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  1. Article ; Online: Updates and New Perspectives on Adenoviral Gene Therapy and Vaccine Vectors.

    Dobner, Thomas / Bertzbach, Luca D

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Adenoviruses are commonly used as efficient high-capacity vectors and excellent gene delivery vehicles [ ... ]. ...

    Abstract Adenoviruses are commonly used as efficient high-capacity vectors and excellent gene delivery vehicles [...].
    MeSH term(s) Genetic Therapy ; Adenoviridae/genetics ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Special Issue on Marek's Disease Virus-The Editors' View.

    Kaufer, Benedikt B / Parcells, Mark S / Bertzbach, Luca D

    Microorganisms

    2023  Volume 11, Issue 3

    Abstract: Marek's disease virus (MDV), an Alphaherpesvirus belonging to the genus Mardivirus, causes T cell lymphomas in chickens and remains one of the greatest threats to poultry production worldwide [ ... ]. ...

    Abstract Marek's disease virus (MDV), an Alphaherpesvirus belonging to the genus Mardivirus, causes T cell lymphomas in chickens and remains one of the greatest threats to poultry production worldwide [...].
    Language English
    Publishing date 2023-03-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11030805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The importance of veterinary specialized generalists in biomedical research.

    Burnett, Deborah L / Bertzbach, Luca D

    Research in veterinary science

    2020  Volume 129, Page(s) 185–186

    Language English
    Publishing date 2020-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2020.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: The adenoviral E4orf3/4 is a regulatory polypeptide with cell transforming properties in vitro.

    Ip, Wing-Hang / Bertzbach, Luca D / Speiseder, Thomas / Dobner, Thomas

    Tumour virus research

    2023  Volume 15, Page(s) 200254

    Abstract: The human adenovirus species C type 5 (HAdV-C5) early region 4 (E4) encodes several distinct polypeptides, defined as E4orf1 to E4orf6/7 according to the order and arrangement of the corresponding open reading frames (ORFs). All E4 gene products operate ... ...

    Abstract The human adenovirus species C type 5 (HAdV-C5) early region 4 (E4) encodes several distinct polypeptides, defined as E4orf1 to E4orf6/7 according to the order and arrangement of the corresponding open reading frames (ORFs). All E4 gene products operate through a complex network of interactions with key viral and cellular regulatory proteins involved in transcription, apoptosis, cell cycle control, and DNA repair. Here, we generated a set of virus mutants carrying point mutations in the individual E4 genes. The phenotypic characterizations of these mutants revealed that mutations of these ORFs had no or only moderate effects on virus replication. Even a triple mutant that fails to produce E4orf3, E4orf4, and the yet uncharacterized alternatively spliced E4orf3/4 fusion protein, was replicating to wild type levels. The E4orf3/4 protein consists of the N-terminal 33 amino acid residues from E4orf3 and the C-terminal 28 amino acid residues from E4orf4. Intriguingly, we found that, similar to E4orf3, E4orf3/4 possesses properties that support the E1A/E1B-induced transformation of primary rodent cells. These results identify and functionally characterize E4orf3/4 and conclude that E4orf3/4 is another E4 region protein that is dispensable for virus replication but promotes the E1A/E1B-induced transformation of primary rodent cells.
    MeSH term(s) Humans ; Transcription Factors/genetics ; Adenoviridae/genetics ; Adenovirus E4 Proteins/genetics ; Peptides ; Amino Acids
    Chemical Substances Transcription Factors ; Adenovirus E4 Proteins ; Peptides ; Amino Acids
    Language English
    Publishing date 2023-01-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-6790
    ISSN (online) 2666-6790
    DOI 10.1016/j.tvr.2023.200254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Special Issue on Marek’s Disease Virus—The Editors’ View

    Benedikt B. Kaufer / Mark S. Parcells / Luca D. Bertzbach

    Microorganisms, Vol 11, Iss 805, p

    2023  Volume 805

    Abstract: Marek’s disease virus (MDV), an Alphaherpesvirus belonging to the genus Mardivirus, causes T cell lymphomas in chickens and remains one of the greatest threats to poultry production worldwide [.] ...

