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  1. Article ; Online: A ten-year retrospective analysis of nocardiosis in a tertiary care center of South-coastal India.

    Kudru, Chandrashekar Udyavara / Kumar, Abishek / Chawla, Kiran / Minnamreddigari, Cheshmitha / Siddalingaiah, Nayana / Guddattu, Vasudeva

    Le infezioni in medicina

    2021  Volume 29, Issue 4, Page(s) 600–608

    Abstract: Nocardiosis is an uncommon life-threatening infection caused ... ...

    Abstract Nocardiosis is an uncommon life-threatening infection caused by
    Language English
    Publishing date 2021-12-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2041081-5
    ISSN 2532-8689 ; 1124-9390
    ISSN (online) 2532-8689
    ISSN 1124-9390
    DOI 10.53854/liim-2904-14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5576: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Ad26.COV2.S boosts antibody and T-cell responses following BNT162b2 vaccination.

    Iketani, Sho / Liu, Lihong / Nair, Manoj S / Chandrashekar, Abishek / Mohri, Hiroshi / Wang, Maple / Barouch, Dan H / Huang, Yaoxing / Ho, David D

    Emerging microbes & infections

    2021  Volume 10, Issue 1, Page(s) 2220–2222

    MeSH term(s) Ad26COVS1/administration & dosage ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; BNT162 Vaccine/administration & dosage ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; T-Lymphocytes/immunology ; Vaccination
    Chemical Substances Ad26COVS1 (JT2NS6183B) ; Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Letter
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2021.2006581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Selective SARS-CoV2 BA.2 escape of antibody Fc/Fc-receptor interactions.

    Bartsch, Yannic C / Cizmeci, Deniz / Kang, Jaewon / Gao, Hailong / Shi, Wei / Chandrashekar, Abishek / Collier, Ai-Ris Y / Chen, Bing / Barouch, Dan H / Alter, Galit

    iScience

    2023  Volume 26, Issue 5, Page(s) 106582

    Abstract: The number of mutations in the omicron (B.1.1.529) BA.1 variant of concern led to an unprecedented evasion of vaccine induced immunity. However, despite rise in global infections, severe disease did not increase proportionally and is likely linked to ... ...

    Abstract The number of mutations in the omicron (B.1.1.529) BA.1 variant of concern led to an unprecedented evasion of vaccine induced immunity. However, despite rise in global infections, severe disease did not increase proportionally and is likely linked to persistent recognition of BA.1 by T cells and non-neutralizing opsonophagocytic antibodies. Yet, the emergence of new sublineage BA.2, which is more transmissible than BA.1 despite relatively preserved neutralizing antibody responses, has raised the possibility that BA.2 may evade other vaccine-induced responses. Here, we comprehensively profiled the BNT162b2 vaccine-induced response to several VOCs, including omicron BA.1 and BA.2. While vaccine-induced immune responses were compromised against both omicron sublineages, vaccine-induced antibody isotype titers, and non-neutralizing Fc effector functions were attenuated to the omicron BA.2 spike compared to BA.1. Conversely, FcγR2a and FcγR2b binding was elevated to BA.2, albeit lower than BA.1 responses, potentially contributing to persistent protection against severity of disease.
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Vaccines Elicit Highly Cross-Reactive Cellular Immunity to the SARS-CoV-2 Omicron Variant.

    Liu, Jinyan / Chandrashekar, Abishek / Sellers, Daniel / Barrett, Julia / Lifton, Michelle / McMahan, Katherine / Sciacca, Michaela / VanWyk, Haley / Wu, Cindy / Yu, Jingyou / Collier, Ai-Ris Y / Barouch, Dan H

    medRxiv : the preprint server for health sciences

    2022  

    Abstract: The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 Spike ... ...

    Abstract The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 Spike immunogen
    Language English
    Publishing date 2022-01-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2022.01.02.22268634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Selective SARS-CoV2 BA.2 escape of antibody Fc/Fc-receptor interactions

    Yannic C. Bartsch / Deniz Cizmeci / Jaewon Kang / Hailong Gao / Wei Shi / Abishek Chandrashekar / Ai-ris Y. Collier / Bing Chen / Dan H. Barouch / Galit Alter

    iScience, Vol 26, Iss 5, Pp 106582- (2023)

    2023  

    Abstract: Summary: The number of mutations in the omicron (B.1.1.529) BA.1 variant of concern led to an unprecedented evasion of vaccine induced immunity. However, despite rise in global infections, severe disease did not increase proportionally and is likely ... ...

