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  1. Article ; Online: Evaluation of gut microbiota predictive potential associated with phenotypic characteristics to identify multifactorial diseases.

    Fonseca, Danielle Cristina / Marques Gomes da Rocha, Ilanna / Depieri Balmant, Bianca / Callado, Leticia / Aguiar Prudêncio, Ana Paula / Tepedino Martins Alves, Juliana / Torrinhas, Raquel Susana / da Rocha Fernandes, Gabriel / Linetzky Waitzberg, Dan

    Gut microbes

    2024  Volume 16, Issue 1, Page(s) 2297815

    Abstract: Gut microbiota has been implicated in various clinical conditions, yet the substantial heterogeneity in gut microbiota research results necessitates a more sophisticated approach than merely identifying statistically different microbial taxa between ... ...

    Abstract Gut microbiota has been implicated in various clinical conditions, yet the substantial heterogeneity in gut microbiota research results necessitates a more sophisticated approach than merely identifying statistically different microbial taxa between healthy and unhealthy individuals. Our study seeks to not only select microbial taxa but also explore their synergy with phenotypic host variables to develop novel predictive models for specific clinical conditions.
    Design: We assessed 50 healthy and 152 unhealthy individuals for phenotypic variables (PV) and gut microbiota (GM) composition by 16S rRNA gene sequencing. The entire modeling process was conducted in the R environment using the Random Forest algorithm. Model performance was assessed through ROC curve construction.
    Results: We evaluated 52 bacterial taxa and pre-selected PV (
    Conclusion: Our findings underscore that the selection of bacterial taxa based solely on differences in relative abundance between groups is insufficient to serve as clinical markers. Machine learning techniques are essential for mitigating the considerable variability observed within gut microbiota. In our study, the use of microbial taxa alone exhibited limited predictive power for health outcomes, while the integration of phenotypic variables into predictive models substantially enhanced their predictive capabilities.
    MeSH term(s) Humans ; Gastrointestinal Microbiome/genetics ; RNA, Ribosomal, 16S/genetics ; Diabetes Mellitus, Type 2 ; Biomarkers
    Chemical Substances RNA, Ribosomal, 16S ; Biomarkers
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2023.2297815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pro-Inflammatory Diet Is Correlated with High

    Rocha, Ilanna Marques Gomes da / Torrinhas, Raquel / Fonseca, Danielle / Lyra, Clelia de Oliveira / de Sousa Alves Neri, Julianna Lys / Balmant, Bianca Depieri / Callado, Letícia / Charlton, Karen / Queiroz, Natalia / Waitzberg, Dan L

    Nutrients

    2023  Volume 15, Issue 19

    Abstract: Inflammatory bowel diseases (IBD) are chronic conditions arising from an intricate interplay of genetics and environmental factors, and are associated with gut dysbiosis, inflammation, and gut permeability. In this study, we investigated whether the ... ...

    Abstract Inflammatory bowel diseases (IBD) are chronic conditions arising from an intricate interplay of genetics and environmental factors, and are associated with gut dysbiosis, inflammation, and gut permeability. In this study, we investigated whether the inflammatory potential of the diet is associated with the gut microbiota profile, inflammation, and permeability in forty patients with IBD in clinical remission. The dietary inflammatory index (DII) score was used to assess the inflammatory potential of the diet. The fecal microbiota profile was analyzed using 16SrRNA (V3-V4) gene sequencing, while fecal zonulin and calprotectin levels were measured with enzyme-linked immunosorbent assays. We found a positive correlation between the DII score and elevated calprotectin levels (Rho = 0.498;
    MeSH term(s) Humans ; Biomarkers ; Inflammatory Bowel Diseases ; Inflammation ; Feces/microbiology ; Chronic Disease ; Diet ; Recurrence ; Leukocyte L1 Antigen Complex
    Chemical Substances Biomarkers ; Leukocyte L1 Antigen Complex
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15194148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SARS-CoV-2 infection, gut dysbiosis, and heterogeneous clinical results of hydroxychloroquine on COVID-19 therapy-Is there a link?

    Balmant, Bianca D / Torrinhas, Raquel S / Rocha, Ilanna M / Fonseca, Danielle C / Formiga, Francisco F C / Bonfá, Eloisa S D O / Borba, Eduardo F / Waitzberg, Dan L

    Nutrition (Burbank, Los Angeles County, Calif.)

    2020  Volume 85, Page(s) 111115

    Abstract: Clinical manifestations of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can include gastrointestinal signals and symptoms. Individuals with previous clinical conditions that usually enroll gut dysbiosis have been ... ...

