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Article ; Online: Meme Kanserli Kadınlarda Tamoksifen veya Tamoksifen+Leuprolid Asetat Tedavisi Alanlarda Endometrial Patoloji Sonuçlarının Karşılaştırılması

Mehmet Musa ASLAN / Vedat UĞUREL

Online Türk Sağlık Bilimleri Dergisi , Vol 4, Iss 2, Pp 148-

2019 Volume 155

Abstract: Meme kanserli olgularda tamoksifen kullanımına GnRH agonisti eklenmesinin endometrial patoloji ve endometrial kanser oranlarına etkisinin araştırılması planlandı. Retrospektif yapılan çalışma 1998 ile 2013 yılları arasında meme kanseri nedeniyle opere ... ...

Abstract	Meme kanserli olgularda tamoksifen kullanımına GnRH agonisti eklenmesinin endometrial patoloji ve endometrial kanser oranlarına etkisinin araştırılması planlandı. Retrospektif yapılan çalışma 1998 ile 2013 yılları arasında meme kanseri nedeniyle opere olan ve Trakya Üniversitesi Tıp Fakültesi Hastanesi jinekoloji polikliniğinde endometriyal örnekleme yapılan 204 olgu, sadece tamoksifen alanlar ve tamoksifen+GnRH agonisti(leuprolide acetate depot 11,25 mg) tedavisi alanlar olarak iki gruba ayrıldı. Tamoksifen ile birlikte GnRH agonisti kullanan premenopozal kadınlar ile tamoksifen kullanan postmenopozal kadınlar arasında ultrason incelemesinde endometrial kalınlık, histopatolojik incelemede endometrial patoloji bulunma ve endometrial kanser görülme oranları açısından gruplar arasında fark bulunmadı. Meme kanserli hastalarda tamoksifen tedavisine GnRH anoloğunun eklenmesi premenopozal kadınlarda premalign lezyon ve endometrium ca riskini arttırmadığını saptadık.
Keywords	Meme kanseri ; tamoksifen ; GnRH analoğu ; leuprolid asetat ; endometrial patoloji ; endometrial kanser ; Breast cancer ; tamoxifen ; GnRH analgesic ; leuprolide acetate ; endometrial pathology ; endometrial cancer ; Medicine (General) ; R5-920
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	University of Sakarya
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hematological Parameters to Predict the Severity of Hyperemesis Gravidarum and Ketonuria.

Aslan, Mehmet Musa / Yeler, Mustafa Taner / Bıyık, İsmail / Yuvacı, Hilal Uslu / Cevrioğlu, Arif Serhan / Özden, Selcuk

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

2022 Volume 44, Issue 5, Page(s) 458–466

Abstract: Objective: Hyperemesis gravidarum (HG) is a pregnancy complication that can progress with persistent nausea and vomiting. The aim of the present study is to evaluate the relationship between hematological parameters and HG.: Method: A total of 532 ... ...

Title translation	Parâmetros hematológicos para prever a gravidade da hiperêmese gravídica e da cetonúria.
Abstract	Objective: Hyperemesis gravidarum (HG) is a pregnancy complication that can progress with persistent nausea and vomiting. The aim of the present study is to evaluate the relationship between hematological parameters and HG. Method: A total of 532 pregnant women with HG who were admitted to the Department of Obstetrics and Gynecology between March 2019 and February 2021, and 534 healthy pregnant women with characteristics similar to those of the case group were included in the study. The hematological parameters of both groups were compared. In addition, the hematological parametersof patients with HG according to the severity of ketonuria were compared. Results: The mean age of the HG group ( Conclusion: The NLR and PLR were high in patients with HG, suggesting the its inflammatory activity. They may be important markers associated with the presence and severity of HG.
MeSH term(s)	Adult ; Female ; Humans ; Hyperemesis Gravidarum/diagnosis ; Ketones ; Ketosis ; Lymphocytes ; Neutrophils ; Pregnancy ; Young Adult
Chemical Substances	Ketones
Language	English
Publishing date	2022-04-11
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2105176-8
ISSN	1806-9339 ; 0100-7203
ISSN (online)	1806-9339
ISSN	0100-7203
DOI	10.1055/s-0042-1743101
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Article: Assessment of increased risk of arrhythmia in advanced age pregnancies.

