LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 640

Search options

  1. Article ; Online: The Role and Mechanism of Action of Mitophagy in Various Liver Diseases.

    Wang, Chunling / Wang, Yijin

    Antioxidants & redox signaling

    2023  Volume 38, Issue 7-9, Page(s) 529–549

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Humans ; Mitophagy ; Autophagy/physiology ; Liver Diseases ; Homeostasis
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2022.0114
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Study of energy-efficient architecture address utilizing topography and geomorphology based on Google Earth and its remote sensing data

    Wang Yijin

    E3S Web of Conferences, Vol 206, p

    2020  Volume 01020

    Abstract: In this paper, we describe the formatting guidelines for ACM SIG Proceedings. With the development of social economy, smart cities, especially green energy-saving buildings, are foremost trend in the future. The location of green buildings has a very ... ...

    Abstract In this paper, we describe the formatting guidelines for ACM SIG Proceedings. With the development of social economy, smart cities, especially green energy-saving buildings, are foremost trend in the future. The location of green buildings has a very important impact on the design and plan of future smart cities. The influence of the natural environment, especially that of the topography and landform on the location of architectural design is very significant. Google Earth (GE) platform can provide sufficient remote sensing data, which greatly interpret and promote surface information. However, just few people have done related research. This article takes Beijing as an example and uses Google Earth platform and the remote sensing data to obtain the 3D digital elevation model (DEM) data; and then Google earth’s geomorphology data are used to analyze the landform features. Finally, by analyzing their characteristics and distribution features, five energy-saving building locations were selected in Beijing. It can be concluded that GE, is an effective and potential platform for providing remote sensing data, and analyzing the DEM and landform. The rational analysis of the building addresses in this paper could help the buildings to avoid potential geological disasters and make full use of natural resources. Moreover, this research on energyefficient building addresses make a suggestion for future smart city planning.
    Keywords Environmental sciences ; GE1-350
    Subject code 720
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Cancer stem cell biomarkers and related signalling pathways.

    Wang, Zhe / Li, Rui / Yang, Guilin / Wang, Yijin

    Journal of drug targeting

    2024  Volume 32, Issue 1, Page(s) 33–44

    Abstract: Cancer stem cells (CSCs) represent a distinct subset of neoplastic cells characterised by their heightened capacity for tumorigenesis. These cells are implicated in the facilitation of cancer metastasis, recurrence, and resistance to conventional ... ...

    Abstract Cancer stem cells (CSCs) represent a distinct subset of neoplastic cells characterised by their heightened capacity for tumorigenesis. These cells are implicated in the facilitation of cancer metastasis, recurrence, and resistance to conventional therapeutic interventions. Extensive scientific research has been devoted to the identification of biomarkers and the elucidation of molecular mechanisms in order to improve targeted therapeutic approaches. Accurate identification of cancer stem cells based on biomarkers can provide a theoretical basis for drug combinations of malignant tumours. Targeted biomarker-based therapies also offer a silver lining for patients with advanced malignancies. This review aims comprehensively to consolidate the latest findings on CSCs biomarkers, targeted agents as well as biomarkers associated signalling pathways in well-established cancer types, thereby contributing to improved prognostic outcomes.
    MeSH term(s) Humans ; Neoplasms/therapy ; Antineoplastic Agents/pharmacology ; Biomarkers/metabolism ; Signal Transduction ; Neoplastic Stem Cells/metabolism ; Biomarkers, Tumor/metabolism
    Chemical Substances Antineoplastic Agents ; Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2023.2295222
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Point Cloud Denoising and Feature Preservation: An Adaptive Kernel Approach Based on Local Density and Global Statistics.

    Wang, Lianchao / Chen, Yijin / Song, Wenhui / Xu, Hanghang

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 6

    Abstract: Noise removal is a critical stage in the preprocessing of point clouds, exerting a significant impact on subsequent processes such as point cloud classification, segmentation, feature extraction, and 3D reconstruction. The exploration of methods capable ... ...

    Abstract Noise removal is a critical stage in the preprocessing of point clouds, exerting a significant impact on subsequent processes such as point cloud classification, segmentation, feature extraction, and 3D reconstruction. The exploration of methods capable of adapting to and effectively handling the noise in point clouds from real-world outdoor scenes remains an open and practically significant issue. Addressing this issue, this study proposes an adaptive kernel approach based on local density and global statistics (AKA-LDGS). This method constructs the overall framework for point cloud denoising using Bayesian estimation theory. It dynamically sets the prior probabilities of real and noise points according to the spatial function relationship, which varies with the distance from the points to the center of the LiDAR. The probability density function (PDF) for real points is constructed using a multivariate Gaussian distribution, while the PDF for noise points is established using a data-driven, non-parametric adaptive kernel density estimation (KDE) approach. Experimental results demonstrate that this method can effectively remove noise from point clouds in real-world outdoor scenes while maintaining the overall structural features of the point cloud.
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24061718
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Enjoyment, boredom, and perceived effectiveness of learners in language MOOCs: the mediating effect of self-regulated learning.