    Abstract Clinical manifestations of the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can include gastrointestinal signals and symptoms. Individuals with previous clinical conditions that usually enroll gut dysbiosis have been identified as being at high risk to develop more severe infectious phenotypes. Actually, intestinal dysbiosis has been observed in infected patients and potentially linked to systemic hyperinflammation. These observations suggest that a previous gut dysbiosis may be aggravated by SARS-CoV-2 infection and related to progression of the coronavirus disease 2019 (COVID-19) into more severe stages. While COVID-19's pathophysiology is not fully understood, it seems relevant to consider the interactions of candidate therapeutic drugs with the host, gut microbiota, and SARS-CoV-2. Here we summarize scientific evidence supporting the potential relevance of these interactions and suggest that unfavorable clinical data on hydroxychloroquine administration in COVID-19 may have been influenced by the dose provided and its impact on gut dysbiosis. The proposition is based on preliminary data on gut microbiota composition from individuals with inactive systemic lupus erythematosus under exclusive continuous hydroxychloroquine treatment, displaying a direct correlation between drug doses and markers typically associated with gut dysbiosis.
    MeSH term(s) COVID-19/drug therapy ; COVID-19/microbiology ; Dysbiosis/chemically induced ; Gastrointestinal Microbiome/drug effects ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/therapeutic use
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2020-12-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2020.111115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2290: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Effects of L-Arginine Supplementation on Leukogram, Inflammatory Bowel Infiltrates and Immunoglobulins with 5-FU Use in Rats.

    Balmant, Bianca D / Araújo, Eloisa O N / Yabuki, Denise / Novais, Amanda B / Genaro, Sandra C / Laposy, Cecilia B / Goiozo, Paulo F I / Chacur, Marcelo G M / Giuffrida, Rogério / Reis, Luis S L S

    Nutrition and cancer

    2018  Volume 70, Issue 2, Page(s) 249–256

    Abstract: This study evaluated the effects of L-arginine supplementation on blood parameters, kidney and liver function, immunoglobulins and noninflammatory infiltrates in the small intestines of rats subjected to chemotherapy with 5-fluorouracil (5-FU). Thirty- ... ...

    Abstract This study evaluated the effects of L-arginine supplementation on blood parameters, kidney and liver function, immunoglobulins and noninflammatory infiltrates in the small intestines of rats subjected to chemotherapy with 5-fluorouracil (5-FU). Thirty-two Wistar rats were randomly distributed into 4 groups (8 rats/group): an untreated control group, and test groups receiving one dose of 5-FU (G
    MeSH term(s) Animals ; Antimetabolites, Antineoplastic/adverse effects ; Arginine/pharmacology ; Dietary Supplements ; Enteritis/chemically induced ; Enteritis/drug therapy ; Fluorouracil/adverse effects ; Immunoglobulins/blood ; Intestine, Small/drug effects ; Intestine, Small/pathology ; Kidney Function Tests ; Leukopenia/chemically induced ; Leukopenia/drug therapy ; Liver/drug effects ; Liver/enzymology ; Male ; Neutropenia/chemically induced ; Neutropenia/drug therapy ; Rats, Wistar
    Chemical Substances Antimetabolites, Antineoplastic ; Immunoglobulins ; Arginine (94ZLA3W45F) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2018-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2018.1424346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Effects of L-Arginine Supplementation on Leukogram, Inflammatory Bowel Infiltrates and Immunoglobulins with 5-FU Use in Rats

    Balmant, Bianca D / Amanda B. Novais / Cecilia B. Laposy / Denise Yabuki / Eloisa O. N. Araújo / Luis S. L. S. Reis / Marcelo G. M. Chacur / Paulo F. I. Goiozo / Rogério Giuffrida / Sandra C. Genaro

    Nutrition and cancer. 2018 Feb. 17, v. 70, no. 2

    2018  

    Abstract: This study evaluated the effects of L-arginine supplementation on blood parameters, kidney and liver function, immunoglobulins and noninflammatory infiltrates in the small intestines of rats subjected to chemotherapy with 5-fluorouracil (5-FU). Thirty- ... ...

    Abstract This study evaluated the effects of L-arginine supplementation on blood parameters, kidney and liver function, immunoglobulins and noninflammatory infiltrates in the small intestines of rats subjected to chemotherapy with 5-fluorouracil (5-FU). Thirty-two Wistar rats were randomly distributed into 4 groups (8 rats/group): an untreated control group, and test groups receiving one dose of 5-FU (G5−FU group), one dose of 5-FU and 295 mg L-arginine/day (GArg295 group) or one dose of 5-FU and 458 mg L-arginine/day (GArg458 group). Neutrophil count, platelet count, serum IgA, and fibrinogen levels in GArg295 and GArg458 remained within normal limits after chemotherapy. In addition, in GArg458 the inflammatory bowel infiltrates improved in 57% of the rats, which showed mild inflammation. The results suggest that daily supplementation with 295 or 458 mg L-arginine attenuates the side effects of 5-FU, including thrombocytopenia and neutropenia, and modulates IgA production. Supplementation with 458 mg of L-arginine/day can also reduce mucositis levels in the small intestine after 5-FU chemotherapy.
    Keywords adverse effects ; arginine ; blood platelet count ; blood serum ; drug therapy ; fibrinogen ; fluorouracil ; immunoglobulin A ; inflammation ; kidneys ; liver function ; neutropenia ; neutrophils ; rats ; small intestine ; thrombocytopenia
    Language English
    Dates of publication 2018-0217
    Size p. 249-256.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2025822-7
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2018.1424346
    Database NAL-Catalogue (AGRICOLA)

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