Aslan, Mehmet Musa / Atici, Adem

Pakistan journal of medical sciences

2018 Volume 34, Issue 3, Page(s) 687–690

Abstract: Background and objective: Cardiovascular deaths usually occur in older pregnancies and arrhythmia is the third most common cause. Our study aimed to determine whether the risk of arrhythmia increases in pregnancy with advanced age.: Methods: In total, ...

Abstract	Background and objective: Cardiovascular deaths usually occur in older pregnancies and arrhythmia is the third most common cause. Our study aimed to determine whether the risk of arrhythmia increases in pregnancy with advanced age. Methods: In total, 280 pregnant women, of whom 98 were of advanced age and 182 were under 35 years of age were included in the study. The risk of arrhythmia was evaluated by calculating the electrocardiographic P-wave duration, QT interval, T peak-to-end interval, and the Tp-e/QT ratio. Results: Although there were no differences in the Tp-e interval and Tp-e/QTc ratio between the groups, the maximum QTc, minimum QTc, and QTc dispersion values were significantly higher in advanced-age pregnancies compared to the control group. In addition, the P dispersion was greater in advanced-age pregnancies. In correlation analysis, the increased dispersion of QTc and P were positively correlated with maternal age. Multiple linear regression analysis showed that QTc dispersion was independently associated with maternal age. Conclusion: Repolarization parameters increase in advanced-age pregnancies even though they remain in the normal range, which should lead to an investigation of whether this is a pathological condition.
Language	English
Publishing date	2018-07-02
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.343.14313
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Article: Clinical Efficacy of Hormonal and Nonhormonal Agents in the Treatment of Vulvovaginal Atrophy.

Ilhan, Gokcen / Aslan, Mehmet Musa / Cevrioglu, Arif Serhan / Yıldırım, Muzaffer / Erkorkmaz, Unal

Journal of menopausal medicine

2021 Volume 27, Issue 1, Page(s) 15–23

Abstract: Objectives: Symptomatic local treatment of vaginal atrophy (VA) in menopausal women includes hormonal and nonhormonal preparations. Some women may be reluctant to use vaginal estradiol preparations because of the concern for developing breast cancer and ...

Abstract	Objectives: Symptomatic local treatment of vaginal atrophy (VA) in menopausal women includes hormonal and nonhormonal preparations. Some women may be reluctant to use vaginal estradiol preparations because of the concern for developing breast cancer and endometrial hyperplasia. Therefore, it is necessary to compare the therapeutic effectiveness of alternative vaginal drugs, such as promestriene, an estrogen agonist, and sodium hyaluronate (NaH), a nonhormonal, water-based agent. Methods: Ninety-one postmenopausal women diagnosed with symptomatic VA were divided into three groups and treated for 12 weeks; 30 women with vaginal estradiol (VE), 30 women with promestriene, and 31 women with NaH. Composite scoring, vaginal maturation index (VMI), pH, frequency of sexual activity, serum hormone levels, and endometrial thickness were evaluated VA before and after treatment. Results: In the comparison of VA examination findings composite scoring, VMI, and vaginal pH values, three different drugs were found to be effective in the treatment ( Conclusions: Based on these findings, we can conclude that the use of promestriene or NaH can prove to be as effective and well tolerated as vaginal estradiol in the symptomatic treatment of vaginal atrophy.
Language	English
Publishing date	2021-05-03
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3021719-2
ISSN	2288-6761 ; 2288-6478
ISSN (online)	2288-6761
ISSN	2288-6478
DOI	10.6118/jmm.20026
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Article ; Online: Association between platelet indices and missed abortion

Fatih Keskin / Mehmet Musa Aslan / İsmail Bıyık

Journal of Surgery and Medicine, Vol 3, Iss 8, Pp 549-

2019 Volume 552

Abstract: Aim: The incidence of missed abortion is around 15% of clinically diagnosed pregnancies, and the etiology is uncertain. Limited studies in the literature report increased platelet indices such as mean platelet volume (MPV), platelet distribution width ( ... ...

