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  1. Article ; Online: Towards stratified treatment of JIA

    Stephanie J.W. Shoop-Worrall / Saskia Lawson-Tovey / Lucy R. Wedderburn / Kimme L. Hyrich / Nophar Geifman / Aline Kimonyo / Alyssia McNeece / Andrew Dick / Andrew Morris / Annie Yarwood / Athimalaipet Ramanan / Bethany R. Jebson / Chris Wallace / Daniela Dastros-Pitei / Damian Tarasek / Elizabeth Ralph / Emil Carlsson / Emily Robinson / Emma Sumner /
    Fatema Merali / Fatjon Dekaj / Helen Neale / Hussein Al-Mossawi / Jacqui Roberts / Jenna F. Gritzfeld / Joanna Fairlie / John Bowes / John Ioannou / Melissa Kartawinata / Melissa Tordoff / Michael Barnes / Michael W. Beresford / Michael Stadler / Paul Martin / Rami Kallala / Sandra Ng / Samantha Smith / Sarah Clarke / Soumya Raychaudhuri / Stephen Eyre / Sumanta Mukherjee / Teresa Duerr / Thierry Sornasse / Vasiliki Alexiou / Victoria J. Burton / Wei-Yu Lin / Wendy Thomson / Zoe Wanstall

    EBioMedicine, Vol 100, Iss , Pp 104946- (2024)

    machine learning identifies subtypes in response to methotrexate from four UK cohortsResearch in context

    2024  

    Abstract: ... anti-rheumatic drug for juvenile idiopathic arthritis (JIA), despite only being either effective or tolerated in half ... of children and young people (CYP). To facilitate stratified treatment of early JIA, novel methods ... UK multicentre prospective cohorts of JIA within the CLUSTER consortium. JADAS components (active ...

    Abstract Summary: Background: Methotrexate (MTX) is the gold-standard first-line disease-modifying anti-rheumatic drug for juvenile idiopathic arthritis (JIA), despite only being either effective or tolerated in half of children and young people (CYP). To facilitate stratified treatment of early JIA, novel methods in machine learning were used to i) identify clusters with distinct disease patterns following MTX initiation; ii) predict cluster membership; and iii) compare clusters to existing treatment response measures. Methods: Discovery and verification cohorts included CYP who first initiated MTX before January 2018 in one of four UK multicentre prospective cohorts of JIA within the CLUSTER consortium. JADAS components (active joint count, physician (PGA) and parental (PGE) global assessments, ESR) were recorded at MTX start and over the following year.Clusters of MTX ‘response’ were uncovered using multivariate group-based trajectory modelling separately in discovery and verification cohorts. Clusters were compared descriptively to ACR Pedi 30/90 scores, and multivariate logistic regression models predicted cluster-group assignment. Findings: The discovery cohorts included 657 CYP and verification cohorts 1241 CYP. Six clusters were identified: Fast improvers (11%), Slow Improvers (16%), Improve-Relapse (7%), Persistent Disease (44%), Persistent PGA (8%) and Persistent PGE (13%), the latter two characterised by improvement in all features except one. Factors associated with clusters included ethnicity, ILAR category, age, PGE, and ESR scores at MTX start, with predictive model area under the curve values of 0.65–0.71. Singular ACR Pedi 30/90 scores at 6 and 12 months could not capture speeds of improvement, relapsing courses or diverging disease patterns. Interpretation: Six distinct patterns following initiation of MTX have been identified using methods in artificial intelligence. These clusters demonstrate the limitations in traditional yes/no treatment response assessment (e.g., ACRPedi30) and can form the basis ...
    Keywords Juvenile idiopathic arthritis ; Machine learning ; Treatment outcome ; Epidemiology ; Methotrexate ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 310
    Language English
    Publishing date 2024-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: [Quality value transfer of material benchmark of Guizhi Jia Gegen Decoction].

    Wan, Xin-Hao / Zhu, Wei-Feng / Yang, Li-Na / Zhong, Ling-Yun / Xia, Mei / Li, Zhe / Chen, Li-Hua / Zang, Zhen-Zhong / Guan, Yong-Mei

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2022  Volume 47, Issue 9, Page(s) 2430–2439

    Abstract: A total of 15 batches of the substance reference of Guizhi Jia Gegen Decoction(GZGGD) were prepared ...

