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  1. Article ; Online: Corrigendum to "SARS-CoV-2 multiplex RT-PCR to detect variants of concern (VOCs) in Malaysia, between January and May 2021" [J. Virol. Methods 301 (2022) 114462].

    Fu, Jolene Yin Ling / Chong, Yoong Min / Sam, I-Ching / Chan, Yoke Fun

    Journal of virological methods

    2022  Volume 309, Page(s) 114596

    Language English
    Publishing date 2022-08-13
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2022.114596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Chikungunya encephalopathy and pneumonia in a young infant presenting with septic shock.

    Chee, Yun Shan / Ahamad Fouzi, Nadiah / Chong, Yoong Min / Sam, I-Ching / Chan, Yoke Fun / Chua, Chong Long / Wang, Qi Yuee

    Journal of paediatrics and child health

    2022  Volume 58, Issue 8, Page(s) 1468–1471

    MeSH term(s) Brain Diseases ; Chikungunya Fever/complications ; Chikungunya Fever/diagnosis ; Humans ; Infant ; Pneumonia/diagnosis ; Pneumonia/etiology ; Sepsis ; Shock, Septic/diagnosis ; Shock, Septic/etiology
    Language English
    Publishing date 2022-02-17
    Publishing country Australia
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.15858
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Low postpandemic wave SARS-CoV-2 seroprevalence in Kuala Lumpur and Selangor, Malaysia.

    Sam, I-Ching / Chong, Yoong Min / Tan, Chee Wah / Chan, Yoke Fun

    Journal of medical virology

    2020  Volume 93, Issue 2, Page(s) 647–648

    MeSH term(s) Adolescent ; Adult ; Aged ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19 Serological Testing ; Child ; Child, Preschool ; Female ; Humans ; Malaysia/epidemiology ; Male ; Mass Screening/statistics & numerical data ; Middle Aged ; Seroepidemiologic Studies ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26426
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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  4. Article ; Online: SARS-CoV-2 multiplex RT-PCR to detect variants of concern (VOCs) in Malaysia, between January to May 2021.

    Fu, Jolene Yin Ling / Chong, Yoong Min / Sam, I-Ching / Chan, Yoke Fun

    Journal of virological methods

    2022  Volume 301, Page(s) 114462

    Abstract: Emerging SARS-CoV-2 variants of concern (VOC) have been associated with enhanced transmissibility and immune escape. Next-generation sequencing (NGS) of the whole genome is the gold standard for variant identification for surveillance but is time- ... ...

    Abstract Emerging SARS-CoV-2 variants of concern (VOC) have been associated with enhanced transmissibility and immune escape. Next-generation sequencing (NGS) of the whole genome is the gold standard for variant identification for surveillance but is time-consuming and costly. Rapid and cost-effective assays that detect SARS-CoV-2 variants are needed. We evaluated Allplex SARS-CoV-2 Master Assay and Variants I Assay to detect HV69/70 deletion, Y144 deletion, E484K, N501Y, and P681H spike mutations in 248 positive samples collected in Kuala Lumpur, Malaysia, between January and May 2021. Spike variants were detected in 78/248 (31.5 %), comprising 60 VOC B.1.351 (beta) and 18 B.1.1.7 (alpha). With NGS as reference for 115 samples, the sensitivity for detecting the spike mutations was 98.7 % with the Master Assay and 100 % with the Variants I Assay. The emergence of beta variants correlated with increasing COVID-19 infections in Malaysia. The prevalence of alpha VOC and lineage B.1.466.2 was low. These assays detect mutations present in alpha, beta and gamma VOCs. Of the VOCs which have subsequently emerged, the assays should detect omicron (B.1.1.529) but not B.1.617.2 (delta). In conclusion, spike variant PCR assays can be used to rapidly monitor selected SARS-CoV-2 VOCs in resource-limited settings, but require updates as new variants emerge.
    MeSH term(s) COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; Humans ; Malaysia ; Multiplex Polymerase Chain Reaction ; Mutation ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2
    Language English
    Publishing date 2022-01-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2022.114462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: SARS-CoV-2 multiplex RT-PCR to detect variants of concern (VOCs) in Malaysia, between January to May 2021

