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  1. Article ; Online: The new look of classification criteria for systemic vasculitis.

    Emmi, Giacomo / Vaglio, Augusto

    Nature reviews. Rheumatology

    2023  Volume 19, Issue 4, Page(s) 198–199

    MeSH term(s) Humans ; Systemic Vasculitis/diagnosis ; Vasculitis/diagnosis
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-023-00933-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6338: Show issues Location:
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  2. Article ; Online: Behçet's syndrome.

    Emmi, Giacomo / Bettiol, Alessandra / Hatemi, Gülen / Prisco, Domenico

    Lancet (London, England)

    2024  Volume 403, Issue 10431, Page(s) 1093–1108

    Abstract: Behçet's syndrome is a rare, chronic multisystemic inflammatory disorder also known as the Silk Route disease due to its geographical distribution. Behçet's syndrome is a multifactorial disease and infectious, genetic, epigenetic, and immunological ... ...

    Abstract Behçet's syndrome is a rare, chronic multisystemic inflammatory disorder also known as the Silk Route disease due to its geographical distribution. Behçet's syndrome is a multifactorial disease and infectious, genetic, epigenetic, and immunological factors contribute to its pathogenesis. Its heterogeneous spectrum of clinical features include mucocutaneous, articular, ocular, vascular, neurological, and gastrointestinal manifestations that can present with a relapsing and remitting course. Differential diagnosis is often hampered by the non-specific clinical presentation and the absence of laboratory biomarkers or pathognomonic histological features. The therapeutic approach is tailored on the basis of patient-specific manifestations and relies on glucocorticoids, colchicine, and traditional and biological immunosuppressants. Despite progress in the knowledge and management of the disease, unmet needs in diagnostics, monitoring, prediction, and treatment personalisation challenge clinical practice, making Behçet's syndrome a complex disorder associated with an increased risk of morbidity.
    MeSH term(s) Humans ; Behcet Syndrome/diagnosis ; Behcet Syndrome/complications ; Behcet Syndrome/drug therapy ; Immunosuppressive Agents/therapeutic use ; Glucocorticoids/therapeutic use ; Recurrence ; Diagnosis, Differential
    Chemical Substances Immunosuppressive Agents ; Glucocorticoids
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02629-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Biologics for eosinophilic granulomatosis with polyangiitis.

    Caminati, Marco / Maule, Matteo / Bello, Federica / Emmi, Giacomo

    Current opinion in allergy and clinical immunology

    2022  Volume 23, Issue 1, Page(s) 36–43

    Abstract: Purpose of review: The link between severe asthma and eosinophilic granulomatosis with polyangiitis (EGPA) in terms of pathophysiological background, clinical manifestations and disease evolution has leaded to investigate the relevance of anti T2 ... ...

    Abstract Purpose of review: The link between severe asthma and eosinophilic granulomatosis with polyangiitis (EGPA) in terms of pathophysiological background, clinical manifestations and disease evolution has leaded to investigate the relevance of anti T2 monoclonal antibodies licensed for severe asthma patients as a treatment option for EGPA. The present review aimed to provide un update on EGPA pathophysiology and to critically summarize the most robust evidence coming from trials and real-life setting on the use of anti T2 biologics in EGPA patients.
    Recent findings: Mepolizumab, an anti-interleukin-5 monoclonal antibody, is the only biologic drug targeting eosinophilic inflammation currently approved for EGPA treatment at the dose of 300 mg/4 weeks. Its use is restricted by the American College of Rheumatology guidelines to specific diseases phases and severity grades. However the most appropriate mepolizumab positioning and dose is still under investigation in the real life practice, which is providing an increasing amount of evidence confirming its efficacy, alone or in combination with other options in different disease stages. The relevance of other monoclonal antibodies interfering with T2 inflammation, including omalizumab and benralizumab, is under investigation but the evidence is still scarce.
    Summary: Taking into account the suboptimal medium-long term safety profile of conventional EGPA treatments, the opportunity of selectively targeting eosinophilic inflammation certainly represents a revolutionary approach. However, further real-word evidence is required to effectively position the new treatments in the light of the disease complexity, including different immunological drivers, and individual variability.
    MeSH term(s) Humans ; Granulomatosis with Polyangiitis/drug therapy ; Churg-Strauss Syndrome/drug therapy ; Biological Products/therapeutic use ; Biological Products/pharmacology ; Eosinophils ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal/pharmacology ; Eosinophilia ; Asthma/therapy ; Inflammation
    Chemical Substances Biological Products ; Antibodies, Monoclonal
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000875
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    Zs.A 5666: Show issues Location:
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  4. Article: SIRT1 and thrombosis.

    Bettiol, Alessandra / Urban, Maria Letizia / Emmi, Giacomo / Galora, Silvia / Argento, Flavia Rita / Fini, Eleonora / Borghi, Serena / Bagni, Giacomo / Mattioli, Irene / Prisco, Domenico / Fiorillo, Claudia / Becatti, Matteo

    Frontiers in molecular biosciences

    2024  Volume 10, Page(s) 1325002

    Abstract: Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin family of NAD + -dependent deacetylases, plays a crucial role in regulating ... ...

