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  1. Article ; Online: Increased serum level of interleukin-6 correlates with negative prognostic factors in extranodal NK/T-cell lymphoma.

    Bao, Changqian / Zhou, De / Zhu, Lixia / Qian, Wenbin / Ye, Xiujin

    Translational cancer research

    2022  Volume 9, Issue 4, Page(s) 2378–2389

    Abstract: Background: Extranodal natural killer/T-cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma (NHL), characterized as mature T- and natural killer (NK)-cell lymphoma, which is more common in East Asia and Latin America than in other parts of ... ...

    Abstract Background: Extranodal natural killer/T-cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma (NHL), characterized as mature T- and natural killer (NK)-cell lymphoma, which is more common in East Asia and Latin America than in other parts of the world. The overproduction of proinflammatory cytokines such as interleukin-6 (IL-6) plays an essential role in the development of lymphoma.
    Methods: We measured serum IL-6 and IL-6 related cytokines of 65 newly diagnosed ENKTL patients to assess biomarkers for prognosis of ENKTL.
    Results: Patients with high IL-6 (>15.920 mg/L) at diagnosis had more adverse clinical features. Patients with low IL-6 (≤15.920 mg/L) at diagnosis had better progression-free survival (PFS; P=0.002), overall survival (OS; P<0.001), and higher complete remission rates (P=0.001). IL-6 correlated with lactate dehydrogenase (LDH), ferritin, C-reactive protein (CRP), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α). Multivariate analysis revealed Ann Arbor stage [P=0.001, risk ratio (RR) =6.011 (2.102-17.191)] and IL-6 [P=0.012, RR =2.367 (1.206-4.643)] to be independent prognostic factors for PFS. Multifactor analysis of OS revealed Ann Arbor stage [P=0.015, RR =3.600 (1.278-10.141)], IL-6 [(P=0.001), RR =3.565 (1.720-7.390)], and chemotherapy that not containing L-asparaginase [(P=0.009, RR =2.717 (1.252-5.780)] to be independent prognostic factors for shorter OS.
    Conclusions: These results suggest serum IL-6 at diagnosis is predictive of prognosis for ENKTL, and IL-6 increase is activity during the pathogenesis of ENKTL and offers new insight into potential therapeutic strategies.
    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2020.03.49
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: LC-MS/MS Based Volatile Organic Compound Biomarkers Analysis for Early Detection of Lung Cancer.

    Sani, Shuaibu Nazifi / Zhou, Wei / Ismail, Balarabe B / Zhang, Yongkui / Chen, Zhijun / Zhang, Binjie / Bao, Changqian / Zhang, Houde / Wang, Xiaozhi

    Cancers

    2023  Volume 15, Issue 4

    Abstract: 1) Background: lung cancer is the world's deadliest cancer, but early diagnosis helps to improve the cure rate and thus reduce the mortality rate. Annual low-dose computed tomography (LD-CT) screening is an efficient lung cancer-screening program for a ... ...

    Abstract (1) Background: lung cancer is the world's deadliest cancer, but early diagnosis helps to improve the cure rate and thus reduce the mortality rate. Annual low-dose computed tomography (LD-CT) screening is an efficient lung cancer-screening program for a high-risk population. However, LD-CT has often been characterized by a higher degree of false-positive results. To meet these challenges, a volatolomic approach, in particular, the breath volatile organic compounds (VOCs) fingerprint analysis, has recently received increased attention for its application in early lung cancer screening thanks to its convenience, non-invasiveness, and being well tolerated by patients. (2) Methods: a LC-MS/MS-based volatolomics analysis was carried out according to P/N 5046800 standard based breath analysis of VOC as novel cancer biomarkers for distinguishing early-stage lung cancer from the healthy control group. The discriminatory accuracy of identified VOCs was assessed using subject work characterization and a random forest risk prediction model. (3) Results: the proposed technique has good performance compared with existing approaches, the differences between the exhaled VOCs of the early lung cancer patients before operation, three to seven days after the operation, as well as four to six weeks after operation under fasting and 1 h after the meal were compared with the healthy controls. The results showed that only 1 h after a meal, the concentration of seven VOCs, including 3-hydroxy-2-butanone (TG-4), glycolaldehyde (TG-7), 2-pentanone (TG-8), acrolein (TG-11), nonaldehyde (TG-19), decanal (TG-20), and crotonaldehyde (TG-22), differ significantly between lung cancer patients and control, with the invasive adenocarcinoma of the lung (IAC) having the most significant difference. (4) Conclusions: this novel, non-invasive approach can improve the detection rate of early lung cancer, and LC-MS/MS-based breath analysis could be a promising method for clinical application.
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Natural killer cells associated with SARS-CoV-2 viral RNA shedding, antibody response and mortality in COVID-19 patients.

