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  1. Article ; Online: Letter to the Editor:

    Ciccullo, Arturo / Iannone, Valentina / Lombardi, Francesca / Borghetti, Alberto / Di Giambenedetto, Simona

    AIDS research and human retroviruses

    2024  

    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2023.0057
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1928: Show issues Location:
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  2. Article ; Online: Early use of tecovirimat in a young man with severe mpox skin lesions: a case report.

    Iannone, Valentina / Ciccullo, Arturo / Farinacci, Damiano / Borghetti, Alberto / Visconti, Elena / Marchetti, Simona / Sanguinetti, Maurizio / Tamburrini, Enrica / Di Giambenedetto, Simona

    Journal of medical virology

    2023  Volume 95, Issue 2, Page(s) e28528

    MeSH term(s) Male ; Humans ; Mpox (monkeypox) ; Benzamides ; Isoindoles
    Chemical Substances Benzamides ; Isoindoles
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28528
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    Zs.A 1320: Show issues Location:
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  3. Article ; Online: Real-life findings on the impact of the COVID-19 pandemic on HIV care.

    Ciccullo, Arturo / Baldin, Gianmaria / Borghetti, Alberto / Di Giambenedetto, Simona

    Antiviral therapy

    2021  Volume 26, Issue 3-5, Page(s) 84–86

    MeSH term(s) COVID-19 ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Influenza, Human/epidemiology ; Pandemics
    Language English
    Publishing date 2021-10-19
    Publishing country England
    Document type Letter
    ZDB-ID 1339842-8
    ISSN 2040-2058 ; 1359-6535
    ISSN (online) 2040-2058
    ISSN 1359-6535
    DOI 10.1177/13596535211052215
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    Zs.A 4877: Show issues Location:
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    Zs.MO 174: Show issues

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  4. Article: Quantification of Total HIV DNA as a Marker to Measure Viral Reservoir: Methods and Potential Implications for Clinical Practice.

    Belmonti, Simone / Di Giambenedetto, Simona / Lombardi, Francesca

    Diagnostics (Basel, Switzerland)

    2021  Volume 12, Issue 1

    Abstract: The focus of this review is to examine the importance of quantifying total HIV DNA to target the HIV reservoir and the clinical implications and challenges involved in its future application in clinical practice. Despite intrinsic limitations, the ... ...

    Abstract The focus of this review is to examine the importance of quantifying total HIV DNA to target the HIV reservoir and the clinical implications and challenges involved in its future application in clinical practice. Despite intrinsic limitations, the quantification of total HIV DNA is currently the most widely used marker for exploring the HIV reservoir. As it allows estimating all forms of HIV DNA in the infected cells, total HIV DNA load is the biomarker of the HIV reservoir that provides most of the insights into HIV pathogenesis. The clinical role of total HIV-DNA in both untreated and treated patients is extensively supported by important lines of evidence. Thus, predictive models that include total HIV DNA load together with other variables could constitute a prognostic tool for use in clinical practice. To date, however, this marker has been primarily used in experimental evaluations. The main challenge is technical. Although the implementation of droplet digital PCR could improve analytical performance over real-time PCR, the lack of standardization has made cross-comparisons of the data difficult. An effort by investigators to compare protocols is needed. Furthermore, the main effort now should be to involve the biomedical industry in the development of certified assays for in vitro diagnostics use.
    Language English
    Publishing date 2021-12-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12010039
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  5. Article ; Online: Quantification of Total HIV DNA as a Marker to Measure Viral Reservoir

    Simone Belmonti / Simona Di Giambenedetto / Francesca Lombardi

    Diagnostics, Vol 12, Iss 39, p

    Methods and Potential Implications for Clinical Practice

    2022  Volume 39

    Abstract: The focus of this review is to examine the importance of quantifying total HIV DNA to target the HIV reservoir and the clinical implications and challenges involved in its future application in clinical practice. Despite intrinsic limitations, the ... ...

    Abstract The focus of this review is to examine the importance of quantifying total HIV DNA to target the HIV reservoir and the clinical implications and challenges involved in its future application in clinical practice. Despite intrinsic limitations, the quantification of total HIV DNA is currently the most widely used marker for exploring the HIV reservoir. As it allows estimating all forms of HIV DNA in the infected cells, total HIV DNA load is the biomarker of the HIV reservoir that provides most of the insights into HIV pathogenesis. The clinical role of total HIV-DNA in both untreated and treated patients is extensively supported by important lines of evidence. Thus, predictive models that include total HIV DNA load together with other variables could constitute a prognostic tool for use in clinical practice. To date, however, this marker has been primarily used in experimental evaluations. The main challenge is technical. Although the implementation of droplet digital PCR could improve analytical performance over real-time PCR, the lack of standardization has made cross-comparisons of the data difficult. An effort by investigators to compare protocols is needed. Furthermore, the main effort now should be to involve the biomedical industry in the development of certified assays for in vitro diagnostics use.
    Keywords HIV ; HIV DNA ; total HIV-1 DNA ; reservoirs ; real-time PCR ; digital droplet PCR ; Medicine (General) ; R5-920
    Subject code 310
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant

    Passerotto, Rosa Anna / Lamanna, Francesco / Farinacci, Damiano / Dusina, Alex / Di Giambenedetto, Simona / Ciccullo, Arturo / Borghetti, Alberto

    Infectious medicine

    2023  Volume 2, Issue 2, Page(s) 143–147

    Abstract: We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit ( ... ...