Abstract	Aim: The incidence of missed abortion is around 15% of clinically diagnosed pregnancies, and the etiology is uncertain. Limited studies in the literature report increased platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT). The number of cases in these studies is low and results are inconsistent. There is no study that investigates all platelet indices. This study has the largest series in the literature and investigates all platelet indices in missed abortion. Methods: In this retrospective case-control study, the complete blood count parameters of patients who were diagnosed with missed abortion were examined. Among 500 cases, 228 women with missed abortion constituted the study group, and 272 healthy pregnant women constituted the control group. Women who were 18–45 years of age and 6–14 weeks of gestational age were included. Results: In the missed abortion group, PDW value was higher (P=0.007), while platelet MPV and PCT values were lower (respectively P<0.001 and P=0.008) than the control group.Conclusion: Platelet indices parameters in missed abortion are inconsistent.
Keywords	missed abortion ; platelet indices ; mean platelet volume ; platelet distribution width ; missed abortus ; platelet indeksleri ; ortalama platelet hacmi ; platelet dağılım genişliği ; Medicine ; R ; Medicine (General) ; R5-920 ; Surgery ; RD1-811
Subject code	630
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	Journal of Surgery and Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of the presence of SARS-COV-2 in the vaginal fluid of reproductive-aged women.

Uslu Yuvacı, Hilal / Aslan, Mehmet Musa / Köse, Osman / Akdemir, Nermin / Toptan, Hande / Cevrioğlu, Arif Serhan / Altındiş, Mustafa / Köroğlu, Mehmet

Ginekologia polska

2021

Abstract: Objectives: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is mainly transmitted through respiration and direct contact. The status of the infection in the female genital system is still unknown. The study aimed to evaluate whether SARS- ... ...

Abstract	Objectives: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is mainly transmitted through respiration and direct contact. The status of the infection in the female genital system is still unknown. The study aimed to evaluate whether SARS-CoV-2 is present in the vaginal fluid of women with COVID-19 infection in reproductive period. Material and methods: Women who were between the ages of 18-50 years and clinically confirmed to have COVID-19 infection at our hospital between 20 April-31 May 2020 were included in the study. Women who were in their menstrual cycle during the study and who had a known cervical intraepithelial lesion and/or cancer, sexually transmitted disease and history and/or symptoms of vaginitis were excluded from the study. In patients in whom no pathology was detected during the examination, a sample was taken from the vaginal fluid for PCR by using Dacron tip swab. Analysis was performed with Genesig Real-Time PCR COVID-19 kit (Primer Design, England). Results: Eighteen women who were in reproductive period and diagnosed with severe COVID-19 pneumonia were included in the study. The mean age of the patients was 38.16 ± 8.54. None of the patients were in their menopause period. The clinical symptoms of these women were similar to those of confirmed severe COVID-19 cases. SARS-CoV-2 was found to be negative in the samples taken from the vaginal fluid in all patients. Conclusions: SARS-CoV-2 virus was not detected in the vaginal fluid of the patients who tested positive for COVID-19 in reproductive period.
Language	English
Publishing date	2021-03-10
Publishing country	Poland
Document type	Journal Article
ZDB-ID	130894-4
ISSN	2543-6767 ; 0017-0011
ISSN (online)	2543-6767
ISSN	0017-0011
DOI	10.5603/GP.a2021.0018
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Article ; Online: A case of postmenopausal ovarian hyperandrogenemia diagnosed only by selective catheterization of ovarian vein

Mehmet Musa Aslan / Koray Elter / Vedat Uğurel

Journal of Surgery and Medicine, Vol 2, Iss 3, Pp 374-

2018 Volume 376

Abstract: Hyperandrogenemia in a postmenopausal woman is usually related to a tumor in either ovaries or adrenal glands. To differentiate between these two endocrine organs is a diagnostic challenge when the tumor size is too small to be detected with the aid of ... ...