    Bao, Changqian / Tao, Xiandong / Cui, Wei / Hao, Yuanyuan / Zheng, Shuaike / Yi, Bin / Pan, Tiewen / Young, Ken H / Qian, Wenbin

    Experimental hematology & oncology

    2021  Volume 10, Issue 1, Page(s) 5

    Abstract: Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Two consecutively negative SARS-CoV-2 viral RNA test ( interval ≥ 24 hours), improved respiratory symptoms ...

    Abstract Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Two consecutively negative SARS-CoV-2 viral RNA test ( interval ≥ 24 hours), improved respiratory symptoms and obvious absorption of inflammation in pulmonary imaging are the discharge criteria for COVID-19 patients. The clearance profile of viral RNA in the upper respiratory tract specimens, including nasopharyngeal swab and/or oropharyngeal swabs, is related to innate immune cells such as Natural Killer cells. A total of 168 patients were included for the study. In this cohort, non-severe and severe groups showed significant differences in white blood cells, neutrophils, lymphocytes, basophils and platelets counts, as well as in infection related parameters such as CRP and serum cytokine IL-6. For lymphocyte subsets tests at admission, the severe group displayed significantly lower cell counts than the non-severe group. Higher counts of total T cells, CD4 + T cells, CD8 + T cells, and NK cells in peripheral blood showed a significant correlation with the shorter time taken to obtain the first negative viral RNA test and first positive IgM/ IgG antibody test. The number of B cells was only correlated with time to achieve the first positive IgM/IgG test. The count of NK cells was also correlated with a higher level of IgG antibody (p = 0.025). The lymphocytopenia group had a significantly worse survival rate (p = 0.022) and a longer duration (p = 0.023) of viral shedding than the normal lymphocyte count group. A lower NK cell count correlates the most with the worse survival rate (p<0.001) and a longer duration (p<0.001) of viral shedding. This study suggests the potential value of allo-Natural Killer cell therapy as an universal COVID-19 treatment strategy.
    Language English
    Publishing date 2021-01-27
    Publishing country England
    Document type Letter
    ZDB-ID 2669066-4
    ISSN 2162-3619
    ISSN 2162-3619
    DOI 10.1186/s40164-021-00199-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Leukocyte Telomere Length Shortening Implies Plaque Instability and Major Adverse Cardiovascular Events in Patients With Angiographically Intermediate Lesions.

    Zhang, Alian / Fan, Li / Bao, Xiaolu / Xu, Zuojun / Yin, Zhaofang / Zhuo, Yang / Zhang, Junfeng / Gu, Jun / Chang, Alex C Y / Fan, Yuqi / Wang, Changqian

    Frontiers in cardiovascular medicine

    2022  Volume 8, Page(s) 812363

    Abstract: Background: Telomere shortening, an indicator of aging, is associated with age-related diseases. This study aims to investigate the association between leukocyte telomere length (LTL) and thin-capped fibroatheromata (TCFA) and the impact of using LTL ... ...