    Abstract Summary: The number of mutations in the omicron (B.1.1.529) BA.1 variant of concern led to an unprecedented evasion of vaccine induced immunity. However, despite rise in global infections, severe disease did not increase proportionally and is likely linked to persistent recognition of BA.1 by T cells and non-neutralizing opsonophagocytic antibodies. Yet, the emergence of new sublineage BA.2, which is more transmissible than BA.1 despite relatively preserved neutralizing antibody responses, has raised the possibility that BA.2 may evade other vaccine-induced responses. Here, we comprehensively profiled the BNT162b2 vaccine-induced response to several VOCs, including omicron BA.1 and BA.2. While vaccine-induced immune responses were compromised against both omicron sublineages, vaccine-induced antibody isotype titers, and non-neutralizing Fc effector functions were attenuated to the omicron BA.2 spike compared to BA.1. Conversely, FcγR2a and FcγR2b binding was elevated to BA.2, albeit lower than BA.1 responses, potentially contributing to persistent protection against severity of disease.
    Keywords Immunology ; Virology ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Adenovirus-vectored vaccine containing multidimensionally conserved parts of the HIV proteome is immunogenic in rhesus macaques.

    Murakowski, Dariusz K / Barton, John P / Peter, Lauren / Chandrashekar, Abishek / Bondzie, Esther / Gao, Ang / Barouch, Dan H / Chakraborty, Arup K

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 5

    Abstract: An effective vaccine that can protect against HIV infection does not exist. A major reason why a vaccine is not available is the high mutability of the virus, which enables it to evolve mutations that can evade human immune responses. This challenge is ... ...

    Abstract An effective vaccine that can protect against HIV infection does not exist. A major reason why a vaccine is not available is the high mutability of the virus, which enables it to evolve mutations that can evade human immune responses. This challenge is exacerbated by the ability of the virus to evolve compensatory mutations that can partially restore the fitness cost of immune-evading mutations. Based on the fitness landscapes of HIV proteins that account for the effects of coupled mutations, we designed a single long peptide immunogen comprising parts of the HIV proteome wherein mutations are likely to be deleterious regardless of the sequence of the rest of the viral protein. This immunogen was then stably expressed in adenovirus vectors that are currently in clinical development. Macaques immunized with these vaccine constructs exhibited T-cell responses that were comparable in magnitude to animals immunized with adenovirus vectors with whole HIV protein inserts. Moreover, the T-cell responses in immunized macaques strongly targeted regions contained in our immunogen. These results suggest that further studies aimed toward using our vaccine construct for HIV prophylaxis and cure are warranted.
    MeSH term(s) AIDS Vaccines/immunology ; Adenoviridae/metabolism ; Amino Acid Sequence ; Animals ; Antigens, Viral/immunology ; Female ; Genetic Vectors/metabolism ; HIV Infections/immunology ; HIV-1/immunology ; Immunization ; Macaca mulatta ; Male ; Proteome/metabolism ; T-Lymphocytes, Cytotoxic/immunology ; Viral Proteins/chemistry ; Viral Proteins/metabolism
    Chemical Substances AIDS Vaccines ; Antigens, Viral ; Proteome ; Viral Proteins
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2022496118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron.

    Liu, Jinyan / Chandrashekar, Abishek / Sellers, Daniel / Barrett, Julia / Jacob-Dolan, Catherine / Lifton, Michelle / McMahan, Katherine / Sciacca, Michaela / VanWyk, Haley / Wu, Cindy / Yu, Jingyou / Collier, Ai-Ris Y / Barouch, Dan H

    Nature

    2022  Volume 603, Issue 7901, Page(s) 493–496

    Abstract: The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike ... ...

    Abstract The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike protein
    MeSH term(s) Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Vaccines/immunology ; Cross Reactions/immunology ; Humans ; Immunity, Cellular ; Immunity, Humoral ; SARS-CoV-2/chemistry ; SARS-CoV-2/classification ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-04465-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  8. Article: Comparable Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants.