Abstract	Hyperandrogenemia in a postmenopausal woman is usually related to a tumor in either ovaries or adrenal glands. To differentiate between these two endocrine organs is a diagnostic challenge when the tumor size is too small to be detected with the aid of usual imaging modalities. 54 years-old postmenopausal woman with signs of virilization was referred to our institution with serum total testosteron levels of 294 ng/dl. Contrast-enhanced computed tomography (CT) revealed a lesion consistent with the tumor 1 cm in diameter in the adrenal gland and magnetic resonance imaging (MRI) could not confirm this finding. The location of androgen hypersecretion could only be determined after selective venous catheterization and hormonal sampling of both adrenal and ovarian veins. The right ovarian venous total testosterone level was found as > 1009.40 ng / dl. A right-sided ovarian Leydig cell tumor was diagnosed in the specimen of laparoscopic hysterectomy and bilateral salpingo-oopherectomy. This case report underlines the importance to carry on the search with the selective venous catheterisation and hormonal sampling from both the ovarian and the adrenal veins when there is difficulty to demonstrate the true source of androgen hypersecretion in a postmenopausal woman.
Keywords	postmenopause ; ovarian neoplasms ; hyperandrogenism ; leydig cell tumor ; selective venous catheterization ; postmenopoz ; hiperandrojenizm ; yumurtalık neoplazmaları ; leydig hücreli tümör ; selektif venöz kateterizasyon ; Medicine ; R ; Medicine (General) ; R5-920 ; Surgery ; RD1-811
Subject code	616
Language	English
Publishing date	2018-09-01T00:00:00Z
Publisher	Journal of Surgery and Medicine
Document type	Article ; Online
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Article: Hematological Parameters to Predict the Severity of Hyperemesis Gravidarum and Ketonuria

Aslan, Mehmet Musa / Yeler, Mustafa Taner / Bıyık, İsmail / Yuvacı, Hilal Uslu / Cevrioğlu, Arif Serhan / Özden, Selcuk

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics

2022 Volume 44, Issue 05, Page(s) 458–466

Abstract	Objective: Hyperemesis gravidarum (HG) is a pregnancy complication that can progress with persistent nausea and vomiting. The aim of the present study is to evaluate the relationship between hematological parameters and HG. Method: A total of 532 pregnant women with HG who were admitted to the Department of Obstetrics and Gynecology between March 2019 and February 2021, and 534 healthy pregnant women with characteristics similar to those of the case group were included in the study. The hematological parameters of both groups were compared. In addition, the hematological parametersof patients with HG according to the severity of ketonuria were compared. Results: The mean age of the HG group ( n = 532) was 26.3 ± 4.1 years, and that of the control group ( n = 534) was 25.9 ± 4.8 years. Among patients with HG, 46% ( n = 249) had ketone (+), 33% ( n = 174), ketone (++), and 21% ( n = 109), ketone (++ + ). The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were higher in the HG group than in the control group: 3.8 (2.8–5.8)/3.2 (2.6–4.0); p < 0.001; and 135.2 ± 30.4/108.9 ± 62.2; p < 0.001 respectively. The neutrophil count, NLR, and PLR were higher in the group with ketone (++ + ) than in the groups with ketone (+) or ketone (++): 7.6 ± 1.9/5.5 ± 2.4; p < 0.001; 3.8(2.8–4.6)/2.9(2.3–3.6); p < 0.001; and 149.9 ± 48.0/135.9 ± 65.7; p < 0.001 respectively. The mean corpuscular hemoglobin (MCH) level, the NLR, and the PLR were identified as independent predictors of the presence of HG and the level of ketone positivity in HG patients. Conclusion: The NLR and PLR were high in patients with HG, suggesting the its inflammatory activity. They may be important markers associated with the presence and severity of HG.
Keywords	hyperemesis gravidarum ; ketonuria ; hematological parameters ; hiperêmese gravídica ; cetonúria ; parâmetros hematológicos
Language	English
Publishing date	2022-04-11
Publisher	Thieme Revinter Publicações Ltda.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2105176-8
ISSN	1806-9339 ; 0100-7203
ISSN (online)	1806-9339
ISSN	0100-7203
DOI	10.1055/s-0042-1743101
Database	Thieme publisher's database

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Article: The attitudes of fertile and infertile women to Oocyte donation in a Muslim and Secular population.

