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  1. Book ; Online: Food Allergies in Modern Life

    Manti, Sara / Marseglia, Gian Luigi / Leonardi, Salvatore

    2022  

    Keywords Research & information: general ; Biology, life sciences ; Food & society ; children ; adolescents ; eosinophilic esophagitis ; eosinophilic gastrointestinal disorders ; growth ; failure to thrive ; malnutrition ; undernutrition ; obesity ; vitamin ; non-IgE gastrointestinal food allergy ; fecal biomarkers ; IgG and IgG4 ; allergen-specific lymphocyte stimulation test ; oral food challenge ; atopy patch test ; clinical score ; endoscopy ; reflux ; GER ; GERD ; cow's milk allergy ; CMA ; infants ; hydrolyzed formula ; alginate ; thickened formula ; cross-reaction ; flour ; food allergy ; individualized diagnostics ; legumes ; lupine ; lipid transfer protein ; peanut ; profilin ; hazelnut ; hypersensitivity ; component-resolved diagnostics ; Cor a 1 ; Cor a 14 ; Cor a 9 ; IgE ; allergy ; environmental factors ; primary prevention ; functional abdominal pain disorders ; functional dyspepsia ; irritable bowel syndrome ; allergen ; sensitization ; Gly m 4 ; Caco-2/Immune cells co-culture ; cytokine ; nsLTP ; plant-food allergy ; Pru p 3 ; peach ; nut ; Rosaceae fruit ; ISAC ; monoclonal antibodies ; biologics ; adults ; almond ; almond allergens ; nutrition
    Language 0|e
    Size 1 electronic resource (202 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021620520
    ISBN 9783036551685 ; 3036551689
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Editorial: Nutrition, diet and allergic diseases.

    Manti, Sara / Galletta, Francesca / Leonardi, Salvatore

    Frontiers in nutrition

    2024  Volume 10, Page(s) 1359005

    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1359005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: An overview on allergic and pulmonary diseases: from birth to childhood.

    Manti, Sara / Gambadauro, Antonella / Li Pomi, Alessandra / Leonardi, Salvatore

    Frontiers in medicine

    2024  Volume 10, Page(s) 1353772

    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1353772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: An overview on the RSV-mediated mechanisms in the onset of non-allergic asthma.

    Manti, Sara / Piedimonte, Giovanni

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 998296

    Abstract: Respiratory syncytial virus (RSV) infection is recognized as an important risk factor for wheezing and asthma, since it commonly affects babies during lung development. While the role of RSV in the onset of atopic asthma is widely recognized, its impact ... ...

    Abstract Respiratory syncytial virus (RSV) infection is recognized as an important risk factor for wheezing and asthma, since it commonly affects babies during lung development. While the role of RSV in the onset of atopic asthma is widely recognized, its impact on the onset of non-atopic asthma, mediated
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.998296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial

    Sara Manti / Antonella Gambadauro / Alessandra Li Pomi / Salvatore Leonardi

    Frontiers in Medicine, Vol

    An overview on allergic and pulmonary diseases: from birth to childhood

    2024  Volume 10

    Keywords allergy ; diagnosis ; pulmonology ; pulmonary diseases ; childhood ; Medicine (General) ; R5-920
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Impact of respiratory viral infections during pregnancy on the neurological outcomes of the newborn: current knowledge.

    Manti, Sara / Spoto, Giulia / Nicotera, Antonio Gennaro / Di Rosa, Gabriella / Piedimonte, Giovanni

    Frontiers in neuroscience

    2024  Volume 17, Page(s) 1320319

    Abstract: Brain development is a complex process that begins during pregnancy, and the events occurring during this sensitive period can affect the offspring's neurodevelopmental outcomes. Respiratory viral infections are frequently reported in pregnant women, and, ...

    Abstract Brain development is a complex process that begins during pregnancy, and the events occurring during this sensitive period can affect the offspring's neurodevelopmental outcomes. Respiratory viral infections are frequently reported in pregnant women, and, in the last few decades, they have been related to numerous neuropsychiatric sequelae. Respiratory viruses can disrupt brain development by directly invading the fetal circulation through vertical transmission or inducing neuroinflammation through the maternal immune activation and production of inflammatory cytokines. Influenza virus gestational infection has been consistently associated with psychotic disorders, such as schizophrenia and autism spectrum disorder, while the recent pandemic raised some concerns regarding the effects of severe acute respiratory syndrome coronavirus 2 on neurodevelopmental outcomes of children born to affected mothers. In addition, emerging evidence supports the possible role of respiratory syncytial virus infection as a risk factor for adverse neuropsychiatric consequences. Understanding the mechanisms underlying developmental dysfunction allows for improving preventive strategies, early diagnosis, and prompt interventions.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1320319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Biochemical and genetic tools to predict the progression to Cystic Fibrosis in CRMS/CFSPID subjects: A systematic review.