    Abstract Background: Telomere shortening, an indicator of aging, is associated with age-related diseases. This study aims to investigate the association between leukocyte telomere length (LTL) and thin-capped fibroatheromata (TCFA) and the impact of using LTL cutoff to determine the incidence of major adverse cardiovascular events (MACEs) in patients with angiographically intermediate coronary lesions.
    Methods: This was a signal-center retrospective study focusing on patients who underwent coronary angiography and optical coherence tomography (OCT). The degree of coronary stenosis was assessed by angiography. The presence of TCFA was determined by OCT imaging. A total of 156 patients with angiographically intermediate coronary lesions were enrolled.
    Results: Leukocyte telomere lengths were significantly shorter in the TCFA group compared with non-TCFA group [11.95 (10.56, 15.21) kb vs. 13.81 (12.06, 16.11) kb,
    Conclusions: Short-LTL was independently associated with the incidence of TCFA and may serve as a prognostic factor for MACE risk on top of conventional risk factors.
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.812363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Decitabine-Mediated Epigenetic Reprograming Enhances Anti-leukemia Efficacy of CD123-Targeted Chimeric Antigen Receptor T-Cells.

    You, Liangshun / Han, Qingmei / Zhu, Li / Zhu, Yijing / Bao, Changqian / Yang, Chunmei / Lei, Wen / Qian, Wenbin

    Frontiers in immunology

    2020  Volume 11, Page(s) 1787

    Abstract: Chimeric antigen receptor (CAR) T cells represent a potentially curative therapy for patients with advanced hematological cancers; however, uncertainties surround the cell-intrinsic fitness as well as the exhaustion that restrict the capacity of CAR-T. ... ...

    Abstract Chimeric antigen receptor (CAR) T cells represent a potentially curative therapy for patients with advanced hematological cancers; however, uncertainties surround the cell-intrinsic fitness as well as the exhaustion that restrict the capacity of CAR-T. Decitabine (DAC), a DNA demethylating agent, has been demonstrated to reverse exhaustion-associated DNA-methylation programs and to improve T cell responses against tumors. Here we show that DAC significantly enhances antileukemia functions of CD123 CAR-T cells
    MeSH term(s) Animals ; Antimetabolites, Antineoplastic/pharmacology ; Cell Line, Tumor ; Cellular Reprogramming/drug effects ; Combined Modality Therapy/methods ; DNA Methylation/drug effects ; Decitabine/pharmacology ; Epigenesis, Genetic ; Female ; Humans ; Immunotherapy, Adoptive/methods ; Interleukin-3 Receptor alpha Subunit ; Leukemia, Myeloid, Acute/therapy ; Mice ; Mice, Inbred NOD ; Receptors, Chimeric Antigen ; Xenograft Model Antitumor Assays
    Chemical Substances Antimetabolites, Antineoplastic ; IL3RA protein, human ; Interleukin-3 Receptor alpha Subunit ; Receptors, Chimeric Antigen ; Decitabine (776B62CQ27)
    Language English
    Publishing date 2020-08-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients.

    Bao, Changqian / Tao, Xiandong / Cui, Wei / Yi, Bin / Pan, Tiewen / Young, Ken H / Qian, Wenbin

    Experimental hematology & oncology

    2020  Volume 9, Page(s) 16

    Abstract: Background: Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease, which lacks well-established diagnostic laboratory parameters that could be used to evaluate disease severity, thromboembolism or cardiovascular events and to predict ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease, which lacks well-established diagnostic laboratory parameters that could be used to evaluate disease severity, thromboembolism or cardiovascular events and to predict clinical prognosis. Coagulation cascade and platelet functions have not been well studied in the COVID-19 patients.
    Methods: A total of 178 patients enrolled in Wuhan Huoshenshan Hospital were included for the study. Blood platelets and coagulation functions were analyzed in COVID-19 patients with non-severe and severe subgroups. Other biochemical laboratory parameters were also analyzed.
    Results: Forty-nine (27.5%) out of 178 patients were diagnosed with severe disease in this study, and 129 patients with non-severe disease. Severe disease group had significant lower platelet count 186.00 (103.50-249.00) ×10
    Conclusions: Low platelet count is associated with abnormal coagulation function and increased risk of DIC, severe disease manifestation and increased mortality in patients with COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2669066-4
    ISSN 2162-3619
    ISSN 2162-3619
    DOI 10.1186/s40164-020-00172-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients

