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Article ; Online: The Spatial Heterogeneity of the Black Scorpionfish, Scorpaena porcus (Scorpaenidae)

Josipa Ferri / Sanja Matić-Skoko

Applied Sciences, Vol 11, Iss 11919, p

Differences in Length, Dietary and Age Compositions

2021 Volume 11919

Abstract: The present study assessed spatial variations in several biological characteristics of Scorpaena porcus Linnaeus, 1758 and estimated length structure, dietary composition and growth parameters for the species. Sampling was carried out in two areas, about ...

Abstract	The present study assessed spatial variations in several biological characteristics of Scorpaena porcus Linnaeus, 1758 and estimated length structure, dietary composition and growth parameters for the species. Sampling was carried out in two areas, about 200 km apart, in the coastal Adriatic Sea, which is the northernmost region of the Mediterranean. A total of 388 specimens of S. porcus were caught, 233 from the Split area and 155 from the Pag Island area, and a higher proportion of individuals in the ≤15 cm length classes were found in the Split area. The results of the age, growth and diet analyses demonstrated that the black scorpionfish is a slow-growing and long-lived species that feeds on a wide variety of plant and animal taxa and shows a high selectivity for crustacean decapods. Detailed comparisons and multivariate analyses showed significant fine-scale spatial structuring of the investigated species, as observed length, dietary and age compositions were heterogeneous among the two areas. Fish from the Pag Island area ingested a greater diversity of the prey types, fed to a greater extent on fishes, reached the highest total length and showed a higher growth rate. Such intraspecific variations could reflect adaptations to different environmental conditions and support the geographical scale at which local black scorpionfish populations should be managed.
Keywords	growth rates ; diets ; location ; intraspecific variation ; multivariate analyses ; Scorpaena porcus ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	590
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: In Vitro Antioxidant and In Vivo Antigenotoxic Features of a Series of 61 Essential Oils and Quantitative Composition-Activity Relationships Modeled through Machine Learning Algorithms.

Mladenović, Milan / Astolfi, Roberta / Tomašević, Nevena / Matić, Sanja / Božović, Mijat / Sapienza, Filippo / Ragno, Rino

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 10

Abstract: The antioxidant activity of essential oils (EOs) is an important and frequently studied property, yet it is not sufficiently understood in terms of the contribution of EOs mixtures' constituents and biological properties. In this study, a series of 61 ... ...

Abstract	The antioxidant activity of essential oils (EOs) is an important and frequently studied property, yet it is not sufficiently understood in terms of the contribution of EOs mixtures' constituents and biological properties. In this study, a series of 61 commercial EOs were first evaluated as antioxidants in vitro, following as closely as possible the cellular pathways of reactive oxygen species (ROS) generation. Hence, EOs were assessed for the ability either to chelate metal ions, thus interfering with ROS generation within the respiratory chain, or to neutralize 2,2-diphenyl-1-picrylhydrazyl (DPPH
Language	English
Publishing date	2023-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12101815
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Article ; Online: Identification of an Additional Metal-Binding Site in Human Dipeptidyl Peptidase III.

Matić, Antonia / Šupljika, Filip / Brkić, Hrvoje / Jurasović, Jasna / Karačić, Zrinka / Tomić, Sanja

International journal of molecular sciences

2023 Volume 24, Issue 16

Abstract: Dipeptidyl peptidase III (DPP III, EC 3.4.14.4) is a monozinc metalloexopeptidase that hydrolyzes dipeptides from the N-terminus of peptides consisting of three or more amino acids. Recently, DPP III has attracted great interest from scientists, and ... ...

Abstract	Dipeptidyl peptidase III (DPP III, EC 3.4.14.4) is a monozinc metalloexopeptidase that hydrolyzes dipeptides from the N-terminus of peptides consisting of three or more amino acids. Recently, DPP III has attracted great interest from scientists, and numerous studies have been conducted showing that it is involved in the regulation of various physiological processes. Since it is the only metalloenzyme among the dipeptidyl peptidases, we considered it important to study the process of binding and exchange of physiologically relevant metal dications in DPP III. Using fluorimetry, we measured the
MeSH term(s)	Humans ; Binding Sites ; Catalytic Domain ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases ; Protein Domains
Chemical Substances	dipeptidyl peptidase III (EC 3.4.14.4) ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (EC 3.4.14.-) ; DPP3 protein, human (EC 3.4.14.4)
Language	English
Publishing date	2023-08-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241612747
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Article ; Online: Unravelling the inhibitory zinc ion binding site and the metal exchange mechanism in human DPP III.

