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  1. Article ; Online: Non-invasive left ventricle pressure-volume loops: a new tool to track treatment response in cardiac transthyretin amyloidosis?

    Fontana, Marianna / Ioannou, Adam / Bandera, Francesco

    European journal of heart failure

    2023  Volume 25, Issue 5, Page(s) 737–739

    MeSH term(s) Humans ; Heart Ventricles/diagnostic imaging ; Heart Failure/etiology ; Amyloid Neuropathies, Familial/drug therapy ; Heart ; Cardiomyopathies/drug therapy
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5299: Show issues Location:
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  2. Article ; Online: Low-intensity pulsed ultrasound increases neurotrophic factors secretion and suppresses inflammation in

    Fontana, Francesco / Iacoponi, Francesco / Orlando, Fabio / Pratellesi, Tiziano / Cafarelli, Andrea / Ricotti, Leonardo

    Journal of neural engineering

    2023  Volume 20, Issue 2

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Humans ; Interleukin-8 ; Interleukin-10 ; Tumor Necrosis Factor-alpha ; Peripheral Nervous System Diseases/therapy ; Reactive Oxygen Species ; Hydrogen Peroxide ; Mechanotransduction, Cellular ; Inflammation/therapy ; Cytokines ; Anti-Inflammatory Agents ; Ultrasonic Waves
    Chemical Substances Interleukin-8 ; Interleukin-10 (130068-27-8) ; Tumor Necrosis Factor-alpha ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Cytokines ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/acc54e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6071: Show issues Location:
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  3. Article ; Online: Silver-positive kidney AL amyloidosis.

    Fontana, Francesco / Alfano, Gaetano / Verga, Laura / Magistroni, Riccardo / Donati, Gabriele

    Journal of nephrology

    2024  

    Language English
    Publishing date 2024-01-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01827-1
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    Zs.A 3369: Show issues Location:
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  4. Article: The Chemistry and the Anti-Inflammatory Activity of Polymethoxyflavonoids from

    Fontana, Gianfranco / Bruno, Maurizio / Sottile, Francesco / Badalamenti, Natale

    Antioxidants (Basel, Switzerland)

    2022  Volume 12, Issue 1

    Abstract: Polymethoxyflavonoids (PMFs) are a large group of compounds belonging to the more general class of flavonoids that possess a flavan carbon framework decorated with a variable number of methoxy groups. Hydroxylated polymethoxyflavonoids (HPMFs), instead, ... ...

    Abstract Polymethoxyflavonoids (PMFs) are a large group of compounds belonging to the more general class of flavonoids that possess a flavan carbon framework decorated with a variable number of methoxy groups. Hydroxylated polymethoxyflavonoids (HPMFs), instead, are characterized by the presence of both hydroxyl and methoxy groups in their structural unities. Some of these compounds are the aglycone part in a glycoside structure in which the glycosidic linkage can involve the -OH at various positions. These compounds are particular to
    Language English
    Publishing date 2022-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12010023
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  5. Article ; Online: Optimal low-intensity pulsed ultrasound stimulation for promoting anti-inflammatory effects in macrophages.

    Iacoponi, Francesco / Cafarelli, Andrea / Fontana, Francesco / Pratellesi, Tiziano / Dumont, Erik / Barravecchia, Ivana / Angeloni, Debora / Ricotti, Leonardo

    APL bioengineering

    2023  Volume 7, Issue 1, Page(s) 16114

    Abstract: In this paper, we stimulated M1-like macrophages (obtained from U937 cells) with low-intensity pulsed ultrasound (LIPUS) to lower pro-inflammatory cytokine production. A systematic screening of different frequencies, intensities, duty cycles, and ... ...

