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  1. Article ; Online: Five Lessons of Resilience in Science.

    Corbett-Helaire, Kizzmekia S

    The Journal of infectious diseases

    2024  

    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae047
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  2. Article ; Online: Career advice from my father: "Go where you are loved".

    Corbett, Kizzmekia S

    Molecular biology of the cell

    2021  Volume 32, Issue 22, Page(s) ae3

    Abstract: I am honored to receive the E. E. Just Award. I applaud ASCB's commitment to recognizing the contributions of researchers from historically excluded racial and ethnic groups and appreciate my inclusion on a long list of accomplished peers. I also thank ... ...

    Abstract I am honored to receive the E. E. Just Award. I applaud ASCB's commitment to recognizing the contributions of researchers from historically excluded racial and ethnic groups and appreciate my inclusion on a long list of accomplished peers. I also thank Barney Graham, who not only had a profound impact on my own career, but has a deep commitment to advancing unrepresented groups in the sciences. Finally, I thank my parents, for encouraging me to use my scholarship to excite change, for reminding me that anything is possible, and for advising me with tenderness along the way. As I recently went through a career transition, I found myself returning to much of my father's sage advice. In this essay, I discuss one important piece of advice that I received from my father in hopes that it will help others navigate their own career choices.
    MeSH term(s) Academic Success ; Awards and Prizes ; COVID-19 ; Career Choice ; Fathers ; Female ; Humans ; Male ; Minority Groups ; Parents ; Research
    Language English
    Publishing date 2021-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E21-08-0398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 410: Show issues

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  3. Article ; Online: Prototype pathogen approach for pandemic preparedness: world on fire.

    Graham, Barney S / Corbett, Kizzmekia S

    The Journal of clinical investigation

    2020  Volume 130, Issue 7, Page(s) 3348–3349

    MeSH term(s) Health Planning/methods ; Humans ; Pandemics/prevention & control
    Keywords covid19
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI139601
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  5. Article ; Online: Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans.

    Ratnasiri, Kalani / Zheng, Hong / Toh, Jiaying / Yao, Zhiyuan / Duran, Veronica / Donato, Michele / Roederer, Mario / Kamath, Megha / Todd, John-Paul M / Gagne, Matthew / Foulds, Kathryn E / Francica, Joseph R / Corbett, Kizzmekia S / Douek, Daniel C / Seder, Robert A / Einav, Shirit / Blish, Catherine A / Khatri, Purvesh

    Cell reports

    2024  Volume 43, Issue 2, Page(s) 113706

    Abstract: Viral pandemics and epidemics pose a significant global threat. While macaque models of viral disease are routinely used, it remains unclear how conserved antiviral responses are between macaques and humans. Therefore, we conducted a cross-species ... ...

    Abstract Viral pandemics and epidemics pose a significant global threat. While macaque models of viral disease are routinely used, it remains unclear how conserved antiviral responses are between macaques and humans. Therefore, we conducted a cross-species analysis of transcriptomic data from over 6,088 blood samples from macaques and humans infected with one of 31 viruses. Our findings demonstrate that irrespective of primate or viral species, there are conserved antiviral responses that are consistent across infection phase (acute, chronic, or latent) and viral genome type (DNA or RNA viruses). Leveraging longitudinal data from experimental challenges, we identify virus-specific response kinetics such as host responses to Coronaviridae and Orthomyxoviridae infections peaking 1-3 days earlier than responses to Filoviridae and Arenaviridae viral infections. Our results underscore macaque studies as a powerful tool for understanding viral pathogenesis and immune responses that translate to humans, with implications for viral therapeutic development and pandemic preparedness.
    MeSH term(s) Animals ; Humans ; Immunoinformatics ; Orthomyxoviridae Infections ; Filoviridae ; Macaca ; Antiviral Agents
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113706
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  6. Article ; Online: Methods to Measure Antibody Neutralization of Live Human Coronavirus OC43.

    Boonyaratanakornkit, Jim / Sholukh, Anton M / Gray, Matthew / Bossard, Emily L / Ford, Emily S / Corbett, Kizzmekia S / Corey, Lawrence / Taylor, Justin J

    Viruses

    2021  Volume 13, Issue 10

    Abstract: The human Betacoronavirus OC43 is a common cause of respiratory viral infections in adults and children. Lung infections with OC43 are associated with mortality, especially in hematopoietic stem cell transplant recipients. Neutralizing antibodies play a ... ...