Tomić, Antonija / Brkić, Hrvoje / Matić, Antonia / Tomić, Sanja

Physical chemistry chemical physics : PCCP

2021 Volume 23, Issue 23, Page(s) 13267–13275

Abstract: Dipeptidyl peptidase III (DPP III), a zinc-dependent exopeptidase, is widely distributed in organisms and present in almost all human tissues. In addition to its involvement in protein catabolism, it plays a role in oxidative stress and blood pressure ... ...

Abstract	Dipeptidyl peptidase III (DPP III), a zinc-dependent exopeptidase, is widely distributed in organisms and present in almost all human tissues. In addition to its involvement in protein catabolism, it plays a role in oxidative stress and blood pressure regulation, and there is evidence of its involvement in pain modulation. Excess zinc ions have been found to inhibit its hydrolytic activity, but the binding affinity, binding site geometry, and mechanism of inhibitory activity have been unknown. Using several different computational approaches, we determined the inhibitory zinc ion binding site, its coordination and relative binding affinity. During some simulations the translocation of the zinc ion from the inhibitory to the catalytic binding site was observed, accompanied by movement of the catalytic zinc ion toward the exit of the substrate binding site. The traced behavior suggests an associative type of metal ion exchange, in which the formation of the ternary complex between enzyme and two metal ions precedes the exit of the catalytic metal ion. Differently from our previous findings that binding of a peptide induces partial opening of hDPP III, the globularity of the protein did not change in MD simulations of the hermorphin-like peptide bound to hDPP III with two zinc ions. However, the entrance to the interdomain cleft widens during Zn diffusion into the protein and was found to be the highest energy barrier in the process of metal translocation from the solvent to the active site. Finally, we discuss why excess zinc reduces enzyme activity.
MeSH term(s)	Binding Sites/drug effects ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/antagonists & inhibitors ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/metabolism ; Humans ; Ions/chemistry ; Ions/pharmacology ; Molecular Dynamics Simulation ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; Zinc/chemistry ; Zinc/pharmacology
Chemical Substances	Ions ; Protease Inhibitors ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (EC 3.4.14.-) ; DPP3 protein, human (EC 3.4.14.4) ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2021-05-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d1cp01302e
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Article: The biology and t heories of aging.

Stanić, Snežana M / Matić, Sanja Lj

Theoretical biology forum

2019 Volume 112, Issue 1-2, Page(s) 79–89

Abstract: Aging is a natural, time-dependent process characterized by irreversible changes in the molecules, cells, tissues, and organs. It occurs as a result of cumulative damage at different levels of the organization, in particular by damaging proteins and DNA. ...

Abstract	Aging is a natural, time-dependent process characterized by irreversible changes in the molecules, cells, tissues, and organs. It occurs as a result of cumulative damage at different levels of the organization, in particular by damaging proteins and DNA. There is no single definition, nor a unique attitude about when and how age arises and what are its causes. The process is extremely complex and most likely a consequence of the effects of different mechanisms (not only genetic but also acquired) that lead to disrupt homeostasis, reduce stress resistance and the more frequent occurrence of the disease. There are many classifications of theories about aging and they often contradict one another. No one theory is sufficiently able to explain the process of aging. The aim of this work is to analyze the different aspects, main characteristics of the aging, individual differences in the speed of this process and theories about the mechanisms of aging.
MeSH term(s)	Aging/physiology ; Animals ; Biological Evolution ; Cellular Senescence ; Homeostasis ; Humans ; Models, Theoretical
Language	English
Publishing date	2019-01-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2624471-8
ISSN	1825-6538 ; 0035-6050
ISSN (online)	1825-6538
ISSN	0035-6050
DOI	10.19272/201911402006
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Article ; Online: Biosynthesis and characterization of silver nanoparticles synthesized using extracts of

Marković, Katarina / Kesić, Ana / Novaković, Mirjana / Grujović, Mirjana / Simijonović, Dušica / Avdović, Edina H / Matić, Sanja / Paunović, Milica / Milutinović, Milena / Nikodijević, Danijela / Stefanović, Olgica / Marković, Zoran

RSC advances

2024 Volume 14, Issue 7, Page(s) 4591–4606

Abstract: This research explores the synthesis, characterization, and biological activities of silver nanoparticles (AgNPs) derived from acetone (AgNPs-acetone) and aqueous (AgNPs- ... ...

