670
DOI	10.1007/s40596-023-01763-z
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Zs.B 2043: Show issues

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Article ; Online: SARS-CoV-2-induced immunodysregulation and the need for higher clinical suspicion for co-infection and secondary infection in COVID-19 patients.

Parrill, Allison / Tsao, Tiffany / Dong, Vinh / Huy, Nguyen Tien

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

2020 Volume 54, Issue 1, Page(s) 105–108

Abstract: Cases of co-infection and secondary infection emerging during the current Coronavirus Disease-19 (COVID-19) pandemic are a major public health concern. Such cases may result from immunodysregulation induced by the SARS-CoV-2 virus. Pandemic preparedness ... ...

Abstract	Cases of co-infection and secondary infection emerging during the current Coronavirus Disease-19 (COVID-19) pandemic are a major public health concern. Such cases may result from immunodysregulation induced by the SARS-CoV-2 virus. Pandemic preparedness must include identification of disease natural history and common secondary infections to implement clinical solutions.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/microbiology ; COVID-19/virology ; Coinfection/epidemiology ; Coinfection/immunology ; Coinfection/virology ; Humans ; Immunosuppression ; Lymphopenia/immunology ; Lymphopenia/microbiology ; Lymphopenia/virology ; Pandemics ; Prevalence ; Public Health ; SARS-CoV-2/immunology ; Superinfection/immunology ; Superinfection/microbiology ; Superinfection/virology
Keywords	covid19
Language	English
Publishing date	2020-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1497590-7
ISSN	1995-9133 ; 1684-1182 ; 0253-2662
ISSN (online)	1995-9133
ISSN	1684-1182 ; 0253-2662
DOI	10.1016/j.jmii.2020.08.016
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Zs.B 2083: Show issues

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Article ; Online: The association between ectopic pregnancy and inflammatory bowel disease, irritable bowel syndrome, and celiac disease: A systematic review.

Talavera, Jonah I R / Parrill, Allison M / Elsayad, Chris / Fogel, Joshua / Riggs, John C / Peng, Bo

The journal of obstetrics and gynaecology research

2021 Volume 47, Issue 5, Page(s) 1601–1609

Abstract: Aim: Inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and celiac disease (CeD) more commonly affect women of reproductive age. The aim of our study is to evaluate the association between ectopic pregnancy (EP) in women with IBD, IBS, ... ...

Abstract	Aim: Inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and celiac disease (CeD) more commonly affect women of reproductive age. The aim of our study is to evaluate the association between ectopic pregnancy (EP) in women with IBD, IBS, and CeD. Methods: We searched MEDLINE, Web of Science, and CINAHL from the database inception date through December 31, 2020. Peer-reviewed publications and abstracts written in English, regarding the association between EP and IBD, IBS, and CeD with controls were included. Quality assessment was conducted based on GRADE criteria. Analyses included odds ratios (ORs) with 95% confidence intervals (CIs). Heterogeneity between studies was presented with I Results: We included five population-based cohort studies. The odds of EP significantly increased in Crohn's disease (CD), but not ulcerative colitis (UC) as compared to IBD-free controls. The odds of EP significantly increased in IBS as compared to women without IBS. No significant difference was observed for odds of EP in women with and without CeD. Conclusions: Possible evidence of associations between EP and CD as well as IBS were observed; however, not with UC and CeD. Pregnant women with chronic inflammatory bowel pathologies may warrant cautious monitoring.
MeSH term(s)	Celiac Disease/complications ; Celiac Disease/epidemiology ; Colitis, Ulcerative ; Female ; Humans ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/epidemiology ; Irritable Bowel Syndrome/epidemiology ; Pregnancy ; Pregnancy, Ectopic
Language	English
Publishing date	2021-03-17
Publishing country	Australia
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.14705
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Article ; Online: Ocular and orbital manifestations of granulomatosis with polyangiitis: a systematic review of published cases.

Moin, Kayvon Ahmad / Yeakle, Madeleine Marta / Parrill, Allison Margaret / Garofalo, Victoria Anne / Tsiyer, Allen Raphael / Bishev, Daniel / Gala, Dhir / Fogel, Joshua / Hatsis, Alexander James / Wickas, Tyler Daniel / Anand, Prachi / Morcos, Marcelle

Romanian journal of ophthalmology

2023 Volume 67, Issue 3, Page(s) 214–221

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Antibodies, Antineutrophil Cytoplasmic ; Retrospective Studies ; Orbital Diseases/diagnosis ; Orbital Diseases/etiology ; Granuloma/diagnosis ; Granuloma/etiology ; Exophthalmos/diagnosis ; Exophthalmos/etiology
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic
Language	English
Publishing date	2023-11-02
Publishing country	Romania
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2842202-8
ISSN	2501-2533 ; 2457-4325
ISSN (online)	2501-2533
ISSN	2457-4325
DOI	10.22336/rjo.2023.38
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Article ; Online: Anti-N-methyl-D-aspartate receptor encephalitis in adults: a systematic review and analysis.