    Terlizzi, Vito / Manti, Sara / D'Amico, Federica / Parisi, Giuseppe F / Chiappini, Elena / Padoan, Rita

    Paediatric respiratory reviews

    2024  

    Abstract: Objectives: Aim of this study was to identify risk factors for a progression to cystic fibrosis (CF) in individuals detected as CF Screening Positive, Inconclusive Diagnosis (CFSPID).: Methods: This is a systematic review through literature databases ...

    Abstract Objectives: Aim of this study was to identify risk factors for a progression to cystic fibrosis (CF) in individuals detected as CF Screening Positive, Inconclusive Diagnosis (CFSPID).
    Methods: This is a systematic review through literature databases (2015-2023). Blood immunoreactive trypsinogen (b-IRT) values, CFTR genotype, sweat chloride (SC) values, isolation of Pseudomonas aeruginosa (Pa) from respiratory samples, Lung Clearance Index (LCI) values in CFSPIDs who converted to CF (CFSPID > CF) and age at CF transition were assessed.
    Results: Percentage of CFSPID > CF varies from 5.3 % to 44 %. Presence of one CF-causing CFTR variant in trans with a variant with variable clinical consequences (VVCC), an initial SC ≥ 40 mmol/L, an increase of SC > 2.5 mmol/L/year and recurrent isolation of pseudomonas aeruginosa (Pa) from airway samples could allow identification of subjects at risk of progression to CF.
    Conclusions: CFSPIDs with CF causing variant/VVCC genotype and first SC in the higher borderline range may require more frequent and prolonged clinical follow-up.
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147664-0
    ISSN 1526-0550 ; 1526-0542
    ISSN (online) 1526-0550
    ISSN 1526-0542
    DOI 10.1016/j.prrv.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5919: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Epidemiological shifts in bronchiolitis patterns and impact of the COVID-19: A two-season comparative study.

    Presti, Santiago / Manti, Sara / Gammeri, Carmela / Parisi, Giuseppe F / Papale, Maria / Leonardi, Salvatore

    Pediatric pulmonology

    2024  Volume 59, Issue 5, Page(s) 1298–1304

    Abstract: Background: Bronchiolitis is a common lower respiratory tract infection (LRTI) affecting infants and young children. Respiratory syncytial virus (RSV) has historically been the primary causative agent, but other viruses also contribute to the LRTI ... ...

    Abstract Background: Bronchiolitis is a common lower respiratory tract infection (LRTI) affecting infants and young children. Respiratory syncytial virus (RSV) has historically been the primary causative agent, but other viruses also contribute to the LRTI epidemiology. Recent changes in epidemiology and clinical patterns due to the coronavirus disease 2019 (COVID-19) pandemic have raised concerns. This study aims to analyze the impact of the pandemic on bronchiolitis epidemiology and severity.
    Methods: Two consecutive bronchiolitis seasons (October 2021 to March 2022 and October 2022 to March 2023) were compared. Data on viral agents, hospitalization duration, clinical severity, and respiratory support requirements were collected from pediatric patients at San Marco Hospital, University of Catania.
    Results: In the 2021-2022 season, RSV was the predominant virus (40%), followed by other viruses, with mild clinical outcomes. In the 2022-2023 season, RSV remained prevalent (58.7%), but other viruses, including rhinovirus (RV) and influenza, showed a significant increase (p < .05) in bronchiolitis cases and severity. Notably, RSV-related bronchiolitis did not exhibit greater severity compared to non-RSV cases in the 2022-2023 season, contrary to the previous year.
    Conclusion: The COVID-19 pandemic appears to have shifted the epidemiological landscape of bronchiolitis, with a peak incidence in November instead of January/February. Non-RSV viruses (RV, influenza A and B, as well as metapneumovirus) have gained prominence, possibly due to viral competition and reduced pandemic-related restrictions. Traditionally, RSV has been the primary pathogen responsible for most bronchiolitis cases. Nonetheless, the findings of this study indicate a shifting landscape in bronchiolitis etiology, with RSV gradually diminishing in its role. Contrary to the previous year, RSV-related bronchiolitis did not exhibit greater severity compared to non-RSV cases in the 2022-2023 season.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/complications ; Infant ; Male ; Female ; Bronchiolitis/epidemiology ; Bronchiolitis/virology ; Seasons ; Hospitalization/statistics & numerical data ; SARS-CoV-2 ; Italy/epidemiology ; Respiratory Syncytial Virus Infections/epidemiology ; Severity of Illness Index ; Child, Preschool ; Infant, Newborn ; Bronchiolitis, Viral/epidemiology
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article ; Comparative Study
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2143: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: An overview on viral interference during SARS-CoV-2 pandemic.