    Abstract A total of 15 batches of the substance reference of Guizhi Jia Gegen Decoction(GZGGD) were prepared and the characteristic fingerprints of them were established. Furthermore, the similarity of the fingerprints and peak attributes were explored. The extraction rate, and the content and the transfer rate ranges of the index components, puerarin, paeoniflorin, liquiritin, and ammonium glycyrrhizate were determined for the analysis of the quality value transfer. The result demonstrated that the fingerprints of the 15 batches of the samples showed high similarity(>0.99). A total of 15 characteristic peaks were identified from the fingerprints, with 10 for Puerariae Lobatae Radix, 1 for Cinnamomi Ramulus, 2 for Paeoniae Radix Alba, and 2 for Glycyrrhizae Radix et Rhizoma. The content of puerarin was 11.05-18.35 mg·g~(-1) and the average transfer rate was 21.27%-39.49%. The corresponding figures were 7.95-10.90 mg·g~(-1) and 23.28%-43.23% for paeoniflorin, 3.25-4.95 mg·g~(-1) and 32.31%-61.27% for ammonium glycyrrhizate, and 3.65-5.80 mg·g~(-1) and 14.57%-27.05% for liquiritin. The extraction rate of the 15 batches of samples was in the range of 16.85%-21.78%. In this paper, the quality value transfer of the substance reference of GZGGD was analyzed based on characteristic fingerprint, content of index components, and the extraction rate. This study is expected to lay a basis for the quality control and further development of GZGGD.
    MeSH term(s) Ammonium Compounds ; Benchmarking ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal ; Paeonia
    Chemical Substances Ammonium Compounds ; Drugs, Chinese Herbal ; kakkon-to
    Language Chinese
    Publishing date 2022-03-05
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20211217.302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Erratum: JIA-WEI SHEN amp; RICHARD A. B. LESCHEN (2020) Revision of Eupines King of New Zealand (Coleoptera: Staphylinidae: Pselaphinae: Goniaceritae) Zootaxa, 4777: 001-084.

    Shen, Jia-Wei / Leschen, Richard A B

    Zootaxa

    2020  Volume 4809, Issue 3, Page(s) zootaxa.4809.3.13

    Language English
    Publishing date 2020-07-08
    Publishing country New Zealand
    Document type Journal Article ; Published Erratum
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.4809.3.13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Erratum: Bao, L.; Cai, W.; Zhang, X.; Liu, J.; Chen, H.; Wei, Y.; Jia, X.; Bai, Z. Distinct Microbial Community of Phyllosphere Associated with Five Tropical Plants on Yongxing Island, South China Sea.

    Bao, Lijun / Cai, Wenyang / Zhang, Xiaofen / Liu, Jinhong / Chen, Hao / Wei, Yuansong / Jia, Xiuxiu / Bai, Zhihui

    Microorganisms

    2020  Volume 8, Issue 4

    Abstract: The authors wish to make the following erratum in this paper [ ... ]. ...

    Abstract The authors wish to make the following erratum in this paper [...].
    Language English
    Publishing date 2020-04-15
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8040570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats.

    Tian, Y E / Teng, Li-Rong / Wang, Zhen-Zuo / Zhao, Min / Meng, Qing-Fan / Lu, Jia-Hui / Tian, Jian-Ming / Zhang, Wei-Wei / Zheng, Xiaoyi / Wang, D I / Teng, LE-Sheng

    Experimental and therapeutic medicine

    2015  Volume 9, Issue 6, Page(s) 2349–2355

    Abstract: Jia-Yuan-Qing pill (JYQP) composed of ...

    Abstract Jia-Yuan-Qing pill (JYQP) composed of
    Language English
    Publishing date 2015-04-15
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2015.2426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Understanding Farm Households’ Participation in Nong Jia Le in China

    Tie Wang / Wei Wang / Zhongjun Wu / Ching-Hui Su / Ming-Hsiang Chen

    Sustainability, Vol 11, Iss 5, p

    2019  Volume 1282

    Abstract: As the dominant form of rural tourism (RT) in China, Nong Jia Le (NJL) has made it possible ...

