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Book ; Online: Desafios contemporâneos da educação

Ribeiro, Ricardo / Lemes, Sebastião de Souza / Silva, Hilda Maria Gonçalves da / David, Célia Maria

2015

Abstract: Se historicamente a educação escolar no Brasil foi marcada por um profundo corte elitista, o processo de democratização do ensino apresentou incontestáveis avanços desde a Constituição de 1988. A caminhada pela universalização, no entanto, não se deu à ... ...

Abstract	Se historicamente a educação escolar no Brasil foi marcada por um profundo corte elitista, o processo de democratização do ensino apresentou incontestáveis avanços desde a Constituição de 1988. A caminhada pela universalização, no entanto, não se deu à margem de suas heranças históricas, bem como novas fronteiras surgiram para o desafio da educação emancipatória.Esta obra reúne 17 ensaios que debatem os dilemas existentes no cotidiano da sala de aula. Divididos em três partes - Educação, culturas realidade social, Políticas educacionais e A escola -, os textos coligidos abordam temas variados relacionados à prática escolar, como cidadania, políticas afirmativas e gestão administrativa, e compõem um cenário contemporâneo dos principais desafios colocados para a educação de nosso tempo
Keywords	Education (General)
Size	1 electronic resource (370 p.)
Publisher	SciELO Books - Editora UNESP
Document type	Book ; Online
Note	Portuguese ; Open Access
HBZ-ID	HT020092200
ISBN	9788579836220 ; 8579836220
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: A systematic review and meta-analysis of the association between uric acid levels and chronic kidney disease.

Gonçalves, Danilo Lemes Naves / Moreira, Tiago Ricardo / da Silva, Luciana Saraiva

Scientific reports

2022 Volume 12, Issue 1, Page(s) 6251

Abstract: The function of uric acid (UA) in the genesis and evolution of chronic kidney disease (CKD) has motivated numerous studies, but the results remain inconclusive. We sought to conduct a systematic review and meta-analysis of cohort studies aiming to ... ...

Abstract	The function of uric acid (UA) in the genesis and evolution of chronic kidney disease (CKD) has motivated numerous studies, but the results remain inconclusive. We sought to conduct a systematic review and meta-analysis of cohort studies aiming to analyze the association of UA levels with the incidence and progression of CKD. Pubmed/Medline, Lilacs/Bireme and Web of Science were searched to identify eligible studies, following the PRISMA protocol. Data were presented for CKD incidence and progression separately. For the meta-analysis, studies with data stratified by subgroups according to serum UA levels were selected. The inverse variance-weighted random effects model was used to generate a combined effect estimate. Meta-regressions were performed to identify the causes of heterogeneity. The Newcastle-Ottawa Scale was used to assess the risk of bias. The publication bias was tested by funnel plot and Egger's test. Eighteen CKD incidence studies (n = 398,663) and six CKD progression studies (n = 13,575) were included. An inverse relationship was observed between UA levels and protection from CKD incidence and progression. Lower UA levels were protective for the risk of CKD incidence (RR 0.65 [95% CI 0.56-0.75]) and progression (RR 0.55 [95% CI 0.44-0.68]). UA seems to be implicated both in the genesis of CKD and its evolution.
MeSH term(s)	Cohort Studies ; Female ; Humans ; Incidence ; Male ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Uric Acid
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2022-04-15
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-10118-x
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Article ; Online: A systematic review and meta-analysis of the association between uric acid levels and chronic kidney disease

Danilo Lemes Naves Gonçalves / Tiago Ricardo Moreira / Luciana Saraiva da Silva

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract The function of uric acid (UA) in the genesis and evolution of chronic kidney disease (CKD) has motivated numerous studies, but the results remain inconclusive. We sought to conduct a systematic review and meta-analysis of cohort studies aiming ... ...

Abstract	Abstract The function of uric acid (UA) in the genesis and evolution of chronic kidney disease (CKD) has motivated numerous studies, but the results remain inconclusive. We sought to conduct a systematic review and meta-analysis of cohort studies aiming to analyze the association of UA levels with the incidence and progression of CKD. Pubmed/Medline, Lilacs/Bireme and Web of Science were searched to identify eligible studies, following the PRISMA protocol. Data were presented for CKD incidence and progression separately. For the meta-analysis, studies with data stratified by subgroups according to serum UA levels were selected. The inverse variance-weighted random effects model was used to generate a combined effect estimate. Meta-regressions were performed to identify the causes of heterogeneity. The Newcastle–Ottawa Scale was used to assess the risk of bias. The publication bias was tested by funnel plot and Egger’s test. Eighteen CKD incidence studies (n = 398,663) and six CKD progression studies (n = 13,575) were included. An inverse relationship was observed between UA levels and protection from CKD incidence and progression. Lower UA levels were protective for the risk of CKD incidence (RR 0.65 [95% CI 0.56–0.75]) and progression (RR 0.55 [95% CI 0.44–0.68]). UA seems to be implicated both in the genesis of CKD and its evolution.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Novel Ehrlichia and Hepatozoon genotypes in white-eared opossums (Didelphis albiventris) and associated ticks from Brazil.