    Matera, Luigi / Manti, Sara / Petrarca, Laura / Pierangeli, Alessandra / Conti, Maria Giulia / Mancino, Enrica / Leonardi, Salvatore / Midulla, Fabio / Nenna, Raffaella

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1308105

    Abstract: ... 2019, when the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) came on the scene. The aim ... discuss recent advances on the topic because, following SARS-CoV-2 restrictions mitigation, we are ... experimenting the co-circulation of respiratory viruses along with SARS-CoV-2. This scenario is raising ...

    Abstract Respiratory viruses represent the most frequent cause of mortality, morbidity and high healthcare costs for emergency visits and hospitalization in the pediatric age. Respiratory viruses can circulate simultaneously and can potentially infect the same host, determining different types of interactions, the so-called viral interference. The role of viral interference has assumed great importance since December 2019, when the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) came on the scene. The aim of this narrative review is to present our perspective regarding research in respiratory virus interference and discuss recent advances on the topic because, following SARS-CoV-2 restrictions mitigation, we are experimenting the co-circulation of respiratory viruses along with SARS-CoV-2. This scenario is raising many concerns about possible virus-virus interactions, both positive and negative, and the clinical, diagnostic and therapeutic management of these coinfections. Moreover, we cannot rule out that also climatic conditions and social behaviours are involved. Thus, this situation can lead to different population epidemic dynamics, including changes in the age of the targeted population, disease course and severity, highlighting the need for prospective epidemiologic studies and mathematical modelling able to predict the timing and magnitude of epidemics caused by SARS-CoV-2/seasonal respiratory virus interactions in order to adjust better public health interventions.
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1308105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Safety of biologics in severe asthmatic patients with SARS-CoV-2 infection: A prospective study.

    Manti, Sara / Giallongo, Alessandro / Pecora, Giulia / Parisi, Giuseppe F / Papale, Maria / Mulè, Enza / Aloisio, Donatella / Rotolo, Novella / Leonardi, Salvatore

    Pediatric pulmonology

    2023  Volume 58, Issue 4, Page(s) 1085–1091

    Abstract: ... with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been little investigated.: Objective: To assess the safety ... of biologics in patients with SARS-CoV-2 infection.: Methods: A pilot, monocentric, prospective study ... Patients aged 6 years old and older with severe asthma on treatment with biologics and confirmed SARS-CoV-2 ...

    Abstract Background: Asthma guidelines have recommended continuing treatment with biologics during coronavirus disease 2019 (COVID-19) pandemic. However, a continuation of treatment with biologics in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been little investigated.
    Objective: To assess the safety of biologics in patients with SARS-CoV-2 infection.
    Methods: A pilot, monocentric, prospective study. Patients aged 6 years old and older with severe asthma on treatment with biologics and confirmed SARS-CoV-2 infection were enrolled. Patients were followed-up with periodic calls at different time points up to 3 months to detect any adverse effect and its relationship with biologic treatment according to the Naranjo Adverse Probability Scale (NAPS). The severity of SARS-CoV-2 infection and clinical outcome were also assessed.
    Results: Overall, we included 21 patients (10 on therapy with omalizumab, 9 with dupilumab, and 2 with mepolizumab). Only a patient-reported two local adverse events. No other adverse event was reported. Twenty out of 21 patients had a mild COVID-19 course, and no adverse outcome was observed.
    Conclusion: We showed that the scheduled dose of the biologic therapy can be administered safely on time in patients with SARS-CoV-2 infection, as the treatment did not result in adverse events or outcomes.
    MeSH term(s) Humans ; Child ; COVID-19/complications ; SARS-CoV-2 ; Prospective Studies ; Asthma/complications ; Asthma/drug therapy ; Biological Products/adverse effects
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2143: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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