Abstract	This research explores the synthesis, characterization, and biological activities of silver nanoparticles (AgNPs) derived from acetone (AgNPs-acetone) and aqueous (AgNPs-H
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra07819a
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Article ; Online: Age, Growth, and Validation of Otolith Morphometrics as Predictors of Age in the Blackspot Seabream, Pagellus bogaraveo , (Brunnich, 1768) from the Eastern Adriatic Sea

Antonela Paladin / Nika Ugrin / Sanja Matić-Skoko / Branko Dragičević / Jakov Dulčić

Fishes, Vol 8, Iss 301, p

2023 Volume 301

Abstract: The age and growth of the blackspot seabream, Pagellus bogaraveo , were determined by examining sagittal otoliths from fish sampled in the eastern Adriatic Sea. A total of 674 specimens (181 males, 90 hermaphrodites, 108 females, and 295 immatures) ... ...

Abstract	The age and growth of the blackspot seabream, Pagellus bogaraveo , were determined by examining sagittal otoliths from fish sampled in the eastern Adriatic Sea. A total of 674 specimens (181 males, 90 hermaphrodites, 108 females, and 295 immatures) ranging from 8.80 to 47.27 cm (21.93 ± 9.00 cm) in total length were analyzed. The maximum observed age for the whole sample was 13 years. The sample was dominated by 1-year-old specimens as a consequence of an abundance of juvenile specimens collected by beach seines. Growth was described by the von Bertalanffy growth curve (L ∞ = 52.3 cm, K = 0.15 year −1 , t 0 = 0.49 year, R 2 = 0.97), and the growth performance index (Φ’) was 2.61. The length, width, thickness, and mass of the otoliths were compared with the total length and age of P. bogaraveo from the eastern Adriatic. The analysis showed that the measures were adequate predictors of age. These results can be of value for more effective management measures aimed at the conservation of this species.
Keywords	Sparidae ; age determination ; Mediterranean Sea ; hermaphroditism ; otolith morphometry ; Biology (General) ; QH301-705.5 ; Genetics ; QH426-470
Subject code	590
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of neutrophil-lymphocyte and platelet-lymphocyte ratio in patients with hashimoto's thyroiditis

Gašić Sanja / Perić Milica / Matić Tamara / Jorgaćević Teodora / Ilić Slađana

Praxis Medica, Vol 51, Iss 1-2, Pp 15-

2022 Volume 19

Abstract: INTRODUCTION: The ratio of neutrophils-lymphocytes (NLR) and platelet-lymphocytes (PLR) is a new parameter in the assessment of patients with Hashimoto's thyroiditis OBJECTIVE: The aim of this study was to investigate the effect of NLR and PLR in ... ...

