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Article: SARS-CoV-2 likely targets cellular PDZ proteins: a common tactic of pathogenic viruses.

Rice, Andrew P / Kimata, Jason T

Future virology

2021

Language	English
Publishing date	2021-05-06
Publishing country	England
Document type	Editorial
ISSN	1746-0794
ISSN	1746-0794
DOI	10.2217/fvl-2020-0365
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Article ; Online: Unexpected Mutations in HIV-1 That Confer Resistance to the Tat Inhibitor Didehydro-Cortistatin A.

Rice, Andrew P

mBio

2019 Volume 10, Issue 4

Abstract: Didehydro-cortistatin A (dCA) is a human immunodeficiency virus type 1 (HIV-1) Tat inhibitor that functions by selectively binding to the RNA binding domain of Tat. In addition to inhibiting viral replication, dCA can drive HIV-1 into a state of "deep ... ...

Abstract	Didehydro-cortistatin A (dCA) is a human immunodeficiency virus type 1 (HIV-1) Tat inhibitor that functions by selectively binding to the RNA binding domain of Tat. In addition to inhibiting viral replication, dCA can drive HIV-1 into a state of "deep latency" in which latent viruses are refractory to reactivation. Mousseau et al. (G. Mousseau, R. Aneja, M. A. Clementz, S. Mediouni, et al., mBio 10:e01750-18, 2019, https://doi.org/10.1128/mBio.01750-18) have now selected dCA-resistant (dCA
MeSH term(s)	HIV-1/genetics ; Heterocyclic Compounds, 4 or More Rings ; Humans ; Isoquinolines ; Mutation ; RNA, Viral ; tat Gene Products, Human Immunodeficiency Virus/genetics
Chemical Substances	Heterocyclic Compounds, 4 or More Rings ; Isoquinolines ; RNA, Viral ; didehydro-cortistatin A ; tat Gene Products, Human Immunodeficiency Virus
Language	English
Publishing date	2019-07-09
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.01547-19
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Article ; Online: Texas Developmental Center for AIDS Research CFAR Diversity, Equity, and Inclusion Pathway Initiative Program.

Pereira, Fred A / Newell, Alana D / Rice, Andrew P

Journal of acquired immune deficiency syndromes (1999)

2023 Volume 94, Issue 2S, Page(s) S80–S85

Abstract: Background: The Texas Developmental Center for AIDS Research (D-CFAR) diversity program, termed the CFAR Diversity, Equity, and Inclusion Pathway Initiative (CDEIPI), was created in 2021 to engage high school students and graduate students from ... ...

Abstract	Background: The Texas Developmental Center for AIDS Research (D-CFAR) diversity program, termed the CFAR Diversity, Equity, and Inclusion Pathway Initiative (CDEIPI), was created in 2021 to engage high school students and graduate students from Underrepresented Minorities/Black, Indigenous, and People of Color populations. Setting: The Texas D-CFAR CDEIPI has partnered with 2 Texas high schools with predominantly economically disadvantaged and minority student populations-Michael E. DeBakey High School for Health Professions in Houston, TX, and the South Texas Independent School District Medical Professions High School in Olmito, TX in the Rio Grande Valley. Methods: A total of 370 high school student learners at both partner schools participated in presentations of research and career paths related to HIV-1 and SARS-CoV-2 during the 2021-2022 academic year. Afterward, learners completed anonymous surveys to share their self-reported interest in research degrees and careers. Results: Learners reported increased knowledge of related science content and interest in research careers, including HIV-1 research, after each of the sessions. Conclusions: The programming has been of interest to student learners, and future additions intend to build upon the Texas D-CFAR CDEIPI.
MeSH term(s)	Humans ; Acquired Immunodeficiency Syndrome/epidemiology ; Acquired Immunodeficiency Syndrome/prevention & control ; Diversity, Equity, Inclusion ; Texas/epidemiology ; COVID-19 ; SARS-CoV-2 ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV-1 ; HIV Seropositivity
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000003253
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Zs.A 2442: Show issues

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Article ; Online: Roles of CDKs in RNA polymerase II transcription of the HIV-1 genome.

Rice, Andrew P

Transcription

2018 Volume 10, Issue 2, Page(s) 111–117

Abstract: Studies of RNA Polymerase II (Pol II) transcription of the HIV-1 genome are of clinical interest, as the insight gained may lead to strategies to selectively reactivate latent viruses in patients in whom viral replication is suppressed by antiviral drugs. ...