André, Marcos Rogério / Calchi, Ana Cláudia / Perles, Livia / Gonçalves, Luiz Ricardo / Uccella, Lucas / Lemes, Jhessye Rafaela Batista / Nantes, Wesley Arruda Gimenes / Santos, Filipe Martins / Porfírio, Grasiela Edith de Oliveira / Barros-Battesti, Darci Moraes / Herrera, Heitor Miraglia / Machado, Rosangela Zacarias

Ticks and tick-borne diseases

2022 Volume 13, Issue 6, Page(s) 102022

Abstract: White-eared opossums (Didelphis albiventris) are well adapted to anthropized areas. The increased contact with domestic animals and humans mediates the transmission of arthropod-borne pathogens. Despite the worldwide occurrence of tick-borne ... ...

Abstract	White-eared opossums (Didelphis albiventris) are well adapted to anthropized areas. The increased contact with domestic animals and humans mediates the transmission of arthropod-borne pathogens. Despite the worldwide occurrence of tick-borne Anaplasmataceae and Hepatozoidae species in a variety of vertebrates, few studies reported serological evidence or molecular detection of theses agentes in marsupials. Up to now, while Ehrlichia/Anaplasma spp. have only been detected in marsupials from Brazil, Hepatozoon spp. have been reported in marsupials from Chile, Australia and Brazil. The present work aimed to investigate, using molecular techniques and blood smear analysis, the presence of Ehrlichia spp., Anaplasma spp., and Hepatozoon sp. in the blood and ticks collected from D. albiventris in urban forest fragments from midwestern Brazil. Between May and December 2017, 43 D. albiventris (27 males and 16 females) were captured for blood and tick collection in the city of Campo Grande, state of Mato Grosso do Sul, midwestern Brazil. Ticks (46 Amblyomma dubitatum nymphs and 24 Amblyomma spp. larvae) were collected from 14 out 43 (32.5%) of the white-eared opossums. Panoptic-stained blood smears were performed using peripheral blood (tail tip) of the captured opossums. DNA extracted from blood and tick samples were subjected to PCR/qPCR assays for Anaplasmataceae agents (rrs, gltA, groEL, sodB, and dsb genes, and 23S-5S intergenic region) and Hepatozoon spp. (18S rRNA gene), followed by Sanger sequencing, BLASTn and phylogenetic analyses. An inclusion resembling Ehrlichia morulae was found in a white-eared opossum's monocyte from a blood smear stained with Panoptic. Five (11.63% [5/43]) white-eared opossums' blood samples and 7 (25% [7/28]) tick samples (2 pools of Amblyomma spp. larvae and 5 pools of A. dubitatum nymphs) were positive for Anaplasmataceae via a PCR assay targeting the conserved rrs gene. Phylogenetic analysis based on the rrs gene positioned three sequences obtained from opossums and ticks together as a subclade within the Ehrlichia canis clade. However, all samples were negative in a qPCR assay specific for E. canis based on the dsb gene. Phylogenetic analyses positioned the gltA and 23S-5S ITS sequences obtained from opossums' blood samples in a separate clade from the other validated Ehrlichia species. One (2.3% [1/43]) opossum blood sample was positive for the 18S rRNA gene of Hepatozoon sp. The phylogenetic analysis positioned the Hepatozoon sp. sequence obtained from a D. albiventris specimen in a clade with a sequence previously detected in a black storm petrel (Oceanodroma melania) from Mexico. All the other sequences of Hepatozoon sp. previously detected in marsupials from Brazil were positioned in a separated clade. The present work showed the occurrence of putative novel genotypes of Ehrlichia sp. and Hepatozoon sp. in white-eared opossums and associated A. dubitatum ticks from midwestern Brazil.
Language	English
Publishing date	2022-08-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2541872-5
ISSN	1877-9603 ; 1877-959X
ISSN (online)	1877-9603
ISSN	1877-959X
DOI	10.1016/j.ttbdis.2022.102022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integrative transcriptome analysis of SARS-CoV-2 human-infected cells combined with deep learning algorithms identifies two potential cellular targets for the treatment of coronavirus disease.