    Abstract Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin family of NAD + -dependent deacetylases, plays a crucial role in regulating thrombosis, modulating key pathways including endothelial activation, platelet aggregation, and coagulation. Furthermore, SIRT1 displays anti-inflammatory activity both
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1325002
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  5. Article ; Online: Microbiome in Behcet's syndrome.

    Bettiol, Alessandra / Emmi, Giacomo / Low, Liying / Sofi, Francesco / Wallace, Graham R

    Clinical immunology (Orlando, Fla.)

    2023  Volume 250, Page(s) 109304

    Abstract: This review will discuss the current understanding of the role of microbiomes in Behcet's Syndrome, their influence on immune response and disease and potential future studies. ...

    Abstract This review will discuss the current understanding of the role of microbiomes in Behcet's Syndrome, their influence on immune response and disease and potential future studies.
    MeSH term(s) Humans ; Behcet Syndrome ; Immunity ; Microbiota
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2023.109304
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    Zs.A 880: Show issues Location:
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  6. Article ; Online: Reply.

    Emmi, Giacomo / Bettiol, Alessandra

    Arthritis & rheumatology (Hoboken, N.J.)

    2019  Volume 71, Issue 4, Page(s) 657–658

    MeSH term(s) Adalimumab ; Antirheumatic Agents ; Behcet Syndrome ; Humans ; Retrospective Studies ; Venous Thrombosis
    Chemical Substances Antirheumatic Agents ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2019-03-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.40794
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    Zs.A 24: Show issues Location:
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  7. Article ; Online: IgG4-related disease: not just a matter of IgG4.

    Trivioli, Giorgio / Bond, Milena / Emmi, Giacomo / Vaglio, Augusto

    Rheumatology (Oxford, England)

    2021  Volume 60, Issue Suppl 3, Page(s) iii35–iii38

    MeSH term(s) Humans ; Immunoglobulin G4-Related Disease/complications ; Immunoglobulin G4-Related Disease/diagnostic imaging ; Male ; Middle Aged ; Retroperitoneal Fibrosis/etiology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-06-17
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keab039
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    Zs.B 240: Show issues Location:
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    Zs.MO 497: Show issues

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  8. Article ; Online: Editorial: "Toward Precision Medicine in Vasculitis".

    Alberici, Federico / Emmi, Giacomo / Kronbichler, Andreas

    Frontiers in immunology

    2020  Volume 11, Page(s) 616221

    MeSH term(s) Humans ; Precision Medicine ; Vasculitis/therapy
    Language English
    Publishing date 2020-11-17
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.616221
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  9. Article ; Online: Behçet's syndrome: focus on pathogenetic background, clinical phenotypes and specific treatments.

    Emmi, Giacomo / Prisco, Domenico

    Internal and emergency medicine

    2019  Volume 14, Issue 5, Page(s) 639–643

    MeSH term(s) Aminopeptidases/adverse effects ; Aminopeptidases/genetics ; Behcet Syndrome/etiology ; Behcet Syndrome/genetics ; HLA Antigens/adverse effects ; HLA Antigens/genetics ; Humans ; Minor Histocompatibility Antigens/adverse effects ; Minor Histocompatibility Antigens/genetics
    Chemical Substances HLA Antigens ; Minor Histocompatibility Antigens ; Aminopeptidases (EC 3.4.11.-) ; ERAP1 protein, human (EC 3.4.11.-)
    Language English
    Publishing date 2019-07-17
    Publishing country Italy
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-019-02154-9
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  10. Article: Eosinophilic Granulomatosis With Polyangiitis: Dissecting the Pathophysiology.

    Fagni, Filippo / Bello, Federica / Emmi, Giacomo

    Frontiers in medicine

    2021  Volume 8, Page(s) 627776

    Abstract: Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare multisystemic disease classified both amongst hypereosinophilic disorders and ANCA-associated vasculitis. Vessel inflammation and eosinophilic proliferation are the hallmarks of the disease ... ...

    Abstract Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare multisystemic disease classified both amongst hypereosinophilic disorders and ANCA-associated vasculitis. Vessel inflammation and eosinophilic proliferation are the hallmarks of the disease and main effectors of organ damage. Two distinct disease phenotypes have classically been described according to ANCA-status: the ANCA-negative subset with eosinophil-driven manifestation and the ANCA-positive one with vasculitic manifestations. An analogous dichotomization has also been backed by histological findings and a distinct genetic background. EGPA is typically consider a Th2-mediated disease and blood and tissue eosinophilia represent the cornerstone of diagnosis. Besides, ANCA are known for inducing endothelial injury and vascular inflammation by activating the circulating neutrophils. Thus, the pathogenesis of EGPA seems to be mediated by two coexisting mechanisms. However, the verbatim application of this strict dualism cannot always be translated into routine clinical practice. In the present review we describe the current knowledge on the eosinophilic and ANCA-mediated aspects of EGPA pathogenesis. Finally, we review the rationale of the currently proposed EGPA dichotomy and future research perspectives.
    Language English
    Publishing date 2021-02-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.627776
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