Abstract	Studies of RNA Polymerase II (Pol II) transcription of the HIV-1 genome are of clinical interest, as the insight gained may lead to strategies to selectively reactivate latent viruses in patients in whom viral replication is suppressed by antiviral drugs. Such a targeted reactivation may contribute to a functional cure of infection. This review discusses five Cyclin-dependent kinases - CDK7, CDK9, CDK11, CDK2, and CDK8 - involved in transcription and processing of HIV-1 RNA. CDK7 is required for Pol II promoter clearance of reactivated viruses; CDK7 also functions as an activating kinase for CDK9 when resting CD4
MeSH term(s)	Cyclin-Dependent Kinases/metabolism ; HIV-1/genetics ; Humans ; Polyadenylation ; RNA Polymerase II/metabolism ; Transcription, Genetic/genetics
Chemical Substances	Cyclin-Dependent Kinases (EC 2.7.11.22) ; RNA Polymerase II (EC 2.7.7.-)
Language	English
Publishing date	2018-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2646974-1
ISSN	2154-1272 ; 2154-1264
ISSN (online)	2154-1272
ISSN	2154-1264
DOI	10.1080/21541264.2018.1542254
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Article ; Online: The HIV-1 Tat Protein: Mechanism of Action and Target for HIV-1 Cure Strategies.

Rice, Andrew P

Current pharmaceutical design

2017 Volume 23, Issue 28, Page(s) 4098–4102

Abstract: The general mechanism involved in Tat activation of RNA Polymerase II (RNAP II) elongation of the integrated HIV-1 was elucidated over 20 years ago. This mechanism involves Tat binding to the TAR RNA element that forms at the 5' end of viral transcripts ... ...

Abstract	The general mechanism involved in Tat activation of RNA Polymerase II (RNAP II) elongation of the integrated HIV-1 was elucidated over 20 years ago. This mechanism involves Tat binding to the TAR RNA element that forms at the 5' end of viral transcripts and recruiting a general RNAP II elongation factor termed as PTEFb. This elongation factor consists of CDK9 and Cyclin T1, and when recruited by Tat to TAR RNA, CDK9 was proposed to phosphorylate the carboxyl terminal domain of RNAP II and thereby activate elongation. Research in the past two decades has shown that the mechanism of Tat action is considerably more complicated than this simple model. In metabolically active cells, CDK9 and Cyclin T1 are now known to be largely sequestered in a RNA-protein complex termed the 7SK RNP. CDK9 and Cyclin T1 are released from the 7SK RNP by mechanisms not yet fully elucidated and along with Tat, bind to TAR RNA and orchestrate the assembly of a Super Elongation Complex (SEC) containing several additional proteins. CDK9 in the SEC then phosphorylates multiple substrates in the RNAP II complex to activate elongation. Importantly for therapeutic strategies, CDK9 and Cyclin T1 functions are down-regulated in resting CD4+ T cells that harbor latent HIV-1, and their up-regulation is required for reactivation of latent virus. Current strategies for a functional cure of HIV-1 infection therefore are likely to require development of latency reversal agents that up-regulate CDK9 and Cyclin T1 function in resting CD4+ T cells.
MeSH term(s)	Anti-HIV Agents/pharmacology ; CD4-Positive T-Lymphocytes/virology ; Cyclin T/metabolism ; Cyclin-Dependent Kinase 9/metabolism ; Down-Regulation/genetics ; Drug Design ; Gene Expression Regulation, Viral/drug effects ; HIV Infections/drug therapy ; HIV Infections/genetics ; HIV-1/drug effects ; HIV-1/genetics ; Humans ; RNA Polymerase II/metabolism ; Up-Regulation/drug effects ; Virus Latency/drug effects ; tat Gene Products, Human Immunodeficiency Virus/metabolism
Chemical Substances	Anti-HIV Agents ; Cyclin T ; tat Gene Products, Human Immunodeficiency Virus ; Cyclin-Dependent Kinase 9 (EC 2.7.11.22) ; RNA Polymerase II (EC 2.7.7.-)
Language	English
Publishing date	2017-07-01
Publishing country	United Arab Emirates
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612823666170704130635
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Zs.A 4714: Show issues

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Article ; Online: Cyclin-dependent kinases as therapeutic targets for HIV-1 infection.

Rice, Andrew P

Expert opinion on therapeutic targets

2016 Volume 20, Issue 12, Page(s) 1453–1461

Abstract: Introduction: A number of cyclin-dependent kinases (CDKs) mediate key steps in the HIV-1 replication cycle and therefore have potential to serve as therapeutic targets for HIV-1 infection, especially in HIV-1 cure strategies. Current HIV-1 cure ... ...