    Abstract In this paper, we stimulated M1-like macrophages (obtained from U937 cells) with low-intensity pulsed ultrasound (LIPUS) to lower pro-inflammatory cytokine production. A systematic screening of different frequencies, intensities, duty cycles, and exposure times was performed. The optimal stimulation conditions leading to a marked decrease in the release of inflammatory cytokines were determined to be 38 kHz, 250 mW/cm
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2473-2877
    ISSN (online) 2473-2877
    DOI 10.1063/5.0137881
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  6. Article ; Online: Home-based treatment of biologics for asthma: who, what, where, when and why.

    Menzella, Francesco / Fontana, Matteo / Ruggiero, Patrizia / Livrieri, Francesco / Facciolongo, Nicola

    Expert review of respiratory medicine

    2022  Volume 16, Issue 4, Page(s) 419–428

    Abstract: Introduction: The advent of biologic therapies for severe asthma has profoundly changed the management of this pathology. The introduction of home administration is therefore an important innovation to optimize the patients' management, even if there ... ...

    Abstract Introduction: The advent of biologic therapies for severe asthma has profoundly changed the management of this pathology. The introduction of home administration is therefore an important innovation to optimize the patients' management, even if there are many aspects that need to be clarified and pointed out.
    Areas covered: This review summarizes the path that led to the possibility of self-administration of biologics, and what the pandemic has changed in the management of these patients.
    Expert opinion: The growing understanding of asthma phenotypes and endotypes is enabling the careful selection of patients suitable for biologics. In this context, the availability of reliable and simple self-injection devices is important in implementing self-administration. The transition to self-injection is also possible thanks to the high safety profile of biologics. With attention, most patients may potentially be suitable for self-administration. The transition process from hospital to home administration can therefore be carried out correctly by clinicians with adequate expertise in the field of severe asthma and biologic therapies, with the support of other health professionals, pharmacists, and general practitioners. Home administration is probably the best way to guarantee high adherence and high-level satisfaction of patients, even in the long term.
    MeSH term(s) Anti-Asthmatic Agents/adverse effects ; Asthma/drug therapy ; Biological Products/adverse effects ; Humans ; Phenotype
    Chemical Substances Anti-Asthmatic Agents ; Biological Products
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2022.2057301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6963: Show issues Location:
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  7. Article: Cerebellar Metastases from Prostate Cancer Detected by PET/CT with

    Filippi, Luca / Fontana, Antonella / Guerrini, Francesco / Pompucci, Angelo / Bagni, Oreste

    Molecular imaging and radionuclide therapy

    2022  Volume 31, Issue 3, Page(s) 227–230

    Abstract: A 76-year-old male, previously submitted enucleation renal-cell carcinoma (pT1) and prostatectomy for prostate cancer (Gleason score 3+5, pT3b pN0 pMx), was submitted to positron emission/computed tomography (PET/CT) ... ...

    Abstract A 76-year-old male, previously submitted enucleation renal-cell carcinoma (pT1) and prostatectomy for prostate cancer (Gleason score 3+5, pT3b pN0 pMx), was submitted to positron emission/computed tomography (PET/CT) with
    Language English
    Publishing date 2022-10-21
    Publishing country Turkey
    Document type Journal Article
    ISSN 2146-1414
    ISSN 2146-1414
    DOI 10.4274/mirt.galenos.2021.59672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effect of near-infrared and blue laser light on vero E6 cells SARS-CoV-2 infection model.

    Zupin, Luisa / Clemente, Libera / Fontana, Francesco / Crovella, Sergio

    Journal of biophotonics

    2023  Volume 16, Issue 3, Page(s) e202200203

    Abstract: Photobiomodulation therapy (PBMT) employing laser light has been emerging as a safe strategy to challenge viruses. In this study the effect of blue and near-infrared (NIR) laser light was assessed in an in vitro model of SARS-CoV-2 infection. PBMT at ... ...