    Abstract Marek’s disease virus (MDV), an Alphaherpesvirus belonging to the genus Mardivirus, causes T cell lymphomas in chickens and remains one of the greatest threats to poultry production worldwide [.]
    Keywords n/a ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The adenovirus DNA-binding protein DBP.

    Bertzbach, Luca D / Seddar, Laura / von Stromberg, Konstantin / Ip, Wing-Hang / Dobner, Thomas / Hidalgo, Paloma

    Journal of virology

    2024  Volume 98, Issue 2, Page(s) e0188523

    Abstract: Adenoviruses are a group of double-stranded DNA viruses that can mainly cause respiratory, gastrointestinal, and eye infections in humans. In addition, adenoviruses are employed as vector vaccines for combatting viral infections, including SARS-CoV-2, ... ...

    Abstract Adenoviruses are a group of double-stranded DNA viruses that can mainly cause respiratory, gastrointestinal, and eye infections in humans. In addition, adenoviruses are employed as vector vaccines for combatting viral infections, including SARS-CoV-2, and serve as excellent gene therapy vectors. These viruses have the ability to modulate the host cell machinery to their advantage and trigger significant restructuring of the nuclei of infected cells through the activity of viral proteins. One of those, the adenovirus DNA-binding protein (DBP), is a multifunctional non-structural protein that is integral to the reorganization processes. DBP is encoded in the E2A transcriptional unit and is highly abundant in infected cells. Its activity is unequivocally linked to the formation, structure, and integrity of virus-induced replication compartments, molecular hubs for the regulation of viral processes, and control of the infected cell. DBP also plays key roles in viral DNA replication, transcription, viral gene expression, and even host range specificity. Notably, post-translational modifications of DBP, such as SUMOylation and extensive phosphorylation, regulate its biological functions. DBP was first investigated in the 1970s, pioneering research on viral DNA-binding proteins. In this literature review, we provide an overview of DBP and specifically summarize key findings related to its complex structure, diverse functions, and significant role in the context of viral replication. Finally, we address novel insights and perspectives for future research.
    MeSH term(s) Humans ; Adenoviridae/physiology ; Adenoviruses, Human/physiology ; DNA Replication ; DNA, Viral/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication
    Chemical Substances DNA, Viral ; DNA-Binding Proteins ; Viral Proteins
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01885-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Animal Models in Human Adenovirus Research.

    Bertzbach, Luca D / Ip, Wing-Hang / Dobner, Thomas

    Biology

    2021  Volume 10, Issue 12

    Abstract: Human adenovirus (HAdV) infections cause a wide variety of clinical symptoms, ranging from mild upper respiratory tract disease to lethal outcomes, particularly in immunocompromised individuals. To date, neither widely available vaccines nor approved ... ...

    Abstract Human adenovirus (HAdV) infections cause a wide variety of clinical symptoms, ranging from mild upper respiratory tract disease to lethal outcomes, particularly in immunocompromised individuals. To date, neither widely available vaccines nor approved antiadenoviral compounds are available to efficiently deal with HAdV infections. Thus, there is a need to thoroughly understand HAdV-induced disease, and for the development and preclinical evaluation of HAdV therapeutics and/or vaccines, and consequently for suitable standardizable in vitro systems and animal models. Current animal models to study HAdV pathogenesis, persistence, and tumorigenesis include rodents such as Syrian hamsters, mice, and cotton rats, as well as rabbits. In addition, a few recent studies on other species, such as pigs and tree shrews, reported promising data. These models mimic (aspects of) HAdV-induced pathological changes in humans and, although they are relevant, an ideal HAdV animal model has yet to be developed. This review summarizes the available animal models of HAdV infection with comprehensive descriptions of virus-induced pathogenesis in different animal species. We also elaborate on rodent HAdV animal models and how they contributed to insights into adenovirus-induced cell transformation and cancer.
    Language English
    Publishing date 2021-12-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10121253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Animal Models in Human Adenovirus Research

    Bertzbach, Luca D. / Ip, Wing-Hang / Dobner, Thomas

    Biology. 2021 Dec. 01, v. 10, no. 12

    2021  

    Abstract: Human adenovirus (HAdV) infections cause a wide variety of clinical symptoms, ranging from mild upper respiratory tract disease to lethal outcomes, particularly in immunocompromised individuals. To date, neither widely available vaccines nor approved ... ...