Abstract	Introduction: A number of cyclin-dependent kinases (CDKs) mediate key steps in the HIV-1 replication cycle and therefore have potential to serve as therapeutic targets for HIV-1 infection, especially in HIV-1 cure strategies. Current HIV-1 cure strategies involve the development of small molecules that are able to activate HIV-1 from latent infection, thereby allowing the immune system to recognize and clear infected cells. Areas covered: The role of seven CDK family members in the HIV-1 replication cycle is reviewed, with a focus on CDK9, as the mechanism whereby the viral Tat protein utilizes CDK9 to enhance viral replication is known in considerable detail. Expert opinion: Given the essential roles of CDKs in cellular proliferation and gene expression, small molecules that inhibit CDKs are unlikely to be feasible therapeutics for HIV-1 infection. However, small molecules that activate CDK9 and other select CDKs such as CDK11 have potential to reactivate latent HIV-1 and contribute to a functional cure of infection.
MeSH term(s)	Anti-HIV Agents/pharmacology ; Cyclin-Dependent Kinase 9/metabolism ; Cyclin-Dependent Kinases/metabolism ; Gene Products, tat/metabolism ; HIV Infections/drug therapy ; HIV Infections/enzymology ; HIV Infections/virology ; HIV-1/enzymology ; Humans ; Molecular Targeted Therapy ; Virus Replication/drug effects
Chemical Substances	Anti-HIV Agents ; Gene Products, tat ; Cyclin-Dependent Kinase 9 (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22)
Language	English
Publishing date	2016-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2055208-7
ISSN	1744-7631 ; 1472-8222
ISSN (online)	1744-7631
ISSN	1472-8222
DOI	10.1080/14728222.2016.1254619
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Zs.A 5244: Show issues

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Article ; Online: Roles of microRNAs and long-noncoding RNAs in human immunodeficiency virus replication.

Rice, Andrew P

Wiley interdisciplinary reviews. RNA

2015 Volume 6, Issue 6, Page(s) 661–670

Abstract: MicroRNAs (miRNAs) and long-noncoding RNAs (lncRNAs) are involved in many biological processes, including viral replication. In this review, the role of miRNAs and lncRNAs in human immunodeficiency virus (HIV) replication will be discussed. The review ... ...

Abstract	MicroRNAs (miRNAs) and long-noncoding RNAs (lncRNAs) are involved in many biological processes, including viral replication. In this review, the role of miRNAs and lncRNAs in human immunodeficiency virus (HIV) replication will be discussed. The review focuses on miRNAs that target cellular proteins involved in HIV replication-proteins that mediate steps in the viral life cycle, as well as proteins of the innate immune system that inhibit HIV replication. Given the large number of miRNAs encoded in the human genome, as well as the large number of cellular proteins involved in HIV replication, the number of miRNAs identified to date that affect viral replication are certainly only the 'tip of the iceberg'. The review also discusses two lncRNAs that are involved in HIV gene regulation-7SK RNA and NEAT1 RNA. 7SK RNA is involved in HIV Tat protein stimulation of RNA polymerase II elongation of the integrated provirus, while NEAT1 RNA is involved in HIV Rev protein export of incompletely spliced viral transcripts.
MeSH term(s)	HIV/genetics ; HIV/physiology ; Humans ; MicroRNAs ; RNA, Long Noncoding ; Virus Replication/genetics
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; long non-coding RNA 7SK, human
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2634714-3
ISSN	1757-7012 ; 1757-7004
ISSN (online)	1757-7012
ISSN	1757-7004
DOI	10.1002/wrna.1308
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Article ; Online: Proteomics, Human Environmental Exposure, and Cardiometabolic Risk.

Perry, Andrew S / Zhang, Kai / Murthy, Venkatesh L / Choi, Bina / Zhao, Shilin / Gajjar, Priya / Colangelo, Laura A / Hou, Lifang / Rice, Mary / Carr, John Jeffrey / Carson, April P / Nigra, Anne E / Vasan, Ramachandran S / Gerszten, Robert E / Khan, Sadiya S / Kalhan, Ravi / Nayor, Matthew / Shah, Ravi V

Circulation research

2024

Abstract: Rationale: ...

Abstract	Rationale:
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.124.324559
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Article ; Online: Endogenous Circadian System Increases Capacity for Enhanced Coronary Microvascular Function in the Morning.

Thosar, Saurabh S / Hodovan, James / Kheiri, Babikir / McHill, Andrew W / Bowles, Nicole P / Butler, Matthew P / Rice, Sean P M / Emens, Jonathan S / Shea, Steven A / Lindner, Jonathan R

Arteriosclerosis, thrombosis, and vascular biology

2023 Volume 43, Issue 6, Page(s) 1078–1080

MeSH term(s)	Cardiovascular Physiological Phenomena ; Circadian Rhythm
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.123.319265
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Article ; Online: P-TEFb as a target to reactivate latent HIV: two Brds are now in hand.

Rice, Andrew P

Cell cycle (Georgetown, Tex.)

2013 Volume 12, Issue 3, Page(s) 392–393

Abstract: Comment on: Boehm D, et al. Cell Cycle 2013; 12(3): In this issue. ...

Abstract	Comment on: Boehm D, et al. Cell Cycle 2013; 12(3): In this issue.
MeSH term(s)	Cell Cycle Proteins ; HIV Infections/virology ; HIV-1/physiology ; Humans ; Nuclear Proteins/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Transcription Factors/metabolism ; tat Gene Products, Human Immunodeficiency Virus/metabolism
Chemical Substances	BRD2 protein, human ; BRD4 protein, human ; Cell Cycle Proteins ; Nuclear Proteins ; Transcription Factors ; tat Gene Products, Human Immunodeficiency Virus ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2013-01-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.23556
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