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  1. Article ; Online: Biochemical rationale for hypoalbuminemia in COVID-19 patients.

    Ambade, Vivek

    Journal of medical virology

    2020  Volume 93, Issue 3, Page(s) 1207–1209

    MeSH term(s) COVID-19 ; Comorbidity ; Humans ; Hypoalbuminemia/epidemiology ; Morbidity ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26542
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    Zs.A 1320: Show issues Location:
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  2. Article: SARS-CoV-2 infecting endothelial cells, biochemical alterations, autopsy findings and outcomes in COVID-19, suggest role of hypoxia-inducible factor-1.

    Ambade, Vivek / Ambade, Sonia

    Journal of medical biochemistry

    2022  Volume 41, Issue 1, Page(s) 14–20

    Abstract: Researchers around the world have experienced the dual nature of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), 'tragically lethal in some people while surprisingly benign in others'. There have been congregating studies of the novel ... ...

    Abstract Researchers around the world have experienced the dual nature of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), 'tragically lethal in some people while surprisingly benign in others'. There have been congregating studies of the novel coronavirus disease (COVID-19), a disease that mainly attacks the lungs but also has mystifying effects on the heart, kidneys and brain. Researchers are also gathering information to ascertain why people are dying of COVID-19, whether it is solely a respiratory disorder, a coagulation disorder or multi-organ failure. Alterations in laboratory parameters like lactate, ferritin and albumin have been established as risk factors and are associated with outcomes, yet none have not been sub stantiated with a scientific biochemical rationale. SARSCoV-2 affects the alveolar type II epithelial cells which significantly disturbs its surfactant homeostasis, deprives Na,K-ATPase of ATP, thereby disturbing the alveolar lining fluid which then gradually decreases the alveolar gaseous exchange initiating the intracellular hypoxic conditions. This activates AMP-activated kinase, which further inhibits Na,K-ATPase, which can progressively cause respiratory distress syndrome. The virus may infect endothelial cell (EC) which, being less energetic, cannot withstand the huge energy requirement towards viral replication. There - fore glycolysis, the prime energy generating pathway, must be mandatorily upregulated. This can be achieved by Hypoxia-inducible factor-1 (HIF-1). However, HIF-1 also activates transcription of von Willebrand factor, plasminogen activator inhibitor-1, and suppresses the release of thrombomodulin. This in turn sets off the coagulation cascade that can lead to in-situ pulmonary thrombosis and micro clots. The proposed HIF-1 hypothesis justifies various features, biochemical alteration, laboratory as well as autopsy findings such as respiratory distress syndrome, increased blood ferritin and lactate levels, hypoalbuminemia, endothelial invasion, in-situ pulmonary thrombosis and micro clots, and multi-organ failure in COVID-19.
    Language English
    Publishing date 2022-03-11
    Publishing country Serbia
    Document type Journal Article
    ZDB-ID 2387367-X
    ISSN 1452-8258
    ISSN 1452-8258
    DOI 10.5937/jomb0-30659
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    Zs.A 3112: Show issues Location:
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  4. Article ; Online: Biochemical rationale for hypoalbuminemia in COVID‐19 patients

    Ambade, Vivek

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26542
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Applications of Latissimus Dorsi Grafts in Reverse Shoulder Arthroplasty.

    Bose, Sushrut / Ambade, Ratnakar / Bhartiya, Yashvi / Velagala, Vivek R

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48469

    Abstract: The shoulder joint is a multiaxial joint in the upper body known for its high degree of motion. It is also infamously known for recurrent dislocations compared to other joints. These dislocations are mainly fixed by closed reduction methods like the ... ...

    Abstract The shoulder joint is a multiaxial joint in the upper body known for its high degree of motion. It is also infamously known for recurrent dislocations compared to other joints. These dislocations are mainly fixed by closed reduction methods like the Hippocrates technique, Stimpson's gravity technique, and the most commonly used modified Kocher's technique. The modified Kocher's technique uses traction followed by external rotation, adduction, and internal rotation. Rotator cuff tears are associated with shoulder joint dislocations. Rotator cuff tears slowly heal and persist for 10-20 years, irrespective of their etiology. When left untreated, fibrosis can set in the joint. After fibrosis, it is repaired with a reverse shoulder arthroplasty. Reverse shoulder arthroplasty allows a greater degree of movement compared to the conventional arthroplasty. In reverse shoulder arthroplasty, the latissimus dorsi tendon is removed from its original insertion and attached to the humerus around the insertion of the deltoid muscle. This change increases the torque and external rotation of the joint and provides better results than the surgeries where the tendon transfer is not done. This article compiles the various etiologies of shoulder dislocation and its treatment, shoulder arthroplasty. It discusses the indications and contraindications of total and reverse total arthroplasty. This article aims to compare conventional shoulder arthroplasty and reverse shoulder arthroplasty. It highlights the advantages of using latissimus dorsi grafts in reverse shoulder arthroplasty in shoulder joint dislocations.
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48469
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  6. Article ; Online: Serum Biomarkers of COPD-Reply.