    Abstract Human adenovirus (HAdV) infections cause a wide variety of clinical symptoms, ranging from mild upper respiratory tract disease to lethal outcomes, particularly in immunocompromised individuals. To date, neither widely available vaccines nor approved antiadenoviral compounds are available to efficiently deal with HAdV infections. Thus, there is a need to thoroughly understand HAdV-induced disease, and for the development and preclinical evaluation of HAdV therapeutics and/or vaccines, and consequently for suitable standardizable in vitro systems and animal models. Current animal models to study HAdV pathogenesis, persistence, and tumorigenesis include rodents such as Syrian hamsters, mice, and cotton rats, as well as rabbits. In addition, a few recent studies on other species, such as pigs and tree shrews, reported promising data. These models mimic (aspects of) HAdV-induced pathological changes in humans and, although they are relevant, an ideal HAdV animal model has yet to be developed. This review summarizes the available animal models of HAdV infection with comprehensive descriptions of virus-induced pathogenesis in different animal species. We also elaborate on rodent HAdV animal models and how they contributed to insights into adenovirus-induced cell transformation and cancer.
    Keywords Mastadenovirus ; animal models ; carcinogenesis ; cotton ; respiratory tract diseases ; therapeutics ; trees
    Language English
    Dates of publication 2021-1201
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10121253
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Correction for You et al., "The Marek's Disease Virus Unique Gene MDV082 Is Dispensable for Virus Replication but Contributes to a Rapid Disease Onset".

    You, Yu / Conradie, Andelé M / Kheimar, Ahmed / Bertzbach, Luca D / Kaufer, Benedikt B

    Journal of virology

    2022  Volume 96, Issue 15, Page(s) e0079722

    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00797-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Applications of mass spectrometry imaging in virus research.

    Bertzbach, Luca D / Kaufer, Benedikt B / Karger, Axel

    Advances in virus research

    2020  Volume 109, Page(s) 31–62

    Abstract: Mass spectrometry imaging (MSI) is a label-free molecular imaging technique allowing an untargeted detection of a broad range of biomolecules and xenobiotics. MSI enables imaging of the spatial distribution of proteins, peptides, lipids and metabolites ... ...

    Abstract Mass spectrometry imaging (MSI) is a label-free molecular imaging technique allowing an untargeted detection of a broad range of biomolecules and xenobiotics. MSI enables imaging of the spatial distribution of proteins, peptides, lipids and metabolites from a wide range of samples. To date, this technique is commonly applied to tissue sections in cancer diagnostics and biomarker development, but also molecular histology in general. Advances in the methodology and bioinformatics improved the resolution of MS images below the single cell level and increased the flexibility of the workflow. However, MSI-based research in virology is just starting to gain momentum and its full potential has not been exploited yet. In this review, we discuss the main applications of MSI in virology. We review important aspects of matrix-assisted laser desorption/ionization (MALDI) MSI, the most widely used MSI technique in virology. In addition, we summarize relevant literature on MSI studies that aim to unravel virus-host interactions and virus pathogenesis, to elucidate antiviral drug kinetics and to improve current viral disease diagnostics. Collectively, these studies strongly improve our general understanding of virus-induced changes in the proteome, metabolome and metabolite distribution in host tissues of humans, animals and plants upon infection. Furthermore, latest MSI research provided important insights into the drug distribution and distribution kinetics, especially in antiretroviral research. Finally, MSI-based investigations of oncogenic viruses greatly increased our knowledge on tumor mass signatures and facilitated the identification of cancer biomarkers.
    MeSH term(s) Animals ; Books ; Humans ; Mass Spectrometry/instrumentation ; Mass Spectrometry/methods ; Metabolomics ; Molecular Imaging/instrumentation ; Molecular Imaging/methods ; Oncogenic Viruses/pathogenicity ; Plant Viruses/pathogenicity ; Plants/virology ; Proteome/metabolism ; Research ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Viruses/chemistry ; Viruses/genetics
    Chemical Substances Proteome
    Language English
    Publishing date 2020-11-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 195-8
    ISSN 1557-8399 ; 0065-3527
    ISSN (online) 1557-8399
    ISSN 0065-3527
    DOI 10.1016/bs.aivir.2020.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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