Gonçalves, Ricardo Lemes / de Souza, Gabriel Augusto Pires / de Souza Terceti, Mateus / de Castro, Renato Fróes Goulart / de Mello Silva, Breno / Novaes, Romulo Dias / Malaquias, Luiz Cosme Cotta / Coelho, Luiz Felipe Leomil

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2022 Volume 54, Issue 1, Page(s) 53–68

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly spread worldwide, leading coronavirus disease 2019 (COVID-19) to hit pandemic level less than 4 months after the first official cases. Hence, the search for drugs and vaccines that ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly spread worldwide, leading coronavirus disease 2019 (COVID-19) to hit pandemic level less than 4 months after the first official cases. Hence, the search for drugs and vaccines that could prevent or treat infections by SARS-CoV-2 began, intending to reduce a possible collapse of health systems. After 2 years, efforts to find therapies to treat COVID-19 continue. However, there is still much to be understood about the virus' pathology. Tools such as transcriptomics have been used to understand the impact of SARS-CoV-2 on different cells isolated from various tissues, leaving datasets in the databases that integrate genes and differentially expressed pathways during SARS-CoV-2 infection. After retrieving transcriptome datasets from different human cells infected with SARS-CoV-2 available in the database, we performed an integrative analysis associated with deep learning algorithms to determine differentially expressed targets mainly after infection. The targets found represented a fructose transporter (GLUT5) and a component of proteasome 26s. These targets were then molecularly modeled, followed by molecular docking that identified potential inhibitors for both structures. Once the inhibition of structures that have the expression increased by the virus can represent a strategy for reducing the viral replication by selecting infected cells, associating these bioinformatics tools, therefore, can be helpful in the screening of molecules being tested for new uses, saving financial resources, time, and making a personalized screening for each infectious disease.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Molecular Docking Simulation ; Deep Learning ; Gene Expression Profiling
Language	English
Publishing date	2022-11-26
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-022-00875-2
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Article ; Online: Mutation of critical residues reveals insights of yellow fever virus nonstructural protein 1 (NS1) stability and its formation.

Menezes, Gabriela de Lima / Gonçalves, Ricardo Lemes / Lima, Raisa Melo / Pereira, Maristela / Moreli, Marcos Lázaro / da Silva, Roosevelt Alves

Journal of biomolecular structure & dynamics

2019 , Page(s) 1–10

Abstract: Communicated by Ramaswamy H. Sarma. ...

Abstract	Communicated by Ramaswamy H. Sarma.
Language	English
Publishing date	2019-11-27
Publishing country	England
Document type	Letter
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2019.1695673
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Article ; Online: Óleo vegetal na dieta de equinos submetidos a exercício

André Eduardo Mello Cerbaro / Rodolfo Noal Gonçalves / Jaqueline Schneider Lemes / Magda Pierezan / Vinícius Leobet Lunkes / Ricardo Zambarda Vaz

Research, Society and Development, Vol 9, Iss

2020 Volume 9

Abstract: Objetivou-se e avaliar os efeitos da adição de óleo de soja nos parâmetros séricos e fisiológicos de equinos submetidos a exercício físico. Foram utilizadas 6 éguas da raça Crioula, com idade de quatro anos, e peso aproximado de 350 kg. Os tratamentos ... ...

Abstract	Objetivou-se e avaliar os efeitos da adição de óleo de soja nos parâmetros séricos e fisiológicos de equinos submetidos a exercício físico. Foram utilizadas 6 éguas da raça Crioula, com idade de quatro anos, e peso aproximado de 350 kg. Os tratamentos foram: Controle 5 kg de MS de aveia (Avena sativa) e 5 kg de MS de Capim Aruana (Panicum Jacq., cv. Aruana); Tratado: 3,52 kg de aveia (Avena sativa), 5 kg de MS de Capim Aruana (Panicum Jacq., cv. Aruana) e 500 g de óleo de soja. Foram efetuadas pesagens e coleta de sangue, no dia 0, 14 e 28 dias de experimento em jejum para análise dos parâmetros séricos. Aos 28 dias de experimentação os equinos foram submetidos a exercício, durante 30 minutos. Antes do início foram realizadas coletas, em jejum, pela manhã e imediatamente após o exercício, 10 minutos e 3 horas após o fim do exercício, além de aferir os parâmetros fisiológicos antes e logo após o exercício. Os valores apresentaram diferença significativa (P<0,05) para colesterol total, HDL, LDL, VLDL e triglicerídeo aos 14 dias de experimento, aos 28 dias diferença apenas para (P<0,05) colesterol total e LDL. Com a realização do exercício não houve diferença nos parâmetros séricos, mas observou-se diferença para os parâmetros fisiológicos entre os períodos de coleta. A adição de óleo de soja na dieta de equinos submetidos a exercício não interfere os parâmetros séricos, tornando-se assim uma alternativa para dietas energéticas.
Keywords	Aveia ; Colesterol ; Parâmetros séricos ; Parâmetros fisiológicos ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390 ; Social Sciences ; H
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A NANOTECNOLOGIA NO BRASIL E O DESENVOLVIMENTO DE PRODUTOS COM ATIVIDADE ANTIMICROBIANA

