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  1. Article ; Online: Transposable elements and Alzheimer's disease pathogenesis.

    Evering, Teresa H / Marston, Jez L / Gan, Li / Nixon, Douglas F

    Trends in neurosciences

    2022  Volume 46, Issue 3, Page(s) 170–172

    Abstract: Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced ... ...

    Abstract Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; DNA Transposable Elements ; Amyloid beta-Peptides/metabolism ; tau Proteins/metabolism ; Neurofibrillary Tangles/metabolism ; Microglia/metabolism ; Plaque, Amyloid/metabolism
    Chemical Substances DNA Transposable Elements ; Amyloid beta-Peptides ; tau Proteins
    Language English
    Publishing date 2022-12-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2022.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 53: Show issues

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  2. Article ; Online: Involvement of Cisgender and Transgender Individuals in Studies on the Impact of Hormonal Therapy on COVID-19.

    Wozniak, Robert J / Nixon, Douglas F / Marston, Jez L

    AIDS patient care and STDs

    2020  Volume 34, Issue 9, Page(s) 367–368

    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; Gender Identity ; Hormone Replacement Therapy/adverse effects ; Humans ; Male ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Transgender Persons
    Keywords covid19
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Letter
    ZDB-ID 1326868-5
    ISSN 1557-7449 ; 0893-5068 ; 1087-2914
    ISSN (online) 1557-7449
    ISSN 0893-5068 ; 1087-2914
    DOI 10.1089/apc.2020.0118
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    Zs.A 2328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Ribosomal profiling of human endogenous retroviruses in healthy tissues.

    Dopkins, Nicholas / Singh, Bhavya / Michael, Stephanie / Zhang, Panpan / Marston, Jez L / Fei, Tongyi / Singh, Manvendra / Feschotte, Cedric / Collins, Nicholas / Bendall, Matthew L / Nixon, Douglas F

    BMC genomics

    2024  Volume 25, Issue 1, Page(s) 5

    Abstract: Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human genome. Our understanding of HERVs in physiology primarily surrounds their non-coding functions, ... ...

    Abstract Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human genome. Our understanding of HERVs in physiology primarily surrounds their non-coding functions, while their protein coding capacity remains virtually uncharacterized. Therefore, we applied the bioinformatic pipeline "hervQuant" to high-resolution ribosomal profiling of healthy tissues to provide a comprehensive overview of translationally active HERVs. We find that HERVs account for 0.1-0.4% of all translation in distinct tissue-specific profiles. Collectively, our study further supports claims that HERVs are actively translated throughout healthy tissues to provide sequences of retroviral origin to the human proteome.
    MeSH term(s) Humans ; Endogenous Retroviruses/genetics ; Ribosomes/genetics
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-023-09909-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: How human endogenous retroviruses interact with the microbiota in health and disease.

    Dopkins, Nicholas / O'Mara, Morgan M / Singh, Bhavya / Marston, Jez L / Bendall, Matthew L / Nixon, Douglas F

    Trends in microbiology

    2022  Volume 30, Issue 9, Page(s) 812–815

    Abstract: The microbiota is a collective of microorganisms whose composition is intimately linked with human health and disease. Emerging evidence demonstrates that endogenous retroviruses facilitate crosstalk between the host and microbiota to fundamentally shape ...

    Abstract The microbiota is a collective of microorganisms whose composition is intimately linked with human health and disease. Emerging evidence demonstrates that endogenous retroviruses facilitate crosstalk between the host and microbiota to fundamentally shape immunity.
    MeSH term(s) Dysbiosis ; Endogenous Retroviruses/genetics ; Humans ; Microbiota
    Language English
    Publishing date 2022-06-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2022.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation.

    Dopkins, Nicholas / Singh, Bhavya / Michael, Stephanie / O'Mara, Morgan M / Marston, Jez L / Fei, Tongyi / Bendall, Matthew L / Nixon, Douglas F

    mBio

    2023  Volume 14, Issue 1, Page(s) e0328022

    Abstract: Transposable elements (TEs) are mobile genomic sequences that encompass roughly 50% of the human genome. Class 1 TEs, or "retrotransposons," mobilize through the production of an RNA intermediate that is then reverse transcribed to form complementary DNA ...

