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  1. Book ; Online ; Thesis: Characterization of antiviral effects of emricasan and SARS-CoV-2 isolates in vitro

    Pfeiffer, Annika Eby [Verfasser] / Bojkova, Denisa [Akademischer Betreuer] / Ciesek, Sandra [Akademischer Betreuer] / Bojkova, Denisa [Gutachter] / Reinheimer, Claudia [Gutachter]

    2024  

    Author's details Annika Eby Pfeiffer ; Gutachter: Denisa Bojkova, Claudia Reinheimer ; Denisa Bojkova, Sandra Ciesek
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
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  2. Article ; Online: Climatically promoted taxonomic homogenization of macroinvertebrates in unaffected streams varies along the river continuum.

    Zhai, Marie / Bojková, Jindřiška / Němejcová, Denisa / Polášek, Marek / Syrovátka, Vít / Horsák, Michal

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 6292

    Abstract: Biotic homogenization appears to be a global consequence of anthropogenic change. However, the underlying environmental factors contributing to homogenization are difficult to identify because their effects usually interact and confound each other. This ... ...

    Abstract Biotic homogenization appears to be a global consequence of anthropogenic change. However, the underlying environmental factors contributing to homogenization are difficult to identify because their effects usually interact and confound each other. This can be the reason why there is very little evidence on the role of climate warming in homogenization. By analysing macroinvertebrate assemblages in 65 streams that were as close to natural conditions as possible, we avoided the confounding effects of common anthropogenic stressors. This approach resulted in revealing a significant effect of increased temperature (both summer and winter) on changes in macroinvertebrate compositional over the past two decades. However, homogenization was significant only at opposite ends of the river continuum (submontane brooks, low-altitude rivers). Surprisingly, species of native origin predominated overall, increasing in frequency and abundance ("winners"), while only a minority of species declined or disappeared ("losers"). We hypothesise that undisturbed conditions mitigate species declines and thus homogenization, and that the temperature increase has so far been beneficial to most native species. Although we may have only captured a transitional state due to extinction debt, this underscores the importance of maintaining ecological conditions in stream to prevent species loss due to climate change.
    MeSH term(s) Animals ; Invertebrates ; Ecosystem ; Rivers ; Environmental Monitoring/methods ; Climate Change
    Language English
    Publishing date 2023-04-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32806-y
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  3. Article ; Online: Trifluridine for treatment of mpox infection in drug combinations in ophthalmic cell models.

    Cinatl, Jindrich / Bechtel, Marco / Reus, Philipp / Ott, Melanie / Rothweiler, Florian / Michaelis, Martin / Ciesek, Sandra / Bojkova, Denisa

    Journal of medical virology

    2024  Volume 96, Issue 1, Page(s) e29354

    Abstract: The Mpox virus can cause severe disease in the susceptible population with dermatologic and systemic manifestations. Furthermore, ophthalmic manifestations of mpox infection are well documented. Topical trifluridine (TFT) eye drops have been used for ... ...

    Abstract The Mpox virus can cause severe disease in the susceptible population with dermatologic and systemic manifestations. Furthermore, ophthalmic manifestations of mpox infection are well documented. Topical trifluridine (TFT) eye drops have been used for therapy of ophthalmic mpox infection in patients, however, its efficacy against mpox virus infection in this scenario has not been previously shown. In the present study, we have established ophthalmic cell models suitable for the infection with mpox virus. We show, that TFT is effective against a broad range of mpox isolates in conjunctival epithelial cells and keratocytes. Further, TFT remained effective against a tecovirimat-resistant virus strain. In the context of drug combinations, a nearly additive effect was observed for TFT combinations with brincidofovir and tecovirimat in conjunctival epithelial cells, while a slight antagonism was observed for both combinations in keratocytes. Altogether, our findings demonstrate TFT as a promising drug for treatment of ophthalmic mpox infection able to overcome tecovirimat resistance. However, conflicting results regarding the effect of drug combinations with approved compounds warrant close monitoring of such use in patients.
    MeSH term(s) Humans ; Trifluridine/pharmacology ; Trifluridine/therapeutic use ; Mpox (monkeypox) ; Eye ; Drug Combinations ; Benzamides ; Isoindoles ; Monkeypox virus
    Chemical Substances Trifluridine (RMW9V5RW38) ; Drug Combinations ; Benzamides ; Isoindoles
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29354
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  4. Article: Discovery of anti-SARS-CoV-2 secondary metabolites from the heartwood of

    Wasilewicz, Andreas / Zwirchmayr, Julia / Kirchweger, Benjamin / Bojkova, Denisa / Cinatl, Jindrich / Rabenau, Holger F / Rollinger, Judith M / Beniddir, Mehdi A / Grienke, Ulrike

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1202394

    Abstract: A pigment-depleted extract from the heartwood ... ...

    Abstract A pigment-depleted extract from the heartwood of
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1202394
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  5. Article: SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment.