    Abstract As the dominant form of rural tourism (RT) in China, Nong Jia Le (NJL) has made it possible for local farm households to benefit. In this article, a four-step strategy based on binary logistic regression was introduced to identify the most important factors influencing the participation of farm households in NJL. Next, a comparative study based on data from two NJL communities was conducted to test the approach and identify the most important influential factors as well as the differences. The results showed that the approach could identify the optimal model and the most influential factors in different rural communities. The comparative study indicated that for Pinglou Village, the most influential factors were “education years” and “gender ratio”, while in Baozi Village, the three most influential factors were “education years”, “consumption level”, and “land area”. Implications were put forward to improve the level of participation and hospitality of NJL.
    Keywords Nong Jia Le ; farm household ; binary logistic regression ; influential factor ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 910
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Understanding Farm Households’ Participation in Nong Jia Le in China

    Wang, Tie / Chen, Ming-Hsiang / Su, Ching-Hui / Wang, Wei / Wu, Zhongjun

    Sustainability. 2019 Feb. 28, v. 11, no. 5

    2019  

    Abstract: As the dominant form of rural tourism (RT) in China, Nong Jia Le (NJL) has made it possible ...

    Abstract As the dominant form of rural tourism (RT) in China, Nong Jia Le (NJL) has made it possible for local farm households to benefit. In this article, a four-step strategy based on binary logistic regression was introduced to identify the most important factors influencing the participation of farm households in NJL. Next, a comparative study based on data from two NJL communities was conducted to test the approach and identify the most important influential factors as well as the differences. The results showed that the approach could identify the optimal model and the most influential factors in different rural communities. The comparative study indicated that for Pinglou Village, the most influential factors were “education years” and “gender ratio”, while in Baozi Village, the three most influential factors were “education years”, “consumption level”, and “land area”. Implications were put forward to improve the level of participation and hospitality of NJL.
    Keywords comparative study ; farms ; households ; models ; regression analysis ; rural communities ; rural tourism ; villages ; China
    Language English
    Dates of publication 2019-0228
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518383-7
    ISSN 2071-1050
    ISSN 2071-1050
    DOI 10.3390/su11051282
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Proteomics analysis reveals suppression of IL-17 signaling pathways contributed to the therapeutic effects of Jia-Wei Bu-Shen-Yi-Qi formula in a murine asthma model.

    Qin, Jingjing / Wuniqiemu, Tulake / Wei, Ying / Teng, Fangzhou / Cui, Jie / Sun, Jing / Yi, La / Tang, Weifeng / Zhu, Xueyi / Xu, Weifang / Dong, Jingcheng

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2021  Volume 95, Page(s) 153803

    Abstract: Background: Jia-Wei Bu-Shen-Yi-Qi formula (JWBSYQF), a Chinese herbal formula, is a commonly used ...

    Abstract Background: Jia-Wei Bu-Shen-Yi-Qi formula (JWBSYQF), a Chinese herbal formula, is a commonly used prescription for treating asthma patients. However, the targeted proteins associated with JWBSYQF treatment remain unknown.
    Purpose: Present study aims to evaluate the therapeutic efficacy of JWBSYQF and identify the targeted proteins in addition to functional pathways.
    Study design: The ovalbumin (OVA)-induced murine asthma model was established to explore the therapeutic effect of JWBSYQF treatment. Proteomic profiling and quantifications were performed using data-independent acquisition (DIA) methods. Differentially expressed proteins (DEPs) were validated via western blot (WB) and immunohistochemistry (IHC).
    Methods: A murine asthma model was made by OVA sensitization and challenge, and JWBSYQF (2.25, 4.50, 9,00 g/kg body weight) or dexamethasone (1 mg/ kg body weight) were administered orally. Airway hyperresponsiveness (AHR) to methacholine (Mch), inflammatory cell counts and classification in bronchoalveolar lavage fluid (BALF), lung histopathology, and cytokine levels were measured. Furthermore, DIA proteomic analyses were performed to explore the DEPs targeted by JWBSYQF and were further validated by WB and IHC.
    Results: Our results exhibited that JWBSYQF attenuated AHR which was mirrored by decreased airway resistance and increased lung compliance. In addition, JWBSYQF-treated mice showed reduced inflammatory score, mucus hypersecretion, as well as reduced the number of BALF leukocytes along with decreased content of BALF Th2 inflammatory cytokines (IL-4, IL-5, IL-13) and serum IgE. Proteomics analysis identified 704 DEPs between the asthmatic mice and control group (MOD vs CON), and 120 DEPs between the JWBSYQF-treatment and the asthmatic mice (JWB-M vs MOD). A total of 33 overlapped DEPs were identified among the three groups. Pathway enrichment analysis showed that DEPs were significantly enriched in IL-17 signaling pathway, in which DEPs, Lcn2, TGF-β1, Gngt2, and Ppp2r5e were common DEPs between three experimental groups. WB and IHC results further validated expressional levels and tendency of these proteins. Our results also showed that JWBSYQF affects mitogen activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways, that are activated by IL-17 signaling.
    Conclusion: The present study suggested that JWBSYQF could attenuate AHR and airway inflammation in OVA-induced asthmatic mice. In addition, proteomics analysis revealed that suppression of IL-17 signaling pathways contributes to the therapeutic effects of JWBSYQF.
    MeSH term(s) Animals ; Asthma/drug therapy ; Bronchoalveolar Lavage Fluid ; Cytokines ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Interleukin-17 ; Lung ; Mice ; Mice, Inbred BALB C ; Ovalbumin ; Proteomics ; Signal Transduction
    Chemical Substances Cytokines ; Drugs, Chinese Herbal ; Interleukin-17 ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2021-10-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2021.153803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Zhu zi bai jia juan

