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  1. Article ; Online: Patient-Reported Outcomes Bridge an Important Gap in Identifying Risk for Early Endocrine Therapy Discontinuation.

    Wagner, Lynne I

    Journal of the National Cancer Institute

    2021  Volume 113, Issue 8, Page(s) 945–947

    MeSH term(s) Antineoplastic Agents, Hormonal/adverse effects ; Aromatase Inhibitors ; Humans ; Patient Reported Outcome Measures
    Chemical Substances Antineoplastic Agents, Hormonal ; Aromatase Inhibitors
    Language English
    Publishing date 2021-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djab024
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    Uh III Zs.131: Show issues Location:
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  2. Article ; Online: The Economic Burden of Injuries in Children With ADHD in the U.S. From 2011 to 2020.

    Shen, Jiabin / Shi, Junxin / Gauthier, Lynne / Li, Wenjun

    Journal of attention disorders

    2023  Volume 27, Issue 14, Page(s) 1561–1570

    Abstract: Objective: Few studies have examined the economic burden of and sociodemographic disparities in injuries on families of children with ADHD on a national scale. The objective of this study was to address these literature gaps.: Methods: Data from 7, ... ...

    Abstract Objective: Few studies have examined the economic burden of and sociodemographic disparities in injuries on families of children with ADHD on a national scale. The objective of this study was to address these literature gaps.
    Methods: Data from 7,102 children with ADHD aged 5 to 17 years in the Medical Expenditure Panel Survey 2011 to 2020 were analyzed for national trends, annualized average, and sociodemographic disparities in injury-related medical expenditures among children with ADHD.
    Results: The national economic burden of injuries for children with ADHD has nearly doubled over the10-year period. These costs were covered by private insurance (62%), public insurance (29%), and families (9%). Asian race was associated with higher total and family expenditures while having low income and public insurance were associated with lower family expenditures.
    Conclusions: Families and society carry significant and increasing economic burdens related to injuries in children with ADHD. Sociodemographic disparities are substantial and of policy relevance.
    MeSH term(s) Child ; Humans ; United States/epidemiology ; Financial Stress ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Health Expenditures ; Poverty
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547231196328
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    Zs.A 5196: Show issues Location:
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  3. Article ; Online: A Population-Based Study on Injury Risk and Disparities Among Children With ADHD.

    Shen, Jiabin / Shi, Junxin / Gauthier, Lynne / Li, Wenjun

    Journal of attention disorders

    2023  Volume 27, Issue 8, Page(s) 859–866

    Abstract: Objective: Impaired attention and inhibitory control put children with ADHD at potentially high risk of injury-one of the leading causes of disability in the general pediatric population. Existing research has yet to examine this important health risk ... ...

    Abstract Objective: Impaired attention and inhibitory control put children with ADHD at potentially high risk of injury-one of the leading causes of disability in the general pediatric population. Existing research has yet to examine this important health risk using nationally representative samples. This population-based study aimed to address this gap.
    Methods: National estimates of injury occurrences were generated from 66,236 children in the Medical Expenditures Panel Survey 2010-2019 datasets. Multiple logistic regression models further examined the impact of injury type, age, race/ethnicity, sex, parental education, income, marital and insurance status on injury prevalence.
    Results: Compared to children without ADHD, those with ADHD have significantly higher injury prevalence (
    Conclusions: Children with ADHD are more likely to experience injury. Future research should investigate mechanisms of injury disparities to inform future preventive efforts.
    MeSH term(s) Child ; Humans ; United States/epidemiology ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Ethnicity ; Prevalence ; Parents ; Multivariate Analysis
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547231158386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Guidelines needed for the management of fear of cancer recurrence in adult survivors of cancer in the United States: A consensus statement.

    Hall, Daniel L / Wagner, Lynne I / Lebel, Sophie / Smith, Allan Ben / Bergerot, Cristiane D / Park, Elyse R

    Cancer

    2024  

    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.35326
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  5. Article ; Online: In Reply to Al-Rashdan.