    Bao, Changqian / Tao, Xiandong / Cui, Wei / Yi, Bin / Pan, Tiewen / Young, Ken H. / Qian, Wenbin

    Experimental Hematology & Oncology

    2020  Volume 9, Issue 1

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2669066-4
    ISSN 2162-3619
    ISSN 2162-3619
    DOI 10.1186/s40164-020-00172-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients

    Changqian Bao / Xiandong Tao / Wei Cui / Bin Yi / Tiewen Pan / Ken H. Young / Wenbin Qian

    Experimental Hematology & Oncology, Vol 9, Iss 1, Pp 1-

    2020  Volume 8

    Abstract: Abstract Background Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease, which lacks well-established diagnostic laboratory parameters that could be used to evaluate disease severity, thromboembolism or cardiovascular events and to ... ...

    Abstract Abstract Background Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease, which lacks well-established diagnostic laboratory parameters that could be used to evaluate disease severity, thromboembolism or cardiovascular events and to predict clinical prognosis. Coagulation cascade and platelet functions have not been well studied in the COVID-19 patients. Methods A total of 178 patients enrolled in Wuhan Huoshenshan Hospital were included for the study. Blood platelets and coagulation functions were analyzed in COVID-19 patients with non-severe and severe subgroups. Other biochemical laboratory parameters were also analyzed. Results Forty-nine (27.5%) out of 178 patients were diagnosed with severe disease in this study, and 129 patients with non-severe disease. Severe disease group had significant lower platelet count 186.00 (103.50–249.00) ×109/L than 251.00 (202.00–317.00) ×109/L of non-severe group, p = 0.000. Severe group also had significantly abnormal coagulation parameters than non-severe group: prothrombin time (PT) 14.55 (13.40–16.53) s vs. 12.70 (12.15–13.59) s, p = 0.000; international normalized ratio (INR) 1.21 (1.13–1.36) vs. 1.06 (1.01–1.13), p = 0.000; thrombin time (TT) 16.35 (15.69–17.47) s vs. 15.68 (14.79–16.69) s, p = 0.011; D-Dimer 1.05 (0.68–5.90) mg/L vs. 0.42 (0.28–0.79) mg/L, p = 0.000; While the liver function parameter alanine aminotransferase (ALT) and aspartate aminotransferase (AST) didn’t show significance between two groups, ALT 30.80 (19.00–58.30) IU/L vs. 28.80 (15.75–50.15) IU/L, p = 0.487; AST 27.80 (19.30–40.55) IU/L vs. 22.6 (16.7–32.03) IU/L, p = 0.102. Disseminated intravascular coagulation (DIC) rate was 6.1% in severe group while 0% in non-severe group. Survival rate of severe disease group was worse than non-severe group, 85.7% vs. 100%, p = 0.000. Thrombocytopenia correlated with coagulation function, DIC rate and survival. Six out of 7 death case had thrombocytopenia during hospitalization, and platelet count decreased subsequently until death. Thrombocytopenia occurred within 1 week after admission in 6 recovered patients. And increased platelet levels followed by positive SARS-CoV-2 IgM/IgG and negative coronavirus nucleic acid tested in 8 recovered patients. Conclusions Low platelet count is associated with abnormal coagulation function and increased risk of DIC, severe disease manifestation and increased mortality in patients with COVID-19.
    Keywords COVID-19 ; SARS-CoV-2 ; Thrombocytopenia ; Coagulation ; DIC ; Diseases of the blood and blood-forming organs ; RC633-647.5 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Prognostic value of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in primary hepatic mucosa-associated lymphoid tissue lymphoma: A case report and review of the literature.

    Bao, Changqian / Wei, Juyin / Zhao, Xin / Lin, Lili / Chen, Donghe / Liu, Kanfeng / Qian, Wenbin / Anas, Jhurry Muhummad / Zhao, Kui

    Medicine

    2018  Volume 97, Issue 10, Page(s) e9877

    Abstract: Introduction: Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is extremely rare and we herein report a case of a patient suffering from primary hepatic MALT lymphoma with concomitant hepatitis B virus infection.: Diagnostic ... ...