Aslan, Mehmet Musa / Ugurel, Vedat / Elter, Koray

Pakistan journal of medical sciences

2017 Volume 33, Issue 5, Page(s) 1260–1264

Abstract: Objective: To determine general attitudes of fertile and infertile women to oocyte donation in a Muslim and secular population.: Methods: The participants consisted of fertile women (n=133) who had at least one healthy living child spontaneously ... ...

Abstract	Objective: To determine general attitudes of fertile and infertile women to oocyte donation in a Muslim and secular population. Methods: The participants consisted of fertile women (n=133) who had at least one healthy living child spontaneously conceived without any fertility treatment and infertile women (n=133) who were diagnosed with primary infertility. Both groups were evaluated with charts comprised of 34 questions addressing demographic characteristics and the social aspects of oocyte and sperm donation. Results: Although the age of fertile women was significantly greater than infertile women, there was no significant difference in terms of duration of marriage, education level, or employment status between the two groups. Most of the women in each group reported that they did not have enough knowledge about oocyte donation to make a decision. Only 12% of fertile women and 18% of infertile women declared that they would have oocytes from another woman if they did not have or could not have a child (p=0.004). Only 9.0% of fertile women and 18.8% of infertile women declared that they would donate oocytes to anyone who is infertile (p=0.021). Conclusion: Despite improvement in health care, most fertile and infertile women are still against oocyte donation. This situation may be related to the conservative leanings of Turkish society in recent decades.
Language	English
Publishing date	2017-11-02
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.335.13556
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Article ; Online: SARS-CoV-2 is not present in the vaginal fluid of pregnant women with COVID-19.

Aslan, Mehmet Musa / Uslu Yuvacı, Hilal / Köse, Osman / Toptan, Hande / Akdemir, Nermin / Köroğlu, Mehmet / Cevrioğlu, Arif Serhan / Özden, Selçuk

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2020 Volume 35, Issue 15, Page(s) 2876–2878

Abstract: Background: Data concerning the presence of SARS-CoV-2 in the female genital system is scarce; however, this information is important for understanding whether the virus can transmit sexually or from mother to child. The aim of this study was to ... ...

Abstract	Background: Data concerning the presence of SARS-CoV-2 in the female genital system is scarce; however, this information is important for understanding whether the virus can transmit sexually or from mother to child. The aim of this study was to investigate whether pregnant women with COVID-19 have virus in their lower genital tract. Methods: In this cross-sectional study, we present an analysis of prospectively gathered data collected at a single tertiary university hospital from 19 April to 19 May 2020. We included 13 pregnant women hospitalized with suspected COVID-19. Results of laboratory tests, imaging tests, and nucleic acid tests on vaginal swabs for SARS-CoV-2 were also analyzed for pregnant women with a clinical diagnosis of COVID-19. Results: Twelve pregnant women with confirmed COVID-19 were included in this study. Mean age was 32 ± 7.9 years. All patients had mild symptoms and were followed in the maternity ward, with none of them needing critical care unit follow-up. All lower genital tract samples were negative for SARS-CoV-2. Conclusion: We demonstrated that SARS-CoV-2 was not present in the vaginal fluid of pregnant women. This finding may indicate that the female genital tract is not a route of SARS-CoV-2 transmission.
MeSH term(s)	Adult ; COVID-19 ; Cross-Sectional Studies ; Female ; Humans ; Infectious Disease Transmission, Vertical ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Pregnant Women ; SARS-CoV-2 ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2020.1793318
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