Giri, Yam R / Parrill, Allison / Damodar, Sreedevi / Fogel, Joshua / Ayed, Nisrin / Syed, Muhammad / Korie, Ijendu / Ayyanar, Sivaranjani / Typhair, Christopher / Hashmi, Seema / Giri, Bom B

Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater

2023

Abstract: Purpose: To analyze predictors of treatment outcome for anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in adults.: Methods: We performed a comprehensive literature search of PubMed, PsycInfo, and OVID. We included 424 patients from case ... ...

Title translation	Anti-N-Methyl-D-Aspartat-Rezeptor-Enzephalitis bei Erwachsenen: eine systematische Übersicht und Analyse.
Abstract	Purpose: To analyze predictors of treatment outcome for anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in adults. Methods: We performed a comprehensive literature search of PubMed, PsycInfo, and OVID. We included 424 patients from case reports and case series. Demographics, anti-NMDAR antibodies, prodromal and presenting symptoms, diagnostic workup, and treatment variables were recorded. Inferential analyses were performed in the subset (n = 299) of those with known treatment outcomes. Multivariate multinomial logistic regression analysis for treatment outcome compared full recovery versus partial recovery and full recovery versus death. Results: Treatment outcomes consisted of 34.67% full recovery (n = 147), 30.90% partial recovery (n = 131), 4.95% death (n = 21), and 29.48% unknown (n = 125). Speech/language abnormality and abnormal electroencephalogram (EEG) were each significantly associated with a higher relative risk for a full recovery. Treatment with intravenous immunoglobulin and plasmapheresis were each significantly associated with a higher relative risk for partial recovery. The analysis comparing death to full recovery found that catatonia was significantly associated with a lower relative risk for death. Increased age, orofacial dyskinesia, and no tumor removal were each significantly associated with a higher relative risk for death. Conclusion: Increased age, orofacial dyskinesia, and no tumor removal were associated with a higher relative risk for death in anti-NMDAR encephalitis in adults. Clinicians should monitor and appropriately treat anti-NMDAR encephalitis with these findings to minimize the risk of death.
Language	English
Publishing date	2023-08-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1027479-0
ISSN	2194-1327 ; 0948-6259
ISSN (online)	2194-1327
ISSN	0948-6259
DOI	10.1007/s40211-023-00478-9
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Zs.A 2881: Show issues

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Article ; Online: SARS-CoV-2-induced immunodysregulation and the need for higher clinical suspicion for co-infection and secondary infection in COVID-19 patients

Parrill, Allison / Tsao, Tiffany / Dong, Vinh / Huy, Nguyen Tien

Journal of Microbiology, Immunology and Infection ; ISSN 1684-1182

2020

Keywords	Immunology and Allergy ; Microbiology (medical) ; General Immunology and Microbiology ; Infectious Diseases ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.jmii.2020.08.016
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: SARS-CoV-2-induced immunodysregulation and the need for higher clinical suspicion for co-infection and secondary infection in COVID-19 patients

Parrill, Allison / Tsao, Tiffany / Dong, Vinh / Huy, Nguyen Tien

J. microbiol. immunol. infect

Abstract	Cases of co-infection and secondary infection emerging during the current Coronavirus Disease-19 (COVID-19) pandemic are a major public health concern. Such cases may result from immunodysregulation induced by the SARS-CoV-2 virus. Pandemic preparedness must include identification of disease natural history and common secondary infections to implement clinical solutions.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #753242
Database	COVID19

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Article: Covid-19-induced coagulopathy and observed benefits with anticoagulation.

Karimzadeh, Sedighe / Dong, Vinh / Hassan, Osama Gamal / Raut, Akshay / Fouda, Ahmed / Parrill, Allison / Eaton, Kimberly / Huy, Nguyen Tien

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2020 Volume 59, Issue 6, Page(s) 102906

MeSH term(s)	Anticoagulants/therapeutic use ; Blood Coagulation Disorders/etiology ; Blood Coagulation Disorders/virology ; COVID-19/complications ; Fibrin Fibrinogen Degradation Products/metabolism ; Hospitalization ; Humans ; Practice Guidelines as Topic ; SARS-CoV-2/physiology ; Thrombosis/etiology ; Thrombosis/virology
Chemical Substances	Anticoagulants ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D
Keywords	covid19
Language	English
Publishing date	2020-08-03
Publishing country	England
Document type	Letter
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2020.102906
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