    Abstract The human Betacoronavirus OC43 is a common cause of respiratory viral infections in adults and children. Lung infections with OC43 are associated with mortality, especially in hematopoietic stem cell transplant recipients. Neutralizing antibodies play a major role in protection against many respiratory viral infections, but to date a live viral neutralization assay for OC43 has not been described. We isolated a human monoclonal antibody (OC2) that binds to the spike protein of OC43 and neutralizes the live virus derived from the original isolate of OC43. We used this monoclonal antibody to develop and test the performance of two readily accessible in vitro assays for measuring antibody neutralization, one utilizing cytopathic effect and another utilizing an ELISA of infected cells. We used both methods to measure the neutralizing activity of the OC2 monoclonal antibody and of human plasma. These assays could prove useful for studying humoral responses to OC43 and cross-neutralization with other medically important betacoronaviruses.
    MeSH term(s) Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Cell Line ; Common Cold/immunology ; Common Cold/pathology ; Common Cold/virology ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Coronavirus OC43, Human/immunology ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Neutralization Tests/methods ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2021-10-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13102075
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  7. Article: Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation.

    Wrapp, Daniel / Wang, Nianshuang / Corbett, Kizzmekia S / Goldsmith, Jory A / Hsieh, Ching-Lin / Abiona, Olubukola / Graham, Barney S / McLellan, Jason S

    bioRxiv : the preprint server for biology

    2020  

    Abstract: ... declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target ... MCM) development we determined a 3.5 Å-resolution cryo-EM structure of the 2019-nCoV S trimer ... evidence that the 2019-nCoV S binds ACE2 with higher affinity than SARS-CoV S. Additionally we tested ...

    Abstract The outbreak of a novel betacoronavirus (2019-nCov) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for urgently needed vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure (MCM) development we determined a 3.5 Å-resolution cryo-EM structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also show biophysical and structural evidence that the 2019-nCoV S binds ACE2 with higher affinity than SARS-CoV S. Additionally we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to nCoV-2019 S, suggesting antibody cross-reactivity may be limited between the two virus RBDs. The atomic-resolution structure of 2019-nCoV S should enable rapid development and evaluation of MCMs to address the ongoing public health crisis.
    Keywords covid19
    Language English
    Publishing date 2020-02-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2020.02.11.944462
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  8. Article ; Online: From mRNA sensing to vaccines.

    Fauci, Anthony S / Merad, Miriam / Swaminathan, Soumya / Hur, Sun / Topol, Eric / Fitzgerald, Kate / Reis e Sousa, Caetano / Corbett, Kizzmekia S / Bauer, Stefan

    Immunity

    2021  Volume 54, Issue 12, Page(s) 2676–2680

    Abstract: The 2005 Immunity paper by Karikó et al. has been hailed as a cornerstone insight that directly led to the design and delivery of the mRNA vaccines against COVID-19. We asked experts in pathogen sensing, vaccine development, and public health to provide ... ...

    Abstract The 2005 Immunity paper by Karikó et al. has been hailed as a cornerstone insight that directly led to the design and delivery of the mRNA vaccines against COVID-19. We asked experts in pathogen sensing, vaccine development, and public health to provide their perspective on the study and its implications.
    MeSH term(s) Animals ; COVID-19/immunology ; COVID-19 Vaccines/immunology ; History, 21st Century ; Humans ; RNA, Messenger/immunology ; SARS-CoV-2/physiology ; Vaccine Development/history ; World Health Organization ; mRNA Vaccines/immunology
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; mRNA Vaccines
    Language English
    Publishing date 2021-11-04
    Publishing country United States
    Document type Historical Article ; Journal Article ; Portrait
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.10.018
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    Zs.A 4227: Show issues Location:
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  9. Article ; Online: Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera.

    Hutchinson, Geoffrey B / Abiona, Olubukola M / Ziwawo, Cynthia T / Werner, Anne P / Ellis, Daniel / Tsybovsky, Yaroslav / Leist, Sarah R / Palandjian, Charis / West, Ande / Fritch, Ethan J / Wang, Nianshuang / Wrapp, Daniel / Boyoglu-Barnum, Seyhan / Ueda, George / Baker, David / Kanekiyo, Masaru / McLellan, Jason S / Baric, Ralph S / King, Neil P /
    Graham, Barney S / Corbett-Helaire, Kizzmekia S

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 6195

    Abstract: ... nanoparticles displaying coronavirus prefusion-stabilized spike (CoV_S-2P) trimers derived from MERS-CoV, SARS ... site on the S N-terminal domain. Moreover, mosaic nanoparticles co-displaying distinct CoV_S-2P trimers ...