    Abstract Transposable elements (TEs) are mobile genomic sequences that encompass roughly 50% of the human genome. Class 1 TEs, or "retrotransposons," mobilize through the production of an RNA intermediate that is then reverse transcribed to form complementary DNA (cDNA) molecules capable of genomic reinsertion. While TEs are traditionally silenced to maintain genomic integrity, the recognition of immunostimulatory cues, such as those provided by microorganisms, drastically alters host transcription to induce the differential expression of TEs. Emerging evidence demonstrates that the inducible production of TE cDNA is not an inert phenomenon but instead has been coopted by host immunity to facilitate cross talk between host and constituents of the microbiota by agonizing intrinsic antiviral receptors. Here, we demonstrate that immunostimulation of toll-like receptor 4 (TLR4) with lipopolysaccharide (LPS) and TLR5 with bacterial flagella (FLA) alters the expression of retrotransposons, such as human endogenous retroviruses (HERVs) and long interspersed nuclear elements (LINEs). Next, we demonstrate that reverse transcriptase inhibitor (RTi) delivery ameliorates the acute production of the proinflammatory cytokine "tumor necrosis factor alpha" (TNF-α) in response to FLA in a monocytic cell line (THP-1). Collectively, our findings demonstrate that TLR5-mediated cross talk between the host and microbiota is partially dependent on the reverse transcription (RT) of retrotransposons.
    MeSH term(s) Humans ; Toll-Like Receptor 5 ; Retroelements ; RNA-Directed DNA Polymerase/genetics ; DNA, Complementary ; Endogenous Retroviruses ; Inflammation/genetics ; Antiviral Agents
    Chemical Substances Toll-Like Receptor 5 ; Retroelements ; RNA-Directed DNA Polymerase (EC 2.7.7.49) ; DNA, Complementary ; Antiviral Agents
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03280-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Involvement of Cisgender and Transgender Individuals in Studies on the Impact of Hormonal Therapy on COVID-19

    Wozniak, Robert J / Nixon, Douglas F / Marston, Jez L

    AIDS Patient Care STDS

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #601737
    Database COVID19

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  7. Article: How human endogenous retroviruses interact with the microbiota in health and disease

    Dopkins, Nicholas / O’Mara, Morgan / Singh, Bhavya / Marston, Jez L. / Bendall, Matthew L. / Nixon, Douglas F.

    Trends in microbiology. 2022,

    2022  

    Abstract: The microbiota is a collective of microorganisms whose composition is intimately linked with human health and disease. Emerging evidence demonstrates that endogenous retroviruses facilitate crosstalk between the host and microbiota to fundamentally shape ...

    Abstract The microbiota is a collective of microorganisms whose composition is intimately linked with human health and disease. Emerging evidence demonstrates that endogenous retroviruses facilitate crosstalk between the host and microbiota to fundamentally shape immunity.
    Keywords Retroviridae ; human health ; humans ; immunity ; microorganisms
    Language English
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2022.05.011
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2005/714: Show issues

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  8. Article ; Online: Involvement of Cisgender and Transgender Individuals in Studies on the Impact of Hormonal Therapy on COVID-19

    Wozniak, Robert J. / Nixon, Douglas F. / Marston, Jez L.

    AIDS Patient Care and STDs

    2020  Volume 34, Issue 9, Page(s) 367–368

    Keywords Public Health, Environmental and Occupational Health ; Infectious Diseases ; covid19
    Language English
    Publisher Mary Ann Liebert Inc
    Publishing country us
    Document type Article ; Online
    ISSN 1087-2914
    DOI 10.1089/apc.2020.0118
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Locus specific human endogenous retroviruses reveal new lymphoma subtypes.

    Singh, Bhavya / Dopkins, Nicholas / Fei, Tongyi / Marston, Jez L / Michael, Stephanie / Reyes-Gopar, Helena / Curty, Gislaine / Heymann, Jonas J / Chadburn, Amy / Martin, Peter / Leal, Fabio E / Cesarman, Ethel / Nixon, Douglas F / Bendall, Matthew L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The heterogeneity of cancers are driven by diverse mechanisms underlying oncogenesis such as differential 'cell-of-origin' (COO) progenitors, mutagenesis, and viral infections. Classification of B-cell lymphomas have been defined by considering these ... ...