    Yu, Jingyou / Collier, Ai-Ris Y / Rowe, Marjorie / Mardas, Fatima / Ventura, John D / Wan, Huahua / Miller, Jessica / Powers, Olivia / Chung, Benjamin / Siamatu, Mazuba / Hachmann, Nicole P / Surve, Nehalee / Nampanya, Felix / Chandrashekar, Abishek / Barouch, Dan H

    medRxiv : the preprint server for health sciences

    2022  

    Abstract: The SARS-CoV-2 Omicron variant (B.1.1.529) has three major lineages BA.1, BA.2, and BA ... ...

    Abstract The SARS-CoV-2 Omicron variant (B.1.1.529) has three major lineages BA.1, BA.2, and BA.3
    Language English
    Publishing date 2022-02-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2022.02.06.22270533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques.

    Jacob-Dolan, Catherine / Yu, Jingyou / McMahan, Katherine / Giffin, Victoria / Chandrashekar, Abishek / Martinot, Amanda J / Anioke, Tochi / Powers, Olivia C / Hall, Kevin / Hope, David / Miller, Jessica / Hachmann, Nichole P / Chung, Benjamin / Gardner, Sarah / Sellers, Daniel / Barrett, Julia / Lewis, Mark G / Andersen, Hanne / Kleanthous, Harry /
    Seo, Ki-Woen / Lee, Su Jeen / Park, Yong Wook / Kim, Hun / Barouch, Dan H

    NPJ vaccines

    2023  Volume 8, Issue 1, Page(s) 23

    Abstract: Despite the availability of several effective SARS-CoV-2 vaccines, additional vaccines will be required for optimal global vaccination. In this study, we investigate the immunogenicity and protective efficacy of the GBP510 protein subunit vaccine ... ...

    Abstract Despite the availability of several effective SARS-CoV-2 vaccines, additional vaccines will be required for optimal global vaccination. In this study, we investigate the immunogenicity and protective efficacy of the GBP510 protein subunit vaccine adjuvanted with AS03, which has recently been authorized for marketing in South Korea under the trade name SKYCovione
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-023-00622-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys.

    Moldt, Brian / Chandrashekar, Abishek / Borducchi, Erica N / Nkolola, Joseph P / Stephenson, Heather / Nagel, Mark / Hung, Magdeleine / Goldsmith, Joshua / Pace, Craig S / Carr, Brian / Thomsen, Nathan D / Blair, Wade S / Geleziunas, Romas / Barouch, Dan H

    PLoS pathogens

    2022  Volume 18, Issue 4, Page(s) e1010467

    Abstract: A key challenge for the development of a cure to HIV-1 infection is the persistent viral reservoir established during early infection. Previous studies using Toll-like receptor 7 (TLR7) agonists and broadly neutralizing antibodies (bNAbs) have shown ... ...

    Abstract A key challenge for the development of a cure to HIV-1 infection is the persistent viral reservoir established during early infection. Previous studies using Toll-like receptor 7 (TLR7) agonists and broadly neutralizing antibodies (bNAbs) have shown delay or prevention of viral rebound following antiretroviral therapy (ART) discontinuation in simian-human immunodeficiency virus (SHIV)-infected rhesus macaques. In these prior studies, ART was initiated early during acute infection, which limited the size and diversity of the viral reservoir. Here we evaluated in SHIV-infected rhesus macaques that did not initiate ART until 1 year into chronic infection whether the TLR7 agonist vesatolimod in combination with the bNAb PGT121, formatted either as a human IgG1, an effector enhanced IgG1, or an anti-CD3 bispecific antibody, would delay or prevent viral rebound following ART discontinuation. We found that all 3 antibody formats in combination with vesatolimod were able to prevent viral rebound following ART discontinuation in a subset of animals. These data indicate that a TLR7 agonist combined with antibodies may be a promising strategy to achieve long-term ART-free HIV remission in humans.
    MeSH term(s) Animals ; Anti-Retroviral Agents/pharmacology ; Anti-Retroviral Agents/therapeutic use ; Broadly Neutralizing Antibodies ; HIV Antibodies/therapeutic use ; HIV Infections ; HIV-1 ; Immunoglobulin G ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome ; Simian Immunodeficiency Virus ; Toll-Like Receptor 7/agonists ; Viral Load
    Chemical Substances Anti-Retroviral Agents ; Broadly Neutralizing Antibodies ; HIV Antibodies ; Immunoglobulin G ; Toll-Like Receptor 7
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1010467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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