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  1. Article: Loss of a Functional Mitochondrial Pyruvate Carrier in

    de Oliveira Junqueira, Ana Caroline / Moreira Melo, Nadielle Tamires / Skorupa Parachin, Nádia / Costa Paes, Hugo

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: Cytosolic pyruvate is an essential metabolite in lactic acid production during microbial fermentation. However, under aerobiosis, pyruvate is transported to the mitochondrial matrix by the mitochondrial pyruvate carrier (MPC) and oxidized in cell ... ...

    Abstract Cytosolic pyruvate is an essential metabolite in lactic acid production during microbial fermentation. However, under aerobiosis, pyruvate is transported to the mitochondrial matrix by the mitochondrial pyruvate carrier (MPC) and oxidized in cell respiration. Previous reports using
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes.

    de Lacerda, Luna / Castro, Guilherme / Gomes, Cristopher / Junqueira, Caroline

    Journal of visualized experiments : JoVE

    2022  , Issue 186

    Abstract: Malaria is a major public health concern, presenting more than 200 million cases per year worldwide. Despite years of scientific efforts, protective immunity to malaria is still poorly understood, mainly due to methodological limitations of long-term ... ...

    Abstract Malaria is a major public health concern, presenting more than 200 million cases per year worldwide. Despite years of scientific efforts, protective immunity to malaria is still poorly understood, mainly due to methodological limitations of long-term Plasmodium culture, especially for Plasmodium vivax. Most studies have focused on adaptive immunity protection against malaria by antibodies, which play a key role in controlling malaria. However, the sterile protection induced by attenuated Plasmodium sporozoites vaccines is related to cellular response, mainly to cytotoxic T lymphocytes, such as CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; Erythrocytes ; Humans ; Malaria/parasitology ; Malaria Vaccines ; Plasmodium ; Sporozoites
    Chemical Substances Malaria Vaccines
    Language English
    Publishing date 2022-08-17
    Publishing country United States
    Document type Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/63987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Panoramic Radiography vs. CBCT in the Evaluation of the Maxillary Third Molar Roots.

    Almeida-Marques, Marcia / Ingold, Mara Magnoler Sampaio / da Silva-Junior, Alberto Ferreira / Franco, Ademir / Junqueira, José Luiz Cintra / Oenning, Anne Caroline

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 11

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Molar, Third/diagnostic imaging ; Spiral Cone-Beam Computed Tomography ; Radiography, Panoramic/methods ; Molar ; Cone-Beam Computed Tomography/methods
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59111975
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  4. Article ; Online: Could Phylogenetic Analysis Be Used for Feline Leukemia Virus (FeLV) Classification?

    Cano-Ortiz, Lucía / Tochetto, Caroline / Roehe, Paulo Michel / Franco, Ana Cláudia / Junqueira, Dennis Maletich

    Viruses

    2022  Volume 14, Issue 2

    Abstract: The surface envelope (SU) protein determines the cell tropism and consequently the pathogenesis of the feline leukemia virus (FeLV) in felids. Recombination of exogenous FeLV (exFeLV) with endogenous retroviruses (enFeLV) allows the emergence of more ... ...

    Abstract The surface envelope (SU) protein determines the cell tropism and consequently the pathogenesis of the feline leukemia virus (FeLV) in felids. Recombination of exogenous FeLV (exFeLV) with endogenous retroviruses (enFeLV) allows the emergence of more pathogenic variants. Currently, phenotypic testing through interference assays is the only method to distinguish among subgroups-namely, FeLV-A, -B, -C, -E, and -T. This study proposes a new method for FeLV classification based on molecular analysis of the
    MeSH term(s) Databases, Genetic ; Geography ; Leukemia Virus, Feline/classification ; Leukemia Virus, Feline/genetics ; Mutation ; Phylogeny ; Recombination, Genetic ; Viral Envelope Proteins/genetics
    Chemical Substances Viral Envelope Proteins
    Language English
    Publishing date 2022-01-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14020249
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  5. Article: CBCT study on the prevalence, morphology and position of the mandibular incisive canal in a North-Brazilian population.

    Martins, Valber-Barbosa / Oenning, Anne-Caroline-Costa / Guimarães, Luciana-Campos / Junqueira, José-Luiz-Cintra / Franco, Ademir

    Journal of clinical and experimental dentistry

    2022  Volume 14, Issue 7, Page(s) e534–e540

    Abstract: Background: The mandibular incisive canal (MIC) is an anatomic structure to be considered in treatment planning for surgeries in the anterior region of the mandible. Awareness of the MIC increased with the use of 3D imaging for treatment planning, such ... ...