    Ambade, Vivek N

    Respiratory care

    2016  Volume 61, Issue 3, Page(s) 395–396

    MeSH term(s) Biomarkers/blood ; Forced Expiratory Volume ; Humans ; Pulmonary Disease, Chronic Obstructive/blood ; Severity of Illness Index
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.04637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant

    Ambade, Shraddha S / Gupta, Vivek Kumar / Bhole, Ritesh P / Khedekar, Pramod B / Chikhale, Rupesh V

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 20

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    MeSH term(s) Humans ; Penicillin-Binding Proteins/chemistry ; Methicillin-Resistant Staphylococcus aureus/metabolism ; Methicillin/metabolism ; Methicillin/pharmacology ; Staphylococcus aureus/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Monobactams/metabolism ; Bacterial Proteins/chemistry ; Microbial Sensitivity Tests
    Chemical Substances Penicillin-Binding Proteins ; Methicillin (Q91FH1328A) ; Anti-Bacterial Agents ; Monobactams ; Bacterial Proteins
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28207008
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  8. Article ; Online: Case report of a lupus patient with flare and symptomatic cardiac tamponade and macrophage activation syndrome

    Amandeep Singh / Kapil Bhatia / Pratibha Misra / Bhasker Mukherjee / Vivek N Ambade

    Medical Journal of Dr. D.Y. Patil Vidyapeeth, Vol 15, Iss 1, Pp 101-

    A biochemical diagnostic perspective

    2022  Volume 103

    Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disorder with multifactorial etiology involving vital organs like the heart and causing rare complications like cardiac tamponade which are indeed difficult to manage especially in a setting of ... ...

    Abstract Systemic lupus erythematosus (SLE) is an autoimmune disorder with multifactorial etiology involving vital organs like the heart and causing rare complications like cardiac tamponade which are indeed difficult to manage especially in a setting of macrophage activation syndrome (MAS) with flare. A case of 25-year-old female with flare having high.grade fever and breathlessness on exertion to begin with. Subsequently, she developed pericardial effusion leading to cardiac tamponade and was managed with pericardiocentesis. With the rising ferritin levels, raised triglycerides, and cytopenia, she was diagnosed as MAS, along with reactivation of tuberculosis. She was discharged on oral steroids and anti-tubercular therapy with regular follow-up. Clinical suspicion, keeping in mind, the rarest complications such as cardiac tamponade, and timely employability of biochemical tests can help in early diagnosis of MAS and can lead to early therapeutic intervention in SLE patients preventing fatal outcomes.
    Keywords anti-tubercular therapy ; anti-nuclear antibody ; macrophage activation syndrome ; pericardial effusion ; systemic lupus erythematosus ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Serum tumor markers

    Amandeep Singh / Kapil Bhatia / Pratibha Misra / Vivek N Ambade / Bhasker Mukherjee / Rakhi Negi

    Medical Journal of Dr. D.Y. Patil Vidyapeeth, Vol 15, Iss 2, Pp 212-

    A study on their rational use in various cancers

    2022  Volume 216

    Abstract: Background: Cancer is among the leading noncommunicable diseases and its screening, diagnosis, management, monitoring, and relapse involve the use of tumor markers. Tumor marker requisition adds to a major financial burden if not used rationally. Aim and ...

    Abstract Background: Cancer is among the leading noncommunicable diseases and its screening, diagnosis, management, monitoring, and relapse involve the use of tumor markers. Tumor marker requisition adds to a major financial burden if not used rationally. Aim and Objectives: The aim was to study the rational use of tumor markers in various cancers with objectives to do requisition analysis of tumor markers with the existing national guidelines by the Indian Council of Medical Research (ICMR) and to assess its financial impact. Materials and Methods: A total of 355 cases were screened and 221 were included in the study. The patient's laboratory requisition form raised by the ordering physician as a part of the screening, diagnosis, management, monitoring, and relapse for different conditions including cancers were studied retrospectively over a period of 5 months, and data were analyzed. Results: Two hundred and twenty-one requisitions for various tumor markers were ordered for screening, diagnosis, management, monitoring, and relapse of various cancers and other conditions. Only 10%–30% of requisitions were found as per the laid down guidelines of the ICMR for different cancers. Carcinoembryonic antigen was ordered in only 20% requisitions as per the ICMR guidelines but has affected maximally in terms of test cost by adding up 88% to the budget of the test. Conclusion: Rational use of tumor markers in different cancers can cut down the cost factor directly. It prevents the physician in overdiagnosing due to multiple requisitions in diagnosed cancers and hence avoiding undue medical procedures thus further reducing the financial burden on the patients and their family.
    Keywords diagnosis ; financial burden ; requisitions ; tumor markers ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: METHODS FOR ESTIMATION OF BLOOD GLUCOSE : A COMPARATIVE EVALUATION.

    Ambade, Vivek N / Sharma, Y V / Somani, B L

    Medical journal, Armed Forces India

    2017  Volume 54, Issue 2, Page(s) 131–133

    Abstract: Glucose in blood is the most frequent analyzed parameter in a clinical chemistry laboratory. In Armed Forces Laboratories, copper reduction method (Modified Folin Wu) is commonly used. Here we have compared this method as well as O-Toluidine and GOD-POD ... ...

    Abstract Glucose in blood is the most frequent analyzed parameter in a clinical chemistry laboratory. In Armed Forces Laboratories, copper reduction method (Modified Folin Wu) is commonly used. Here we have compared this method as well as O-Toluidine and GOD-POD method with reference UV-Hexokinase method. Both Modified Folin Wu and O-Toluidine showed upward deviation with substantial imprecision (CV=4.9% - 3.5% and 6% - 5.8% respectively) and inaccuracy (Average deviation = 5.76% and 10.68% respectively). GOD-POD method was found linear (up to 500 mg/dl), with good precision (CV=0.7% to 1.4%) and accuracy (Average deviation= -0.97%). This method is simple, rapid, economical and sensitive, and can be adopted to a routine colorimeter.
    Language English
    Publishing date 2017-06-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 196342-9
    ISSN 0377-1237
    ISSN 0377-1237
    DOI 10.1016/S0377-1237(17)30502-6
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