    Abstract The heterogeneity of cancers are driven by diverse mechanisms underlying oncogenesis such as differential 'cell-of-origin' (COO) progenitors, mutagenesis, and viral infections. Classification of B-cell lymphomas have been defined by considering these characteristics. However, the expression and contribution of transposable elements (TEs) to B cell lymphoma oncogenesis or classification have been overlooked. We hypothesized that incorporating TE signatures would increase the resolution of B-cell identity during healthy and malignant conditions. Here, we present the first comprehensive, locus-specific characterization of TE expression in benign germinal center (GC) B-cells, diffuse large B-cell lymphoma (DLBCL), Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt lymphoma (BL), and follicular lymphoma (FL). Our findings demonstrate unique human endogenous retrovirus (HERV) signatures in the GC and lymphoma subtypes whose activity can be used in combination with gene expression to define B-cell lineage in lymphoid malignancies, highlighting the potential of retrotranscriptomic analyses as a tool in lymphoma classification, diagnosis, and the identification of novel treatment groups.
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.08.544208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elements.

    Marston, Jez L / Greenig, Matthew / Singh, Manvendra / Bendall, Matthew L / Duarte, Rodrigo R R / Feschotte, Cédric / Iñiguez, Luis P / Nixon, Douglas F

    JCI insight

    2021  Volume 6, Issue 24

    Abstract: SARS-CoV-2 promotes an imbalanced host response that underlies the development and severity of COVID-19. Infections with viruses are known to modulate transposable elements (TEs), which can exert downstream effects by modulating host gene expression, ... ...

    Abstract SARS-CoV-2 promotes an imbalanced host response that underlies the development and severity of COVID-19. Infections with viruses are known to modulate transposable elements (TEs), which can exert downstream effects by modulating host gene expression, innate immune sensing, or activities encoded by their protein products. We investigated the impact of SARS-CoV-2 infection on TE expression using RNA-Seq data from cell lines and from primary patient samples. Using a bioinformatics tool, Telescope, we showed that SARS-CoV-2 infection led to upregulation or downregulation of TE transcripts, a subset of which differed from cells infected with SARS, Middle East respiratory syndrome coronavirus (MERS-CoV or MERS), influenza A virus (IAV), respiratory syncytial virus (RSV), and human parainfluenza virus type 3 (HPIV3). Differential expression of key retroelements specifically identified distinct virus families, such as Coronaviridae, with unique retroelement expression subdividing viral species. Analysis of ChIP-Seq data showed that TEs differentially expressed in SARS-CoV-2 infection were enriched for binding sites for transcription factors involved in immune responses and for pioneer transcription factors. In samples from patients with COVID-19, there was significant TE overexpression in bronchoalveolar lavage fluid and downregulation in PBMCs. Thus, although the host gene transcriptome is altered by infection with SARS-CoV-2, the retrotranscriptome may contain the most distinctive features of the cellular response to SARS-CoV-2 infection.
    MeSH term(s) A549 Cells ; COVID-19/genetics ; Cell Line ; Chromatin Immunoprecipitation Sequencing ; Computational Biology ; Coronavirus Infections/genetics ; DNA Transposable Elements/genetics ; Down-Regulation ; Endogenous Retroviruses/genetics ; Host Microbial Interactions/genetics ; Humans ; In Vitro Techniques ; Influenza A virus ; Influenza, Human/genetics ; Long Interspersed Nucleotide Elements/genetics ; Middle East Respiratory Syndrome Coronavirus ; Parainfluenza Virus 3, Human ; RNA-Seq ; Respiratory Syncytial Virus Infections/genetics ; Respiratory Syncytial Viruses ; Respirovirus Infections/genetics ; Retroelements/genetics ; SARS Virus ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/genetics ; Transcriptome ; Up-Regulation
    Chemical Substances DNA Transposable Elements ; Retroelements
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.147170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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