    Fu, Jolene Yin Ling / Chong, Yoong Min / Sam, I-Ching / Chan, Yoke Fun

    Journal of Virological Methods. 2022 Mar., v. 301 p.114462-

    2022  

    Abstract: Emerging SARS-CoV-2 variants of concern (VOC) have been associated with enhanced transmissibility and immune escape. Next-generation sequencing (NGS) of the whole genome is the gold standard for variant identification for surveillance but is time- ... ...

    Abstract Emerging SARS-CoV-2 variants of concern (VOC) have been associated with enhanced transmissibility and immune escape. Next-generation sequencing (NGS) of the whole genome is the gold standard for variant identification for surveillance but is time-consuming and costly. Rapid and cost-effective assays that detect SARS-CoV-2 variants are needed. We evaluated Allplex SARS-CoV-2 Master Assay and Variants I Assay to detect HV69/70 deletion, Y144 deletion, E484K, N501Y, and P681H spike mutations in 248 positive samples collected in Kuala Lumpur, Malaysia, between January and May 2021. Spike variants were detected in 78/248 (31.5 %), comprising 60 VOC B.1.351 (beta) and 18 B.1.1.7 (alpha). With NGS as reference for 115 samples, the sensitivity for detecting the spike mutations was 98.7 % with the Master Assay and 100 % with the Variants I Assay. The emergence of beta variants correlated with increasing COVID-19 infections in Malaysia. The prevalence of alpha VOC and lineage B.1.466.2 was low. These assays detect mutations present in alpha, beta and gamma VOCs. Of the VOCs which have subsequently emerged, the assays should detect omicron (B.1.1.529) but not B.1.617.2 (delta). In conclusion, spike variant PCR assays can be used to rapidly monitor selected SARS-CoV-2 VOCs in resource-limited settings, but require updates as new variants emerge.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; cost effectiveness ; genome ; monitoring ; Malaysia ; COVID-19 ; SARS-CoV-2 ; Next-generation sequencing ; RT-qPCR ; Variants of concern
    Language English
    Dates of publication 2022-03
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2022.114462
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor.

    Chong, Yoong Min / Kaur, Gurjeet / Tan, Mei Lan

    Journal of Asian natural products research

    2019  Volume 21, Issue 8, Page(s) 754–771

    Abstract: Andrographolide, a major bioactive compound isolated ... ...

    Abstract Andrographolide, a major bioactive compound isolated from
    MeSH term(s) Animals ; CHO Cells ; Cell Proliferation/drug effects ; Cricetulus ; Diterpenes/pharmacokinetics ; Diterpenes/pharmacology ; Herb-Drug Interactions ; Humans ; Molecular Docking Simulation ; Organic Anion Transport Protein 1/analysis ; Organic Anion Transport Protein 1/antagonists & inhibitors ; Organic Anion Transport Protein 1/chemistry ; Organic Anion Transport Protein 1/genetics ; Probenecid/chemistry ; Probenecid/pharmacology ; p-Aminohippuric Acid/pharmacokinetics
    Chemical Substances Diterpenes ; Organic Anion Transport Protein 1 ; andrographolide (410105JHGR) ; Probenecid (PO572Z7917) ; p-Aminohippuric Acid (Y79XT83BJ9)
    Language English
    Publishing date 2019-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2018.1520704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor

    Chong, Yoong Min / Kaur, Gurjeet / Tan, Mei Lan

    Journal of Asian natural products research. 2019 Aug. 3, v. 21, no. 8

    2019  

    Abstract: Andrographolide, a major bioactive compound isolated from Andrographis paniculata (Burm. F.) Nees, was evaluated for its effects on the hOAT1 membrane transporter. Substrate determination and inhibition of hOAT1-mediated uptake transport assay was ... ...