    Abstract Introduction: Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is extremely rare and we herein report a case of a patient suffering from primary hepatic MALT lymphoma with concomitant hepatitis B virus infection.
    Diagnostic modalities and outcome: Double masses were found in a 59-year-old Chinese female patient. We reported the laboratory results, computed tomography (CT) and fluorine-18-fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/CT images among other findings. As far as we know, only 9 cases have been reported till now using F-FDG PET/CT imaging. Our patient's lesions were found to conform to standard uptake values of FDG.
    Conclusion: It indicates that hepatic MALT lymphoma can be studied with F-FDG PET/CT like other F-FDG-avid lymphomas. It was also noted that delayed-time-point FDG PET imaging may further improve the detection of the MALT lymphoma in liver. Although the patient in this case refused further treatment, potential management options, including rituximab, which is also discussed in this review.
    MeSH term(s) Female ; Fluorodeoxyglucose F18 ; Humans ; Liver/diagnostic imaging ; Liver Neoplasms/diagnostic imaging ; Lymphoma, B-Cell, Marginal Zone/diagnostic imaging ; Middle Aged ; Positron Emission Tomography Computed Tomography/methods ; Prognosis ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2018-03-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000009877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients

    Bao, Changqian / Tao, Xiandong / Cui, Wei / Yi, Bin / Pan, Tiewen / Young, Ken H. / Qian, Wenbin

    Exp. Hematol. Oncol.

    Abstract: Background: Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease, which lacks well-established diagnostic laboratory parameters that could be used to evaluate disease severity, thromboembolism or cardiovascular events and to predict ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease, which lacks well-established diagnostic laboratory parameters that could be used to evaluate disease severity, thromboembolism or cardiovascular events and to predict clinical prognosis. Coagulation cascade and platelet functions have not been well studied in the COVID-19 patients. Methods: A total of 178 patients enrolled in Wuhan Huoshenshan Hospital were included for the study. Blood platelets and coagulation functions were analyzed in COVID-19 patients with non-severe and severe subgroups. Other biochemical laboratory parameters were also analyzed. Results: Forty-nine (27.5%) out of 178 patients were diagnosed with severe disease in this study, and 129 patients with non-severe disease. Severe disease group had significant lower platelet count 186.00 (103.50-249.00) ×109/L than 251.00 (202.00-317.00) ×109/L of non-severe group, p = 0.000. Severe group also had significantly abnormal coagulation parameters than non-severe group: prothrombin time (PT) 14.55 (13.40-16.53) s vs. 12.70 (12.15-13.59) s, p = 0.000; international normalized ratio (INR) 1.21 (1.13-1.36) vs. 1.06 (1.01-1.13), p = 0.000; thrombin time (TT) 16.35 (15.69-17.47) s vs. 15.68 (14.79-16.69) s, p = 0.011; D-Dimer 1.05 (0.68-5.90) mg/L vs. 0.42 (0.28-0.79) mg/L, p = 0.000; While the liver function parameter alanine aminotransferase (ALT) and aspartate aminotransferase (AST) didn't show significance between two groups, ALT 30.80 (19.00-58.30) IU/L vs. 28.80 (15.75-50.15) IU/L, p = 0.487; AST 27.80 (19.30-40.55) IU/L vs. 22.6 (16.7-32.03) IU/L, p = 0.102. Disseminated intravascular coagulation (DIC) rate was 6.1% in severe group while 0% in non-severe group. Survival rate of severe disease group was worse than non-severe group, 85.7% vs. 100%, p = 0.000. Thrombocytopenia correlated with coagulation function, DIC rate and survival. Six out of 7 death case had thrombocytopenia during hospitalization, and platelet count decreased subsequently until death. Thrombocytopenia occurred within 1 week after admission in 6 recovered patients. And increased platelet levels followed by positive SARS-CoV-2 IgM/IgG and negative coronavirus nucleic acid tested in 8 recovered patients. Conclusions: Low platelet count is associated with abnormal coagulation function and increased risk of DIC, severe disease manifestation and increased mortality in patients with COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #657404
    Database COVID19

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