    Bojkova, Denisa / Rothenburger, Tamara / Ciesek, Sandra / Wass, Mark N / Michaelis, Martin / Cinatl, Jindrich

    Cell discovery

    2022  Volume 8, Issue 1, Page(s) 42

    Language English
    Publishing date 2022-05-10
    Publishing country England
    Document type Letter
    ISSN 2056-5968
    ISSN 2056-5968
    DOI 10.1038/s41421-022-00408-z
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  6. Article ; Online: Impact of the COVID-19 pandemic on the circulation of other pathogens in England.

    Hayes, Lauren J / Uri, Hannah / Bojkova, Denisa / Cinatl, Jindrich / Wass, Mark N / Michaelis, Martin

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28401

    MeSH term(s) Humans ; COVID-19/epidemiology ; Pandemics ; England/epidemiology
    Language English
    Publishing date 2022-12-13
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28401
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  7. Article ; Online: Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates.

    Bojkova, Denisa / Widera, Marek / Ciesek, Sandra / Wass, Mark N / Michaelis, Martin / Cinatl, Jindrich

    Cell research

    2022  Volume 32, Issue 3, Page(s) 319–321

    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Humans ; Interferons ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Interferons (9008-11-1)
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-022-00619-9
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    Zs.A 5283: Show issues Location:
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  8. Article ; Online: Silver N-heterocyclic carbene complexes are potent uncompetitive inhibitors of the papain-like protease with antiviral activity against SARS-CoV-2.

    Gil-Moles, Maria / O'Beirne, Cillian / Esarev, Igor V / Lippmann, Petra / Tacke, Matthias / Cinatl, Jindrich / Bojkova, Denisa / Ott, Ingo

    RSC medicinal chemistry

    2023  Volume 14, Issue 7, Page(s) 1260–1271

    Abstract: The ongoing SARS-CoV-2 pandemic has caused a high demand for novel innovative antiviral drug candidates. Despite promising results, metal complexes have been relatively unexplored as antiviral agents in general and in particular against SARS-CoV-2. Here ... ...

    Abstract The ongoing SARS-CoV-2 pandemic has caused a high demand for novel innovative antiviral drug candidates. Despite promising results, metal complexes have been relatively unexplored as antiviral agents in general and in particular against SARS-CoV-2. Here we report on silver NHC complexes with chloride or iodide counter ligands that are potent inhibitors of the SARS-CoV-2 papain-like protease (PL
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d3md00067b
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  9. Article ; Online: Correction: Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.

    Armstrong, Lee A / Lange, Sven M / Cesare, Virginia De / Matthews, Stephen P / Nirujogi, Raja Sekhar / Cole, Isobel / Hope, Anthony / Cunningham, Fraser / Toth, Rachel / Mukherjee, Rukmini / Bojkova, Denisa / Gruber, Franz / Gray, David / Wyatt, Paul G / Cinatl, Jindrich / Dikic, Ivan / Davies, Paul / Kulathu, Yogesh

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0302418

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0253364.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0253364.].
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0302418
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  10. Article ; Online: SARS-CoV-2 Variants Show Different Host Cell Proteome Profiles With Delayed Immune Response Activation in Omicron-Infected Cells.

    Metzler, Melinda / Tharyan, Rebecca George / Klann, Kevin / Grikscheit, Katharina / Bojkova, Denisa / Cinatl, Jindrich / Tascher, Georg / Ciesek, Sandra / Münch, Christian

    Molecular & cellular proteomics : MCP

    2023  Volume 22, Issue 5, Page(s) 100537

    Abstract: The ancestral SARS-CoV-2 strain that initiated the Covid-19 pandemic at the end of 2019 has rapidly mutated into multiple variants of concern with variable pathogenicity and increasing immune escape strategies. However, differences in host cellular ... ...

    Abstract The ancestral SARS-CoV-2 strain that initiated the Covid-19 pandemic at the end of 2019 has rapidly mutated into multiple variants of concern with variable pathogenicity and increasing immune escape strategies. However, differences in host cellular antiviral responses upon infection with SARS-CoV-2 variants remain elusive. Leveraging whole-cell proteomics, we determined host signaling pathways that are differentially modulated upon infection with the clinical isolates of the ancestral SARS-CoV-2 B.1 and the variants of concern Delta and Omicron BA.1. Our findings illustrate alterations in the global host proteome landscape upon infection with SARS-CoV-2 variants and the resulting host immune responses. Additionally, viral proteome kinetics reveal declining levels of viral protein expression during Omicron BA.1 infection when compared to ancestral B.1 and Delta variants, consistent with its reduced replication rates. Moreover, molecular assays reveal deferral activation of specific host antiviral signaling upon Omicron BA.1 and BA.2 infections. Our study provides an overview of host proteome profile of multiple SARS-CoV-2 variants and brings forth a better understanding of the instigation of key immune signaling pathways causative for the differential pathogenicity of SARS-CoV-2 variants.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Proteome ; Pandemics ; Antiviral Agents ; Antibodies, Neutralizing
    Chemical Substances Proteome ; Antiviral Agents ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075924-1
    ISSN 1535-9484 ; 1535-9476
    ISSN (online) 1535-9484
    ISSN 1535-9476
    DOI 10.1016/j.mcpro.2023.100537
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