    Small, William / Wagner, Lynne I / Bruner, Deborah Watkins

    International journal of radiation oncology, biology, physics

    2021  Volume 111, Issue 2, Page(s) 578

    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2021.05.130
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    Zs.A 1218: Show issues Location:
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  6. Article ; Online: In Vitro Profiling of Potential Fish Probiotics, Enterococcus hirae Strains, Isolated from Jade Perch, and Safety Properties Assessed Using Whole Genome Sequencing.

    Li, Wenrui / Lim, Chiun Hao / Zhao, Zhongtian / Wang, Yulan / Conway, Patricia Lynne / Loo, Say Chye Joachim

    Probiotics and antimicrobial proteins

    2024  

    Abstract: The demands of intensified aquaculture production and escalating disease prevalence underscore the need for efficacious probiotic strategies to enhance fish health. This study focused on isolating and characterising potential probiotics from the gut ... ...

    Abstract The demands of intensified aquaculture production and escalating disease prevalence underscore the need for efficacious probiotic strategies to enhance fish health. This study focused on isolating and characterising potential probiotics from the gut microbiota of the emerging aquaculture species jade perch (Scortum barcoo). Eighty-seven lactic acid bacteria and 149 other bacteria were isolated from the digestive tract of five adult jade perch. The screening revealed that 24 Enterococcus hirae isolates inhibited the freshwater pathogens Aeromonas sobria and Streptococcus iniae. Co-incubating E. hirae with the host gut suspensions demonstrated a two- to five-fold increase in the size of growth inhibition zones compared to the results when using gut suspensions from tilapia (a non-host), indicating host-specificity. Genome analysis of the lead isolate, E. hirae R44, predicted the presence of antimicrobial compounds like enterolysin A, class II lanthipeptide, and terpenes, which underlay its antibacterial attributes. Isolate R44 exhibited desirable probiotic characteristics, including survival at pH values within the range of 3 to 12, bile tolerance, antioxidant activity, ampicillin sensitivity, and absence of transferable antimicrobial resistance genes and virulence factors commonly associated with hospital Enterococcus strains (IS16, hylEfm, and esp). This study offers a foundation for sourcing host-adapted probiotics from underexplored aquaculture species. Characterisation of novel probiotics like E. hirae R44 can expedite the development of disease mitigation strategies to support aquaculture intensification.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2487792-X
    ISSN 1867-1314 ; 1867-1306
    ISSN (online) 1867-1314
    ISSN 1867-1306
    DOI 10.1007/s12602-024-10244-0
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  7. Article ; Online: Arecoline in buccal cells reflects Areca nut dose.

    Lai, Jennifer F / Mendez, Ana Joy / Li, Xingnan / Wilkens, Lynne R / Herzog, Thaddeus / Franke, Adrian A

    Drug testing and analysis

    2024  

    Abstract: Areca nut (AN) is a carcinogen; its chewing cessation is, therefore, of worldwide interest. However, cessation biomarkers are lacking. We sought to establish arecoline in chewers' buccal cells (BCs) as a biomarker for AN dose. Self-reported AN doses, ... ...

    Abstract Areca nut (AN) is a carcinogen; its chewing cessation is, therefore, of worldwide interest. However, cessation biomarkers are lacking. We sought to establish arecoline in chewers' buccal cells (BCs) as a biomarker for AN dose. Self-reported AN doses, expressed as the average AN load ("AANL"), the product of AN amount, chewing time, and chewing frequency, were correlated by regression analysis with chewers' BC arecoline, measured by liquid chromatography mass spectrometry. We then determined whether associations differed between Class 1 chewers (who consume AN alone or with slaked lime, leaf, and/or spices) and Class 2 chewers (who consume any combination of the aforementioned ingredients plus tobacco). Among the 103 chewers, 28 Class 1 and 39 Class 2 chewers had detectable arecoline levels, which were used for analyses. A linear regression of cube-root transformed AANL on equally transformed BC arecoline levels provided the best model fit; resulting slopes and corresponding correlation coefficients were 0.86 and 0.40 (p < 0.01) for all; 1.09 and 0.51 (p < 0.01) for Class 1 chewers; 0.35 and 0.17 (p = 0.29) for Class 2 chewers; and 0.94 and 0.45 (p < 0.01), and 0.79 and 0.37 (p = 0.08), respectively, for those who included or excluded lime. Relationships between AANL and BC arecoline levels were similar between chewers who included or excluded lime (p = 0.76), but less between chewing classes (p = 0.14). This provides confidence that BC arecoline can generally act as a reliable biomarker for AN dose, useful for estimating efficacy in AN cessation studies and population-based chewing assessments.
    Language English
    Publishing date 2024-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3684
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    Zs.A 6792: Show issues Location:
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  8. Article: Rethinking Physical Activity Promotion During the COVID-19 Pandemic: Focus on a 24-hour Day.