    Abstract Photobiomodulation therapy (PBMT) employing laser light has been emerging as a safe strategy to challenge viruses. In this study the effect of blue and near-infrared (NIR) laser light was assessed in an in vitro model of SARS-CoV-2 infection. PBMT at blue wavelength inhibited viral amplification when the virus was directly irradiated and then transferred to cell culture and when cells already infected were treated. The NIR wavelength resulted less efficacious showing a minor effect on the reduction of the viral load. The cells receiving the irradiated virus or directly irradiated rescued their viability to level comparable to not treated cells. Virion integrity and antigenicity were preserved after blue and NIR irradiation, suggesting that the PBMT antiviral effect was not correlated to viral lipidic envelope disruption. Our results suggested that PBMT can be considered a valid strategy to counteract SARS-CoV-2 infection, at least in vitro.
    MeSH term(s) Animals ; Chlorocebus aethiops ; Humans ; COVID-19 ; SARS-CoV-2 ; Vero Cells ; Light ; Lasers
    Language English
    Publishing date 2023-01-03
    Publishing country Germany
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202200203
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    Zs.A 6723: Show issues Location:
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  9. Article: Stem cells treatment in chronic ischemic heart disease: a narrative review.

    Carbone, Roberto G / Negrini, Simone / Murdaca, Giuseppe / Fontana, Vincenzo / Puppo, Francesco

    American journal of stem cells

    2023  Volume 12, Issue 4, Page(s) 65–72

    Abstract: Chronic ischemic heart disease remains a major cause of morbidity and mortality worldwide. Several trials have been performed to evaluate benefit of stem cells transplantation to restore cardiac function in short- and long-term period after myocardial ... ...

    Abstract Chronic ischemic heart disease remains a major cause of morbidity and mortality worldwide. Several trials have been performed to evaluate benefit of stem cells transplantation to restore cardiac function in short- and long-term period after myocardial infarction. This narrative review analyzes 24 clinical trials between 2005 and 2023 comprising 1824 patients with chronic heart disease without heart failure. Percent increase in left ventricular ejection fraction (LVEF) and decrease in New York Heart Association (NYHA) class at 6/12 months after stem cells transplantation are reported. Thirteen trials showed a statistically significant percent LVEF increase between 4% to 19% at 6/12 months after stem cells transplantation (
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2708996-4
    ISSN 2160-4150
    ISSN 2160-4150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Substance P-Botulinum Mediates Long-term Silencing of Pain Pathways that can be Re-instated with a Second Injection of the Construct in Mice.

    Maiarù, Maria / Leese, Charlotte / Silva-Hucha, Silvia / Fontana-Giusti, Sofia / Tait, Luke / Tamagnini, Francesco / Davletov, Bazbek / Hunt, Stephen P

    The journal of pain

    2024  

    Abstract: Chronic pain presents an enormous personal and economic burden and there is an urgent need for effective treatments. In a mouse model of chronic neuropathic pain, selective silencing of key neurons in spinal pain signalling networks with botulinum ... ...

    Abstract Chronic pain presents an enormous personal and economic burden and there is an urgent need for effective treatments. In a mouse model of chronic neuropathic pain, selective silencing of key neurons in spinal pain signalling networks with botulinum constructs resulted in a reduction of pain behaviours associated with the peripheral nerve. However, to establish clinical relevance it was important to know how long this silencing period lasted. Now, we show that neuronal silencing and the concomitant reduction of neuropathic mechanical and thermal hypersensitivity lasts for up to 120d following a single injection of botulinum construct. Crucially, we show that silencing and analgesia can then be reinstated with a second injection of the botulinum conjugate. Here we demonstrate that single doses of botulinum-toxin conjugates are a powerful new way of providing long-term neuronal silencing and pain relief. PERSPECTIVE: This research demonstrates that botulinum-toxin conjugates are a powerful new way of providing long-term neuronal silencing without toxicity following a single injection of the conjugate and have the potential for repeated dosing when silencing reverses.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018789-0
    ISSN 1528-8447 ; 1526-5900
    ISSN (online) 1528-8447
    ISSN 1526-5900
    DOI 10.1016/j.jpain.2024.01.331
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