    Luo, Rong / Wang, Yijin

    Frontiers in psychology

    2023  Volume 14, Page(s) 1145773

    Abstract: Self-regulated learning in technology-supported environments has attracted much scholarly attention in recent years. With the rapid expansion of online education, students' emotions have also been studied extensively in second language acquisition. ... ...

    Abstract Self-regulated learning in technology-supported environments has attracted much scholarly attention in recent years. With the rapid expansion of online education, students' emotions have also been studied extensively in second language acquisition. However, few empirical studies have examined the interrelationship between students' self-regulated learning and emotions in the emerging field of language MOOCs (LMOOCs). This study bridged this gap by exploring the relationship between foreign language enjoyment (FLE), boredom (FLB), self-regulated learning (SRL), and perceived effectiveness in LMOOC learning. Data were collected among 356 successful learners of a language MOOC in mainland China through a cross-sectional study. The results showed that LMOOC learners had a high level of enjoyment and a moderate level of boredom. A significantly positive relationship was noted between FLE and SRL while a negative relationship was found between FLB and SRL. SRL was confirmed to be the mediator between FLE, FLB, and PE, which partially mediated the effects of FLE on PE and fully mediated the effects of FLB on PE. Perceived effectiveness was predicted by all SRL strategies and time management significantly predicted perceived effectiveness. The results provided pedagogical implications for students to develop positive emotions and effective SRL strategies to achieve better learning outcomes in LMOOC learning.
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1145773
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A Review for Artificial Intelligence Based Protein Subcellular Localization.

    Xiao, Hanyu / Zou, Yijin / Wang, Jieqiong / Wan, Shibiao

    Biomolecules

    2024  Volume 14, Issue 4

    Abstract: Proteins need to be located in appropriate spatiotemporal contexts to carry out their diverse biological functions. Mislocalized proteins may lead to a broad range of diseases, such as cancer and Alzheimer's disease. Knowing where a target protein ... ...

    Abstract Proteins need to be located in appropriate spatiotemporal contexts to carry out their diverse biological functions. Mislocalized proteins may lead to a broad range of diseases, such as cancer and Alzheimer's disease. Knowing where a target protein resides within a cell will give insights into tailored drug design for a disease. As the gold validation standard, the conventional wet lab uses fluorescent microscopy imaging, immunoelectron microscopy, and fluorescent biomarker tags for protein subcellular location identification. However, the booming era of proteomics and high-throughput sequencing generates tons of newly discovered proteins, making protein subcellular localization by wet-lab experiments a mission impossible. To tackle this concern, in the past decades, artificial intelligence (AI) and machine learning (ML), especially deep learning methods, have made significant progress in this research area. In this article, we review the latest advances in AI-based method development in three typical types of approaches, including sequence-based, knowledge-based, and image-based methods. We also elaborately discuss existing challenges and future directions in AI-based method development in this research field.
    MeSH term(s) Artificial Intelligence ; Humans ; Proteins/metabolism ; Proteins/chemistry ; Proteins/analysis ; Machine Learning ; Proteomics/methods ; Animals ; Deep Learning
    Chemical Substances Proteins
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040409
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Editorial: Diagnosis, treatment and prognosis of viral hepatitis, volume II.

    Wu, Jian / Xu, Zhipeng / Zhu, Chuanlong / Lin, Wenyu / Wang, Yijin

    Frontiers in medicine

    2023  Volume 9, Page(s) 1098625

    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1098625
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Editorial: Diagnosis, Treatment, and Prognosis of Viral Hepatitis.

    Wu, Jian / Wang, Yijin / Zhu, Chuanlong / Lin, Wenyu

    Frontiers in medicine

    2022  Volume 9, Page(s) 882878

    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.882878
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: CD8

    Huang, Yijin / Jia, Anna / Wang, Yufei / Liu, Guangwei

    Immunology

    2022  Volume 168, Issue 1, Page(s) 30–48

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; T-Cell Exhaustion ; Immunotherapy ; Neoplasms/therapy ; Cytokines
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-11-14
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.13588
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.181: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Vitamin D and neurodegenerative diseases.

    Wang, Weixia / Li, Yijin / Meng, Xianfang

    Heliyon

    2023  Volume 9, Issue 1, Page(s) e12877

    Abstract: Neurodegenerative diseases, featured by progressive loss of structure or function of neurons, are considered incurable at present. Movement disorders like tremor and postural instability, cognitive or behavioral disorders such as memory impairment are ... ...

    Abstract Neurodegenerative diseases, featured by progressive loss of structure or function of neurons, are considered incurable at present. Movement disorders like tremor and postural instability, cognitive or behavioral disorders such as memory impairment are the most common symptoms of them and the growing patient population of neurodegenerative diseases poses a serious threat to public health and a burden on economic development. Hence, it is vital to prevent the occurrence of the diseases and delay their progress. Vitamin D can be transformed into a hormone
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e12877
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top