    Abstract Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predominantly aimed at targeting conserved epitopes of the receptor binding domain. However, targeting conserved non-RBD epitopes could limit the potential for antigenic escape. To explore new potential targets, we engineered protein nanoparticles displaying coronavirus prefusion-stabilized spike (CoV_S-2P) trimers derived from MERS-CoV, SARS-CoV-1, SARS-CoV-2, hCoV-HKU1, and hCoV-OC43 and assessed their immunogenicity in female mice. Monotypic SARS-1 nanoparticles elicit cross-neutralizing antibodies against MERS-CoV and protect against MERS-CoV challenge. MERS and SARS nanoparticles elicit S1-focused antibodies, revealing a conserved site on the S N-terminal domain. Moreover, mosaic nanoparticles co-displaying distinct CoV_S-2P trimers elicit antibody responses to distant cross-group antigens and protect male and female mice against MERS-CoV challenge. Our findings will inform further efforts toward the development of pan-coronavirus vaccines.
    MeSH term(s) Male ; Female ; Animals ; Mice ; Antibodies, Viral ; Antibody Formation ; Middle East Respiratory Syndrome Coronavirus ; Epitopes/metabolism ; Vaccines ; Spike Glycoprotein, Coronavirus ; Antibodies, Neutralizing
    Chemical Substances Antibodies, Viral ; Epitopes ; Vaccines ; Spike Glycoprotein, Coronavirus ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-41661-4
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  10. Article ; Online: Adjuvanted SARS-CoV-2 spike protein vaccination elicits long-lived plasma cells in nonhuman primates.

    Prabhakaran, Madhu / Matassoli, Flavio / Leggat, David / Hoover, Abigayle / Srikanth, Abhinaya / Wu, Weiwei / Henry, Amy R / Wang, Jennifer / Lin, Bob C / Teng, I-Ting / Schramm, Chaim A / Castro, Mike / Serebryannyy, Leonid / Jean-Baptiste, Nazaire / Moore, Christopher / Gajjala, Suprabhath / Todd, John-Paul M / McCarthy, Elizabeth / Narpala, Sandeep /
    Francica, Joseph / Program, Vrc Production / Corbett-Helaire, Kizzmekia S / Douek, Daniel C / Kwong, Peter D / Seder, Robert A / Andrews, Sarah F / McDermott, Adrian B

    Science translational medicine

    2024  Volume 16, Issue 728, Page(s) eadd5960

    Abstract: Durable humoral immunity is mediated by long-lived plasma cells (LLPCs) that reside in the bone marrow. It remains unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein vaccination is able to elicit and maintain LLPCs. ...

    Abstract Durable humoral immunity is mediated by long-lived plasma cells (LLPCs) that reside in the bone marrow. It remains unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein vaccination is able to elicit and maintain LLPCs. Here, we describe a sensitive method to identify and isolate antigen-specific LLPCs by tethering antibodies secreted by these cells onto the cell surface. Using this method, we found that two doses of adjuvanted SARS-CoV-2 spike protein vaccination are able to induce spike protein-specific LLPC reservoirs enriched for receptor binding domain specificities in the bone marrow of nonhuman primates that are detectable for several months after vaccination. Immunoglobulin gene sequencing confirmed that several of these LLPCs were clones of memory B cells elicited 2 weeks after boost that had undergone further somatic hypermutation. Many of the antibodies secreted by these LLPCs also exhibited improved neutralization and cross-reactivity compared with earlier time points. These findings establish our method as a means to sensitively and reliably detect rare antigen-specific LLPCs and demonstrate that adjuvanted SARS-CoV-2 spike protein vaccination establishes spike protein-specific LLPC reservoirs.
    MeSH term(s) Animals ; Humans ; Spike Glycoprotein, Coronavirus ; Plasma Cells/metabolism ; Antibodies, Viral ; SARS-CoV-2 ; COVID-19/prevention & control ; Vaccination ; Adjuvants, Immunologic ; Primates ; Antibodies, Neutralizing
    Chemical Substances spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Antibodies, Viral ; Adjuvants, Immunologic ; Antibodies, Neutralizing
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.add5960
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