    Abstract Background: The mandibular incisive canal (MIC) is an anatomic structure to be considered in treatment planning for surgeries in the anterior region of the mandible. Awareness of the MIC increased with the use of 3D imaging for treatment planning, such as cone beam computed tomography (CBCT). This study aimed to use CBCT to assess the prevalence, morphology and position of the MIC among North-Brazilians.
    Material and methods: The sample consisted of CBCT scans of 100 hemi-mandibles (50 individuals) that were assessed for the absolute (n) and relative frequency of the MIC. The morphological component of this study was the diameter (mm) of the detected MIC in five anatomic sites between the mental foramen and the midline. Within the interformainal region, the position of the MIC was assessed by measuring (mm) the distances between the MIC and the basal, vestibular and lingual cortical bone surfaces.
    Results: The prevalence of the MIC was >76% considering the different anatomic regions screened in CBCT. The mean diameter of the MIC progressively reduced from 1.29 mm to 0.86 throughout the five anatomic regions measured. The position of the MIC showed a downward trajectory away from the lingual cortical bone surface.
    Conclusions: MIC was a highly prevalent anatomic structure in the studied sample. The funnel-shaped outline of the MIC and its trajectory into the interforaminal region highlighted a major risk of damage to the neurovascular bundle in surgeries (e.g. implant placement) that are close to the mental foramen and the vestibular cortical bone.
    Language English
    Publishing date 2022-07-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.59487
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  6. Article ; Online: Particulate matter from a tropical city in southeast Brazil: Impact of biomass burning on polycyclic aromatic compounds levels, health risks, and in vitro toxicity.

    Scaramboni, Caroline / Urban, Roberta Cerasi / Oliveira, Danielle Palma de / Dorta, Daniel Junqueira / Campos, Maria Lucia Arruda Moura

    Chemosphere

    2023  Volume 350, Page(s) 141072

    Abstract: In the context of a rising global temperature, biomass burning represents an increasing risk to human health, due to emissions of highly toxic substances such as polycyclic aromatic hydrocarbon (PAHs). Size-segregated particulate matter (PM) was ... ...

    Abstract In the context of a rising global temperature, biomass burning represents an increasing risk to human health, due to emissions of highly toxic substances such as polycyclic aromatic hydrocarbon (PAHs). Size-segregated particulate matter (PM) was collected in a region within the sugarcane belt of São Paulo state (Brazil), where biomass burning is still frequent, despite the phasing out of manual harvesting preceded by fire. The median of the total concentration of the 15 PAHs determined was 2.3 ± 1.8 ng m
    MeSH term(s) Humans ; Particulate Matter/toxicity ; Particulate Matter/analysis ; Air Pollutants/toxicity ; Air Pollutants/analysis ; Polycyclic Compounds/analysis ; Brazil ; Biomass ; Biodiversity ; Environmental Monitoring ; Temperature ; Polycyclic Aromatic Hydrocarbons/toxicity ; Polycyclic Aromatic Hydrocarbons/analysis ; Organic Chemicals/analysis ; Seasons
    Chemical Substances Particulate Matter ; Air Pollutants ; Polycyclic Compounds ; Polycyclic Aromatic Hydrocarbons ; Organic Chemicals
    Language English
    Publishing date 2023-12-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.141072
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Analysis of uterine evacuation methods in postabortion care after implementation of a surveillance network (CLAP MUSA-Network) at a university hospital

    Nelio N. Veiga-Junior / Caroline Eugeni / Beatriz D. Kajiura / Priscilla B. F. Dantas / Caroline B. Trabach / Aline A. Junqueira / Carina C. Nunes / Luiz F. Baccaro

    PLoS ONE, Vol 18, Iss

    2023  Volume 12

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Human-to-swine introductions and onward transmission of 2009 H1N1 pandemic influenza viruses in Brazil.

    Junqueira, Dennis Maletich / Tochetto, Caroline / Anderson, Tavis K / Gava, Danielle / Haach, Vanessa / Cantão, Maurício E / Baker, Amy L Vincent / Schaefer, Rejane

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1243567

    Abstract: Introduction: Once established in the human population, the 2009 H1N1 pandemic virus (H1N1pdm09) was repeatedly introduced into swine populations globally with subsequent onward transmission among pigs.: Methods: To identify and characterize human-to- ...

    Abstract Introduction: Once established in the human population, the 2009 H1N1 pandemic virus (H1N1pdm09) was repeatedly introduced into swine populations globally with subsequent onward transmission among pigs.
    Methods: To identify and characterize human-to-swine H1N1pdm09 introductions in Brazil, we conducted a large-scale phylogenetic analysis of 4,141 H1pdm09 hemagglutinin (HA) and 3,227 N1pdm09 neuraminidase (NA) gene sequences isolated globally from humans and swine between 2009 and 2022.
    Results: Phylodynamic analysis revealed that during the period between 2009 and 2011, there was a rapid transmission of the H1N1pdm09 virus from humans to swine in Brazil. Multiple introductions of the virus were observed, but most of them resulted in self-limited infections in swine, with limited onward transmission. Only a few sustained transmission clusters were identified during this period. After 2012, there was a reduction in the number of human-to-swine H1N1pdm09 transmissions in Brazil.
    Discussion: The virus underwent continuous antigenic drift, and a balance was established between swine-to-swine transmission and extinction, with minimal sustained onward transmission from humans to swine. These results emphasize the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1243567
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  9. Article ; Online: Introductions of Human-Origin Seasonal H3N2, H1N2 and Pre-2009 H1N1 Influenza Viruses to Swine in Brazil.

