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  1. Article: A 40-Year-Old Female With Mycobacterium abscessus Successfully Treated With a Dual Beta-Lactam Combination.

    Moguillansky, Natalia / DeSear, Kathryn / Dousa, Khalid M

    Cureus

    2023  Volume 15, Issue 6, Page(s) e40993

    Abstract: Nontuberculous mycobacteria (NTM) infections are difficult to treat conditions, ... ...

    Abstract Nontuberculous mycobacteria (NTM) infections are difficult to treat conditions, specially
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.40993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Case Commentary: Another prong of attack? Topical antibiotic instillation with negative pressure wound therapy for nontuberculous mycobacterial skin and soft tissue infections.

    Nguyen, David C / Buettner, Angel M / Dousa, Khalid M

    Antimicrobial agents and chemotherapy

    2023  Volume 67, Issue 12, Page(s) e0104823

    Abstract: Nontuberculous mycobacteria (NTM) skin infections remain therapeutically challenging. Given the diversity in infections, host responses, and antimicrobials, clinical guidelines are often built on case series and observational studies. In this commentary, ...

    Abstract Nontuberculous mycobacteria (NTM) skin infections remain therapeutically challenging. Given the diversity in infections, host responses, and antimicrobials, clinical guidelines are often built on case series and observational studies. In this commentary, we respond to a paper by Stemkens et al. that introduces an emerging strategy: adjunctive negative pressure wound therapy with instillation and dwell time combined with topical antibiotics for refractory NTM skin and soft tissue infections. We delve into the primary considerations surrounding this innovative approach.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Nontuberculous Mycobacteria ; Soft Tissue Infections/drug therapy ; Soft Tissue Infections/microbiology ; Negative-Pressure Wound Therapy ; Skin Diseases, Bacterial/drug therapy ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/microbiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01048-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
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  3. Article: Eradicating Pulmonary

    Alahmdi, Bayan / Dousa, Khalid M / Kurz, Sebastian G / Kaufman, Andrew / Bonomo, Robert A / Taimur, Sarah

    Open forum infectious diseases

    2023  Volume 10, Issue 6, Page(s) ofad312

    Abstract: Macrolide resistance has rendered the treatment ... ...

    Abstract Macrolide resistance has rendered the treatment of
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad312
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  4. Article ; Online: Durlobactam, a Diazabicyclooctane β-Lactamase Inhibitor, Inhibits BlaC and Peptidoglycan Transpeptidases of

    Nantongo, Mary / Nguyen, David C / Bethel, Christopher R / Taracila, Magdalena A / Li, Qing / Dousa, Khalid M / Shin, Eunjeong / Kurz, Sebastian G / Nguyen, Liem / Kreiswirth, Barry N / Boom, W Henry / Plummer, Mark S / Bonomo, Robert A

    ACS infectious diseases

    2024  

    Abstract: Peptidoglycan synthesis is an underutilized drug target ... ...

    Abstract Peptidoglycan synthesis is an underutilized drug target in
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.4c00119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Containment of COVID-19 outbreak at a veterans affairs community living center.

    Dousa, Khalid M / Hmiel, Laura / Klonowski, Brian / Zabarsky, Trina F / Pyatt, Kimberly / Stiefel, Usha / Donskey, Curtis J / Jump, Robin Lp

    Journal of infection prevention

    2023  Volume 24, Issue 3, Page(s) 132–136

    Abstract: Asymptomatic and pre-symptomatic staff and residents likely contribute to widespread transmission of COVID-19 in long-term care settings. Here, we describe the successful containment of a COVID-19 outbreak on one floor of a 163-bed Veterans Affairs (VA) ... ...

    Abstract Asymptomatic and pre-symptomatic staff and residents likely contribute to widespread transmission of COVID-19 in long-term care settings. Here, we describe the successful containment of a COVID-19 outbreak on one floor of a 163-bed Veterans Affairs (VA) Community Living Center (CLC). Testing using nasopharyngeal swabs with a rapid turn-around-time identified 3 of 28 (11%) residents and 2 of 41 (5%) healthcare personnel (HCP) with COVID-19. Both HCP likely worked on the floor while pre-symptomatic. When one HCP reported a cough to the secondary (employee) screening clinic, she was erroneously advised to work. Protocols to limit the risk for HCP to import COVID-19 were reinforced with Community Living Center staff as well as with personnel in secondary screening. Further, the CLC implemented an expanded screening tool that assessed residents for typical and atypical symptoms of COVID-19. No further cases of COVID-19 were detected on the CLC floor in the subsequent 6 weeks. Swift recognition and response helped contain the outbreak and prevent further COVID-19 infections among other residents and staff.
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2595000-9
    ISSN 1757-1782 ; 1757-1774
    ISSN (online) 1757-1782
    ISSN 1757-1774
    DOI 10.1177/17571774231158205
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  6. Article ; Online: Drug-Resistant Tuberculosis: A Glance at Progress and Global Challenges.