    Li, Linda C / Feehan, Lynne M / Hoens, Alison M

    The Journal of rheumatology

    2021  Volume 48, Issue 8, Page(s) 1205–1207

    MeSH term(s) COVID-19 ; Exercise ; Health Promotion ; Humans ; Pandemics
    Language English
    Publishing date 2021-02-15
    Publishing country Canada
    Document type Editorial
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.201595
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    Zs.A 1168: Show issues Location:
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    Zs.MO 135: Show issues

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  9. Article ; Online: Comparisons of

    Sabra, Rayan / Narula, Akshay / Taylor, Lynne S / Li, Na

    Molecular pharmaceutics

    2022  Volume 19, Issue 9, Page(s) 3412–3428

    Abstract: The spontaneous formation of amorphous drug nanoparticles following the release of a drug from a supersaturating formulation is gaining increasing attention due to their potential contribution to increased oral bioavailability. The formation of nanosized ...

    Abstract The spontaneous formation of amorphous drug nanoparticles following the release of a drug from a supersaturating formulation is gaining increasing attention due to their potential contribution to increased oral bioavailability. The formation of nanosized drug particles also has considerable implications for the interpretation of
    MeSH term(s) Animals ; Cell Membrane Permeability ; Dogs ; Nanoparticles ; Permeability ; Rats ; Rats, Long-Evans ; Solubility
    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.2c00565
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  10. Article: Translation and cross-cultural adaptation of the National Health Service Sustainability Model to the Chinese healthcare context.

    Lai, Jie / Maher, Lynne / Li, Chaixiu / Zhou, Chunlan / Alelayan, Hasan / Fu, Jiaqi / Wu, Yanni

    BMC nursing

    2023  Volume 22, Issue 1, Page(s) 124

    Abstract: Background: International attention is being paid to the issue of making evidence sustainable after implementation. Developing an identification model is essential to promote and monitor the sustainability of evidence implementation. However, this model ...

    Abstract Background: International attention is being paid to the issue of making evidence sustainable after implementation. Developing an identification model is essential to promote and monitor the sustainability of evidence implementation. However, this model is not available in Chinese. This study aims to translate the National Health Service Sustainability Model into Chinese and to verify whether the model is adapted to the Chinese healthcare environment.
    Methods: This study follows the translation and validation guidelines developed by Sousa and Rojjanasrirat. The translations include forward and backward translations and their comparison. Expert reviews were used to validate the content validity of the Chinese version of the National Health Service sustainability model. Cognitive interviews were used to assess the validity of the language in the Chinese setting.
    Results: The translation was conducted by a bilingual research team and took 12 months. Expert reviews were undertaken with eight experts, and cognitive interviews with six participants. The content validity of the model is excellent, but at least 20% of the experts still felt that items one, three, five and nine needed refinements. In the cognitive interviews, most items, instructions and response options were well understood by the participants responsible for the evidence-based practice project. However, some language issues were still identified in items one, three, four, five, seven, nine, and ten. Participants reported that the sustainability results of the model assessment were consistent with their previous judgments of the items. Based on the expert review and interview results, items one, three, four, five, seven, nine and ten require further refinement. In summary, seven of the ten items have been amended.
    Conclusions: This study provides insight into how the National Health Service sustainability model can be used in the Chinese healthcare setting and paves the way for future large-scale psychometric testing.
    Language English
    Publishing date 2023-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091496-9
    ISSN 1472-6955
    ISSN 1472-6955
    DOI 10.1186/s12912-023-01293-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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