    Abstract Andrographolide, a major bioactive compound isolated from Andrographis paniculata (Burm. F.) Nees, was evaluated for its effects on the hOAT1 membrane transporter. Substrate determination and inhibition of hOAT1-mediated uptake transport assay was carried out using recombinant CHO-hOAT1 cells. The results showed that the uptake ratio of andrographolide was less than 2.0 at all concentrations tested, indicating that andrographolide is not a hOAT1 substrate. Andrographolide has no significant effects on the p-aminohippuric acid uptake and on the mRNA and protein expression of hOAT1. In conclusion, andrographolide may not pose a drug–herb interaction risk related to hOAT1.
    Keywords Andrographis paniculata ; andrographolide ; bioactive compounds ; humans ; messenger RNA ; protein synthesis ; risk
    Language English
    Dates of publication 2019-0803
    Size p. 754-771.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2018.1520704
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Low postpandemic wave SARS‐CoV‐2 seroprevalence in Kuala Lumpur and Selangor, Malaysia

    Sam, I‐Ching / Chong, Yoong Min / Tan, Chee Wah / Chan, Yoke Fun

    Journal of Medical Virology ; ISSN 0146-6615 1096-9071

    2020  

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/jmv.26426
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Rhinovirus/enterovirus was the most common respiratory virus detected in adults with severe acute respiratory infections pre-COVID-19 in Kuala Lumpur, Malaysia.

    Chong, Yoong Min / Chan, Yoke Fun / Jamaluddin, Mohamad Fadhil Hadi / Hasan, M Shahnaz / Pang, Yong Kek / Ponnampalavanar, Sasheela / Syed Omar, Sharifah Faridah / Sam, I-Ching

    PloS one

    2022  Volume 17, Issue 9, Page(s) e0273697

    Abstract: Background: Severe acute respiratory infections (SARI) pose a great global burden. The contribution of respiratory viruses to adult SARI is relatively understudied in Asia. We aimed to determine viral aetiology of adult SARI patients in Kuala Lumpur, ... ...

    Abstract Background: Severe acute respiratory infections (SARI) pose a great global burden. The contribution of respiratory viruses to adult SARI is relatively understudied in Asia. We aimed to determine viral aetiology of adult SARI patients in Kuala Lumpur, Malaysia.
    Methods: The prevalence of 20 common (mainly viral) respiratory pathogens, and MERS-CoV, SARS-CoV and 5 bacterial select agents was investigated from May 2017 to October 2019 in 489 SARI adult patients in Kuala Lumpur, Malaysia, using molecular assays (Luminex NxTAG-RPP kit and qPCR assays). Viral metagenomics analysis was performed on 105 negative samples.
    Results: Viral respiratory pathogens were detected by PCR in 279 cases (57.1%), including 10 (2.0%) additional detections by metagenomics analysis. The most detected viruses were rhinovirus/enterovirus (RV/EV) (49.1%) and influenza virus (7.4%). Three melioidosis cases were detected but no SARS-CoV, MERS-CoV or other bacterial select agents. Bacterial/viral co-detections and viral co-detections were found in 44 (9.0%) and 27 (5.5%) cases respectively, mostly involving RV/EV. Independent predictors of critical disease were male gender, chronic lung disease, lack of runny nose and positive blood culture with a significant bacterial pathogen. Asthma and sore throat were associated with increased risk of RV/EV detection, while among RV/EV cases, males and those with neurological disease were at increased risk of critical disease.
    Conclusions: Prior to the COVID-19 pandemic, the high prevalence of respiratory viruses in adults with SARI was mainly attributed to RV/EV. Continued surveillance of respiratory virus trends contributes to effective diagnostic, prevention, and treatment strategies.
    MeSH term(s) Adult ; COVID-19/epidemiology ; Enterovirus/genetics ; Female ; Humans ; Malaysia/epidemiology ; Male ; Pandemics ; Real-Time Polymerase Chain Reaction ; Respiratory Tract Infections ; Rhinovirus/genetics ; Viruses/genetics
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0273697
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