    Dousa, Khalid M / Kurz, Sebastian G / Bark, Charles M / Bonomo, Robert A / Furin, Jennifer J

    Infectious disease clinics of North America

    2020  Volume 34, Issue 4, Page(s) 863–886

    Abstract: Multidrug-resistant Mycobacterium tuberculosis remains a major public health threat; its management poses a significant economic burden. Treatment requires a programmatic approach with access to laboratory services, second-line medications, and adequate ... ...

    Abstract Multidrug-resistant Mycobacterium tuberculosis remains a major public health threat; its management poses a significant economic burden. Treatment requires a programmatic approach with access to laboratory services, second-line medications, and adequate clinical resources. In recent years, we have seen rapid developments in diagnostic techniques with whole genome sequencing-based drug susceptibility prediction now in reach, an array of new drugs that transform treatment regimens to purely oral formulations, and a steady stream of multinational trials that inform us about most efficient combinations. Our hope is that the current momentum keeps the ambitious goal to end tuberculosis in 2030 in reach.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Antitubercular Agents/pharmacology ; Early Diagnosis ; Genome, Bacterial ; Humans ; Microbial Sensitivity Tests ; Mutation ; Mycobacterium tuberculosis/classification ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Tuberculosis, Multidrug-Resistant/diagnosis ; Tuberculosis, Multidrug-Resistant/drug therapy ; Whole Genome Sequencing
    Chemical Substances Anti-Bacterial Agents ; Antitubercular Agents
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2020.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1187: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Mycobacterial Tenosynovitis After Sea Urchin Spine Injury in an Immunocompromised Patient.

    Vargas, Christina R / Kanwar, Anubhav / Dousa, Khalid M / Skalweit, Marion J / Rowe, David / Gatherwright, James

    Open forum infectious diseases

    2018  Volume 5, Issue 11, Page(s) ofy285

    Language English
    Publishing date 2018-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofy285
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  8. Article: SARS-CoV-2 infection in a patient on chronic hydroxychloroquine therapy: Implications for prophylaxis.

    Dousa, Khalid M / Malavade, Sharad S / Furin, Jennifer / Gripshover, Barbara / Hatszegi, Marjorie / Hojat, Leila / Saade, Elie / Salata, Robert A

    IDCases

    2020  Volume 20, Page(s) e00778

    Abstract: People exposed to COVID-19 have a risk of developing disease, and health care workers are at risk at a time when they are badly needed during a health care crisis. Hydroxychloroquine and chloroquine have been used as treatment and are being considered as ...

    Abstract People exposed to COVID-19 have a risk of developing disease, and health care workers are at risk at a time when they are badly needed during a health care crisis. Hydroxychloroquine and chloroquine have been used as treatment and are being considered as prophylaxis. Our patient developed COVID-19 while on hydroxychloroquine and although more work is needed, this calls into question the role of these medications as preventive therapy.
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2020.e00778
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  9. Article: Renal infarction in vascular Ehlers-Danlos syndrome masquerading as pyelonephritis.

    Dousa, Khalid M / Khan, Kashif / Alencherry, Ben / Deng, Lin / Salata, Robert A

    Clinical case reports

    2018  Volume 6, Issue 8, Page(s) 1478–1480

    Abstract: Symptoms associated with numerous diseases can be indistinguishable from those of the urinary system disorders because receptors of many visceral organs as well as the body wall transmit sensation through pain fibers shared with the kidneys. Disregarding ...

    Abstract Symptoms associated with numerous diseases can be indistinguishable from those of the urinary system disorders because receptors of many visceral organs as well as the body wall transmit sensation through pain fibers shared with the kidneys. Disregarding important family background of genetic disorder can be detrimental for some patients.
    Language English
    Publishing date 2018-06-13
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.1639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Progressive and disseminated histoplasma infection and hemophagocytic lymphohistiocytosis in an immunocompetent adult.

    Dousa, Khalid M / De la Hoz, Alejandro / Church, Elizabeth / Onger, Tiffany / Perez, Federico / Saade, Elie

    Clinical case reports

    2019  Volume 7, Issue 5, Page(s) 913–916

    Abstract: Hemophagocytic lymphohistiocytosis (HLH) in adults is a life-threatening underdiagnosed disorder that complicates different infectious syndromes and overlaps with sepsis. No guidelines are available for the management of HLH in adults. A high index of ... ...

    Abstract Hemophagocytic lymphohistiocytosis (HLH) in adults is a life-threatening underdiagnosed disorder that complicates different infectious syndromes and overlaps with sepsis. No guidelines are available for the management of HLH in adults. A high index of suspicion is required in patients with disseminated histoplasmosis.
    Language English
    Publishing date 2019-03-27
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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