    Tochetto, Caroline / Junqueira, Dennis M / Anderson, Tavis K / Gava, Danielle / Haach, Vanessa / Cantão, Mauricio E / Vincent Baker, Amy L / Schaefer, Rejane

    Viruses

    2023  Volume 15, Issue 2

    Abstract: In South America, the evolutionary history of influenza A virus (IAV) in swine has been obscured by historically low levels of surveillance, and this has hampered the assessment of the zoonotic risk of emerging viruses. The extensive genetic diversity of ...

    Abstract In South America, the evolutionary history of influenza A virus (IAV) in swine has been obscured by historically low levels of surveillance, and this has hampered the assessment of the zoonotic risk of emerging viruses. The extensive genetic diversity of IAV in swine observed globally has been attributed mainly to bidirectional transmission between humans and pigs. We conducted surveillance in swine in Brazil during 2011-2020 and characterized 107 H1N1, H1N2, and H3N2 IAVs. Phylogenetic analysis based on HA and NA segments revealed that human seasonal IAVs were introduced at least eight times into swine in Brazil since the mid-late 1980s. Our analyses revealed three genetic clades of H1 within the 1B lineage originated from three distinct spillover events, and an H3 lineage that has diversified into three genetic clades. The N2 segment from human seasonal H1N2 and H3N2 viruses was introduced into swine six times and a single introduction of an N1 segment from the human H1N1 virus was identified. Additional analysis revealed further reassortment with H1N1pdm09 viruses. All these introductions resulted in IAVs that apparently circulate only in Brazilian herds. These results reinforce the significant contributions of human IAVs to the genetic diversity of IAV in swine and reiterate the importance of surveillance of IAV in pigs.
    MeSH term(s) Humans ; Animals ; Swine ; Brazil/epidemiology ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N2 Subtype/genetics ; Phylogeny ; Seasons ; Influenza A virus
    Language English
    Publishing date 2023-02-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020576
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  10. Article ; Online: Influence of CBCT-derived panoramic curve variability in the measurements for dental implant planning.

    Adames, Cyntia / Gaêta-Araujo, Hugo / Franco, Ademir / Soares, Mariana Quirino Silveira / Junqueira, José Luiz Cintra / Oenning, Anne Caroline

    Oral radiology

    2023  Volume 40, Issue 1, Page(s) 30–36

    Abstract: Objective: To investigate whether the curve markings performed prior to panoramic and cross-sectional reconstructions can influence the planning of oral implants.: Methods: Twenty oral radiologists landmarked the reference panoramic curves in 25 CBCT ...

    Abstract Objective: To investigate whether the curve markings performed prior to panoramic and cross-sectional reconstructions can influence the planning of oral implants.
    Methods: Twenty oral radiologists landmarked the reference panoramic curves in 25 CBCT scans of the mandible. Bone height was measured on the resulting cross-sectional slices in the edentulous region of the lower first molar. The following data were recorded: (1) number of landmarks used to build each reference curve; (2) shape of the reference curve (inverted "U", inverted "V" or "horseshoe"); and (3) measurement in the first molar region. The data were assessed for variability based on the number of landmarks, the shape of the reference curve, and the measurements obtained.
    Results: The number of landmarks used to guide the panoramic reconstruction varied among radiologists (p < 0.05), but most of them draw curves in inverted "U" shape (68-100%). The reproducibility of the measurements taken in the edentulous mandibular first molar region was excellent (84.7%). The number of landmarks and the shape of the curve did not have a significant influence on the reproducibility of the measurements (p > 0.05).
    Conclusion: Variations of the operator-dependent steps during the panoramic reconstructions occur but do not play a significant part changing the measurements taken for oral implant planning.
    MeSH term(s) Radiography, Panoramic ; Spiral Cone-Beam Computed Tomography ; Cone-Beam Computed Tomography ; Dental Implants ; Reproducibility of Results ; Cross-Sectional Studies
    Chemical Substances Dental Implants
    Language English
    Publishing date 2023-08-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 639456-5
    ISSN 1613-9674 ; 0911-6028
    ISSN (online) 1613-9674
    ISSN 0911-6028
    DOI 10.1007/s11282-023-00703-9
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    In stock of ZB MED Cologne/Königswinter

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