    Wei, Chuanzhong

    (Guo xue mo yun : 国学墨韵 ; : wei chuan zhong shu guo xue ming ju zuo pin xuan / Wei chuan zhong shu ; 2)

    2014  

    Series title Guo xue mo yun : 国学墨韵
    : wei chuan zhong shu guo xue ming ju zuo pin xuan / Wei chuan zhong shu ; 2
    Language Chinese
    Size 130 S, ill
    Edition Di 1 ban
    Publisher Ren min mei shu chu ban she
    Publishing place Bei jing
    Document type Book
    ISBN 9787102069838 ; 7102069839
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Studies on the analgesic activities of Jia-Yuan-Qing pill and its safety evaluation in mice.

    Tian, Ye / Teng, Li-rong / Song, Jing-jing / Meng, Qing-fan / Lu, Jia-hui / Zhang, Wei-wei / Wei, Kang / Wang, Ning / Wang, Di / Teng, Le-sheng

    Protoplasma

    2014  Volume 251, Issue 5, Page(s) 1245–1253

    Abstract: ... Paniculati have been reported in recent years. A new formula named Jia-Yuan-Qing pill (JYQP) is ...

    Abstract The analgesic activity of Porcellio laevis Latreille, Rhizoma Corydalis, and Radix Cynanchi Paniculati have been reported in recent years. A new formula named Jia-Yuan-Qing pill (JYQP) is therefore created by combining the three herbs at 9:7:7 ratio according to traditional Chinese theories. The present study aims to evaluate the effect of JYQP as a novel painkiller in various models. Acute toxicity test was applied to evaluate the safety of JYQP. Acetic-acid-induced writhing, hot plate test, formalin test, and naloxone-pretreated writhing test were employed to elaborate the analgesic activity of JYQP and its possible mechanism. A bone cancer pain mouse model was performed to further assess the effect of JYQP in relieving cancer pain. Test on naloxone-precipitated withdrawal symptoms was conduct to examine the physical dependence of mice on JYQP. Data revealed that JYQP reduced writhing and stretching induced by acetic acid; however, this effect could not be blocked by naloxone. JYQP specifically suppressed the phase II reaction time in formalin-treated mice; meanwhile, no analgesic effect of JYQP in hot plate test was observed, indicating that JYQP exerts analgesic activity against inflammatory pain rather than neurogenic pain. Furthermore, JYQP could successfully relieve bone cancer pain in mice. No physical dependence could be observed upon long-term administration in mice. Collectively, our present results provide experimental evidence in supporting clinical use of JYQP as an effective and safe agent for pain treatment.
    MeSH term(s) Analgesics/adverse effects ; Analgesics/pharmacology ; Animals ; Bone Neoplasms/pathology ; Corydalis/metabolism ; Cynanchum/metabolism ; Female ; Inflammation/pathology ; Isopoda/metabolism ; Male ; Medicine, Chinese Traditional/adverse effects ; Mice ; Mice, Inbred C57BL ; Naloxone/pharmacology ; Narcotic Antagonists/pharmacology ; Pain/drug therapy ; Phytotherapy ; Plant Extracts/adverse effects ; Plant Extracts/pharmacology
    Chemical Substances Analgesics ; Narcotic Antagonists ; Plant Extracts ; Naloxone (36B82AMQ7N)
    Language English
    Publishing date 2014-03-28
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123809-7
    ISSN 1615-6102 ; 0033-183X
    ISSN (online) 1615-6102
    ISSN 0033-183X
    DOI 10.1007/s00709-014-0637-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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