Article ; Online: Protective effects of Chinese Fenggang zinc selenium tea on metabolic syndrome in high-sucrose-high-fat diet-induced obese rats.
2018 Volume 8, Issue 1, Page(s) 3528
Abstract: The protective effect of zinc selenium tea against metabolic syndrome (MetS) was tested by using a high-sucrose-high-fat diet (HSHFD)-induced MetS model. Fifty Sprague-Dawley rats were randomly divided into five groups: normal diet (C-group), HSHFD (CH- ... ...
Abstract | The protective effect of zinc selenium tea against metabolic syndrome (MetS) was tested by using a high-sucrose-high-fat diet (HSHFD)-induced MetS model. Fifty Sprague-Dawley rats were randomly divided into five groups: normal diet (C-group), HSHFD (CH-group), HSHFD + green tea (0.24 g/kg/day) (TH-group), HSHFD + low-dose zinc selenium organic tea (0.24 g/kg/day) (ZTHL-group), and HSHFD + high-dose zinc selenium organic tea (1.20 g/kg/day) (ZTHH-group). After 8 weeks, compared to both the C-group and CH-group, the hepatosomatic index (HI) was significantly reduced in the ZTHL-group (p < 0.05). Fasting blood glucose (FBG) levels were highest in the TH-group, followed by the CH-group, then the ZTHL-group, then the ZTHH-group, and finally the C-group. Compared with the CH-group, the serum total cholesterol (TC) and low density lipid-cholesterol (LDL-C) concentrations were significantly lower in the ZTHH-group (p < 0.05). Significant decreases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acids (TBA), alkaline phosphatase (ALP), and direct bilirubin (DBIL) levels were observed in ZTHL-group versus the CH-group (p < 0.05). Serum alpha-L-fucosidase (AFU) levels in the ZTHH-group were lower than in the CH-group (P < 0.01). Histopathological examination of the liver and fat biopsies illustrates that the liver cells showed a decrease in the extent of necrosis and dropsy in the ZTHL-group and ZTHH-group versus the CH-group. Zinc selenium tea showed a protection effect against hepatic damage. |
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MeSH term(s) | Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Animals ; Antioxidants/pharmacology ; Aspartate Aminotransferases/blood ; Bilirubin/blood ; Blood Glucose/metabolism ; Cholesterol, LDL/antagonists & inhibitors ; Cholesterol, LDL/blood ; Diet, High-Fat/adverse effects ; Dose-Response Relationship, Drug ; Fasting ; Female ; Hypoglycemic Agents/pharmacology ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Function Tests ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/drug therapy ; Metabolic Syndrome/etiology ; Metabolic Syndrome/pathology ; Obesity/blood ; Obesity/drug therapy ; Obesity/etiology ; Obesity/pathology ; Rats ; Rats, Sprague-Dawley ; Selenium Compounds/pharmacology ; Sucrose/administration & dosage ; Tea/chemistry ; Zinc Compounds/pharmacology ; alpha-L-Fucosidase/blood |
Chemical Substances | Antioxidants ; Blood Glucose ; Cholesterol, LDL ; Hypoglycemic Agents ; Selenium Compounds ; Tea ; Zinc Compounds ; zinc selenite (13597-46-1) ; Sucrose (57-50-1) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Alkaline Phosphatase (EC 3.1.3.1) ; alpha-L-Fucosidase (EC 3.2.1.51) ; Bilirubin (RFM9X3LJ49) |
Language | English |
Publishing date | 2018-02-23 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2615211-3 |
ISSN | 2045-2322 ; 2045-2322 |
ISSN (online) | 2045-2322 |
ISSN | 2045-2322 |
DOI | 10.1038/s41598-018-21913-w |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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