Article ; Online: SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression.
2020 Volume 143, Page(s) 110102
Abstract: Since the WHO declared COVID-19 a pandemic, a great effort has been made to understand this serious disease. Thousands of studies are being devoted to understanding its epidemiology, its molecular characteristics, its mechanisms, and the clinical ... ...
| Abstract | Since the WHO declared COVID-19 a pandemic, a great effort has been made to understand this serious disease. Thousands of studies are being devoted to understanding its epidemiology, its molecular characteristics, its mechanisms, and the clinical evolution of this viral infection. However, little has been published on its pathogenesis and the host response mechanisms in the progress of the disease. Therefore, we propose a hypothesis based on strong scientific documentation, associating oxidative stress with changes found in patients with COVID-19, such as its participation in the amplification and perpetuation of the cytokine storm, coagulopathy, and cell hypoxia. Finally, we suggest a therapeutic strategy to reduce oxidative stress using antioxidants, NF-κB inhibitors, Nrf2 activators, and iron complexing agents. We believe that this hypothesis can guide new studies and therapeutic strategies on this topic. |
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| MeSH term(s) | Antioxidants/metabolism ; Antioxidants/pharmacology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/physiopathology ; Cytokines/metabolism ; Disease Progression ; Humans ; Hypoxia ; Iron/metabolism ; NF-E2-Related Factor 2/antagonists & inhibitors ; NF-kappa B/antagonists & inhibitors ; Oxidative Stress ; Pandemics ; Pneumonia, Viral/physiopathology ; SARS-CoV-2 |
| Chemical Substances | Antioxidants ; Cytokines ; NF-E2-Related Factor 2 ; NF-kappa B ; NFE2L2 protein, human ; Iron (E1UOL152H7) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-07-13 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 193145-3 |
| ISSN | 1532-2777 ; 0306-9877 |
| ISSN (online) | 1532-2777 |
| ISSN | 0306-9877 |
| DOI | 10.1016/j.mehy.2020.110102 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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