    Abstract We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit (ICU). The hospitalization was complicated by bacteraemic ventilator-associated pneumonia (VAP) caused by multidrug-resistant
    Language English
    Publishing date 2023-03-04
    Publishing country China
    Document type Case Reports
    ISSN 2772-431X
    ISSN (online) 2772-431X
    DOI 10.1016/j.imj.2023.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comment on: Long-term outcome of dolutegravir-containing regimens according to sex: data from the ICONA study.

    Ciccullo, Arturo / Baldin, Gianmaria / Sterrantino, Gaetana / Madeddu, Giordano / D'ettorre, Gabriella / Mussini, Cristina / Di Giambenedetto, Simona

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 7, Page(s) 1808–1809

    MeSH term(s) Humans ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Oxazines/therapeutic use ; Heterocyclic Compounds, 3-Ring/adverse effects ; Pyridones/therapeutic use
    Chemical Substances dolutegravir (DKO1W9H7M1) ; Anti-HIV Agents ; Oxazines ; Heterocyclic Compounds, 3-Ring ; Pyridones
    Language English
    Publishing date 2023-05-22
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Letter ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad151
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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  8. Article ; Online: Rapid improvement of severe Mpox lesions with oral tecovirimat.

    Raccagni, Angelo Roberto / Leoni, Davide / Ciccullo, Arturo / Verdenelli, Stefano / Cattelan, Anna Maria / Di Giambenedetto, Simona / Falcone, Marco / Mileto, Davide / Castagna, Antonella / Nozza, Silvia

    Journal of medical virology

    2023  Volume 95, Issue 6, Page(s) e28825

    MeSH term(s) Humans ; Mpox (monkeypox)
    Language English
    Publishing date 2023-05-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28825
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  9. Article ; Online: Home Care Assistance: Has Covid-19 had an Impact on the Complex Management of HIV Patients?

    Dusina, Alex / Lombardi, Francesca / Tamburrini, Enrica / Onorati, Fiorella / Petrucci, Massimo / Di Giambenedetto, Simona

    AIDS and behavior

    2022  Volume 27, Issue 4, Page(s) 1173–1181

    Abstract: ... the period 2015-2020, both the activities of our home care assistance unit, the "Unità di Trattamento ...

    Abstract During the COVID-19 pandemic, people living with HIV (PLWH) could have had to face problems with treatment adherence because of the difficulty of accessing services connected with antiretroviral therapy (ART) dispensation, which could have undermined their health. In this article, we described, over the period 2015-2020, both the activities of our home care assistance unit, the "Unità di Trattamento Domiciliare (UTD)", and the characteristics of the comorbid HIV patients followed-up. To determine whether the COVID-19 pandemic affected this service, we compared the number/type of services provided in 2020 with those provided in the preceding 5 years, i.e., 2015-2019. We also compared the proportion of monthly interventions carried out in 2018, 2019 and 2020. We found comparable values with some differences in the types of performances due to the heterogeneity of the population and their medical assistance needs. We also observed a stable viro-immunological status of the patients. All of these data suggest that the UTD was consistently active during the lockdown months and pandemic waves preventing therapy discontinuation, and was able to maintain optimal control of patients' HIV infections.
    MeSH term(s) Humans ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; COVID-19/epidemiology ; Pandemics ; Communicable Disease Control ; Home Care Services
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-022-03854-8
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    Zs.A 6451: Show issues Location:
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  10. Article ; Online: Two-Drug Regimen Containing Darunavir: Metabolic Evaluation of an Old Dual Therapy.

    Farinacci, Damiano / Iannone, Valentina / D'Angelillo, Anna / Borghetti, Alberto / Passerotto, Rosa Anna / Lamanna, Francesco / Di Giambenedetto, Simona

    AIDS research and human retroviruses

    2023  Volume 39, Issue 12, Page(s) 633–635

    Abstract: Regimens containing darunavir are one of the first one with two drugs that demonstrated good efficacy as a simplification strategy. We wanted to describe the characteristics of patients followed in our center on a dual therapy regimen containing ... ...

    Abstract Regimens containing darunavir are one of the first one with two drugs that demonstrated good efficacy as a simplification strategy. We wanted to describe the characteristics of patients followed in our center on a dual therapy regimen containing darunavir evaluating the metabolic aspects during follow-ups. We collected data from 208 patients switching to lamivudine plus darunavir with either ritonavir or cobicistat between 2010 and 2019. In all patients we found an increase in low-density lipoprotein (LDL), with no rising in creatinine, total cholesterol, or triglycerides. Twenty-five patients reached 120 weeks of follow-up. In these patients, no significant metabolic changes were described without concomitant treatment with drugs for dyslipidemia. These regimens seem to be more tolerable in metabolic profile compared with the data concerning three-drug therapies, leading only to a slight increase in LDL. The main reason for discontinuation was for a single-tablet therapy. None of the patients started treatment for dyslipidemia.
    MeSH term(s) Humans ; Darunavir ; HIV Infections/drug therapy ; Anti-HIV Agents/adverse effects ; Cobicistat/therapeutic use ; Ritonavir/therapeutic use ; Ritonavir/adverse effects ; Drug Therapy, Combination ; Viral Load ; Dyslipidemias/drug therapy ; Dyslipidemias/chemically induced
    Chemical Substances Darunavir (YO603Y8113) ; Anti-HIV Agents ; Cobicistat (LW2E03M5PG) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2023.0023
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