Abstract	INTRODUCTION: The ratio of neutrophils-lymphocytes (NLR) and platelet-lymphocytes (PLR) is a new parameter in the assessment of patients with Hashimoto's thyroiditis OBJECTIVE: The aim of this study was to investigate the effect of NLR and PLR in patients with Hashimoto's thyroiditis MATERIALS AND METHODS: In this cross-sectional study, subjects were subjected to tests of thyroid gland function, antithyroid antibodies, as well as laboratory analyzes of blood count with determination of NLR and PLR. The respondents were grouped into two groups. The first group was patients with Hashimoto's thyroiditis (HT), while the second group consisted of healthy individuals who represented the control group. RESULTS: NLR was statistically significantly higher in patients with HT compared to the control group (2.62±0.8 and 2.43±0.8, respectively; p=0.02), while PLR was higher in people with HT compared to the control group, but without statistical significance significance (169±42.5; 159±40.3; p=0.08). Among the examined patients with HT, the group with hypothyroidism showed statistically higher NLR values compared to the group of patients with euthyroid status (2.7±0.9 2.31±0.7 p=0.03). Among the examined patients with HT, the group with hypothyroidism showed statistically higher PLR values compared to the group of patients with euthyroid status, as well as the group with subclinical hypothyroidism (177.8±48.2; 148.3±39.3; 155.5±42.5 p=0.04). NLR and PLR show a statistically significant positive correlation with the level of TSH, Anti TPO and TG At in the group with HT. CONCLUSION: NLR and PLR can serve as practical and valuable markers of the clinical course of the disease, but also markers of autoimmune diseases that progress with chronic inflammation.
Keywords	nlr ; plr ; hashimoto's thyroiditis ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Medicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društva
Document type	Article ; Online
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Article ; Online: New ruthenium(II) complexes with quinone diimine and substituted bipyridine as inert ligands: synthesis, characterization, mechanism of action, DNA/HSA binding affinity and cytotoxic activity.

Međedović, Milica / Rilak Simović, Ana / Ćoćić, Dušan / Senft, Laura / Matić, Sanja / Todorović, Danijela / Popović, Suzana / Baskić, Dejan / Petrović, Biljana

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 5, Page(s) 1323–1344

Abstract: This paper presents the synthesis and structural characterization of a series of new ruthenium(II) complexes 1-7, with the general ... ...

Abstract	This paper presents the synthesis and structural characterization of a series of new ruthenium(II) complexes 1-7, with the general formula
MeSH term(s)	Humans ; Ruthenium/pharmacology ; Ruthenium/chemistry ; Ligands ; Molecular Docking Simulation ; Antineoplastic Agents/chemistry ; DNA/chemistry ; Quinones ; Adenocarcinoma ; Coordination Complexes/chemistry ; Cell Line, Tumor
Chemical Substances	Ruthenium (7UI0TKC3U5) ; Ligands ; Antineoplastic Agents ; DNA (9007-49-2) ; Quinones ; quinone (3T006GV98U) ; Coordination Complexes
Language	English
Publishing date	2023-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d2dt02993f
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Article: Long-Term Prognosis after ST-Elevation Myocardial Infarction in Patients with Premature Coronary Artery Disease.

Savic, Lidija / Mrdovic, Igor / Asanin, Milika / Stankovic, Sanja / Lasica, Ratko / Krljanac, Gordana / Simic, Damjan / Matic, Dragan

Journal of personalized medicine

2024 Volume 14, Issue 3

Abstract: Background: A significant percentage of younger patients with myocardial infarction have premature coronary artery disease (CAD). The aims of this study were to analyze all-cause mortality and major adverse cardiovascular events (MACEs cardiovascular ... ...

Abstract	Background: A significant percentage of younger patients with myocardial infarction have premature coronary artery disease (CAD). The aims of this study were to analyze all-cause mortality and major adverse cardiovascular events (MACEs cardiovascular death, non-fatal reinfarction, stroke, target vessel revascularization) during eight-year follow-up in patients with ST-elevation myocardial infarction (STEMI) and premature CAD. Method: We analyzed 2560 STEMI patients without previous CAD and without cardiogenic shock at admission who were treated with primary PCI. CAD was classified as premature in men aged <50 years and women <55 years. Results: Premature CAD was found in 630 (24.6%) patients. Patients with premature CAD have fewer comorbidities and better initial angiographic findings compared to patients without premature CAD. The incidence of non-fatal adverse ischemic events was similar to the incidence in older patients. Premature CAD was an independent predictor for lower mortality (HR 0.50 95%CI 0.28-0.91) and MACEs (HR 0.27 95%CI 0.15-0.47). In patients with premature CAD, EF < 40% was the only independent predictor of mortality (HR 5.59 95%CI 2.18-8.52) and MACEs (HR 4.18, 95%CI 1.98-8.13). Conclusions: Premature CAD was an independent predictor for lower mortality and MACEs. In patients with premature CAD, EF < 40% was an independent predictor of eight-year mortality and MACEs.
Language	English
Publishing date	2024-02-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14030231
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