Bruna de Paula Dias / Erica Milena de Castro Ribeiro / Ricardo Lemes Gonçalves / Diego Santos Oliveira / Tiago Hilário Ferreira / Breno de Mello Silva

Química Nova, Vol 44, Iss 8, Pp 1084-

2021 Volume 1092

Abstract: NANOTECHNOLOGY IN BRAZIL AND THE DEVELOPMENT OF PRODUCTS WITH ANTIMICROBIAL ACTIVITY. Due to the tremendous technological potential and applicability in various industry branches, nanotechnology investments have been increasing over the years. In ... ...

Abstract	NANOTECHNOLOGY IN BRAZIL AND THE DEVELOPMENT OF PRODUCTS WITH ANTIMICROBIAL ACTIVITY. Due to the tremendous technological potential and applicability in various industry branches, nanotechnology investments have been increasing over the years. In particular, the control of microorganisms using nanomaterials with antimicrobial action has aroused great interest in the industry. This control makes it necessary in the most diverse situations, such as food conservation, pharmaceutical industry, hospital environments, and even domestic and commercial environments. This extraordinary interest is due, in particular, to the physical-chemical characteristics of materials on a nanoscale that attributes greater efficiency in combating microorganisms. Therefore, researchers and entrepreneurs have directed investments and efforts towards developing new products and/or new applications for antimicrobial products already existing on the market. In this work, we made a brief presentation of the history of nanotechnology in Brazil with a focus on Brazilian companies that developed products or services with nanomaterials with antimicrobial action, and on the description of some of the existing applications in the Brazilian market, highlighting the productive potential of the parents.
Keywords	nanotechnology ; antimicrobials ; innovation ; Chemistry ; QD1-999
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Sociedade Brasileira de Química
Document type	Article ; Online
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Article ; Online: SARS-CoV-2 mutations and where to find them: an

Gonçalves, Ricardo Lemes / Leite, Túlio César Rodrigues / Dias, Bruna de Paula / Caetano, Camila Carla da Silva / de Souza, Ana Clara Gomes / Batista, Ubiratan da Silva / Barbosa, Camila Cavadas / Reyes-Sandoval, Arturo / Coelho, Luiz Felipe Leomil / Silva, Breno de Mello

Journal of biomolecular structure & dynamics

2020 Volume 40, Issue 7, Page(s) 3336–3346

Abstract: Communicated by Ramaswamy H. Sarma. ...

Abstract	Communicated by Ramaswamy H. Sarma.
MeSH term(s)	COVID-19 ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutation ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
Chemical Substances	Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-06
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2020.1844052
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Article: Isohemigossypolone: Antiophidic properties of a naphthoquinone isolated from Pachira aquatica Aubl.

Vieira, Sâmela Alves Pereira Batista / Dos Santos, Benedito Matheus / Santos Júnior, Célio Dias / de Paula, Vanderlúcia Fonseca / Gomes, Mario Sergio Rocha / Ferreira, Glaucio Monteiro / Gonçalves, Ricardo Lemes / Hirata, Mario Hiroyuki / da Silva, Roosevelt Alves / Brandeburgo, Maria Inês Homsi / Mendes, Mirian Machado

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

2021 Volume 245, Page(s) 109028

Abstract: We investigated the antiophidic properties of isohemigossypolone (ISO), a naphthoquinone isolated from the outer bark of the Pachira aquatic Aubl. The inhibition of phospholipase ... ...

Abstract	We investigated the antiophidic properties of isohemigossypolone (ISO), a naphthoquinone isolated from the outer bark of the Pachira aquatic Aubl. The inhibition of phospholipase A
MeSH term(s)	Animals ; Bombacaceae/chemistry ; Crotalid Venoms/antagonists & inhibitors ; Male ; Metalloproteases/metabolism ; Mice ; Naphthoquinones/chemistry ; Naphthoquinones/pharmacology ; Phospholipases A2/metabolism ; Plant Bark/chemistry ; Plant Extracts/pharmacology ; Snake Bites/drug therapy
Chemical Substances	Crotalid Venoms ; Naphthoquinones ; Plant Extracts ; Phospholipases A2 (EC 3.1.1.4) ; Metalloproteases (EC 3.4.-)
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	189285-x
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
ISSN	1532-0456 ; 0306-4492 ; 0742-8413
DOI	10.1016/j.cbpc.2021.109028
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